kfupm.edu.

sa

Paper-based disposable analytical devices for on-

site applications

Name: Shuaib Ahmed Mubarak

ID : 201708650
 why paper based analytical devices.

μPAD
In expensive
Sensitive Paper
Specific Capillary action
Biocompatible
User-friendly
Thin and flexible
Rapid and robust Easy and cheap
Equibment free manufacture
Delivarable to Hyrophilicity
end user High surface area
Biologically Easy to fabricate
compatible
 Fabrication methods
Wax printing
Inkjet printing
Photolithography
Feloxothogrpahy
Laser treatment
Plotting
Stamping
 Wax printing

Advantages

 Simple method
 Rapid process
 Adequate for most μPADs
 Hydrophilic wax channels not
exposed to polymers or solvents

Disadvantages
 Expensive wax
 Extra heating step after deposition
 Design of patterns must account
for wax spreading
 Ink jet printing

Advantages
 Produce large scale fast and simple
 Uses cheap patterning agents
 Reagents easily inkjet printed

Disadvantages
 Requires custom inject printer
 Can be slow
 hydrophilic areas exposed to polymers
 Photolithography

Advantages

 high resolution of microfluidic

Channels
 sharp barriers
 Rapid method

Disadvantages

 Requires expensive equipment;

 complex steps
 expensive reagents
 Vulnerable to bending
Fabrication methods of 3D μPAD
Applications

(Gabriel et al. 2017)

Color scale for visual detection of tear glucose levels.

(Gabriel et al. 2017)

(Lopez-Ruiz et al. 2014)
Microfluidic device with the
reagents placed in each
sensing area

(Lopez-Ruiz et al. 2014)

 Conclusion
Based on the literature review paper based
analytical devises is used in :

 Biochemical detection
 Immunological detection
 Molecular detection
 Environmental detection
 Other detection methods
 References
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[3] Y. Yang, E. Noviana, M. P. Nguyen, B. J. Geiss, D. S. Dandy, and
C. S. Henry, “Paper-Based Microfluidic Devices: Emerging Themes and
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[4] D. M. Cate, J. A. Adkins, J. Mettakoonpitak, and C. S. Henry,
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[5] Y. Xia, J. Si, and Z. Li, “Fabrication techniques for microfluidic
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testing: A review,” Biosens. Bioelectron., vol. 77, pp. 774–789, 2016.