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• Pharmacotherapeutics
– Control partial and generalized seizures
– Prevent and treat seizures post neurosurgery
– Treat status epilepticus after administering a benzodiazepine
– Normal blood level : 10-20 mcg/ ml
– Small changes in the dose may produce larger than expected
changes in the serum concentration of the drug
Great variability exists among how individuals metabolize this
Slight deviations from the therapeutic range may produce: non-
therapeutic effects or adverse effects