Académique Documents
Professionnel Documents
Culture Documents
Kwang-Ryeol Lee
Future Technology Research Division
Korea Institute of Science and Technology
krlee@kist.re.kr
http://diamond.kist.re.kr/DLC
Acknowledgement
• Dr. R. Hauert (EMPA, Switzerland)
for valuable discussion and providing me the presentation materials on this issu
e.
• Prof. Jeong-Ku Kim (SKKU, Korea)
for corrosion test in body fluid condition
• Prof. In-Seop Lee (Yonsei Univ., Korea)
for tribological test of DLC coated Ti alloys in body fluid
• Prof. Hyeonee Kim (SNU, Korea)
for cell attachment and hemocompatbility test
• Prof. R. Wang (UBC, Canada)
for mechanical stability test
• Mr. Sejun Park, Mr. Heon-Woong Choi and Ms. Youngjin Lee
• Biological Compatibility
– Nontoxic, Noncarcinogenic, Noninflammatory
• Chemical Compatibility
– Corrosion Resistance
• Mechanical Compatibility
– Surface Hardness, Wear Resistance
Diamond-like Carbon :
as a Strong Candidate Coating
Contents
1. Introduction to DLC
sp3 diamond
t-aC
t-aC:H
DLC
Polymer-like
Graphitic
graphite No film
sp2 H
Properties of Solid Carbon
Spacer Tool
Wrist Pin
Razor Blade
Blood Contacting Applications
• Heart valves, Stents, Blood pumps etc.
- Surface has to prevent thrombus formation and restenosis
Formation of a thrombus
Thrombus on a mechanical heart valve
(courtesy of RWTH-Aachen)
Protein Adsorption on DLC
1.4
a high ratio of
Jones et al.
Dion et al. albumin/fibrinogen
Albumin / Fibrinogen Ratio
1.2
Cui et al.
1
0.4
On DLC
On glass
Excellent Hemocompatibility
PC coated accelerator
1400
1200
Potential (mV vs SCE)
1000
800
600
400
200
-200
-400
-600
-14 -13 -12 -11 -10 -9 -8 -7 -6 -5 -4 -3 -2 -1 0 1
10 10 10 10 10 10 10 10 10 10 10 10 10 10 10 10
2
Current Density (A/cm )
DLC Coated Stents
Evolution of Coating Failure
500
400
(c) (d)
(b)
Force (N)
300
200
(a)
100
0
0.00 0.02 0.04 0.06 0.08 0.10 0.12
L/L
Cathode
RF Power
In vitro Wear Test
DLC/UHMWPE (literature overview)
Hip joint simulator
(Lappalainen, Finnland)
Pin on Disk Hip joint simulator
Lubrication: Lubrication:
- air - diluted calf serum
- dest. water - synovial fluid
- 1wt% NaCl in water
reduction of no change in
UHMWPE wear UHMWPE wear
Pin on Disk
To be clinically relevant, tribological
investigations on DLC/UHMWPE require:
- Adequate tribological setup
- Adequate lubricant
In vitro Test
Tribological setup Lubrication Surface quality
Lubrication:
- diluted calf serum
- synovial fluid Characterize surface
Texture
200 ㎛ 200 ㎛
DLC Coated Artificial Joints
• Stents
– Stability of the coating with respect to the plastic deformation
– Interface design would be helpful to increase the reliability.
• Artificial Joints
– Characterization of the coating under an adequate test condition
• Does it really reduce the PE debris?
• Is it possible to have new design such as DLC/DLC or DLC/metal?
– Stability of the coating during sliding in body fluid condition
– Need tight control of the substrate surface
Diamond-like Carbon Coating for
Bio-medical Implant Materials
Kwang-Ryeol Lee
Future Technology Research Division
Korea Institute of Science and Technology
krlee@kist.re.kr
http://diamond.kist.re.kr/DLC
Cells in contact with DLC
Proliferation Differentiation
100000 0.20
80000
Cell Number [/cm2]
0.15
ALP Activity
60000
0.10
40000
0.05
20000
0 0.00
Thermanox DLC si-DLC Thermanox DLC si-DLC
3 days 10 days
Protein adsorption on Ti-DLC
Molecular weight
184 kD Tunable protein
115 kD adsorption between
86.3 kD Ti and DLC by the
61.5 kD
Ti concentration in
50.8 kD Ti-DLC.
37.6 kD
25.4 kD
Plasma Glas Ti 23 13 7 0
a-C:H, at% Ti
Tunable
poisoning:
Poisoning of the
a-C:H/3% V a-C:H
BMC cells due to
vanadium
dissolution out of
the V-DLC film
a-C:H/7.4% V a-C:H/15% V