PROTEIN & PEPTIDE DRUG

DELIVERY SYSTEM

AAKASH SONI
M . P H A R M A I ST S E M .
GUIDANCE BY:- DR. KEERTI JAIN
DELHI PHARMACEUTICAL SCIENCES AND
RESEARCH UNIVERSITY
 CONTENTS
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 Protein & Peptide

 Structure of protein
 Classification of Protein
 Drug Delivery System

Protein & Peptide Drug Delivery System

 PROTEIN AND PEPTIDES
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 Proteins:- proteins are the large organic compounds

made of amino acids arranged in a linear chain and
joined together by peptide bonds.
Proteins>50 amino acids
 Peptides:- These are short polymers formed from the
linking, in a defines order of amino acids.
Peptide < 50 amino acids

Protein & Peptide Drug Delivery System

 WHY PROTEIN AND PEPTIDE ARE USED
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 The protein and peptides are very important in biological

cells.
 Lack of proteins and peptides causes disease like diabetes
mellitus.
 Diabetes mellitus is caused due to the lack of protein
called INSULIN.
 Now a days R-DNA technology and hybridoma
techniques also used in protein and peptide based
pharmaceutical.
Protein & Peptide Drug Delivery System
 ADVANTAGE
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 Erythropoietin used for production of RBC

 Tissue plasminogen activator is used for Heart attack,
stroke.
 Oxytocin maintain labor pain.
 Bradykinin increases the periphaeral circulation.
 Somatostatin decrease bleeding in gastric ulcer.
 Gonadotropin induce ovulation.
 Insulin maintain blood sugar level.

Protein & Peptide Drug Delivery System

 FUNCTIONS
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 https://www.slideshare.net/BrajeshKumar67/protein-
and-peptide-drug?from_m_app=android
 Transport and storage of small molecules.
 Cordinated motion via muscle contraction.
 Mechanical support from fibrous protein.
 Generation and transmission of Nerve Impulses.
 Enzymatic catalysis
 Immune protection through antibodies.
 Control of Growth and Differentiation via Hormones.
Protein & Peptide Drug Delivery System
 STRUCTURE OF PROTEIN
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 The structure of protein divided into four types:-

 Primary Structure:- The Amino Acid sequence
 Secondary Structure:- Regularly repeating local
structures stabilized by hydrogen bond.
 Tertiary Structure:-Three Dimensional structure of
polypeptide.
 Quaternary Structure:- The Structure formed by several
protein molecules.

Protein & Peptide Drug Delivery System

 CLASSIFICATION OF PROTEIN
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Depending on the number of amino acids they are :-

 Polypeptide Protein
 Oligo peptides proteins
 Fibrous proteins
 Globular proteins
 Oligo meric protein

Protein & Peptide Drug Delivery System

 DELIVERY OF PROTEINS
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Drug delievery

Route of Drug
Administration Modification

Pulmonary Miscellaneous Parental Oral PEGylation Pro-Drug Polymer Depot

Transdemal

Implants Ocular Nasal

Protein & Peptide Drug Delivery System

 PARENTRAL ROUTES OF ADMINISTRATION
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 Parentral route is most efficient way for systemic

delivery of proteins and peptides.
 This is the best choice to achieve therapeutic activity.
Mainly 3 routes of administration:-
 Intravascular
 Intramuscular
 Subcutaneous
Protein & Peptide Drug Delivery System
 ADVANTAGE & DISADVANTAGE
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Advantage:- Disadvantage:-
 Route of Delivery for 95% of •Problems with overdosing,
proteins necrosis
 Allows rapid and complete •Local tissue
absorption reaction/hypersensitivity
 Avoids first pass metabolism •Everyone hates getting a needle

Protein & Peptide Drug Delivery System

Thankyou