• H, ducreyiruin network intradermal so that ruin epithelium,
• stimulate kertinosit, Fibroblast, cell endothelial so that
menyeksresikan IL-6 and IL-8. • stimulation CD-4 and IL-8 will stimulate spending PMN and makarofag • happen cumulation cells infiltrates so that inflict papule and pustules,
• These bacteria too release Sitoletal Desending toxin (HdCDT)
• apoptosis and necrosis from cell so that happen ulcer,