Académique Documents
Professionnel Documents
Culture Documents
Innovation Mysteries
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Pandoras Box
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From Wikipedia This is an engraving of Pandora trying to close the "box" that she had opened out of curiosity. At left, the evils of the world taunt her as they escape. The engraving is based on a painting by F.S. Church. Navneet Bhushan (navneet.bhushan@crafitti.com) Crafitti Consulting (www.crafitti.com)
Confidential
Artist assistants stand next to 3,604 cups of coffee which have been made into a giant Mona Lisa in Sydney , Australia . The 3,604 cups of coffee were each filled with different amounts of milk to create the different shades!!
Confidential Crafitti Consulting Private Ltd. April 19, 2012 6
http://www.fastcodesign.com/1662020/eye-candy-solidvase-is-a-3-d-pic-of-splashing-milk
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The Singaporean designer Fung Kwok Pan has managed to capture the flow of water in solid form, and the results are stunning.
Confidential Crafitti Consulting Private Ltd. April 19, 2012 9
Innovation Mystery #1
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Higher the position in a company, more the person talks about Innovation and less he actually do it. Why?
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Innovation Mystery #2
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Everyone is interested in produce of innovation but rarely people are interested in knowing how to innovate
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"Everybody wants to goto to heaven but no one is willing to die (put in hard work)". :)
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Innovation Mystery #3
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Most of us like to advise others on innovation rarely applying those advisory principles on our own self
Confidential Crafitti Consulting Private Ltd. April 19, 2012 12
Innovation Mystery #4
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Post Facto - every innovation is obvious but when we were at the change point rarely we will choose the change path
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Innovation Mystery #5
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Innovation Mystery #6
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It is all about
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Execution!
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Innovation Mystery #7
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Innovation Mystery #8
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Innovation Mystery #9
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Lawyers know about patent law means they know about innovation!!
Confidential Crafitti Consulting Private Ltd.
INVENTORS
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WHAT IS INNOVATION ..
M.K. Gandhi You be the CHANGE that you want to see in the world
Successful exploitation of IDEAS (New/Old) to change the way one understands, generate options, choose options, implement options to generate desired effects
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INNOVATION
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do Innovation by Thinking
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INNOVATION
BUT
It is Taught OUT of US
A childs Creativity LET US REDecreases 90% from 5 to LEARN TO age 7? At 40 it is mere INVENT!!!! 2% of what we had!!!!!!!
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crafting i novation together While the definingn measurement of (old world) was weight the defining measurement of the globalization system is speed speed of commerce, travel, communication and innovation
Flattening World
And we dont even realize it
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Number of alternatives Time pressure Need for analysis Information de-coherence Connections Networks
Connections create Value and Dependencies create complexity Future is approaching us Faster than History is leaving us! Increasing distance between user requirements of what they really need versus what they want. With every choice we make today we Kill many possible futures
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The Magical Number Seven, Plus or Minus Two: Some Limits on our Capacity for cProcessingi oInformation rafting innovat n together
George A. Miller (1956) Harvard University First published in Psychological Review, 63, 81-97.
[1] This paper was first read as an Invited Address before the Eastern Psychological Association in Philadelphia on April 15, 1955.
The point seems to be that, as we add more variables to the display, we increase the total capacity, but we decrease the accuracy for any particular variable. In other words, we can make
relatively crude judgments of several things simultaneously.
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Extent of Connectedness
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Time
Taleb
* Assume a large field which has somewhere underground a box of diamonds. Problem solving is like digging for treasure in a field
If a hole already exists, our inclination is to dig it deeper The deeper the hole, the more difficult it is to see whats happening in other parts of the field If someone else comes along, we encourage them to jump in the hole with us
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Main sources of Psychological Inertia: One discipline only / Not outside your specialty / Looking for Solutions where we feel comfortable
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How do we Kill Ideas Killer Phrases should not be used during Idea Generation*
1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20. "Yes, but. . . " "We tried that before." "That's irrelevant." "We haven't got the manpower." "Obviously, you misread my request." "Don't rock the boat!" "The boss (or competition) will eat you alive." "Don't waste time thinking." "Great idea, but not for us." "It'll never fly." "Don't be ridiculous." "People don't want change." "It's not in the budget." "Put it in writing." "It will be more trouble than it's worth." "It isn't your responsibility." "That's not in your job description." "You can't teach an old dog new tricks." "Let's stick with what works."C "We've done all right so far." 21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40.
"The boss will never go for it." "It's too far ahead of the times." . . . laughter. . . . . . suppressed laughter. . . . . . condescending grin. . . . . . dirty looks. . . "Don't fight city hall!" "I'm the one who gets paid to think." "What will people say?" "Get a committee to look into that." "If it ain't broke, don't fix it." "You have got to be kidding." "No!" "We've always done it this way." "It's all right in theory. . . but. . ." "Be practical!" "Do you realize the paperwork it will create?" "Because I said so." * Reference: What A Great Idea by Charles Chick "I'll get back to you." Thompson, 1992, . . . silence. . . HarperCollins Publishers
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Purpose
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1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. 18. 19. 20.
"Yes, but. . . " "We tried that before." "That's irrelevant." "We haven't got the manpower." "Obviously, you misread my request." "Don't rock the boat!" "The boss (or competition) will eat you alive." "Don't waste time thinking." "Great idea, but not for us." "It'll never fly." "Don't be ridiculous." "People don't want change." "It's not in the budget." "Put it in writing." "It will be more trouble than it's worth." "It isn't your responsibility." "That's not in your job description." "You can't teach an old dog new tricks." "Let's stick with what works."C "We've done all right so far."
21. 22. 23. 24. 25. 26. 27. 28. 29. 30. 31. 32. 33. 34. 35. 36. 37. 38. 39. 40.
"The boss will never go for it." "It's too far ahead of the times." . . . laughter. . . . . . suppressed laughter. . . . . . condescending grin. . . . . . dirty looks. . . "Don't fight city hall!" "I'm the one who gets paid to think." "What will people say?" "Get a committee to look into that." "If it ain't broke, don't fix it." "You have got to be kidding." "No!" "We've always done it this way." "It's all right in theory. . . but. . ." "Be practical!" "Do you realize the paperwork it will create?" "Because I said so." * Reference: What A Great Idea by Charles Chick "I'll get back to you." Thompson, 1992, . . . silence. . . HarperCollins Publishers
Confidential
Failures/Mistakes/Errors
Burning your hand is a small price to pay for a good idea.
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What is Value?
Customer defined Opaque Contextual Multidimensional Tradeoff Relative It is a Mindset
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The perceived worth of the set of benefits received by a customer in exchange for the total cost of the offering, taking into consideration available competitive offerings and pricings Prof Mohanbir Sahney
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25 New Directions to Think for designing the New Capability for Cleaning Teeth
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Desorption Acoustic Cavitation Acoustic Vibration Cavitation Combustion Jet Erosion Spark Erosion Electrochemical Erosion Electron Impact Desorption Laser Evaporation Ionic Action Radioactivity
Redox Reactions Hydrodynamic Cavitation Laser Gettering Ultrasonic Oscillation Friction Cryolysis Photo-Oxidation Optohydraulic Effect Explosion Thermo-destruction Dissolution Mechanical Action/Brushes Electrolysis
Cleans at 41,000 gentle sonic strokes per minute Patented spring-action bristles Attacks heavy plaque build-up and staining Reaches awkward areas with ease Power handle light indicates system is recharging
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Patent Information
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TECHNOLOGICAL ADVANCEMENTS
In return for disclosing an invention publicly so that others can learn from it, and paying the processing fees, the Govt. of the country will grant the inventor of the invention the rights to exclude others from making, using, or selling the invention for a limited period of time
First Systematic Study of Patent Literature started after second world war by Russian Genrich S. Altshuller
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1946 Patent Officer in Russian Navy Discovered patterns in patents, published paper. Sent to Gulag 1954 released, analysed 2,500,000 patents Identified what makes a successful patent 1956-1985 TRIZ formulated
TRIZ itself does not solve problems. Problems are solved by people. TRIZ teaches how to solve problems.
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TRIZ Busted 4 Key Myths in 1985 However since TRIZ came out recently the Myths continue
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How to Invent? (a) Look out for problems and solutions across domains if you search only in your field and domain you will continue to be repeating the same!
Problems and Solutions are same in different industries (Myth: My field is Unique ) Evolution paths for all technical systems can be deciphered (Myth: Evolution is Completely Random) Strong Inventions in a domain used outside ideas (Myth: Innovation happens through Deeper Knowledge) Strong Inventions uncover and eliminate conflicts (Myth: Optimization is the Focus)
(c) Apply Knowledge from other fields by focusing on key functions that system needs to deliver
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(d) Identify System Conflicts and provide outside knowledge to domain experts to invent solutions Private Ltd. optimization 19, 2012 beyond Crafitti Consulting April
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5 Levels of Inventions
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Pioneering Invention based on newly discovered phenomenon Pushing existing technology to a higher level Revolutionary
New System Developed Interdisciplinary solutions Replacing old technology with New
Radical change or elimination of one principal system component One Engineering Discipline Resolution of a physical contradiction
Slight Modification of the system Knowledge from different areas within the industry Resolution of a technical contradiction
A simple improvement Knowledge within the trade No system conflicts are resolved
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No known means for solution High psychological inertia Contains one or more contradictions
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A contradiction is a situation where an attempt to improve one feature of the system leads to the degradation of another feature.
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1. Unintentional activation of functions due to unintentional touch 2. Locking and Unlocking mechanism implemented 3. Problems with locking/unlocking ease of use of the device in general is a problem
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In TRIZ parlance .. .It starts with a contradiction We try to improve one system parameter but some other parameter gets affected
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TRIZ
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By Locking and Unlocking mechanism ease of use of the device in general became a problem
What system parameter(s) you are trying to improve?
27 Reliability
What system parameter(s) degrade?
33 Convenience of Use
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Principle 27. Cheap short-living objects A. Replace an expensive object with a multiple of inexpensive objects, comprising certain qualitiesr a(such nasaservicehlife, for c fting in ov tion toget er instance).
Use disposable paper objects to avoid the cost of cleaning and storing durable objects. Plastic cups in motels, disposable diapers, many kinds of medical supplies.
STORIES OF CHANGE
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Universe as an Evolutionary System a new understanding (NASA report 2009) Cosmic Evolution, the idea that the universe
and its constituent parts are constantly evolving, has become widely accepted only in the last 50 years. It was also during the last 50 yearsa century after Darwin proposed that evolution by natural selection applies to life on our own planetthat researchers from a variety of disciplines began to seriously study the possibilities of extraterrestrial life and the biological universe.
Cosmos and Culture : Cultural Evolution in a Cosmic Context / Steven J. Dick and Mark Lupisella, editors. (NASA Report 2009)
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In the light of the above Altshullers postulate in 1946 that technological systems are evolutionary and obeys certain laws is amazing! More important: he created a framework to apply 64 April 2012 NEXT! these Laws to invent19,the Crafitti Consulting Private
Altshuller was the first to realize that the direction of progress, or technical evolution, is defined by increasing the ideality level An Ideal system does not exist, but all of its functions are fulfilled at the right time and at the right place without energy, substance, or other resources, and without any ill effects.
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IDEALITY The Cardinal Law (Technical Systems are striving for Perfection)
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Evolution of Eye-Glasses
Contact Lens
Ideality
The bifocals
TIME
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1. Define, Describe, Explore, Imagine and Investigate the system, problem, scenario or situation from multiple perspectives using different tools 2. Find out what key functions the system is performing or need to perform. Describe an ideal way the system can get to performing the function. Find out how many ways does the world knows about performing the specific functions. 3. Generate Ideas about performing these functions using specific TRIZ methods utilizing resources to the max. 4. Develop these ideas into solution directions that can be implemented
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1. What is my Ideal Final Result How can I achieve the functionality without spending any resources or cost 2. How the problem/situation/system looks in time and space coordinates 3. Am I using all the existing resources or potential resources to the fullest 4. What is the main useful function I need to deliver. What are various ways in which I can deliver the function 5. How others have solved the same problem in the past
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Copyri
TRIZ Impact
TRIZ
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Number of Ideas
Insertion of new solution suggestions
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Time
Confidential Copyri
2. Law of Non-uniform evolution of subsystems -> Leads to System Conflicts 3. Law of Transition to a higher Level system 4. Law of Increasing dynamism (flexibility) -> from simple to more complex -> More adaptable to change
6. Law of Completeness
7. Law of Shortening of Energy Flow Path -> Reduction in Energy/Info transformation stages 8. Law of Increasing controllability -> Evolution of controlled interactions of system elements 9. Law of Harmonization of rhythms -> Synchronization of natural frequencies of elements
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LINES OF EVOLUTION
Lines of evolution specify stages of a systems evolution along a general direction. They also provide the upper limit of evolution as per todays technological limits
Stage 1
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Stage 2 Line 1
Stage 3
Stage 4
LAW
Line 2
Line 3
On each line there are discrete stages of evolution of systems
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Very clearly visible in the software based Era of technical systems that we are in!
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Transhuman Systems
SYSTEMS
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Most of the commercial software systems are trying to move towards Brilliant systems today
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Making systems Brilliant any/all technical system brilliant using software is the method for next 10-15 years
Brilliant
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By 2050-2060 Transhuman systems will start emerging (Singularity is near ~ Ray Kurzweil)
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Mutually Exclusive: The two ideas which are unrelated without any connection between them. One is a result of second: The arrow represents the direction of origin of idea. Combination of two ideas gives a valuable or a bigger idea. Nullification: The combination of two ideas annuls each other. Negative output: The combination of two ideas would produce a negative output.
From the list of ideas that we have obtained from various sessions start reading each one by one. As you read 1, 2, 3, ., start looking at relationships between ideas. Pick up the first idea and put write down 1 on a paper. Read the second idea is it related to first if yes write 2 next to 1 or write 2 some distance away from 1. One by one you keep doing this picking and sorting into classes. This will result in some sort of clusters such as 1, 5, 7, 8, 12 2, 3, 9, 15, 19 4, 6, 10, 11, 13, 20 14, 16, 17, 18 Each of these clusters may be termed as a concept, subtheme or theme.
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Raw Ideas/Concept
Raw Ideas/Concept
About 30% raw ideas are generic If you need to create a concept maximum 21 number of non-generic raw ideas are needed
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Our study on 15+ Invention Projects in 5 different organizations creating more than 200 new concepts using Crafittis end to end process indicates that raw ideas per concept is stochastic process it follows Poisson distribution with average 6 and standard deviation 6 Maximum 28 Raw Ideas will ensure a Concept
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1 7 13 19 25 31 37 43 49 55 61 67 73 79 85 91 97 103 109 115 121 127 133 139 145 151 157 163 169 175 181 187 193 199 205 211 217
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Technical Dec 2011 Paper at Hyderabad: Oct 2010 Public Workshop Advanced Advanced Patent presentation Patent Analysis using TRIZ Analysis @ 7th Session on IPR: Public Workshop - Lean International Talk at SPIN: Strategy and Business Inventive Systems Thinking Symposium Feb 2009 Effective Lean Implications at TRIZ Session @ on Fuels Management for WeSchool Talk: TRIZ for GIS Sobha Developers and Software Delivery at CAIR, DRDO Bangalore Lubricants, Talk at Subex: Ideas and Triggering Ideas with Delhi Talk Innovation Talk at Russian Inventive Principles Crafting at KCE Culture and TRIZ: Session at WeSchool Talk at Philips: Science Centre: Innovation and TRIZ for June 2008 Advanced Patent Innovation and Management Team of Analysis using TRIZ Patents using TRIZ First Indian Company, Talk at BMA: Lean Talk at Ranbaxy: Bangalore Thinking Talk at BarCamp: Vedic Innovation Algorithms Inventive Principles Talk at New Horizon Talk at CCSTDS: TRIZ for ICRISAT @ College of Management: TRIZ in Patent Hyderabad Talk: Role of IP in Lean Thinking Business Valuation Analysis
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Crafitti organized the FIRST TRIZ INDIA SUMMIT 29-30 July 2010 Bangalore
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Organization
Embedding Innovation DNA , Technology and business strategy, process productivity and value generation, IPR advisory services, Patent analysis and portfolio management
Lean Thinking, Systems Thinking, Value Engineering, Design Thinking, Inventive Thinking, Decision Engineering
People
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Crafitti is an innovation research and consulting firm and facilitates innovation in business, science and technology contexts Crafitti is currently incubated at the NSR centre for Entrepreneurial Learning at IIM Bangalore
Navneet Bhushan and Karthikeyan Iyer, the founding directors of the firm, have close to 30 years of collective industry experience and have been focused on researching and facilitating innovation in diverse enterprise contexts over the past decade
Crafittis frameworks are a distillation of this experience and provide a potent platform to accelerate innovation in contexts as diverse as building innovative business strategies, conceptualizing and designing new breakthrough products and services, designing technological alternatives, intellectual property portfolio management, process innovation and embedding innovation DNA in organizations.
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Founder director of CRAFITTI CONSULTING (www.crafitti.com) a research and consulting think tank - co-crafting Innovation with global enterprises.
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Principal author of Strategic Decision Making- Applying the Analytic Hierarchy Process published by SpringerVerlag, UK, as part of the Decision Engineering Series. The book has been featured at Harvard Business School Working Knowledge for Business Leaders. Has authored more than 65 research papers and articles. Associate editor of the International Journal of Analytic Hierarchy Process and reviews research papers for defence science journal. Blogs at http://innovationcrafting.blogspot.com
Previously held various corporate positions Vice-President and Head (Innovation) with Hexaware Technologies), Principal Consultant with Wipro Technologies CEO of CREAX Information Technologies Pvt Ltd., Technology Specialist at Philips global Intellectual Property & Standards (IP&S) division, Senior Research Associate with Infosys Technologies Limited (http://www.infosys.com). Scientist in DRDO 1990-2000.
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Thank You
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If a light wave was to be stationary one could scoop out a handful of light just like ice-cream?
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When in 1946 A 20 years old engineer. in Soviet Union Navy discovered (after studying large number of inventions, patterns in Technical systems) and proposed
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Technological Systems also just like living systems evolve and One can identify stages of evolution of technical systems
which can be used to predict and develop next generation technical systems .
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Whether you are small or big has nothing to do with your size
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Thank You
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Case Studies
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Objectives and Process The objective of a Technological Alternative Study (TAS) is to analyze a given Patent and explore various ways in which the invention described in the patent can be transformed to next levels in its evolution. There are four main phases of this study and it is always carried out with the domain experts from client organization.
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Phase I: Patent study and analysis Phase II: Phase II: Preliminary ideation Phase III: Collective brainstorm in a workshop setting (To be carried out during the workshop) Phase IV: Solution evaluation and final report submission (To be carried out during the workshop)
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Lines System completeness Reduction in the number of energy transformation stages Decreasing time to perform the function
Multi-systems
Increasing Convolution
Evolution of Materials Increasing flexibility of physical Field structures Transition to fluids and fields Change of Scale Increasing fragmentation Layered Increasing degree of voids-filled-withIncreasing Fragmentation voidness substance Transition to continuously Multi-state system Increasing functional flexibility variable system Transition to active adaptive Operator-controlled systems system Transition to self-adapting Rigid system systems Transition towards forward No feedback sensing Proliferation of energy forms Increasing controllability of Biological that are easier to control Energy sources
Choose the system Total stage from drop Number Any Sub-lines down menu of stages Technology Dislodging of human Emergence of 3 2 involvement engine Reduced c r a f t i n g energy v a t i o n t Few t h e r number of i n n o oge 3 2 transformation stages transformations Function distribution among one two or more simultaneously system(subsystem) 3 1 operating systems per function Transition to a peak mode of Continuous 4 1 performance Transition to preliminary Partial preliminary 2 1 action action Increasing number of Poly-system 3 3 systems Increasing diversity of Heterogeneous 4 3 components Increasing Convolution of bi Separate systems 3 1 and poly systems Increasing non-uniformity of Homogeneous 3 1 materials 6 6 4 3 3 4 3 6 6 2 3 2 2 1 1 6
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Relevant Lines are chosen and current state of the field mapped to specific stage. On each line of evolution, one can move from current state to next state guided by Lines.
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Results
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In July, 2011 a workshop was conducted by Crafitti at YYY center on Strengthening Patent Portfolios It was attended by more than 20 Scientists and Engineers of YYY As part of the workshop an exercise was conducted to find technological alternatives to a patent. In the live case study, a specific patent was chosen and Crafittis systematic process for inventing was applied. 122 raw ideas were generated in 3 hours using Inventive principles, Laws/Lines of system evolution and patent claims.
The Strategic Bubble Chart gives us a plot of all 7 concepts on NoveltyFeasibility Plane. The size of Bubble indicates the relative business potential.The Strategic Bubble Chart gives us a clear direction and road map for each concept. It was mentioned that If we carry out similar exercise for other 9 themes we should be able to create at least 40-60 concepts.
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How to Analyze Patents using Social Network Analysis (SNA) and TRIZ
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CDK Inhibitors
In general, pharmacological inhibitors of CDKs display selective anti-proliferative rafting inno ation tog ther effects onccycling cells,v especiallye tumour cells. Many compounds with very high potency against CDKs in vitro are available, which (like the pyridine based inhibitors) are structural analogues of ATP. However, in many cases this biochemical potency does not translate into cellular potency, presumably due to unknown mechanistic reasons and perhaps because of high physiological ATP concentrations. Connected with this problem is the question of what are the actual cellular targets of a biochemical CDK inhibitor. Most of the CDK inhibitors like any protein kinase inhibitors are ATP analogues and bind to the ATP binding pocket of the enzyme, this lead them to bind non-specifically across the class of CDKs.
The state of art CDK inhibitor development is facing two challenges (subject matter of US 7271193) improving potency of inhibitor improving specificity of inhibitor
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TRIZ Way of Analyzing a Patent for Finding out Strength and Inventive Principles
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The state of art CDK inhibitor development is facing two challenges (subject matter of US 7271193) improving potency of inhibitor improving specificity of inhibitor
Make each part of an object function in conditions most suitable for its operation. Make each part of an object fulfil a different and useful function. IDEA TO EXPLORE - Inhibitor has two parts with one, it should bind strongly to the enzyme via its ATP binding pocket, and the second part is designed so that the chemical groups are able to reach residues outside of the ATP binding sites(1). Another way of looking at it is to design bi-substrate analogue(2).
References (1) The AAPS Journal 2006; 8 (1) Article 25 ;Selectivity and Potency of Cyclin-dependent Kinase Inhibitors; Jayalakshmi Sridhar ,1 Nagaraju Akula, 1 and Nagarajan Pattabiraman. (2) Nature Structural Biology , volume 8 number 1,2001,Mechanism-based design of a protein kinase inhibitor; Keykavous Parang, et al.
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Inventive Principle (13) The other way round Invert the action(s) used to solve the problem (e.g. instead of cooling an object, heat it) IDEA TO EXPLORE instead of competitive inhibition of the kinases make the enzyme-substrate complex un-dissociate able. Make movable parts (or the external environment) fixed, and fixed parts movable. IDEA TO EXPLORE This can be employed while performing chemical substitution of the inhibitors, substituting fixed amino acid/chemical groups with flexible ones and vice a versa Inventive Principle (21) Skipping Conduct a process, or certain stages (e.g. destructible, harmful or hazardous operations) at high speed. IDEA TO EXPLORE Improving the rate of association and/or dissociation between enzyme and inhibitors.
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The physical contradiction which need to be resolved is inhibitor present and inhibitor absent at the same time. This physical contradiction can be resolved by separation in space
Where do I want inhibitor to be present: at the site of cdk4 Where do I want inhibitor to be absent: at the site of cdk2
Segmentation Taking out Local quality Another dimension Other way round Curvature Asymmetry Nested doll Flexible shells/thin films Intermediary Copying
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Local quality
-Inhibitor shaped exactly complementary to cdk4 active site to facilitate stable locking or stable enzymeinhibitor complex formation. -Make the inhibitor in such a way so that when it is in contact with the desired enzyme it will make the enzyme properly orient, by forming special bonds or make the inhibitor inactive when it gets exposed to undesired enzyme. -In addition to ATP-binding site of CDK4 which can be exploited for various sites of interaction, the residues outside the main ATP-binding cleft have been identified that could be targeted to increase specificity and potency for particular enzyme Make the structure of a inhibitor non-planar and is therefore not likely to intercalate with DNA, and thus reducing toxicity. Varying the chain length between the substituents, as well as changing the bond from single to double or vice a versa, degree of flexibility can be achieved in the inhibitor molecule itself. This will cause increase or decrease the interaction between cdk and enzyme.
Another dimension
Intermediary
Increase accessibility of the active site using hydrophilic solvent, which also increases hydrogen bonding.
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Curvature
Switch between linear and rotary motion to enhance desired interaction between enzyme and inhibitor
Prepare a particular stereoisomer or geometrical isomer of the inhibitor which will interact with the desired active site of the enzyme
The data obtained through X-ray Crystallography (structure of enzymeinhibitor complex), and molecular modeling or molecular dynamics simulations will enhance the chances to prepare highly selective and efficient inhibitor.
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Asymmetry
Copying
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Mapping the Patent to TRIZ Lines of System Evolution Finding Further Invention Potential
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Invention Potential
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Pioneering Invention based on newly discovered phenomenon Pushing existing technology to a higher level Revolutionary
New System Developed Interdisciplinary solutions Replacing old technology with New
Radical change or elimination of one principal system component One Engineering Discipline Resolution of a physical contradiction
Slight Modification of the system Knowledge from different areas within the industry Resolution of a technical contradiction
A simple improvement Knowledge within the trade No system conflicts are resolved
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US 7271193
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CRAFITTI BRINGS HOLISTIC THINKING IN THE FORM OF LEAN INVENTIVE SYSTEMS THINKING TO CO-CRAFTi nCHANGEg e..r crafting novation to the
Inventive Thinking
(inventive triggers, laws of evolution, scenario building, focus on function)
Lean Thinking
(Value maximization, experimentation, learning approach, elegance)
Systems Thinking
(holistic approach, global optima, expanded and connected system context)
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FINAL POINTS
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The World is Not What it Used to Be . We Need New Type of Organizations Innovative Learning Enterprises All of us can be the Innovators of the new world New ways of looking at reality are needed We need to design organization as a Innovative Learning Enterprise Artful Making, Lean Thinking, TRIZ, Social Computing, Open Innovation, Scenario Planning needs to be integrated as a framework
Lean Inventive Systems Thinking LIST we propose to be the new framework for INNOVATION!
Confidential CRAFITTI CONSULTING