PATHOPHISIOLOGY OF ASTHMA

Triger (trigger) causes exacerbations of asthma due to

airway inflammation or acute bronchospasm or both. Triggers
can be allergens, air pollution, respiratory infections, etc.
Another factor that probably is rhinitis, bacterial sinusitis, etc.
The mechanism of airflow limitation varies in
accordance with the stimuli. The allergen will trigger
bronkhokontriksi result of Ig-E release from mast cell
dependent respiratory tract, including histamine,
prostaglandins, leukotrienes that will happen smooth muscle
contraction. The airflow limitation may also occur because of
the respiratory tract of patients with asthma are very hyper
responsive to a variety of stimuli.