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CHORIOCARCINOMA
BY
Malignant variety
-Invasive moles ( chorioadenoma destruens)
-placenta site trophoblastic tumour
-Choriocarcinoma
-
Non gestational trophoblastic dx
- Choriocarcinoma of ovary
-Choriocarcinoma of Testis
Pathology
Generally tumors arise from the fetal tissues within the
maternal host and composed of syncytiotrophoblast
and cytotrophoblastic cells except PSTT.
-complete- 46xx(90%)/ 46xy(10%)
-partial -69xxy or 69xxx
Invasive mole
-invades myometrium
- persistent placenta villous structure.
- Does not progress to choriocarcinoma
-regresses spontaneously
Placenta site trophoblastic dx.
-composed mainly of cytotrophoblastic cells
-Low HCG and High HPL
-Tumor confined to uterus but metastasizes late in its
course
Gestational choriocarcinoma
Arising from trophoblastic epithelium
Malignant
Composed of cytotrophoblastic and syncytiotroblastic
elements
Some cytotrophoblastic choriocarcinoma carcinoma
secrete little HCG while syncytiotroblastic
choriocarcinoma secrete HPL.
Metastases –local sites such as cervix or vagina
- distance sites- lungs brain and liver
-Lymph node metastasis rare
- may suggest a non gestational origin(
Germ cells)
Gestational choriocarcinoma cont.