Pendahuluan Mata Kuliah

Fitoterapi
Prodi Farmasi
Universitas Sahid Surakarta
 S.SYARF PST S.SYARF TEPI

S.SYARF LIMFATIK
S.ENDOKRIN
SIRKULASI DARAH
S.GASTROINTEST

S.RESPIRASI JANTUNG

NERVAL INDIVIDU HORMONAL

SAKIT SEHAT

PERSPEKTIF
MEDIK BARAT MEDIK TIMUR

•Tdk ada keluhan •Tidak nyaman

•Ada keluhan •Nyaman
•Data klinik
ADH
VASOPRESIN
Batang Otak Ginjal
OTAK
Hipotalamus
 SELF HEALTH CARE PREVENTION TREATMENT

DISEASE
FOOD QUALITY

INDIVIDU METABOLISME
SEL

FISIOLOGI

SIST PERED DARAH JANTUNG

SIST OTOT SIST PENCERNAAN

Enzim Hormon Mikroba

HIPOTALAMUS
TIPE PAGI / MALAM BIOLOGICAL CLOCK SIST LIMBIC

TDK ADA KESEIMBANGAN

CHRONOPHARMACOLOGY
STATUS
 Hypothalamus CNS
(limbic system)

Corticotropin Thyrotropin Prolactin Gonadotropin Releasing

Releasing Releasing Releasing Releasing Hormones
Hormone Hormone Factor Hormone

Hormones
PITUITARY GLAND

Tropic
Adrenocorticotropic Thyroid-stimulating Luteinizing Follicle-stimulating
Hormone (ACTH) Hormone (TSH) Prolactin Hormone (LH) Hormone (FSH)

Glands
Target
Thyroid Mammary Ovary Ovary
Adrenal Testis
Gland Gland (Corpus Luteum) (Follicle)
Cortex

Endogenous
Hormone
Corticosteroid Testosterone Progesterone Estradiol

Pool
Thyroid Hormone
Metabolic Metabolic Reproduction
Effect Effect Lactation Metabolic Effect

Hormonal cascade and feedback regulation in the production of hormones (Robbers & Tyler,2000,pg 186
Braun et al., 2005

HOLISTIC CARE

PATIENT ORIENTED

HOLISTIC OR INTEGRATIVE MEDICINE

 SIST SYARAF PUSAT
HEPAR (CNS)
IMUNO MODULATOR

SAL EMPEDU
DIARE

UROLOGI
OBSTIPASI

ANXIOLYTIC
SAL PENCERNAAAN

SAL PERNAPASAN FITOTERAPI ANTIDEPRESAN

NYERI  REMATIK
PENY.KHRONIS
KULIT & KELAMIN
GANGGUAN VENA

PEDIATRI
PENYUMBATAN
ARTERI PERIFER ANTIDEMENSIA

PEREDARAN DARAH
 Standardized 5W, 2H
Herbals/extracts FITOTERAPI

GASTRO BLOOD HEART NEURALGIA

INTESTINAL CIRCULATION
-arrhytmia -O.A
-Constipation -High Blood presure -congestive -rheumatics
-Diarrhoe - heart failure -Ost porosis
-Renalstone - -decomp.cordis -Low Back Pain
-cholelitiacis - -

Soya, Glycine max (genistein, ENDOCRINE Momordica charantia L.

Daidzein, ononin, isoformono SYSTEM Gymnema silvstris
Netin, coumestrol; linoleic acid Andrographis paniculata
Linolenic acid) -diabetes mellitus
-phytoestrogen
OH
-hormonal imbalance(women)
OH O OH O

O Cimifuga racemosa
AcO
HO O HO O O
H O O OH
Vitex agnuscastus
Coumestrol
Genistein H
O
HO
O
HO H
OH

ACTEIN
 Hambat (re)absorbsi
Neurotransmitter
(serotonin, dopamin; Noradrenalin)

Regulasi Ulang reseptor Hambat (re)absorbsi

Beta adrenergik Antidepressan Gamma-Amino-Butyric Acid (GABA),
Dan L-asam glutamat

Terjadi ikatan dengan reseptor

Kompleks GABA A DAN GABA B
 FITOTERPI – INTEGRATIVE MEDICINE

FITOTERAPI TERAPI MEDIK/MODERN

INTEGRATIVE MEDICINE
AROMA THERAPY
NUTRACEUTICAL
FOOD SUPLEMEN TERAPI

JUICE THERAPY
MUSIC THERAPY
PENYAKIT KRONIS  JANGKA PANJANG (EFEK SAMPING )

TENSI TINGGI : Ca antagonis; beta bloker, HCT

Diuretika tumbuhan: kumis kucing

 DAMPAK DINAMIKA MASYARAKAT  NYERI
KONDISI KESEHATAN
INPUT – PROCESS - OUTPUT
NORMAL TIDAK NORMAL
KUALITAS HIDUP DASAR BERPIKIR KETURUNAN PENUAAN
(SEIMBANG) (REAKSI ENZIMATIK TIDAK
SEIMBANG)
INFLAMASI N Y E R I SENDI (REMATIK)

DEGENRATIF
OP; OA; RA; EKSTRA
ARTIKULER

PENGELOLAAN (MENEJEMEN ) NYERI

DIET RENDAH PRAL PSIKO-FISIOTERAPI

NUTRACEUTICAL OBAT (KONVENSIONAL – HERBAL )
CAM ACUPUNCTURE
DALAM
LUAR

IMUN MODULATOR
ANALGETIKA ANTIINFLAMASI
(ADAPTOGEN) ANALGETIKA ANTIINFLAMASI
ANTI OKSIDAN
 NH2
O
7 N N
6 5 N
H N1
2
3 4
8
H2N N N EKSTR KURKUMINOID
N9
H2N N HOCH2 O RIMPANG KUNYIT
HOCH2 O

GOUT OH OH
OH OH ADENOSIN
GUANOSIN H2O
KURKUMINOID
Pi
H3N
P-Rib O IS0-,LIQUIRETIGENIN
O
7 N
HN
H N1 6 5 N
8
2 H2N N N
3 4
H2N N N9
H HOCH2 O
BROMELAIN
GUANIN

H2O
OH OH
Allopurinol NH3
INOSIN
Pi
O Polysachharide rhich substance
7 O
P-Rib
1
N 6 5 N 7 Antioksidan, imunomodul, antiradang
8 1 5 N
6
2
3 4 N 8 COX
O N N9 2
3 4
H N N9
( Kurkumin, Gingerol, Luteolin, H
XANTIN
Kuersetin, Silibin in vitro)
Pauft and Hille, 2009 HIPOKSANTIN
XANTIN OKSIDASE Palu et al., 2009
O
O H O O-
N H2N NH2
N1 6 N H2N
5 7
8 O O
2
3 4 9
N
N N O N O N N O
O H H H H H
ASAM URAT ALANTOIN ASAM ALANTOINAT
Mutschler et al., 1995

CLASSIFICATION OF PAIN WITH RESPECT TO LOCALIZATION

Myelinated Aδ Fiber(primary pain)

FIRST PAIN
SURFACE PAIN SKIN MUSCLE & JOINT
SECOND PAIN
Unmyelinated C Fiber(primary pain)
SOMATIC PAIN MUSCLE
CONNECTIVE TISSUE
DEEP PAIN BONE
JOINT Kapsaisin
Gingerol
VISCERAL PAIN ABDOMEN Piperin
O
Transmitter at pain synapsis
O Neuropeptide SUBSTANCE P
N

O
Piperin
O OH

H3CO CH3 Neurogenic

(CH2)n Inflamation
O Thermoregulation
HO H3CO
N Chemical inisiated pain
(n=4) : [6]-gingerol H E
(n=6) : [8]-gingerol
HO Capsaicin ( 63-77%)
(n=8) : [10]-gingerol
RANTAI
POLIPEPTIDA TANIN TANIN TANIN
= Bawang putih
Alliine, Ajoen
 Mechanism of Action of Herbal Antidiabetics

*Adrenomimeticism, pancreatic beta cell potassium channel

blocking, cAMP (2nd messenger) stimulation
*Inhibition in renal glucose reabsorption
*Stimulation of insulin secretion from beta cells of islets or/and
*inhibition of insulin degradative processes

IRANIAN JOURNAL OF PHARMACOLOGY & THERAPEUTICS

IJPT 7:97-106, 2008