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• H, ducreyiruin network intradermal so that ruin epithelium,

• stimulate kertinosit, Fibroblast, cell endothelial so that


menyeksresikan IL-6 and IL-8.
• stimulation CD-4 and IL-8 will stimulate spending PMN and
makarofag
• happen cumulation cells infiltrates so that inflict papule and
pustules,

• These bacteria too release Sitoletal Desending toxin (HdCDT)


• apoptosis and necrosis from cell so that happen ulcer,

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