Science Project

Recommendations (4)


http://www.chineseowl.idv.tw


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During our most recent weekly group meeting,
participants expressed concern over the potential threat of anaphylaxis.
A wound dressing attempts to ensure optimal healing by
easing pain and preventing trauma infection. Composition of the wound
dressing and its adherence to the skin largely deteriorates its
therapeutic effectiveness. Additionally, composition of the medicine
enables the wound to heal, while the medicine carrier ensures the
staying power of the wound dressing on the skin.
Wounded skin often destroys its collagen, necessitating that the wound
dressing contains collagen. Also, collagen extracted from an animal
organism often requires adding other materials to facilitate extraction,
possibly causing the user to become allergic to the wound dressing.
(NOTE : Add 2-4 sentences that describe characteristics of the
problem or statistics that reflect its severity) As is
widely assumed, cysteine protease is the predominant class of
protease in plants. Its use in medicine can help to remove wound
bacterium and shorten treatment time, providing alternatives
conventional treatment methods which are unable to do so.
The inability to resolve the potential threat of anaphylaxis
may incur other adverse side effects and reduce the effectiveness of
therapeutic treatment.
(:)
Therefore, we recommend developing a novel
composition from plants that is more effective than animal collagen in
reducing the likelihood of anaphylaxis. Additionally, the proper carrier can
be used to transport the composition in order to maintain its therapeutic
effectiveness. To do so, cysteine protease can be
extracted and purified from sesame. Polysaccharide can then be purified
from the fruiting body of an edible Jews Ear mushroom. Next, the
complex can be applied to the wound through the interaction between
cysteine protease and polysccharide. As anticipated, the
stable formation of the novel composition can function as an entrapping
reservoir for active ingredients that can be sustained to ensure a
prolonged release. In addition to its economic benefits, the
novel composition proposed herein can not only treat wounds but, more
importantly, reduce the incidence rate of anaphylaxis. (NOTE : Add 2-4
more sentences that describe more thoroughly how the proposed method
contributes to a particular field or sector)
(:)
At a recent meeting, our scientists discussed the
complexity in detecting the lowest levels of platelet formation.
Recent changes in the daily diets of Taiwanese towards foods
with high cholesterol contents and high energy, along with sedentary
life styles, have increased the annual rate of thrombosis. Anti-platelet
aggregation and development of an anti-coagulation drug are of priority
concern in combating thrombosis. However, given the
many categories of anticoagulation drugs, the adverse effects of
commonly administered drugs is too high, while the sensitivity of
traditional platelet function assays is too low. (NOTE : Add 2-4
sentences that describe characteristics of the problem or statistics that
reflect its severity) For instance, using
radioimmunossay determination, only PF4 basal levels of 10-50 ng/ml
are obtained. However, a highly sensitive determination of PF4 by
ELISA could detect as little as 0.6 ng/ml of PF4 basal levels.
The inability to alleviate these adverse effects will lead to
hemorrhaging or allergies following administration of anticoagulation
drugs. Moreover, the inability to increase the sensitivity of
determination makes it impossible to detect the lowest levels of platelet
formation.
(:)
Therefore, we recommend developing a highly sensitive
determination method, capable of assessing the lowest levels of
secretion from an activated platelet and facilitating efforts to develop a
new anticoagulation drug. To do so, anti-platelet
aggregation compounds can be isolated from Chinese herbal medicine.
Secretion from an activated platelet can then be assessed,
demonstrating several biological activities in these compounds, including
antioxidant activity and anti-inflammation. Next, the role of inhibited
stimulators in inducing platelet aggregation to developing an
anticoagulation drug can be assessed. As anticipated, the
proposed determination method can facilitate the use of Chinese herbal
medicine as an anticoagulation drug by reducing adverse effects by at
least 80%. In addition to contributing to the effectiveness of
Chinese herbal medicine in preventing thrombosis-related complications
and myocardial infarction, the proposed determination method can
assess the lowest levels of secretion from an activated platelet and
detect inherited deficiencies. (NOTE : Add 2-4 more sentences that
describe more thoroughly how the proposed method contributes to a
particular field or sector)
Further details can be found at
http://www.chineseowl.idv.tw