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disease worldwide
• Closely associated with poverty,
malnutrition and overcrowding
Transmission: airborne
Pathophysiology
Clinical manifestations:
insidious in onset
History and PE
Tuberculin skin test
Chest X ray
AFB smear
Sputum culture
Tuberculin skin test /
Mantoux test
Determine if the person has been
infected
PPD: injected intradermal
Area of induration is read at 48-72
hours
Interpretation:
• 0-4mm - not significant
∀ > or = to 5mm - significant for individuals
at risk (HIV)
• > or= to 10 mm- significant in normal
individuals
Classification of TB
Class 0 no exposure, no infection
Class 1 (+) exposure, no evidence
of infection
Class 2 latent infection, no
disease
Class 3 (+) disease, clinically active
Class 4 (+) disease, not clinically
active
Class 5 suspect, diagnosis pending
Medical Management:
Chemotherapeutic agents for 6-
12 months
• To ensure eradication and prevent
relapse
Multidrug treatment: to prevent
development of resistant strains
Considered non-infectious after
2-3 weeks of therapy
Medical Management:
TB DOTS
Categor
y
Type of TB Intensive Maintenanc
e