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Via do mevalonato
Pirofosfato de isopentenilo (IPP)
Via da desoxixilulose ou da
2-C-metil-D-eritritol 4-fosfato
Recentemente descoberta Pirofosfato de dimetilalilo (DMAPP)
No citosol
A via da desoxixilulose fosfato
na biossíntese de terpenos
Via mevalonato:
AACT, acetoacetyl-CoA thiolase;
HMGS, 3-hydroxy-3-methylglutaryl-CoA synthase;
HMGR, 3-hydroxy-3-methylglutaryl- CoA reductase;
Desoxixilulose MK, mevalonate kinase;
fosfato
PMK, 5-phosphomevalonate kinase;
Estatinas DPMDC, 5-diphosphomevalonate decarboxylase;
IPPI, isopentenyl diphosphate-dimethylallyl diphosphate
2-C-metil-D-
(Mevinolina eritritol-4-fosfato
isomerase.
ou DMAPP, dimethylallyl diphosphate;
Lovastatina) HMGCoA, 3-hydroxy-3-methylglutaryl-CoA;
4-(citidina -5`-
IPP, isopentenyl diphosphate.
difosfo)-2-C-
metil-D-eritritol Via desoxixilulose fosfato:
DXS, 1-deoxy-D-xylulose-5-phosphate synthase;
DXR, 1-deoxy-D-xylulose-5-phosphate reductoisomerase;
MCT, 2-C-methyl-D-erythritol-4-phosphate cytidyl transferase;
CMK, 4-(cytidine 5`-diphospho)-2-C-methyl-D-erythritol kinase;
MCS, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase;
HDS, 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate synthase;
HDR, 1-hydroxy-2-methyl-2-(E)-butenyl-4-diphosphate
reductase;
IPPI, IPP-DMAPP isomerase.
CDP-ME, 4-(cytidine 5`-diphospho)-2-C-methyl-D-erythritol;
CDP-MEP, 2-phospho-4-(cytidine 5`-diphospho)-2-C-methyl-D-
erythritol;
DMAPP, dimethylallyl diphosphate;
DXP, 1-deoxy-D-xylulose-5-phosphate;
HMBPP, 1-hydroxy-2-methyl-2-(E)-butenyl 4-phosphate;
IPP, isopentenyl diphosphate;
ME-CPP, 2-C-methyl-D-erythritol-2,4-cyclodiphosphate;
MEP, 2-C-methyl-D-erythritol-4-phosphate.
Florence Bouvier, Alain Rahier, Bilal Camara. Biogenesis, molecular regulation and function of plant
Isoprenoids. Progress in Lipid Research. 44 (2005) 357–429.
De forma geral,
nas plantas:
Desoxixilulose (Plastídeos)
Esteróides
Mycobacterium tuberculosis
Plasmodium falciparum
Helicobacter pylori
Importância da via da desoxixilulose fosfato para a terapêutica
Importância da via da desoxixilulose fosfato para a terapêutica
Paclitaxel
Taxol R
Formação dos precursores de cada classe de compostos terpénicos.
DXP
Sesquiterpenos C15
Diterpenos C20