FISIOLOGIA DEL TEJIDO ADIPOSO

MPSSI FEDERICO W. VON SON DE FERNEX

DIPLOMADO EN NUTRICION ANTI-ENVEJECIMIENTO Y ESTETICA

2015 - 11va Generación
ADIPOGENESIS
2 PASOS
PRIMORDIALES

Jean-Philippe Bastard et al. Physiology and Physiopathology of Adipose Tissue. 2013

Regeneración de tejido adiposo dependiente de
“STEM CELL POOL”.
• ADIPOCITOS MADUROS NO SE DIVIDEN

Maumus M, Sengenes C, Decaunes P et al (2008) Evidence of in situ proliferation of adult adipose tissue-derived progenitor
cells: influence of fat mass microenvironment and growth
Jean-Philippe Bastard et al. Physiology and Physiopathology of Adipose Tissue. 2013
HISTOLOGY
TEJIDO CONECTIVO

WAT BAT
 BAT

Magnus Borga et al. Brown Adipose Tissue in Humans: Detection and Functional Analysis
Using PET (Positron Emission Tomography), MRI (Magnetic Resonance Imaging), and DECT
(Dual Energy Computed Tomography). Methods in Enzymology, Volume 537, 2014
 BAT

1996–2014 themedicalbiochemistrypage.org
 WAT
• TEJIDO CONECTIVO LAXO
• MULTIPLES ESTIRPES CELULARES, CELULAS INMUNES
• SEPTADO
• ALMACENA LIPIDO
• DISTRIBUCION VARIABLE DE ACUERDO A EDAD, SEXO, PATOLOGIAS.
• SUBCUTANEA, VISCERAL

• Función :

• Reserva Energética

• Protección mecánica

• Aislamiento Térmico

• Función Secretora
WAT METABOLIC FUNCTION
HYPOGLICEMIA
WAT
• CORTISOL
• GH
• GLUCAGON
GLUCOSE • ADRENALINE

INS

GLUT4 ?
SENSITIZER

ADIPOCYTE

• OREXIN A
• ADENOSINE
• Nos
WAT FATTY ACID METABOLISM
WAT
10-20 kg of TRIGLYCERIDES
=
90´000 – 180´000 kcal.

ENERGY

FATTY ACIDS 60-70 days

of survival
 SOURCES
1 2
WAT
3
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
LYPOLISIS
WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Sheila Collins. A heart–adipose tissue connection in the regulation of energy metabolism. NATURE
REVIEWS, ENDOCRINOLOGY, VOLUME 10, MARCH 2014, 157.
 WAT

Gwendolyn A. Obesity, Growth Hormone and Exercise. Sports Med (2013) 43:839–849
WAT AND POLLUTANTS WAT
Persistent organic pollutants (POP) • Pesticides
• Dioxins
• Furans

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
Endocrine Functions of Adipocyte WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
Innervation of White Adipose Tissue

WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of

Adipose Tissue.

Sarah Stanley et al. Identification of neuronal subpopulations that project from hypothalamus
to both liver and adipose tissue polysynaptically. PNAS | April 13, 2010 | vol. 107 | no. 15
WAT
Nonesterified fatty
acids (NEFAs)
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
ADIPOKINES
WAT

Haitao Pan et al. Advances in understanding the interrelations between leptin resistance and
obesity. Physiology & Behavior 130 (2014) 157–169.
 WAT

Tiziana Ronti, Graziana Lupattelli and Elmo Mannarino. The endocrine function of
adipose tissue: an update. Clinical Endocrinology (2006) 64, 355–365
WAT
 LEPTIN
WAT

Haitao Pan et al. Advances in understanding the interrelations between leptin resistance and obesity. Physiology & Behavior
130 (2014) 157–169.
ADIPONECTIN
WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 APELIN
WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
INFLAMMATION
WAT

Christine McGown. Adipose Tissue as an Endocrine Organ. Clin Liver Dis 18 (2014) 41–58
H. James Harwood Jr. The adipocyte as an endocrine organ in the regulation of metabolic homeostasis.
Neuropharmacology 63 (2012) 57-75.
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.
 WAT

Helen Luck et al. Regulation of Obesity-Related Insulin Resistance with Gut Anti-inflammatory Agents.
2015, Cell Metabolism 21, 527–542
 WAT

Fredrik Karpe and Katherine E. Pinnick. Biology of upper-body and lower-body adipose tissue—link
to whole-body phenotypes. NATURE REVIEWS | ENDOCRINOLOGY VOLUME 11 | FEBRUARY 2015
 WAT

Jean-Philippe Bastard • and Bruno Fève. Physiology and Physiopathology of Adipose Tissue.