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  • Metabolisme As - Amino

    Transféré par

    Regatta Ringga Hanessa Putry
    8 vues24 pages
    Metabolism of amino acids involves catabolism and biosynthesis. Catabolism of amino acid nitrogen involves transamination, oxidative deamination, production and transport of ammonia, and the urea cycle. Catabolism of amino acid carbons can be either glucogenic, ketogenic, or mixed. Imbalances in nitrogen metabolism can occur in conditions such as growth, healing, starvation, or illness. Disorders can also occur in the urea cycle or in amino acid catabolism pathways.

    Description originale:

    metabolisme asam lemak

    Titre original

    13. Metabolisme as.amino

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    Metabolism of amino acids involves catabolism and biosynthesis. Catabolism of amino acid nitrogen involves transamination, oxidative deamination, production and transport of ammonia, and the urea cycle. Catabolism of amino acid carbons can be either glucogenic, ketogenic, or mixed. Imbalances in nitrogen metabolism can occur in conditions such as growth, healing, starvation, or illness. Disorders can also occur in the urea cycle or in amino acid catabolism pathways.

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    8 vues24 pages

    Metabolisme As - Amino

    Transféré par

    Regatta Ringga Hanessa Putry
    Metabolism of amino acids involves catabolism and biosynthesis. Catabolism of amino acid nitrogen involves transamination, oxidative deamination, production and transport of ammonia, and the urea cycle. Catabolism of amino acid carbons can be either glucogenic, ketogenic, or mixed. Imbalances in nitrogen metabolism can occur in conditions such as growth, healing, starvation, or illness. Disorders can also occur in the urea cycle or in amino acid catabolism pathways.

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    sur 24

    METABOLISME

    ASAM AMINO
    METABOLISME ASAM
    AMINO
     Metabolisme Asam Amino
     Katabolisme Asam Amino
     Katabolisme Atom N
     Transaminasi
     Deaminasi Oksidatif
     Pembentukan & Transport NH3
     Siklus Urea & Gangguannya
     Katabolisme Atom C
     Biosintesis Asam Amino
     Produk Khusus
    METABOLISME ASAM
    AMINO
    STRUKTUR ASAM AMINO
    KESEIMBANGAN NITROGEN

     N positif (sintesis > katabolisme)


    mis. pertumbuhan, penyembuhan,hamil
     N seimbang (sintesis = katabolisme)
    mis. dewasa normal, sehat
     N negatif (sintesis < katabolisme)
    mis. kelaparan, sakit
    KATABOLISME ASAM AMINO
    KATABOLISME ATOM N

     Transaminasi
     Deaminasi oksidatif
     Produksi dan transport amonia (NH3)
     Siklus urea
    KATABOLISME ATOM N

     Ureotelik : mamalia  urea


     Urikotelik : reptil, burung  asam urat
     Ammonotelik : ikan bertulang  amonia
    TRANSAMINASI
    Asam amino alfa ketoglutarat NH3 CO2

    Asam alfaketo L-Glutamat Urea


    R-CH-NH2 R-C=O
    | |
    HOOC HOOC

    R`-C=O R`-CH-NH2
    | |
    HOOC HOOC
    O O
    C- NH2 C - OH
    CH2 CH2
    CH2 CH2
    H -C- NH2 H - C- NH2
    COOH COOH
    Glutamin Glutamat
    PEMBENTUKAN UREA
    PEMBENTUKAN UREA
    PEMBENTUKAN UREA
    GANGGUAN PADA SIKLUS
    UREA
    UCD Enzyme deficiency
     Hyperammonemia type I 1
     Hyperammonemia type II 2
     Citrulinemia 3
     Arginino suksinat aciduria 4
     Hyperargininemia 5
    KATABOLISME ATOM C
    ASAM AMINO

    Glikogenik Ketogenik campuran


    ala hip leu ileu
    arg met lis
    asp pro fen
    sis ser tir
    glu treo trip
    gli val
    his
    Ala ser
    Cys thr
    Gly trp
    Ile
    hyp
    Leu
    Trp glu Arg
    pir
    His
    Asetil koA
    sitrat Alfaketoglutarat
    Gln
    pro

    Asetoasetil
    KoA
    asp asn
    Ile
    Leu Trp
    Met
    hil Lis Tyr
    oksaloasetat Suksinil koA
    val
    tir tir
    phe
    phe sis

    fumarat
    Gangguan Metabolisme A A
    Nama Penyakit Gangguan
     Glisinuria glisin
    Hiperoksaluria primer
     Fenilketonuria fenilalanin
     Tirosinosis,Tirosinemia, tirosin
    Alkaptonuria
     Histidinemia,Imidazol- histidin
    aminoaciduria
     Prolinemia,Hidroksiprolin- prolin,hip
    emia
    Nama Penyakit Gangguan
     Hiperlisinemia,Hiper- lisin
    lisinemia persisten
     Sistinuria,Sistinosis, sistein, metionin
    Homosistinuria
     Hipervalinemia,Maple leusin,valin,
    syrup urine disease, isoleusin
    Intermitent branched
    chain ketonuria,Isovale-
    ricacidemia
    Nama Penyakit Gangguan

     Hartnup`s disease triptofan


    BIOSINTESIS ASAM AMINO
    BIOSINTESIS ASAM AMINO
    PRODUK KHUSUS DARI
    ASAM AMINO

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