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Ludwigs Angina

Ernest E. Wang MD, FACEP


Evanston Northwestern Healthcare Northwestern University Medical School

Ludwigs Angina
Extension of localized periapical infection
Anterior mandibular Sublingual Posterior mandibular (molar) Submandibular

Fascial planes

Historical cues
Recent dental extraction or work Dental caries Fever Swelling of mouth, face, neck Compromised host Co-morbidities (diabetes)

Physical exam
Toxicity Brawny bilateral boardlike edema Submandibular, submental, sublingual Trismus Tongue elevation No fluctuance

Figure 66-32 A, Ludwig angina may initially appear benign. B, In Ludwig angina, rapid progression may compromise the airway in a few hours.
Roberts and Hedges, p. 1339

Etiology
Streptococcus Staphylococcus Mixed aerobic/anaerobic infection
B. Fragilis

-lactamase resistance (<= 40%)

Diagnosis
Clinical CT scan

4-month-old with fever, irritability, and decreased oral intake x 24 hours. Swelling x 10 hrs
(Maimon et al, Ann Emerg Med, 2006)

Treatment
Airway control - EARLY
Fiberoptic Deterioration may be rapid Cricothyrotomy or tracheostomy may be necessary

Surgical consultation mandatory


Oral maxillofacial surgeon or ENT Definitive surgical drainage and debridement

ICU

Antibiotics
Extended spectrum penicillins
Ampicillin/Sulbactam (Unasyn) Ticarcillin/Clauvulate (Timentin) Piperacillin/Tazobactam (Zosyn)

Clindamycin + Cipro (PCN allergy) Flagyl (B. Fragilis)

Steroids
Reduce edema Used routinely when airway compromise suspected (Larawin et al.) Dexamethasone 10-20 mg IV
Then 4-6 mg Q6 for 8 doses (Busch)

Deep Neck Space Infections


103 patients (1993 - 2005) Ludwigs Angina (n=38, 37%) Odontogenic (n=25, 67%) Tracheostomy (n=4) Medical management (n=13) Medical and surgical management (n=25)

Larawin et al. Head and neck space infections. Otolaryngol Head Neck Surg. 2006, 135(6):899-993.

Deep Neck Space Infections


Complications
Upper airway obstruction (n=4) Reinfection (n=3) Asphyxiation (n=1) Descending mediastinitis (n=1) Spread to other spaces (n=1) Death (n=2)

Larawin et al. Head and neck space infections. Otolaryngol Head Neck Surg. 2006, 135(6):899-993.

Ludwigs Angina Summary


Serious deep space infection Potentially fatal Aggressive manage airway as indicated Surgical consultation Antibiotics and steroids ICU

References
Larawin V, Naipao J, Dubey SP. Head and neck space infections. Otolaryngol Head Neck Surg. 2006 Dec;135(6):889-93. Marple BF. Ludwig angina: a review of current airway management. Arch Otolaryngol Head Neck Surg. 1999;125:596-599. Busch RF. Ludwig angina: early aggressive therapy. Arch Otolaryngol Head Neck Surg. 1999 Nov;125(11):1283-4. Maimon MS, Janjuh AS, and Goldman RD. Images in emergency medicine. Ludwigs Angina in a 4 Month Old Infant. Ann Emerg Med, 2006 May;47(5):503, 507. Amsterdam J. Chapter 65: Oral Medicine. In Marx J, Hockberger R, Walls R: Rosen's Emergency Medicine, Concepts and Clinical Practice, 5th ed. St. Louis, Mosby, 2002, 892908 pp. Benko, K. Chapter 66: Emergency Dental Procedures. In Roberts J, Hedges J: Clinical Procedures in Emergency Medicine, 4th ed. 4th ed, Philadelphia, Saunders, 2004, 13171340 pp.

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