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Rheumatoid Arthritis

Prepared by: Kelvin Chua

Overview
What is Arthritis Rheumatoid Arthritis Etiology Symptoms Rate of Incidence Risk Factors Diagnosing RA Current Treatment
Image from: http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/article.htm

What is Arthritis?
Arthritis inflammation of a joint Most common cause of disability Over 100 conditions related to arthritis Some common types of arthritis:
Osteoarthritis Septic Arthritis Juvenile Arthritis Rheumatoid Arthritis
CDC (2006). http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5540a2.htm

Rheumatoid Arthritis
Chronic inflammatory autoimmune disease Inflammation of the joints and other organs Leading to chronic pain, permanent join damage or even deformity

Image from: http://www.niams.nih.gov/Health_Info/Rheumatic_Disease/default.asp

Etiology
How the condition attacks the joints
Malfunction of the immune system

Still very much idiopathic Interaction between other factors:


Genetic susceptibility Environmental trigger

Image from: http://www.nature.com/nrd/journal/v6/n1/fig_tab/nrd2196_F1.html Gregersen, P. K., (2010). Susceptibility genes for from: Google Images Image rheumatoid arthritis.

Symptoms
Joint swelling (small joints, ie. Fingers, wrists) Symmetrical Movement limitation Pain and loss of strength Joint stiffness after inactivity Feeling unwell and fatigue

Image from: http://www.cedars-sinai.edu/Patients/Health-Conditions/Arthritis--Image from: http://kashmirmonitor.org/08102011-ND-poor-sleep-may-worsenImage from: http://www.scienceclarified.com/Al-As/Arthritis.html Image from: Google Images Rheumatoid-Arthritis-Osteoarthritis-and-Spinal-Arthritis.aspx. rheumatoid-arthritis-disability-9609.aspx

Rate of Incidence
Affects 0.5 - 1.0% of adults 2 to 3 times more common in females RA may begin at any time from childhood (juvenile arthritis) to later life General onset between 40 60 years of age

Scott, DL, Wolfe F, Huizinga TW.,(2010). Rheumatoid arthritis.

Risk Factors
Gender
Females more likely to develop RA

Age
Most commonly between 40 and 60 years of age

Genetic Heredity/Susceptibility
Increased risk if a family member has RA

Smoking

Rindfleisch, J. A., & Muller, D, (2005). Diagnosis and management of rheumatoid arthritis.

How is RA Diagnosed
Medical history Physical examination Laboratory tests
Rheumatic factor Anti-CCP antibodies Erythrocyte sedimentation rate

Imaging techniques
X-Ray
Image from: http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/article.htm

Current Treatment
Hot & Cold Tx Medications
NSAIDs Corticosteroids DMARDs

Surgery
Arthroscopy Joint replacement
Image Image http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/article.htm from: from: http://arthritis.about.com/od/rheumatoidarthritis/ss/pictures_photos_6.htm

Exercise As Treatment
Improve muscle strength & joint mobility Reduce swelling and pain Improve mood and quality of life Choosing the correct exercise
Eg. Stretching, swimming, water aerobics

Image from: http://www.medicinenet.com/rheumatoid_arthritis_pictures_slideshow/article.htm

Conclusion
On a whole, cause of RA is still unknown Important for patients to know how it affects the body And understand the treatment options This eventually will aid patients to live with the disease

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