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Neuroanatomy
Brain Cranial nerves Spinal cord
Brain Anatomy
Massive area will try and give you a brief overview not all the detail is included, just enough to give you a rough understanding of the layout of the brain Developmentally the brain can be divided into the:
Forebrain Midbrain Hindbrain
White matter
Contains the axons of the neurons, 3 types:
Association fibers interconnect the cortex within one hemisphere Commisural fibers interconnect hemispheres Projection fibers link cortex to lower structures (diencephalon, brainstem, cerebellum, spinal cord) form the internal capsule
Forebrain
Cerebral hemispheres Basal ganglia Diencephalon
Thalamus Hypothalamus
Limbic system
Amygdala Hippocampus
Forebrain
Cerebral hemispheres Basal ganglia Diencephalon
Thalamus Hypothalamus
Limbic system
Amygdala Hippocampus
Cerebral hemispheres
Two hemispheres separated by the longitudinal fissure and connected by the corpus callosum Contains unique pattern of sulci and gyri:
Central sulcus between frontal and parietal lobes Lateral sulcus between frontal and temporal lobes Parieto-occipital sulcus
Four lobes
Frontal primary motor area (precentral gyrus), executive function Parietal primary sensory area (postcentral gyrus) Temporal auditory and olfactory Occipital visual cortex
Cerebral hemispheres
Contain association areas where sensory and motor inputs are integrated:
Somatic motor association area in the frontal lobe Somatic sensory association area in the parietal lobe Brocas area speech, fronto-temporal region (usually left) Wernickes area integration of auditory and speech, end of the lateral sulcus
Forebrain
Cerebral hemispheres Basal nuclei Diencephalon
Thalamus Hypothalamus
Limbic system
Amygdala Hippocampus
Basal Nuclei
Grey matter which deals with a lot of the subconscious sensory input and motor commands Considered part of the basal ganglia which also include motor nuclei in the diencephalon and midbrain Include:
Caudate nucleus Lentiform nucleus
Globus pallidus Putamen
Information arrives at the caudate nucleus and putamen from the cortex and is relayed via the globus pallidus to the thalamus and then back to the cortex. This can be used eg to modify ongoing movements
Forebrain
Cerebral hemispheres Basal ganglia Diencephalon
Thalamus Hypothalamus
Limbic system
Amygdala Hippocampus
Diencephalon
Lies at the top of the brainstem and links the brainstem to the cortex, filtering and integrating conscious and unconscious sensory and motor signals Four parts:
Epithalamus roof of the diencephalon, contains choroid plexus and the pineal gland which secretes melatonin and regulates the day cycle Thalamus Hypothalamus Subthalamus between the thalamus and hypothalamus, contains portions of the substantia nigra and red nucleus, communicates with the basal ganglia to coordinate movement
Thalamus
All ascending tracts of the spinal and cranial nerves (except olfactory) synapse with nuclei in the thalamus before being relayed to the cortex and becoming conscious ie the thalamus filters sensory input
Hypothalamus
Floor of the diencephalon Link between the neural and endocrine systems integrates activities of the ANS and the pituitary gland
Has various nuclei and control centres eg feeding reflexes, control of HR and BP, thermoregulation
Releases the regulatory hormones that control secretion of hormones from the anterior pituitary gland The posterior pituitary gland is actually an extension of the hypothalamus and releases two important hormones ADH and oxytocin
Forebrain
Cerebral hemispheres Basal ganglia Diencephalon
Thalamus Hypothalamus
Limbic system
Amygdala Hippocampus
Limbic system
Complex area, not fully understood Contains a number of structures (each one located in both hemispheres):
Hippocampus involved in formation of long-term memories Amygdala involved in emotions and their link to memories Mammilary body formation of memories Fornix links hippocampus and mammilary body
Midbrain (Mesencephalon)
Tectum
Superior colliculi Inferior colliculi
Tegmentum
Red nucleus Substantia nigra
Cerebral peduncles Tectum and tegmentum are grey matter, cerebral peduncles are white matter
Midbrain (Mesencephalon)
Tectum
Superior colliculi Inferior colliculi
Tegmentum
Red nucleus Substantia nigra
Cerebral peduncles Tectum and tegmentum are grey matter, cerebral peduncles are white matter
Tectum
Roof of the midbrain Two pairs of sensory nuclei
Superior colliculi integrate visual information with sensory information, initiate reflex responses to visual stimuli Inferior colliculi as above except auditory
Midbrain (Mesencephalon)
Tectum
Superior colliculi Inferior colliculi
Tegmentum
Red nucleus Substantia nigra
Cerebral peduncles Tectum and tegmentum are grey matter, cerebral peduncles are white matter
Tentorum
Red nucleus control upper limb position and background muscle tone, high number of blood vessels give it red colour
Substantia nigra regulate activity in basal nuclei eg movement, also involved in reward and addition. Contains darkly pigmented dopaminergic neurons
Midbrain (Mesencephalon)
Tectum
Superior colliculi Inferior colliculi
Tegmentum
Red nucleus Substantia nigra
Cerebral peduncles Tectum and tegmentum are grey matter, cerebral peduncles are white matter
Cerebral peduncles
Descending fibres
Connect cerebrum to cerebellum via the pons Carry voluntary commands issued by the cerebrum
Hindbrain
Cerebellum Pons Medulla oblongata
Hindbrain
Cerebellum Pons Medulla oblongata
Cerebellum
Lies posterior to the brainstem Two hemispheres separated by a raised band of cortex called the vermis Anterior and posterior lobes divided by the primary fissure Outer layer of cortex responsible for:
Balance and equilibrium by adusting muscle posture Comparing intended movements with those produced to smooth and coordinate movement
Hindbrain
Cerebellum Pons Medulla oblongata
Pons
Lies between mesencephalon and medulla oblongata Four main functions:
Links cerebellum to rest of brain and spinal cord Contains two areas important in respiratory control (apneustic centre and pneumotaxic centre) Nuclei of cranial nerves V-VIII Transverse fibers connecting nuclei of pons to cerebellar hemisphere on opposite side
Hindbrain
Cerebellum Pons Medulla oblongata
Medulla oblongata
Grey matter
Centres for control of vomiting, coughing, sneezing, hiccoughs, HR, breathing, blood vessel diameter, autonomic function Nuclei of cranial nerves VIII-XII
Ventricles
Chambers in the brain lined by a membrane called the ependyma through which CSF circulates Each cerebral hemisphere contains a large lateral ventricle, they are separated by the septum pellucidum The diencephalon contains the third ventricle connected to the lateral ventricles by the interventricular foramen This connects to the fourth ventricle, which lies between the pons and cerebellum, through the cerebral (mesencephalic) aqueduct The fourth ventricle narrows to become continuous with the central canal of the spinal cord Foramina (or apertures) in the fourth ventricle connect it to the subarachnoid space
Meninges
Three layers which are similar to those of the spinal cord with some small differences Dura mater
Outer (endosteal) and inner (meningeal) layers, outer is fused to the periosteum of the skull so there is no epidural space Gap between contains blood vessels and the venous sinuses Dural folds provide support and create sinuses:
Falx cerebri between cerebral hemispheres Tentorum cerebelli separates cerebrum and cerebellum Falx cerebelli separates cerebellar hemispheres
Arachnoid mater
Consists of arachnoid membrane which is attached to the inner dural layer and the arachnoid trabeculae which make up the subarachnoid space
Pia mater
Innermost layer and only one which follows all the brain folds, anchored to the CNS by astrocytes
Cranial Nerves
Cranial Nerves
Many many mnemonics to remember them! Oh, Oh, Oh, They Traveled And Found Voldermort Guarding Very Secret Hallows
Olfactory - Sensory Optic - Sensory Oculomotor - Motor Trochlea - Motor Trigeminal Both Abducens - Motor Facial - Both Vestibulocochlear - Sensory Glossopharyngeal - Both Vagus - Both Spinal accessory - Motor Hypoglossal Motor
To remember their functions: Some Say Marry Money, But My Brother Says Big Brains Matter Most
I Olfactory
Olfactory forms olfactory bulbs above the cribriform plate of the ethmoid bone and olfactory nerve fibers extend through this Responsible for sense of smell
II Optic
Form the retinas, as they travel back into the brain half the fibres on each side crossover at the optic chiasm and all fibres terminate in the occipital lobe
Facial
Motor muscles of facial expression, as well as the stapedius muscle which tightens the bones of the ear Sensory anterior 2/3 of the tongue
Glossopharyngeal
Sensory sensation of the pharynx and middle, taste from the posterior 1/3 of the tongue Motor swallowing by the stylopharyngeus muscle
Spinal Accessory
Motor sternocleidomastoid and trapezius muscles, movement of the neck and shoulders
Hypoglossal
Muscles of the tongue
Spinal Cord
Spinal Cord
Continuation from the medulla oblongata Begins at C1, descends in the vertebral canal and ends at L1-L2 in the adult Tapers to the conus medullaris, spinal nerves continue beyond here as the cauda equina Two enlargements cervical and lumbar where nerves of the limbs emerge
Spinal Nerves
31 pairs - 8 cervical, 12 thoracic, 5 lumbar, 5 sacral, 1 coccygeal Each nerve emerges from the dorsolateral (posterolateral) and ventrolateral (anterolateral) aspects of the cord and joins together to form the nerve which passes through the intervertebral foramen Dorsal roots contain sensory neurons whose cell bodies lie just outside the spinal cord in the dorsal root ganglion Ventral roots contain motor neurons whose cell bodies lie within the spinal cord
The spinal nerve divides into the dorsal ramus (posterior trunk) and ventral ramus (anterior trunk)
Spinal Cord
Divided in half by the dorsal median sulcus and the anterior median fissure Grey matter
Dorsal horn sensory neurons Ventral horn cell bodies of motor neurons Lateral horn sympathetic neurons (only thoracic and lumbar)
White matter
Dorsal, ventral and lateral columns
Spinal Tracts
Motor
Descending tracts extend from the cortex in the brain to the muscles consist of two neurons the upper and lower motor neurons
Sensory
Ascending tracts Consist of three neurons between a receptor in the periphery to the sensory cortex in the brain
Begins in the motor cortex, descend in internal capsule and past thalamus and into pyramids swellings in the medulla
As it descends 90% decussate (switch side) at the medulla while the other 10% decussate at the ventral horn At the ventral horn the upper motor neuron synapses with the lower which innervates the muscle Some other neurons which effect movement descend in other tracts as the extrapyramidal fibers
Myotomes
Know which nerves are tested by testing reflexes:
Triceps C7, C8 Biceps C5, C6 Supinator C5, C6 Knee L3, L4 Ankle S1, S2
Clinical Neurology