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ù nteraction between host & environmental factor
ù his lead into of self & triggering autoimmunity

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autoantibodies
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R mach subtype manifest different clinical features and the diagnosis
is made from anamnesis, physical examination and labaratory
results
R 22: ystemic juvenile-onset rheumatoid arthritis
ncologic disease (leukemia, lymphoma)
thervasculitic disorders
2ermatomyositis
Fibromyalgia
2rug-induced lupus
Pitfalls
R herapy: photoprotection, topical steroids, hydroxycloquine,
antimalaria (in severe and refractory case), cytotoxic agents ( in
patients with organ threatening systemic disease) systemic
corticosteroids (for treatment active m with heart , kidney ,
hematologic , and central nervous system involvement)
R mducation to reduce/relieve anxiety and to recruit the patient as an
active participant in the treatment regimen