Electrical Network Modeling of
Genes and Study Their Behavior to
Identify Cancer Disease
1,2 Institute of Radio Physics and Electronics, University of Calcutta, Kolkata-700009
Introduction
• In recent years, electrical network modeling
is gaining its importance in genomics
research,
• Study the structure and function of DNA .
• Investigate the roles and functions of
genetic molecules.
• Diagnose different kinds of genetic
diseases.
• Network modeling is done based on two
types of methods,
• Nucleotide composition based technique.
• Amino acid composition based technique.
• Realization of network models based on
amino acid composition is more significant
than nucleotide composition, since
• Less complex circuitry as well low
computational load.
• Sensitive and responsive for genetic
disease prediction.
• Amino acid based models are used to
design equivalent electrical gene network
model.
• Homo Sapiens genes are identified by
investigating the behavior of electrical gene
model.
Related Work
• An equivalent electrical network is
developed using resistor and capacitor for
modeling DNA/RNA and classifying amino
acids. [R. Marshall, “Modeling DNA/RNA strings
using resistor–capacitor (RC) ladder networks,”
The Computer Journal, vol. 53, pp. 644-660, 2010]
• A stepwise LC oscillatory circuitry is
demonstrated to investigate the charge
transport mechanism in a DNA molecule. [K.
Xu, “DNA Circuit System and Charge Transfer
Mechanism,” Engineering, vol. 5, no.10, pp. 381-
385, 2013]
• A passive electrical circuit model is
introduced to study behavior of protein
structure. [G. Sampath, “RLC(M) circuit models of
protein structure: analysis, visualization, shape
synthesis, and pattern matching,” Proceedings of
the 40th Conference on Information Science and
Systems (CISS 06)]
Objectives
• The main focus of our research work is:
• Early Prediction and accurate
identification of cancer disease based on
two biological features i.e. “dominance of
hydrophilic amino acid and genetic
instability in cancerous genes”.
• Control of cancer progression using
control mechanism.
Motivation
• Generally, biopsy is is very painful
procedure and most of all invasive.
• Various data-driven methods are used,
which cannot describe biological system
properly without model.
• Image classification is extremely
challenging owing to similar color
intensities and textures in normal and
malignant images.
• Considering these challenges, electrical
network models are developed to identify
cancer disease, and also very useful in
further bio-sensor design.
TEMPLATE DESIGN © 2008
www.PosterPresentations.c
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Tanusree Roy ,
1 Soma
Graphical Overview of Research Work
• Identification of cancer disease.
• Application of control strategy along with the
electrical gene system model to control the
cancer progression.
* The AP John Institute For Cancer Research.
https://www.apjohncancerinstitute.org/caat-protocol.
# National Center For Biotechnology Information.
http://www.ncbi.nlm.nih.gov.
Cancer Identification Methodology
• Twenty amino acids are modeled individually
using passive components R, L and C.
• AA models are cascaded to form gene
network system.
• System characteristics are judged by Bode
analysis, transient analysis and pole-zero
analysis.
Barman2
Cancer Identification Results Control of Cancer Progression
• Before applying control strategy, pole-zero
• Simulated phase responses reflect
distribution reflects the genetic instability.
dominance of hydrophilic amino acids in
cancer genes.
• After applying control mechanism, cancer
gene behaving like healthy gene.
Publications
Journals:
1) Roy, T. and Barman, S. (2014). A behavioral
study of healthy and cancer genes by modeling
electrical network. Gene, Elsevier, vol. 550, no. 1,
pp. 81-92. doi: 10.1016/j.gene.2014.08.020.
2) Roy, T. and Barman, S. (2015). Performance
analysis of network model to identify healthy and
cancerous colon genes. IEEE Journal of
Biomedical and Health Informatics, doi:
10.1109/JBHI.2015.2408366.
3) Roy, T. and Barman, S. (2015). Design and
development of cancer regulatory system by
modeling electrical network of gene. Microsystem
Technologies, Springer, vol. 21, no. 5. doi:
10.1007/s00542-015-2548-x.
Conference:
1) Roy, T. and Barman, S. (2013) ‘Modeling of
Amino Acids using Electrical Circuits’,
September, Second International Conference on
Computing and Systems -2013(ICCS), ISBN-13:
• Step response and pole-zero distribution of 978-9-35-134273-1, pp. 341-347.
2) Roy, T. and Barman, S. (2013) ‘Electrical Network
gene system model reflect genetic instability.
Modeling of Amino Acid and its Characterization’,
• The electrical system model achieved 97%
August, 4th International Conference on
accuracy in identifying cancer genes. Technical and Managerial Innovation in
Computing and Communications in Industry and
Cancer Regulatory System Academia IEMCON 2013, ISBN: 978-81-923777-
9-7, pp. 272-277.
3) Roy, T. and Barman, S. (2014) ‘Electrical System
Model Realization to Study Genetic Behavior of
Cancer and Normal Homo Sapiens Genes’, July,
1st International Conference on Microelectronics,
Circuits & Systems (Micro-2014), ISBN: 81-
85824-46-0, pp. 25-32.
4) Roy, T. and Barman, S. (2014) ‘Modeling of
Protein Using Electrical Circuit and its
Classification’, 1st International Science &
• Restriction of Tyrosine and Phenylalanine Technology Congress, (IEMCON-2014), Elsevier,
(Tyr and Phe), and Glutamine or Methionine ISBN: 9789351072485, pp. 167-171
(Gln/Met) results in prostate cancer cell Book Chapter:
death. [Fu et.al(2006), J Cell Physio 209:522–534] 1) Roy, T., Das, S. and Barman, S. ‘Electrical
• High Tryptophan (Trp) degradation increases Network Modeling of Amino Acid String and its
the risk of prostate cancer. [Schroecksnadel et. application in Cancer Cell Prediction’, Intelligent
al(2005), Cancer Lett 223:323–329]
Computing, Networking, and Informatics,
Advances in Intelligent Systems and Computing
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 Acknowledgements
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 Calcutta, and University Grants Commission
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