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Tonic Clonic common 2 mi8n. Cry-tonic; both hemispheres; clonic- contrac+relax of SK. Muscles. Absence : Children ; 1-2 min.;1 directional Atonic: Unconcious; muscel relaxed; loss of posture; sagging head Myoclonic:Isolated jerks; bursts of momem=ntary contraction of muscles; limbs Infantile: Myoclonic jerks; prog.mental det.; epileptic symdrome
Mech. Of Action
Altered ion conduction Inc. NA++ contrac.- inactivation Dec. CA++ current thalamus Inc. GABA Dec. Glutamate- NMDA, AMDA; Kainic Acid Genetic Mech. ECT VNS ; DBS; TMS
TMS Pharmacology
Repetitive TMS in 14 randomised controlled trials in patients with depression has been prospective. Regional changes in neurotransmitter/ neuromodulator release. Trans-synaptic efficiency Signaling pathways EPILEPCY- Trials in pipeline? Gene transcription brought about by TMS resembles antidepressant drug therapy.
Limitations of SIT
Widely accepted in Diagnosis and Drug delivery, but treatment?
Cost Patient acceptability Restricted clinical trials Considered complex by many of the medical practitioners