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AND THRUSTING)
AKUPUNKTUR
TERHADAP
KEBERHASILAN TERAPI
Kelompok Model (M)
Kelompok manipulasi
akupunktur (A)
Kelompok kolagenasi
sebelum perlakuan (JM)
Kelompok kolagenase
sebelum perlakuan +
manipulasi akupunktur (JA)
Sham Operation Group (N).
This group was injected with 50�L saline at bilateral
“Quchi” acupoint areas and, 30min later, injected with
saline at the dosage of 1mL/kg at the rabbit ear vein
without endotoxin injection or acupuncture.
Model Group (M).
This group was injected with 50 �L saline at bilateral
“Quchi” acupoint areas and 30 min later, injected with
3 mg/mL bacterial endotoxin at the dosage of 1mL/kg
at the rabbit ear vein to establish the fever model
without any treatment.
Acupuncture without Manipulation Group (W).
We followed the same protocol as in the model group
but 1.5 hours after modeling we applied acupuncture
at bilateral “Quchi” acupoint areas without
manipulation
Acupunctural Manipulation Group (A).
Protocol as in the model group but 1.5 hours after
modeling we applied acupuncture with L&T
manipulation at bilateral “Quchi”acupoint areas.
Collagenase Pretreatment Group (JM).
This group was injected with 2mg/ml type I
collagenase of 50 �L at bilateral “Quchi” acupoint
areas to destroy the underneath collagen fibers,
followed, 30 min later, by an injection of 3 �g/mL
bacterial endotoxin at the dosage of 1mL/kg at the
rabbit ear vein to establish the fever model without
any treatment.
Collagenase Pretreatment + Acupuncture
Manipulation Group (JA).
We followed the same protocol as in Group JM but 1.5
hours after modeling we applied acupuncture with
L&T manipulation at bilateral “Quchi” acupoints.
HASIL
Penelian pada kelinci NZW jantan untuk model demam
diinduksi endotoksin pada Quchi LI11, dibandingkan
dengan kelompok M (model demam tanpa akupunktur),
kadar IL-1� dan TNF� pada kelompok W (akupunktur
tanpa manipulasi) dan kelompok A (akupunktur dengan
manipulasi) lebih rendah secara bermakna dan kadar IL-
4 lebih tinggi secara signifikan (P<0.05)
Dibandingkan dengan kelompok W, kadar IL- 1� dan
TNF� pada kelompok A lebih rendah dan kadar IL-4
lebih tinggi secara bermakna (P<0.05)
KESIMPULAN
Respon peradangan diinduksi endotoksin dapat
dihambat secara bermakna oleh akupunktur, dimana
efikasinya juga ditingkatkan secara bermakna oleh
manipulasi akupunktur
Pemberian kolagenase sebelum akupunktur akan
mempengaruhi efikasi manipulasi akupunktur dan
serat kolagen di titik akupunktur mungkin
merupakan reseptor pertama dari kekuatan mekanik
manupulasi L & T
EFEK LOKASI
PENUSUKAN
AKUPUNKTUR
TERHADAP
KEBERHASILAN TERAPI
Randomised clinical trial: an assessment of
acupuncture on specific meridian or specific
acupoint vs. sham acupuncture for treating
functional dyspepsia.
Ma, TT dkk.
Aliment Pharmacol Ther 2012; 35: 552–561
A: titik akupunktur spesifik
meridian Lambung (ST
34,36,40,42)
Kelompok
(ST 32,33,35,38)
F: Itopride
Randomisasi & Perlakuan 4 Pengukuran Analisis statistik
Blinding minggu luaran
TERIMAKASIH