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OVERVIEW OF
AMINOGLYCOSIDES AND
OTHER PROTEIN SYNTHESIS
INHIBITORS
Presented By
H2N NH
HO OH
Streptidine
OH
H2N NH O
O
NH CHO
CH3 L-Streptose
OH O
HO
O
HO NHCH3 N-Methyl-L- Glucosamine
OH
Streptomycin
Neomycin sulfate
Neosamine C
CH2NH2
6 5 O
1 NH2 2
HO 3
3 4 6 NH2
HO NH2 O 1
5
OH
5 Deoxystreptamine
6 CH2OH O
CH2NH2 O
5 4 1
HO O 3 2
3 1
HO
NH2 O OH
Neosamine C D-Ribose
Neomycin C
Kanamycin sulfate
CH2R1 Ring I
6` 5` O Ring II
1` NH2 2
HO 3
3` 4 6 NH2
HO R2 1
O 5
O
HO
1``
HOCH 2 5`` O OH
HO 4``
2``
H2N Ring III
Amikacin
CH2NH2 Ring I
6` 5` O Ring II O OH
1` NH2 2
HO 3
3` 4 6 NH-C-C-CH2CH2NH2
HO OH O 1
5 H
O
HO
1``
HOCH 2 5`` O OH
HO 4``
2``
H2 N Ring III
Amikacin
Gentamicin sulfate
Netilmicin sulfate
6`
CH2OH
5`
4`
Ring I O
2`
3` NH2
1`
3 2 Ring II
H2 N 4 6 1 NHR
O 5
O
HO
1``
5`` O OH Ring III
CH3 4`` 2``
3``
NHCH3
OH
Sisomicin R= H
Netilmicin R= C2H5
Other Protein Synthesis Inhibitors
Tetracycline
Chloramphenicol
Macrolides
Mupirocin
Quinolones
Mechanisms action of tetracycline
Commercially available tetracyclines
First generation (Dose intervals shorter)
Chlorotetracycline
Oxytetracycline
Tetracycline
Dmeclocycline
• Second Generation (Dose interval longer)
Minocycline
Methacycline
Doxycycline
• Third Generation
Glycylcycline
Mechanism action of chloramphenicol
Structure of cloramphenicol
MUPIROCIN