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Anxiety
o Panic Disorder
o Generalized Anxiety Disorder
o Phobic Disorders
o Stress Disorders
o Obsessive-Compulsive Disorder
Anti anxiety drugs
MOA:
By post synaptic inhibition through
BZD receptor
PK of Benzodiazepines
Site of action:
Dorsal raphe seretoninergic neurones
Azapirones
Advantages: Disadvantages
No sedation
No tolerance or physical Slow onset of action
dependence not suitable for acute
No abuse liability anxiety
Less psychomotor Requires thrice daily
impairment admin
Does not potentiate the
effect of other CNS drugs
PK
given orally, rapidly absorbed
Extensive first pass metabolism
Excreted through urine and faeces
ADR
Dizziness ,headache, Nausea
Tachycardia , Pupillary Constriction
Treatment