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8.

4 Transcription TEKS 4B, 6C, 9C

First 10 minutes of class.


• Bell Ringer 15 Select the correct answer and explain why that is the best answer.
8.4 Transcription TEKS 4B, 6C, 9C
8.4 Transcription TEKS 4B, 6C, 9C

KEY CONCEPT
Transcription converts a gene into a single-stranded
RNA molecule.
8.4 Transcription TEKS 4B, 6C, 9C

MAIN IDEA

• RNA carries DNA’s instructions.


• Transcription makes three main types of RNA.
• The transcription process is similar to replication.
• Amino acids are coded by mRNA base sequences.
• Amino acids are linked to become a protein
8.4 Transcription TEKS 4B, 6C, 9C

WORDS TO KNOW
8.4 Transcription TEKS 4B, 6C, 9C

RNA carries DNA’s instructions.

• The central dogma


states that information
flows in one direction
from DNA to RNA to
proteins.
• These steps are
important for protein
synthesis; the process
in which cells make
proteins.
8.4 Transcription TEKS 4B, 6C, 9C

• The central dogma includes three processes.


– Replication
– Transcription replication

– Translation
• RNA is a link between transcription

DNA and proteins.

translation
8.4 Transcription TEKS 4B, 6C, 9C

Introducing Ribonucleic Acid (RNA)

Ribonucleic acid (RNA) Deoxyribonucleic acid (DNA)


• is a single-stranded •  is a molecule that
nucleic acid that carries contains
out the instructions coded the biological instruction
in DNA. s that make each species
unique. 
8.4 Transcription TEKS 4B, 6C, 9C

• RNA differs from DNA in three major ways.


1. RNA has a ribose sugar.

RNA DNA
8.4 Transcription TEKS 4B, 6C, 9C

• RNA differs from DNA in three major ways.


2. RNA has uracil instead of thymine.
8.4 Transcription TEKS 4B, 6C, 9C

• RNA differs from DNA in three major ways.


3. RNA is a single-stranded structure.
8.4 Transcription TEKS 4B, 6C, 9C

Transcription makes three types of RNA.


• Transcription copies DNA to make a strand of RNA.
8.4 Transcription TEKS 4B, 6C, 9C

• Transcription is catalyzed by RNA polymerase.


– RNA polymerase and other proteins form a
transcription complex.
– The transcription complex recognizes the start of
a gene and unwinds a segment of it.

transcription complex
start site

nucleotides
8.4 Transcription TEKS 4B, 6C, 9C

– Nucleotides pair with one strand of the DNA.


– RNA polymerase bonds the nucleotides together to
make a new RNA molecule.
– The DNA helix winds again as the gene is transcribed.

DNA

RNA polymerase
moves along the DNA
8.4 Transcription TEKS 4B, 6C, 9C

– The RNA strand detaches from the DNA once the gene
is transcribed.
– a Gene; a specific sequence of nucleotides in DNA or
RNA that is located usually on a chromosome and that is
the functional unit of inheritance

mRNA
8.4 Transcription TEKS 4B, 6C, 9C

• Transcription makes three types of RNA.


– Messenger RNA (mRNA) carries the message that will
be translated to form a protein.
– Ribosomal RNA (rRNA) forms part of ribosomes where
proteins are made.
– Transfer RNA (tRNA) brings amino acids from the
cytoplasm to a ribosome.
8.4 Transcription TEKS 4B, 6C, 9C

The transcription process is similar to replication.


• Transcription and replication both involve complex
enzymes and complementary base pairing.
• The two processes have different end results.
– Replication copies
all the DNA;
transcription copies one
gene growing RNA strands
a gene.
– Replication makes
one copy; DNA
transcription can
make many copies.
8.4 Transcription TEKS 4B, 6C, 9C

What transcription tells scientist.

• Because mRNA encode for only a single gene, studying


mRNA can help researchers learn where genes begin
and end on a chromosome.
• It could also indicate what genes are active in specific
types of cells
8.4 Transcription TEKS 4B, 6C, 9C

Translation, the big picture

• Translation converts mRNA messages into polypeptides.


• A polypeptides; a chain of amino acids linked together 
8.4 Transcription TEKS 4B, 6C, 9C

Translation is the process of gene expression.

• Genes a segment of DNA • Traits a genetically


that is located in the determined
chromosome and that codes characteristic.
for a specific hereditary trait.
8.4 Transcription TEKS 4B, 6C, 9C

Amino acids are coded by mRNA base sequences.

• codon is a sequence of three nucleotides that codes for


a particular amino acid.
• Amino acid are any one of 20 different organic molecules
that combine to from proteins.
codon for codon for
methionine (Met) leucine (Leu)
8.4 Transcription TEKS 4B, 6C, 9C

•  Many codons are redundant, meaning they code for the


same amino acid. 
• Codon charts are used to find the Amino Acid that
corresponds to DNA and RNA to produce a chain of amino
acids aka a polypeptide
8.4 Transcription TEKS 4B, 6C, 9C

Important Codons

• stop codon; signal the end of the amino acid chain.


• start codon; which signals the start of translation and the
amino acid methionine.
– This means that translation always begins with
methionine.
• There are a total of 20 amino acids used to make up all
the proteins in the human body.
8.4 Transcription TEKS 4B, 6C, 9C

Amino acids are linked to become a protein.


• An anticodon is a set of three nucleotides that is
complementary to an mRNA codon.
• An anticodon is carried by a tRNA.
8.4 Transcription TEKS 4B, 6C, 9C

INDEPENDENT WORK 30-45 MINS

• Answer questions on the Class Notes Tab. Use


complete sentences.
• Define and add Images to Vocabulary Words
“Protein Synthesis”
• 5 Question Multiple Choice Quiz “Protein
Synthesis”

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