Académique Documents
Professionnel Documents
Culture Documents
Presented By:
Mr. Kiran D. Baviskar,
Assist. Professor
Dept. of Pharmaceutics,
Gemmule formation-
In fresh water sponges, formation of gemmules takes place by
aggregation of archeocytes.
A layer of amoebocytes secrete hard, chitinous membrane
around these archeocytes.
Gemmule formation is the formation of internal bud to
overcome unfavourable conditions.
On return of favourable conditions gemmules hatch and
develop into new individuals eg. Spongilla, Ephydatia.
BUDDING:
A few multi-cellular animals like coelenterates and ascidians
produce small buds which grow gradually.
Testes are soft, smooth, pinkish oval organs about 4.5 cm long,
2.5 cm wide and 3 cm thick.
Epididyms-
These are a pair of “C” shaped structures lying along the
posterior border of each testis.
In the tail, sperms are stored for short period and then
enter the vas deferens.
Labia minora:
These are smaller and thinner lip like folds located just
medially to the labia majora.
Posteriorly the labia minora are fused together to form the
fourchette.
Mons pubis:
It is fleshy elevation above the labia majora.
Clitoris:
It is a small erectile organ lying at the anterior end of the labia
minora.
It is homologous to the penis of males. It shows presence of
erectile tissues.
Vestibule:
It is a median vertical depression of vulva enclosing vagina
and urethral opening.
Hymen:
It is a thin layer of mucous membrane which partially occludes
the opening of the vagina.
Vestibular glands:
These are a pair of vestibular gland or Bartholin’s glands
which occur on each sides of the vaginal opening.
These glands are homologous to the Cowper’s glands of the
male.
They secrete a lubricating fluid.
Breasts: These are a pair of rounded structures found in
pectoral region on ventral thoracic wall.
It has an erectile nipple in the middle.
These are a pair of modified sweat glands. Each breast
contains fatty connective tissue and numerous lactiferous
glands.
It has 15- 20 openings of lactiferous ducts which carry milk
from mammary glands to nipples.
Lactiferous ducts dilate and form lactiferous sinuses just
beneath the nipple to store the milk.
The base of the nipple shows dark brown rounded area called
areola.
Release of milk from breast is under the control of prolactin
and oxytocin of pituitary gland.
The female reproductive system consists of-
Ovaries
Fallopian tubes
Uterus
Vagina
Ovaries:
A pair of ovaries are the primary sex organs of the female
reproductive system.
They are almond- shaped bodies each measuring about 3 cm
long, 1.5 cm wide and I cm thick.
The ovaries lie in the lower part of the abdomen.
Each ovary is suspended from the dorsal body wall (to broad
ligament) by a fold of peritoneum.- the mesovarium.
Ovary is connected to uterus by an ovarian ligament and is
connected to lateral body wall by a suspensory ligament.
Ovaries produce ova and also female sex hormones- oestrogen
and progesterone.
These two hormones control menstrual cycle and secondary
sexual character.
Structure of Ovary :
Each ovary is a compact structure consisting of inner medulla
and outer cortex.
The medulla contains connective tissue called stroma.
The cortex is lined by germinal epithelium.
Oogonia arise from endoderm of the yolk sac and migrate to
ovaries during embryonic development.
The process of oogenesis begins even before the birth of
female baby.
The ovaries contain 2 millions or more oogonia which become
primary oocytes about six months before a human female is
born.
At the time of birth, about 1 million primordial follicles are
present in each ovary and only about 40,000 remain by the
time of puberty, rest being degenerated.
Out of these, during every menstrual cycle only one Graafian
follicle reaches to maturity and then ovulation takes place.
The remaining follicles degenerate (atrefied).
Menarch (onset of the menstrual cycle) is at the age of about
thirteen years and menopause (end of menstrual cycle) is at the
age of about forty five years.
So the reproductive span is approximately thirty two years.
There are about 13 menstrual cycles per years.
So 32 X 13= 416 eggs may be released.
Histology of ovary -
Tunica albuginea is a whitish capsule of dense irregular
connective tissue located immediately inside the germinal
epithelium.
Ovary shows cyclic changes during menstrual cycle.
Cortical region shows different stages of development of
ovarian follicles or Graafian follicles.
Each follicle contains a large ovum surrounded by many
layers of follicle cells.
The follicle cells of a maturing follicle secrete oestrogen.
Different stages of developing ovarian follicles are seen in the
cortex and consists of oocytes in various stages of
development.
In the beginning, a single layer of follicular cells surround
each oocyte and the entire structure is called a primordial
follicle.
Although the stimulating mechanism is unclear, a few
primordial follicles periodically start to grow even during
childhood.
They become primary follicles which are surrounded first by
one layer of follicular cells and then by 6 - 7 layers of
granulosa cells.
As the follicle grows, it forms a clean glycoprotein layer,
called the zone pellucid between primary oocyte and
granulose cells.
The innermost layer of granulose cells become firmly attached
to zone pellucid to form corona radiata. (corona-crown;
radiate-radiating)
The outermost granulose cells rest on a basement membrane.
Encircling the basement membrane is a region called theca
folliculi.
Many capillaries are present in the theca folliculi.
Uterus:
It is also known as womb. It is a pear- shaped, highly
muscular, thick walled, hollow organ. It is about 8 cm long. 5
cm wide, and 2 cm thick.
It is present in the pelvic cavity between the rectum from
behind and urinary bladder in front.
It is attached to the body wall by double fold of peritoneum
called mesometrium or broad ligament.
It is differentiated into:
(i)A dome shaped part above the opening of uterine tubes is
called fundus.
(ii)Broad upper part called body or corpus
(iii)Narrow cylindrical part called cervix.
Body of uterus receives the oviduct at its right and left upper
angles.
The cervix projects and opens into vagina.
The cervix communicates above with the body of the uterus by
an aperture, the internal os and with vagina below by an
opening, external os.
The highly distensible uterine wall consists of an outer serous
layer derived from peritoneum called perimetrium.
The middle thick muscular layer of smooth muscles is called
myometrium.
The inner highly vascular mucosa is called endometrium.
It shows many uterine glands. It undergoes cyclic changes in
thickness during menstrual cycle.
Uterus receives the ovum from Fallopian tube. It forms
placenta for the development of the foetus.
It expels the young one at birth.
Vagina-
This is highly collapsible and highly distensible fibro-
muscular tube in which cervix opens.
It measures about 7.5 cm to 10 cm in length. It opens into the
vestibule of vulva.
Inner lining cells of vagina store glycogen.
Vaginal bacteria mainly Lactobacilli ferment the glycogen and
this makes the mucous acidic.
Highly acidic medium in vagina prevents infection by fungus.
In girls the opening of vagina into the vestibule of vulva is
partially covered over by a fold of mucous membrane called
hymen.
Vagina is a copulatory passage as it receives erected penis
during intercourse. It allows passage of menstrual flow.
It serves as the birth canal during parturition.
Puberty in females:
Puberty is the age at which the internal reproductive organs
reach maturity.
This is called the menarche which marks the beginning of the
child bearing period.
The ovaries are stimulated by the gonadotropins from the
anterior pituitary- the follicle stimulating hormone and
luteinizing hormone.
The age of puberty varies between 10 to 14 years.
Menopause or climactic period is the ceasing of menstrual
cycle i.e. end of childbearing period.
It usually occurs between the age of 45 to 50 yrs.
During menopause the ovaries gradually become less
responsive to the FSH and LH.
The menstrual cycle becomes irregular and then stops.
It also shows secondary effects of menopause like
osteoporosis, increase in blood cholesterol and hot flushing,
sweating and palpitation.
MENSTRUAL CYCLE ( FEMALE REPRODUCTIVE
CYCLE OR OVARIAN CYCLE):
The menstrual cycle is characteristic of primates (monkeys,
apes and humans).
It starts at the time of puberty and the period is called
menarche.
Menstrual cycle in humans lasts for 28days.
The days are numbered from the first day of blood flow in
the menstrual period.
A series of events occur regularly in females after every 26 to
30 days throughout the childbearing period of about 32 yrs.
The menstrual cycle consists of a series of changes that take
place simultaneously in the ovaries and uterine wall
(endometrium) stimulated by different concentrations of
gonadotropins like FSH and LH.
Follicle stimulating hormone promotes the maturation of
ovarian follicles and secretion of oestrogen leading to
ovulation while luteinizing hormone stimulates the
development of corpus luteum and secretion of progesterone
Changes in uterus:
Oestrogen secreted by follicular cells of ovary stimulate
endometrial glands.
This causes repair of endometrium .
]The endometrial cells proliferate and thickness of
endometrium grows to about 3mm to 5mm.
Ill) Ovulatory Phase
Ovulation is the process in which there is rupture of Graafian
follicle with discharge of ovum into abdominal cavity.
It is Changes in ovary under the influence of luteinizing
hormone.
A sudden rise in level of LH stimulates ovulation which occurs
usually on 14th day of menstrual cycle.
The rupture of Graafian follicle results in oozing out of
follicular fluid.
The ovum along with radially arranged cells (corona radiata)
is released into the abdominal cavity.
The ovum enters the Fallopian tube through ostium assisted by
fimbriae.
The Ovum is released on 14th day , but till 9 to 16 days are
considered as fertilization period, Why?
Change in ovary-
After ovulation, the ruptured follicle develops into a yellow
body called corpus luteum.
After the discharge of ovum, the remaining cells of Graafian
follicle together form corpus luteum.
It acts as temporary endocrine gland which secretes
progesterone.
Progesterone secretion is under the influence of luteinizing
hormone.
Progesterone helps in maintaining the thickness of
endometrium. So it is also called pregnancy hormone.
Corpus luteum is active till the placenta takes up the function
of secretion of hormone human chorionic gonadotropin
(HCG).
HCG is similar to LH.
(Abortion occurs if corpus luteum becomes inactive before the
formation of placenta about three months of pregnancy}.
Spermatogenesis:
The process of spermatogenesis takes place in male gonads
called Testes.
Each testis has seminiferous tubules which are lined by
cuboidal epithelium called germinal epithelium.
The cells of germinal epithelium undergo spermatogenesis to
produce sperms.
In between germinal cells are present Sertoil cells or Nurse
cells.
Sertoil cells provide nourishment to the sperms.
Germinal cells in testes are known as primary germinal cells
or primordial germ cells.
Primordial cell passes through three phases namely,
Multiplication phase
growth phase
maturation phase.
Neck:
It is very short region having two centrioles.
The proximal centriole plays a role in first cleavage of
zygote.
The distal centriole gives rise to the axial filament of the
sperm.
Middle piece:
It serves as power house for sperm.
It has many mitochondria spirally coiled (Nebenkern) around
the axial filament.
The mitochondria provide energy for the movement of the
sperm in the female genital tract.
Posterior half of nucleus, neck , middle piece of sperm are
covered by a sheath.
i) Multiplication phase:
Germinal cells undergo mitosis to form large number of
oogonia.
Oogonia in human beings are formed in ovary of female baby
even before her birth.
Its foetal surface is smooth and has the umbilical cord attached
near its centre.
Structure:
Human placenta consists of chorion only.
Hence, it is called a chorionic placenta. Allantois remains
small.
The allantoic blood vessels, however, extend to vascularise it.
A large number of branching villi from the vascular chorion
penetrate the corresponding pits, the crypts, formed in the
uterine wall.
The latter becomes very thick and highly vascular to receive
the villi.
The intimate connection established between the foetal
membrane and the uterine wall is known as the placenta.
The placenta has two parts; the part contributed by the foetus,
i.e. chorionic villi, is called the foetal placenta: and the part
shared by the mother, i.e. part of uterine wall, is termed the
maternal palcenta.
The chorionic villi receive blood from the embryo by
umbilical artery and return it by umbilical vein.
The placenta is fully formed by the end of the third month and
it lasts throughout pregnancy.
When complete, it is redish-brown disc.
In the placenta, the foetal blood comes very close to the
maternal blood, and this permits the exchange of materials
between the two
Food (glucose, amino acids, simple proteins, lipids), water,
mineral salts, vitamins, hormones, antibodies and oxygen pass
from the maternal blood into the foetal blood and foetal
metabolic wastes such as carbon dioxide and urea, also water
and hormones, pass into the maternal blood.
These must be kept fitted for at least six hours after sexual
intercourse, The diaphragm and cervical cap are the
counterparts of condoms in the female.
c) Intrauterine contraceptive device (IUCD) are plastic or
metal objects placed in the uterus by a doctor.
These include loop, copper-T, Spiral, ring, bowl, shield, etc.
The birth control pills have side effects such as nausea, breast
tenderness, weight gain and break through bleeding (slight
blood loss between menstrual periods).
A combined pill is the most commonly used birth control pill.
It contains progesterone and estrogen.
The pill Saheli is taken weekly.
(6) Other Contraceptives:
Certain contraceptives are implanted under the skin of the
upper arm. They prevent pregnancy for 3 to 4 years.