are endogens polypeptides mediators of cell-cell interaction, which regulate developing of organism, form protect immune reactions against

antigens, control of hematopoiesis and other processes.

 Are polypeptides They produced by different cells in small concentration

(pg/ml) redundancy (it mean, that each type of cells can produce different cytokines and each cytokine can produced by different cells) Multifunctionality (it mean that cytokines can activate different cells)
Actions of cytokines is mediated by special

receptors

Cells, which produce cytokines

cell-target

Cells, which produce cytokines

cell-target

 Recognition and Presentation of antigens Hematopoiesis

Cell migration
Activation and proliferation of cells

Immune response

 Il-1, TNF, Il-6, - stimulate

expression of MHC on APC

 Recognition and Presentation of antigens Hematopoiesis

Cells migration
Activation and proliferation of cells Immune response

autoimmune disease
Th1

IFN Th2

Allergy

Il-4, Il-5, Il-13 Th0

Th17

Inflammation, graft-versus-host disease

Treg

Il-17, Il-21, Il-22

immunesupression
Il-10, TGF

 Recognition and Presentation of antigens Hematopoiesis

Cells migration
Activation and proliferation of cells Immune response

 Recognition and Presentation of antigens Hematopoiesis

Cells migration
Activation and proliferation of cells Immune response

 Recognition and Presentation of antigens Hematopoiesis

Cells migration
Activation and proliferation of cells Immune response

 Interleukins (Il-1 l-33 )

Interferons (IFN, IFN -, IFN -)

Tumor necrosis factors (TNF- TNF- ) Growth Factors

Chemokines

 Defect of mechanisms of induction and

regulation of cytokines synthesis Defect of cytokines genes Defect of cytokines receptors

 Inflammotory cytokines provide

inflammation Il-1, TNF, Il-8

 - particular medical condition, which develops as a

outcome of the inflammatory process. The pathological process by virtue of the inadequacy of the body's defenses is shown a generalized dissimination pathogen in terms of increasing immunosuppression

 - Il-10, TGF

Il-4, Il-13, TNF

Mast Cells

chemokines producing Activation of T-cells, basophiles and eosinophils

h1 produce IFN

h2 produce Il-4, -5, -13

Recombination cytokins

Extracorporal cytokinotherapy

Autocytokinotherapy

Gene cytokinotherapy

Anticytokinotherapy

Autologic complex of immune molecules

leucocytes

Peripheral blood

Patients

 Recombination cytokins

Extracorporal cytokinotherapy
Gene cytokinotherapy Anticytokinotherapy