Immunoregulation is the control of specific

immune response and interactions between B

and T lymphocytes and macrophages.
Immunoregulation
Immune response is determined by
many factors
Regulation of the immune response
Different antigens elicit different
kinds of immune response
Antigen route of administration can
determine whether an immune
response occurs
THE APC MAY AFFECT THE
IMMUNE RESPONSE
IMMUNOGLOBULIN
CAN INFLUENCE THE
IMMUNE RESPONSE
Immune complexes may
enhance or suppress
immune responses
Idiotypic interactions may enhance or
suppress antibody responses
T CELLS REGULATE THE IMMUNE
RESPONSE

○Cytokines are part of an extracellular

signaling network that controls every
function of the innate and adaptive
immune system and have:
●numerous effects on cell phenotypes; and
●the ability to regulate the type of immune
response generated.
SENESCENCE OF CELLS IS REGULATED BY
TELOMERE EROSION
Apoptosis maintains homeostasis
in the immune system

○Apoptosis is a
cellular clearance
mechanism through
which homeostasis
is maintained.
SELECTIVE MIGRATION OF
LYMPHOCYTE SUBSETS CAN
MODULATE THE IMMUNE RESPONSE

○Chemokines regulate the migration of

lymphocytes
THE NEUROENDOCRINE SYSTEM
INFLUENCES IMMUNE RESPONSES
Cytokines

○Cytokines are proteins secreted by the

cells of innate and adaptive immunity that
mediate many df the functions of these
cells.
1. CYTOKINES THAT
MEDIATE AND REGULATE
INNATE IMMUNITY
Cytokines that mediate innate immunity are produced
mainly by activated macrophages and include the
following:
2. CYTOKINES THAT
MEDIATE AND REGULATE
ADAPTIVE IMMUNITY
Immunoregulation

Lymphocytes
Cytokines Apoptosis
activation
The cytokines that mediate and regulate adaptive immune
responses are produced mainly by antigen-stimulated T
lymphocytes, and they include the following:
Terimakasih