Komposisi (mg) F1 F2 F3 F4 F5 F6 F7 F8

Bisprolol 62.5 62.5 62.5 62.5 62.5 62.5 62.5 62.5

HPMC E15 300 300 300 300 600 600 600 600
Maltodextrin 50 50 150 150 50 50 150 150
PEG 400 50 90 50 90 50 90 50 90
Asam Sitrat 18 18 18 18 18 18 18 18
Menthol qs qs qs qs qs qs qs qs
Sorbitol 50 50 50 50 50 50 50 50
Aquadest qs qs qs qs qs qs qs qs
Berat total 530.5 570.5 630.5 670.5 830.5 870.5 930.5 970.5

Berat masing2 film 21.22 22.82 25.22 26.82 33.22 34.82 37.22 38.82
 Pemeriksaan Organoleptis
Formula
Warna Tekstur Sisi
F1 Bening, transparan Homogen Kedua sisi lembut
F2 Bening, transparan Homogen Kedua sisi lembut
F3 Bening, transparan Homogen Kedua sisi lembut
F4 Bening, transparan Homogen Kedua sisi lembut
F5 Bening, transparan Homogen Kedua sisi lembut
F6 Bening, transparan Homogen Kedua sisi lembut
F7 Bening, transparan Homogen Kedua sisi lembut
F8 Bening, transparan Homogen Kedua sisi lembut
 Ketebalan (mm)
No.
F1 F2 F3 F4 F5 F6 F7 F8
1 0.062 0.076 0.088 0.092 0.103 0.115 0.124 0.130
2 0.063 0.077 0.089 0.099 0.100 0.114 0.122 0.131
3 0.061 0.078 0.086 0.098 0.105 0.114 0.121 0.130
4 0.063 0.075 0.088 0.097 0.106 0.113 0.120 0.131
5 0.062 0.076 0.085 0.096 0.104 0.110 0.120 0.132
6 0.062 0.076 0.087 0.095 0.104 0.110 0.120 0.133
7 0.061 0.076 0.085 0.099 0.102 0.112 0.120 0.135
8 0.062 0.078 0.086 0.097 0.104 0.110 0.120 0.136
9 0.062 0.077 0.088 0.097 0.102 0.110 0.124 0.137
10 0.060 0.078 0.089 0.098 0.100 0.112 0.120 0.132
Rata - rata 0.062 0.077 0.087 0.097 0.103 0.112 0.121 0.133
SD 0.001 0.001 0.002 0.002 0.002 0.002 0.002 0.002
CV (%) 1.487 1.381 1.750 2.167 1.942 1.735 1.374 1.881
 Keseragaman Bobot ODF Bisoprolol Fumarat

Keseragaman Bobot (mg)

No.
F1 F2 F3 F4 F5 F6 F7 F8
1 50.50 50.98 53.31 56.67 67.02 66.50 70.42 71.42
2 50.40 50.88 54.01 60.05 62.80 67.70 65.70 69.70
3 52.20 51.02 55.02 57.89 63.50 68.60 66.60 69.90
4 51.40 49.98 53.02 60.08 62.20 65.60 68.89 68.89
5 53.23 50.88 49.99 60.10 63.60 65.70 70.12 71.12
6 50.22 50.78 53.30 60.07 66.01 68.50 70.20 70.20
7 49.80 49.90 54.55 60.02 64.90 68.80 68.80 70.76
8 49.70 50.99 49.87 57.76 62.30 70.23 70.65 70.65
9 52.20 50.82 49.99 58.68 64.60 70.33 70.76 72.76
10 51.34 49.89 54.55 60.04 65.80 70.12 70.76 70.76
11 50.30 50.44 53.67 58.80 64.50 69.80 69.90 71.20
12 49.88 51.05 55.89 58.67 65.90 68.60 69.80 71.44
13 49.91 50.77 53.65 57.80 62.20 70.34 70.34 70.34
14 49.90 54.40 54.08 60.12 64.50 70.44 70.44 70.44
15 50.20 49.88 54.78 60.02 65.80 70.23 70.23 70.23
16 50.23 49.88 56.04 58.87 65.70 70.33 70.33 70.33
17 50.41 51.99 53.05 57.67 63.30 70.52 70.52 70.52
18 52.33 52.65 55.50 60.07 63.50 70.45 70.45 70.45
19 51.23 54.56 56.72 58.78 65.40 70.22 70.22 70.22
20 51.55 52.34 54.70 58.67 65.20 70.60 70.60 70.60
Rata - rata 50.85 51.20 53.78 59.04 64.44 69.18 69.79 70.60
SD 1.02 1.36 1.94 1.08 1.44 1.64 1.36 0.78
CV (%) 2.01% 2.66% 3.61% 1.82% 2.23% 2.37% 1.95% 1.11%
Range 7,5% BB 47.03 47.36 49.75 54.61 59.60 63.99 64.55 65.30
Range 7,5% BA 54.66 55.04 57.82 63.47 69.27 74.37 75.02 75.89
Range 15% BB 43.22 43.52 45.72 50.19 54.77 58.80 59.32 60.01
Range 15% BA 58.47 58.88 61.85 67.90 74.10 79.56 80.25 81.19
Penetapan Kadar
Y = 0,0588x + 0,0985

Formula 1 Formula 2
Faktor Terukur
Replikasi Absorbansi Kadar (ppm) pengenceran (mg) Replikasi Absorbansi

1 0.400 5.13 20 5.13 1 0.401

2 0.386 4.89 20 4.89 2 0.389
3 0.399 5.11 20 5.11 3 0.399
4 0.389 4.94 20 4.94 4 0.389
5 0.395 5.04 20 5.04 5 0.387
6 0.382 4.82 20 4.82 6 0.383
Rata - Rata 4.99 Rata - Rata
%Rata - rata kadar 99.77 %Rata - rata kadar
SD 0.12 SD
%CV 2.49 %CV

Formula 5 Formula 6
Faktor Terukur
Replikasi Absorbansi Kadar (ppm) Pengenceran (mg) Replikasi Absorbansi

1 0.396 5.06 20 5.06 1 0.397

2 0.381 4.80 20 4.80 2 0.390
3 0.392 4.99 20 4.99 3 0.391
4 0.390 4.96 20 4.96 4 0.384
5 0.394 5.03 20 5.03 5 0.387
6 0.398 5.09 20 5.09 6 0.396
Rata - Rata 4.99 Rata - Rata
%Rata - rata kadar 99.77 %Rata - rata kadar
SD 0.10 SD
%CV 2.05 %CV
 Formula 3
Faktor Terukur Faktor
Kadar (ppm) Pengenceran (mg) Replikasi Absorbansi Kadar (ppm) Pengenceran

5.14 20 5.14 1 0.401 5.14 20

4.94 20 4.94 2 0.387 4.91 20
5.11 20 5.11 3 0.396 5.06 20
4.94 20 4.94 4 0.389 4.94 20
4.91 20 4.91 5 0.386 4.89 20
4.84 20 4.84 6 0.385 4.87 20
Rata - Rata 4.98 Rata - Rata
%Rata - rata kadar 99.60 %Rata - rata kadar
SD 0.12 SD
%CV 2.42 %CV

Formula 7
Faktor Terukur Faktor
Kadar (ppm) Pengenceran (mg) Replikasi Absorbansi Kadar (ppm) Pengenceran

5.08 20 5.08 1 0.393 5.01 20

4.96 20 4.96 2 0.390 4.96 20
4.97 20 4.97 3 0.400 5.13 20
4.86 20 4.86 4 0.389 4.94 20
4.91 20 4.91 5 0.396 5.06 20
5.06 20 5.06 6 0.381 4.80 20
Rata - Rata 4.97 Rata - Rata
%Rata - rata kadar 99.43 %Rata - rata kadar
SD 0.09 SD
%CV 1.72 %CV
 Formula 4
Terukur Kadar Faktor Terukur
(mg) Replikasi Absorbansi (ppm) Pengenceran (mg)
5.14 1 0.401 5.14 20 5.14
4.91 2 0.402 5.16 20 5.16
5.06 3 0.384 4.86 20 4.86
4.94 4 0.385 4.87 20 4.87
4.89 5 0.391 4.97 20 4.97
4.87 6 0.388 4.92 20 4.92
4.97 Rata - Rata 4.99
99.38 %Rata - rata kadar 99.77
0.11 SD 0.13
2.19 %CV 2.69

Formula 8
Terukur Kadar Faktor Terukur
(mg) Replikasi Absorbansi (ppm) Pengenceran (mg)
5.01 1 0.381 4.80 20 4.80
4.96 2 0.400 5.13 20 5.13
5.13 3 0.399 5.11 20 5.11
4.94 4 0.389 4.94 20 4.94
5.06 5 0.391 4.97 20 4.97
4.80 6 0.383 4.84 20 4.84
4.98 Rata - Rata 4.97
99.66 %Rata - rata kadar 99.32
0.11 SD 0.13
2.23 %CV 2.70
 Folding Endurance
Replikasi
F1 F2 F3 F4 F5 F6 F7 F8
I 988 1020 1110 1302 1504 1633 1803 2003
II 978 1032 1130 1322 1514 1644 1811 2013
III 997 1012 1125 1313 1523 1656 1823 2021
Rata - rata 987.67 1021.33 1121.67 1312.33 1513.67 1644.33 1812.33 2012.33
SD 9.50 10.07 10.41 10.02 9.50 11.50 10.07 9.02
%CV 0.96 0.99 0.93 0.76 0.63 0.70 0.56 0.45
 Uji Folding Endurance
2500.00
2012.33
2000.00 1812.33
1644.33
Jumlah lipatan

1513.67
1500.00 1312.33
1121.67
987.67 1021.33
1000.00

500.00

0.00
F1 F2 F3 F4 F5 F6 F7 F8
Formula
 pH
Replikasi
F1 F2 F3 F4 F5 F6 F7 F8
I 6.66 6.82 6.86 6.86 6.88 6.99 6.98 6.99
II 6.73 6.73 6.77 6.93 6.92 6.94 7.00 7.00
III 6.67 6.77 6.89 6.87 6.93 6.95 6.97 6.98
Rata - rata 6.69 6.77 6.84 6.89 6.91 6.96 6.98 6.99
SD 0.04 0.05 0.06 0.04 0.03 0.03 0.02 0.01
%CV 0.57 0.67 0.91 0.55 0.38 0.38 0.22 0.14

pH Permukaan
7.10
6.96 6.98 6.99
7.00
6.91
pH permukaan

6.89
6.90 6.84
6.80 6.77
6.69
6.70
6.60
6.50
F1 F2 F3 F4 F5 F6 F7 F8
Formula
 In Vitro Disintegration (Drop Method) (detik)
Replikasi
F1 F2 F3 F4 F5 F6 F7 F8
I 20.88 20.99 20.27 20.57 18.76 18.89 17.67 18.44
II 20.67 21.21 20.16 20.44 18.56 18.95 17.44 18.23
III 20.73 21.01 20.03 20.54 18.43 18.78 17.65 18.33
Rata - rata 20.76 21.07 20.15 20.52 18.58 18.87 17.59 18.33
SD 0.11 0.12 0.12 0.07 0.17 0.09 0.13 0.11
%CV 0.52 0.58 0.60 0.33 0.89 0.46 0.72 0.57

In Vitro Disintegration (Petridish Method) (detik)

Replikasi
F1 F2 F3 F4 F5 F6 F7 F8
I 30.56 30.98 30.18 30.36 29.66 29.87 27.67 27.98
II 30.43 30.89 30.08 30.23 29.54 29.78 27.32 27.04
III 30.23 30.78 30.2 30.03 29.42 29.98 27.45 27.88
Rata - rata 30.41 30.88 30.15 30.21 29.54 29.88 27.48 27.63
SD 0.17 0.10 0.06 0.17 0.12 0.10 0.18 0.52
%CV 0.55 0.32 0.21 0.55 0.41 0.34 0.64 1.87
Y = 0,0588x + 0,0985

Formula 1
Replikasi 1
Jumlah Obat
Waktu Kadar Bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.229 1 2.22 1.11 0.000 0.000
20 0.316 1 3.70 1.85 0.022 0.022
30 0.344 1 4.18 2.09 0.037 0.059
40 0.344 1 4.18 2.09 0.042 0.101
50 0.366 1 4.55 2.27 0.042 0.143
60 0.372 1 4.65 2.33 0.045 0.188
80 0.392 1 4.99 2.50 0.047 0.235
100 0.425 1 5.55 2.78 0.050 0.285
120 0.475 1 6.40 3.20 0.056 0.340
140 0.487 1 6.61 3.30 0.064 0.404
160 0.522 1 7.20 3.60 0.066 0.470
240 0.549 1 7.66 3.83 0.072 0.542
300 0.581 1 8.21 4.10 0.077 0.619

Formula 2
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)

10 0.221 1 2.08 1.04 0.000 0.000

20 0.308 1 3.56 1.78 0.021 0.021
30 0.345 1 4.19 2.10 0.036 0.056
40 0.350 1 4.28 2.14 0.042 0.098
50 0.369 1 4.60 2.30 0.043 0.141
60 0.379 1 4.77 2.39 0.046 0.187
80 0.397 1 5.08 2.54 0.048 0.235
100 0.427 1 5.59 2.79 0.051 0.286
120 0.468 1 6.28 3.14 0.056 0.341
140 0.482 1 6.52 3.26 0.063 0.404
160 0.529 1 7.32 3.66 0.065 0.470
240 0.540 1 7.51 3.75 0.073 0.543
300 0.572 1 8.05 4.03 0.075 0.618
Formula 3
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.238 1 2.37 1.19 0.000 0.000
20 0.235 1 2.32 1.16 0.024 0.024
30 0.249 1 2.56 1.28 0.023 0.047
40 0.296 1 3.36 1.68 0.026 0.073
50 0.334 1 4.01 2.00 0.034 0.106
60 0.354 1 4.35 2.17 0.040 0.146
80 0.383 1 4.84 2.42 0.043 0.190
100 0.412 1 5.33 2.67 0.048 0.238
120 0.469 1 6.30 3.15 0.053 0.291
140 0.494 1 6.73 3.36 0.063 0.354
160 0.573 1 8.07 4.03 0.067 0.422
240 0.588 1 8.32 4.16 0.081 0.502
300 0.594 1 8.43 4.21 0.083 0.586

Formula 4
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.238 1 2.37 1.19 0.000 0.000
20 0.287 1 3.21 1.60 0.024 0.024
30 0.295 1 3.34 1.67 0.032 0.056
40 0.336 1 4.04 2.02 0.033 0.089
50 0.343 1 4.16 2.08 0.040 0.130
60 0.378 1 4.75 2.38 0.042 0.171
80 0.408 1 5.26 2.63 0.048 0.219
100 0.433 1 5.69 2.84 0.053 0.271
120 0.467 1 6.27 3.13 0.057 0.328
140 0.505 1 6.91 3.46 0.063 0.391
160 0.557 1 7.80 3.90 0.069 0.460
240 0.548 1 7.64 3.82 0.078 0.538
300 0.587 1 8.31 4.15 0.076 0.614
Formula 5
Replikasi 1

Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.248 1 2.54 1.27 0.000 0.000
20 0.255 1 2.66 1.33 0.025 0.025
30 0.279 1 3.07 1.53 0.027 0.052
40 0.296 1 3.36 1.68 0.031 0.083
50 0.319 1 3.75 1.88 0.034 0.116
60 0.332 1 3.97 1.99 0.038 0.154
80 0.353 1 4.33 2.16 0.040 0.194
100 0.431 1 5.65 2.83 0.043 0.237
120 0.481 1 6.51 3.25 0.057 0.293
140 0.554 1 7.75 3.87 0.065 0.358
160 0.576 1 8.12 4.06 0.077 0.436
240 0.588 1 8.32 4.16 0.081 0.517
300 0.600 1 8.53 4.26 0.083 0.600

Formula 6
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.242 1 2.44 1.22 0.000 0.000
20 0.251 1 2.59 1.30 0.024 0.024
30 0.273 1 2.97 1.48 0.026 0.050
40 0.290 1 3.26 1.63 0.030 0.080
50 0.310 1 3.60 1.80 0.033 0.113
60 0.330 1 3.94 1.97 0.036 0.149
80 0.346 1 4.21 2.10 0.039 0.188
100 0.427 1 5.59 2.79 0.042 0.230
120 0.471 1 6.34 3.17 0.056 0.286
140 0.550 1 7.68 3.84 0.063 0.349
160 0.572 1 8.05 4.03 0.077 0.426
240 0.586 1 8.29 4.15 0.081 0.507
300 0.596 1 8.46 4.23 0.083 0.589
Formula 7
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.252 1 2.61 1.31 0.000 0.000
20 0.264 1 2.81 1.41 0.026 0.026
30 0.287 1 3.21 1.60 0.028 0.054
40 0.290 1 3.26 1.63 0.032 0.086
50 0.324 1 3.84 1.92 0.033 0.119
60 0.356 1 4.38 2.19 0.038 0.157
80 0.388 1 4.92 2.46 0.044 0.201
100 0.427 1 5.59 2.79 0.049 0.250
120 0.476 1 6.42 3.21 0.056 0.306
140 0.565 1 7.93 3.97 0.064 0.370
160 0.577 1 8.14 4.07 0.079 0.450
240 0.587 1 8.31 4.15 0.081 0.531
300 0.607 1 8.65 4.32 0.083 0.614

Formula 8
Replikasi 1

Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.249 1 2.56 1.28 0.000 0.000
20 0.254 1 2.64 1.32 0.026 0.026
30 0.277 1 3.04 1.52 0.026 0.052
40 0.281 1 3.10 1.55 0.030 0.082
50 0.314 1 3.66 1.83 0.031 0.113
60 0.346 1 4.21 2.10 0.037 0.150
80 0.378 1 4.75 2.38 0.042 0.192
100 0.424 1 5.54 2.77 0.048 0.240
120 0.472 1 6.35 3.18 0.055 0.295
140 0.564 1 7.92 3.96 0.064 0.359
160 0.575 1 8.10 4.05 0.079 0.438
240 0.584 1 8.26 4.13 0.081 0.519
300 0.607 1 8.65 4.32 0.083 0.601
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.11 22.24 10 0.225 1 2.15 1.08
1.87 37.51 20 0.312 1 3.63 1.82
2.15 43.02 30 0.345 1 4.19 2.10
2.19 43.86 40 0.347 1 4.23 2.11
2.42 48.44 50 0.362 1 4.48 2.24
2.51 50.38 60 0.376 1 4.72 2.36
2.73 54.72 80 0.397 1 5.08 2.54
3.06 61.34 100 0.425 1 5.55 2.78
3.54 70.98 120 0.472 1 6.35 3.18
3.71 74.30 140 0.485 1 6.57 3.29
4.07 81.59 160 0.527 1 7.29 3.64
4.37 87.64 240 0.548 1 7.64 3.82
4.72 94.62 300 0.579 1 8.17 4.09

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)

1.04 20.92 10 0.219 1 2.05 1.02

1.80 36.19 20 0.313 1 3.65 1.82
2.15 43.22 30 0.337 1 4.06 2.03
2.24 44.92 40 0.354 1 4.35 2.17
2.44 49.02 50 0.368 1 4.58 2.29
2.57 51.65 60 0.372 1 4.65 2.33
2.77 55.69 80 0.399 1 5.11 2.56
3.08 61.83 100 0.429 1 5.62 2.81
3.48 69.95 120 0.470 1 6.32 3.16
3.67 73.60 140 0.487 1 6.61 3.30
4.13 82.94 160 0.523 1 7.22 3.61
4.30 86.29 240 0.533 1 7.39 3.69
4.64 93.26 300 0.580 1 8.19 4.09
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.19 23.87 10 0.237 1 2.36 1.18
1.18 23.83 20 0.236 1 2.34 1.17
1.33 26.69 30 0.250 1 2.58 1.29
1.75 35.25 40 0.278 1 3.05 1.53
2.11 42.43 50 0.347 1 4.23 2.11
2.32 46.66 60 0.350 1 4.28 2.14
2.61 52.49 80 0.386 1 4.89 2.44
2.90 58.43 100 0.409 1 5.28 2.64
3.44 69.25 120 0.477 1 6.44 3.22
3.72 74.80 140 0.490 1 6.66 3.33
4.46 89.67 160 0.570 1 8.02 4.01
4.66 93.86 240 0.589 1 8.34 4.17
4.80 96.56 300 0.593 1 8.41 4.20

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.19 23.77 10 0.236 1 2.34 1.17
1.63 32.60 20 0.282 1 3.12 1.56
1.73 34.60 30 0.293 1 3.31 1.65
2.11 42.26 40 0.329 1 3.92 1.96
2.21 44.26 50 0.346 1 4.21 2.10
2.55 51.06 60 0.366 1 4.55 2.27
2.85 57.12 80 0.419 1 5.45 2.73
3.12 62.44 100 0.420 1 5.47 2.73
3.46 69.37 120 0.482 1 6.52 3.26
3.85 77.10 140 0.505 1 6.91 3.46
4.36 87.35 160 0.528 1 7.30 3.65
4.36 87.38 240 0.559 1 7.83 3.92
4.77 95.56 300 0.588 1 8.32 4.16
 Replikasi 2

Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.27 25.48 10 0.243 1 2.46 1.23
1.36 27.18 20 0.265 1 2.83 1.42
1.59 31.80 30 0.274 1 2.98 1.49
1.76 35.31 40 0.296 1 3.36 1.68
1.99 39.91 50 0.314 1 3.66 1.83
2.14 42.87 60 0.332 1 3.97 1.99
2.36 47.25 80 0.353 1 4.33 2.16
3.06 61.41 100 0.435 1 5.72 2.86
3.55 71.06 120 0.481 1 6.51 3.25
4.23 84.80 140 0.550 1 7.68 3.84
4.50 90.11 160 0.576 1 8.12 4.06
4.68 93.78 240 0.589 1 8.34 4.17
4.86 97.49 300 0.600 1 8.53 4.26

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.22 24.55 10 0.240 1 2.41 1.20
1.32 26.58 20 0.253 1 2.63 1.31
1.53 30.87 30 0.274 1 2.98 1.49
1.71 34.37 40 0.294 1 3.32 1.66
1.91 38.45 50 0.299 1 3.41 1.70
2.12 42.60 60 0.330 1 3.94 1.97
2.29 46.13 80 0.342 1 4.14 2.07
3.02 60.83 100 0.427 1 5.59 2.79
3.45 69.48 120 0.473 1 6.37 3.18
4.19 84.28 140 0.550 1 7.68 3.84
4.45 89.59 160 0.572 1 8.05 4.03
4.65 93.60 240 0.586 1 8.29 4.15
4.82 96.98 300 0.596 1 8.46 4.23
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.31 26.21 10 0.254 1 2.64 1.32
1.43 28.78 20 0.267 1 2.87 1.43
1.66 33.28 30 0.284 1 3.15 1.58
1.71 34.43 40 0.287 1 3.21 1.60
2.04 40.89 50 0.327 1 3.89 1.94
2.35 47.13 60 0.356 1 4.38 2.19
2.66 53.47 80 0.389 1 4.94 2.47
3.04 61.12 100 0.429 1 5.62 2.81
3.52 70.61 120 0.473 1 6.37 3.18
4.34 87.09 140 0.568 1 7.98 3.99
4.52 90.73 160 0.579 1 8.17 4.09
4.68 94.08 240 0.589 1 8.34 4.17
4.94 99.16 300 0.607 1 8.65 4.32

Replikasi 2

Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.28 25.75 10 0.246 1 2.51 1.25
1.35 27.12 20 0.257 1 2.70 1.35
1.57 31.59 30 0.275 1 3.00 1.50
1.63 32.88 40 0.284 1 3.15 1.58
1.95 39.15 50 0.316 1 3.70 1.85
2.25 45.37 60 0.342 1 4.14 2.07
2.57 51.69 80 0.374 1 4.69 2.34
3.01 60.51 100 0.427 1 5.59 2.79
3.47 69.84 120 0.479 1 6.47 3.24
4.32 86.86 140 0.568 1 7.98 3.99
4.49 90.33 160 0.578 1 8.15 4.08
4.65 93.50 240 0.586 1 8.29 4.15
4.93 99.10 300 0.607 1 8.65 4.32
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)
0.00 0.00 1.08 21.56 10 0.223 1
0.02 0.02 1.84 36.81 20 0.319 1
0.04 0.06 2.15 43.16 30 0.345 1
0.04 0.10 2.21 44.35 40 0.341 1
0.04 0.14 2.38 47.75 50 0.365 1
0.04 0.19 2.55 51.03 60 0.370 1
0.05 0.23 2.77 55.56 80 0.393 1
0.05 0.28 3.06 61.35 100 0.427 1
0.06 0.34 3.52 70.47 120 0.473 1
0.06 0.40 3.69 73.96 140 0.489 1
0.07 0.47 4.11 82.43 160 0.525 1
0.07 0.54 4.36 87.47 240 0.545 1
0.08 0.62 4.70 94.28 300 0.588 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.02 20.58 10 0.228 1

0.02 0.02 1.84 37.04 20 0.313 1
0.04 0.06 2.09 41.87 30 0.339 1
0.04 0.10 2.27 45.59 40 0.354 1
0.04 0.14 2.43 48.85 50 0.358 1
0.05 0.19 2.51 50.45 60 0.373 1
0.05 0.23 2.79 56.00 80 0.399 1
0.05 0.28 3.09 62.14 100 0.430 1
0.06 0.34 3.50 70.27 120 0.470 1
0.06 0.40 3.71 74.45 140 0.486 1
0.07 0.47 4.08 81.92 160 0.512 1
0.07 0.54 4.24 85.08 240 0.544 1
0.07 0.62 4.71 94.59 300 0.574 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.18 23.70 10 0.236 1

0.02 0.02 1.19 24.00 20 0.235 1
0.02 0.05 1.34 26.87 30 0.250 1
0.03 0.07 1.60 32.17 40 0.278 1
0.03 0.10 2.22 44.59 50 0.349 1
0.04 0.15 2.28 45.96 60 0.350 1
0.04 0.19 2.63 52.98 80 0.386 1
0.05 0.24 2.88 57.90 100 0.408 1
0.05 0.29 3.51 70.59 120 0.482 1
0.06 0.35 3.68 74.11 140 0.492 1
0.07 0.42 4.43 89.14 160 0.569 1
0.08 0.50 4.67 94.00 240 0.587 1
0.08 0.58 4.79 96.37 300 0.592 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.17 23.43 10 0.237 1

0.02 0.02 1.58 31.74 20 0.289 1
0.03 0.05 1.71 34.24 30 0.296 1
0.03 0.09 2.05 41.04 40 0.321 1
0.04 0.13 2.23 44.72 50 0.340 1
0.04 0.17 2.44 48.97 60 0.359 1
0.05 0.21 2.94 58.91 80 0.417 1
0.05 0.27 3.00 60.18 100 0.428 1
0.05 0.32 3.58 71.84 120 0.478 1
0.07 0.39 3.85 77.06 140 0.488 1
0.07 0.46 4.11 82.37 160 0.572 1
0.07 0.53 4.45 89.12 240 0.544 1
0.08 0.61 4.77 95.63 300 0.583 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.23 24.62 10 0.246 1

0.02 0.02 1.44 28.87 20 0.255 1
0.03 0.05 1.55 30.97 30 0.279 1
0.03 0.08 1.76 35.31 40 0.295 1
0.03 0.12 1.95 39.05 50 0.319 1
0.04 0.15 2.14 42.86 60 0.332 1
0.04 0.19 2.36 47.23 80 0.353 1
0.04 0.24 3.10 62.07 100 0.431 1
0.06 0.29 3.55 71.06 120 0.483 1
0.07 0.36 4.20 84.12 140 0.554 1
0.08 0.44 4.50 90.09 160 0.574 1
0.08 0.52 4.69 93.93 240 0.587 1
0.08 0.60 4.86 97.48 300 0.599 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.20 24.21 10 0.243 1

0.02 0.02 1.34 26.92 20 0.253 1
0.03 0.05 1.54 31.04 30 0.276 1
0.03 0.08 1.74 35.06 40 0.294 1
0.03 0.11 1.82 36.59 50 0.300 1
0.03 0.15 2.12 42.58 60 0.330 1
0.04 0.19 2.26 45.42 80 0.344 1
0.04 0.23 3.02 60.80 100 0.427 1
0.06 0.28 3.47 69.79 120 0.474 1
0.06 0.35 4.19 84.25 140 0.550 1
0.08 0.42 4.45 89.56 160 0.572 1
0.08 0.51 4.65 93.57 240 0.586 1
0.08 0.59 4.82 96.95 300 0.598 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.32 26.55 10 0.257 1

0.03 0.03 1.46 29.30 20 0.267 1
0.03 0.06 1.63 32.78 30 0.285 1
0.03 0.09 1.69 33.93 40 0.298 1
0.03 0.12 2.06 41.40 50 0.323 1
0.04 0.16 2.35 47.13 60 0.358 1
0.04 0.20 2.67 53.65 80 0.388 1
0.05 0.25 3.06 61.47 100 0.427 1
0.06 0.31 3.49 70.11 120 0.477 1
0.06 0.37 4.36 87.61 140 0.567 1
0.08 0.45 4.54 91.09 160 0.579 1
0.08 0.53 4.70 94.44 240 0.585 1
0.08 0.62 4.94 99.19 300 0.606 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.25 25.24 10 0.245 1

0.03 0.03 1.37 27.62 20 0.257 1
0.03 0.05 1.55 31.25 30 0.278 1
0.03 0.08 1.66 33.39 40 0.284 1
0.03 0.11 1.96 39.50 50 0.315 1
0.04 0.15 2.22 44.69 60 0.345 1
0.04 0.19 2.53 51.00 80 0.375 1
0.05 0.24 3.03 61.01 100 0.424 1
0.06 0.29 3.53 71.03 120 0.476 1
0.06 0.36 4.35 87.56 140 0.565 1
0.08 0.44 4.52 90.88 160 0.575 1
0.08 0.52 4.67 93.89 240 0.585 1
0.08 0.60 4.93 99.15 300 0.607 1
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.12 1.06 0.00 0.00 1.06 21.22
3.75 1.88 0.02 0.02 1.90 38.00
4.19 2.10 0.04 0.06 2.15 43.18
4.12 2.06 0.04 0.10 2.16 43.34
4.53 2.27 0.04 0.14 2.41 48.26
4.62 2.31 0.05 0.19 2.50 50.02
5.01 2.50 0.05 0.23 2.74 54.86
5.59 2.79 0.05 0.28 3.08 61.66
6.37 3.18 0.06 0.34 3.52 70.62
6.64 3.32 0.06 0.40 3.72 74.62
7.25 3.63 0.07 0.47 4.10 82.09
7.59 3.80 0.07 0.54 4.34 86.95
8.32 4.16 0.08 0.62 4.78 95.80

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)

2.20 1.10 0.00 0.00 1.10 22.11

3.65 1.82 0.02 0.02 1.85 37.07
4.09 2.05 0.04 0.06 2.10 42.24
4.35 2.17 0.04 0.10 2.27 45.62
4.41 2.21 0.04 0.14 2.35 47.18
4.67 2.33 0.04 0.19 2.52 50.63
5.11 2.56 0.05 0.23 2.79 56.00
5.64 2.82 0.05 0.28 3.10 62.32
6.32 3.16 0.06 0.34 3.50 70.28
6.59 3.30 0.06 0.40 3.70 74.29
7.03 3.52 0.07 0.47 3.99 80.05
7.58 3.79 0.07 0.54 4.33 86.92
8.09 4.04 0.08 0.62 4.66 93.57
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.34 1.17 0.00 0.00 1.17 23.53
2.32 1.16 0.02 0.02 1.18 23.82
2.58 1.29 0.02 0.05 1.33 26.86
3.05 1.53 0.03 0.07 1.60 32.17
4.26 2.13 0.03 0.10 2.23 44.93
4.28 2.14 0.04 0.15 2.28 45.96
4.89 2.44 0.04 0.19 2.63 52.98
5.26 2.63 0.05 0.24 2.87 57.73
6.52 3.26 0.05 0.29 3.55 71.45
6.69 3.35 0.07 0.36 3.70 74.47
8.00 4.00 0.07 0.42 4.42 88.99
8.31 4.15 0.08 0.50 4.66 93.68
8.39 4.20 0.08 0.59 4.78 96.21

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.36 1.18 0.00 0.00 1.18 23.60
3.24 1.62 0.02 0.02 1.64 32.93
3.36 1.68 0.03 0.06 1.74 34.78
3.78 1.89 0.03 0.09 1.98 39.71
4.11 2.05 0.04 0.13 2.18 43.71
4.43 2.22 0.04 0.17 2.38 47.77
5.42 2.71 0.04 0.21 2.92 58.54
5.60 2.80 0.05 0.27 3.07 61.50
6.45 3.23 0.06 0.32 3.55 71.14
6.62 3.31 0.06 0.39 3.70 74.14
8.05 4.03 0.07 0.45 4.48 89.78
7.58 3.79 0.08 0.53 4.32 86.62
8.24 4.12 0.08 0.61 4.73 94.79
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.51 1.25 0.00 0.00 1.25 25.14
2.66 1.33 0.03 0.03 1.36 27.17
3.07 1.53 0.03 0.05 1.59 31.79
3.34 1.67 0.03 0.08 1.75 35.14
3.75 1.88 0.03 0.12 1.99 39.90
3.97 1.99 0.04 0.15 2.14 42.86
4.33 2.16 0.04 0.19 2.36 47.24
5.65 2.83 0.04 0.24 3.06 61.40
6.54 3.27 0.06 0.29 3.56 71.39
7.75 3.87 0.07 0.36 4.23 84.80
8.09 4.04 0.08 0.44 4.48 89.76
8.31 4.15 0.08 0.52 4.67 93.60
8.51 4.26 0.08 0.60 4.86 97.31

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.46 1.23 0.00 0.00 1.23 24.72
2.63 1.31 0.02 0.02 1.34 26.93
3.02 1.51 0.03 0.05 1.56 31.39
3.32 1.66 0.03 0.08 1.74 35.08
3.43 1.71 0.03 0.11 1.83 36.78
3.94 1.97 0.03 0.15 2.12 42.60
4.18 2.09 0.04 0.19 2.28 45.78
5.59 2.79 0.04 0.23 3.02 60.83
6.39 3.19 0.06 0.29 3.48 69.99
7.68 3.84 0.06 0.35 4.19 84.28
8.05 4.03 0.08 0.43 4.45 89.59
8.29 4.15 0.08 0.51 4.65 93.60
8.49 4.25 0.08 0.59 4.84 97.33
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.70 1.35 0.00 0.00 1.35 27.06
2.87 1.43 0.03 0.03 1.46 29.31
3.17 1.59 0.03 0.06 1.64 32.96
3.39 1.70 0.03 0.09 1.78 35.82
3.82 1.91 0.03 0.12 2.03 40.77
4.41 2.21 0.04 0.16 2.37 47.51
4.92 2.46 0.04 0.20 2.67 53.52
5.59 2.79 0.05 0.25 3.05 61.17
6.44 3.22 0.06 0.31 3.53 70.83
7.97 3.98 0.06 0.37 4.36 87.49
8.17 4.09 0.08 0.45 4.54 91.14
8.27 4.14 0.08 0.53 4.67 93.80
8.63 4.32 0.08 0.62 4.93 99.05

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.49 1.25 0.00 0.00 1.25 25.07
2.70 1.35 0.02 0.02 1.37 27.62
3.05 1.53 0.03 0.05 1.58 31.76
3.15 1.58 0.03 0.08 1.66 33.40
3.68 1.84 0.03 0.11 1.95 39.33
4.19 2.10 0.04 0.15 2.25 45.21
4.70 2.35 0.04 0.19 2.54 51.18
5.54 2.77 0.05 0.24 3.01 60.51
6.42 3.21 0.06 0.30 3.51 70.53
7.93 3.97 0.06 0.36 4.33 87.04
8.10 4.05 0.08 0.44 4.49 90.35
8.27 4.14 0.08 0.52 4.66 93.69
8.65 4.32 0.08 0.60 4.93 99.12
Formula 1 Formula 1

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 21.67 0.52 2.40 10 111.19 107.78

20 37.44 0.60 1.59 20 298.74 291.85
30 43.12 0.09 0.20 30 402.65 399.89
40 43.85 0.50 1.15 40 434.40 437.55
50 48.15 0.36 0.75 50 461.51 460.47
60 50.48 0.51 1.02 60 494.11 493.90
80 55.05 0.45 0.81 80 1050.96 1065.89
100 61.45 0.18 0.30 100 1160.60 1169.02
120 70.69 0.26 0.37 120 1323.17 1318.13
140 74.29 0.33 0.45 140 2905.57 2888.46
160 82.04 0.42 0.51 160 1558.95 1563.86
240 87.35 0.36 0.41 240 6769.12 6795.97
300 94.90 0.79 0.84 300 5467.82 5452.59
Total AUC 22438.80 22445.38
Luas Total 30000 30000
DE 300 (%) 74.80 74.82

Formula 2 Formula 2

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 21.20 0.81 3.81 10 104.59 102.88

20 36.77 0.50 1.35 20 285.54 288.07
30 42.44 0.70 1.65 30 397.07 394.53
40 45.38 0.40 0.87 40 440.72 437.27
50 48.35 1.02 2.11 50 469.71 472.17
60 50.91 0.65 1.28 60 503.38 496.50
80 55.89 0.18 0.32 80 1073.39 1064.48
100 62.10 0.25 0.40 100 1175.13 1181.41
120 70.17 0.19 0.27 120 1317.77 1324.19
140 74.11 0.45 0.60 140 2871.04 2894.40
160 81.63 1.47 1.80 160 1565.39 1563.65
240 86.10 0.94 1.09 240 6768.91 6679.85
300 93.80 0.69 0.74 300 5386.29 5389.88
Total AUC 22358.93 22289.27
Luas Total 30000.00 30000.00
 DE 300 (%) 74.53 74.30

Formula 3 Formula 3

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 23.70 0.17 0.72 10 119.34 118.48

20 23.89 0.10 0.41 20 238.50 238.48
30 26.81 0.10 0.36 30 252.63 254.32
40 33.20 1.78 5.36 40 309.72 295.20
50 43.98 1.36 3.09 50 388.39 383.84
60 46.19 0.40 0.87 60 445.42 452.76
80 52.82 0.28 0.53 80 991.48 989.35
100 58.02 0.37 0.63 100 1109.19 1108.74
120 70.43 1.11 1.57 120 1276.79 1284.90
140 74.46 0.34 0.46 140 2880.99 2894.13
160 89.27 0.36 0.40 160 1644.65 1632.53
240 93.85 0.16 0.17 240 7340.98 7325.79
300 96.38 0.18 0.18 300 5712.49 5711.15
Total AUC 22710.57 22689.70
Luas Total 30000.00 30000.00
DE 300 (%) 75.70 75.63

Formula 4 Formula 4

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 23.60 0.17 0.72 10 118.86 117.16

20 32.42 0.62 1.90 20 281.85 275.85
30 34.54 0.27 0.80 30 336.00 329.89
40 41.00 1.27 3.11 40 384.31 376.37
50 44.23 0.51 1.15 50 432.61 428.77
60 49.27 1.67 3.38 60 476.61 468.45
80 58.19 0.94 1.62 80 1081.84 1078.84
100 61.37 1.14 1.85 100 1195.64 1190.90
120 70.78 1.27 1.79 120 1318.13 1320.14
140 76.10 1.70 2.23 140 2929.57 2978.03
160 86.50 3.78 4.37 160 1644.56 1594.33
240 87.71 1.28 1.46 240 6989.28 6859.36
300 95.32 0.47 0.49 300 5488.17 5542.26
Total AUC 22677.44 22560.35
Luas Total 30000.00 30000.00
DE 300 (%) 75.59 75.20
Formula 5 Formula 5

AUC (mg/detik)
Rata-rata
Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 25.08 0.43 1.71 10 127.38 123.12

20 27.74 0.98 3.52 20 263.27 267.45
30 31.52 0.48 1.52 30 294.90 299.16
40 35.25 0.10 0.29 40 335.58 331.40
50 39.62 0.49 1.23 50 376.10 371.84
60 42.86 0.01 0.02 60 413.90 409.55
80 47.24 0.01 0.02 80 901.21 900.87
100 61.62 0.39 0.63 100 1086.54 1093.02
120 71.17 0.19 0.27 120 1324.67 1331.29
140 84.57 0.39 0.47 140 3117.29 3103.52
160 89.98 0.19 0.22 160 1749.09 1742.07
240 93.77 0.17 0.18 240 7355.32 7360.78
300 97.43 0.10 0.11 300 5738.06 5742.25
Total AUC 23083.32 23076.31
Luas Total 30000.00 30000.00
DE 300 (%) 76.94 76.92

Formula 6 Formula 6

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 24.50 0.26 1.07 10 122.76 121.05

20 26.81 0.20 0.73 20 255.68 255.64
30 31.10 0.27 0.86 30 287.26 289.79
40 34.84 0.40 1.15 40 326.22 330.51
50 37.27 1.03 2.75 50 364.13 358.25
60 42.59 0.01 0.03 60 405.25 395.82
80 45.78 0.35 0.77 80 887.25 879.99
100 60.82 0.02 0.03 100 1069.60 1062.21
120 69.76 0.26 0.37 120 1303.18 1305.91
140 84.27 0.02 0.02 140 3075.22 3080.83
160 89.58 0.02 0.02 160 1738.61 1738.06
240 93.59 0.02 0.02 240 7327.43 7325.24
300 97.09 0.21 0.21 300 5717.42 5715.77
Total AUC 22879.99 22859.08
Luas Total 30000.00 30000.00
DE 300 (%) 76.27 76.20
Formula 7 Formula 7

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 26.61 0.43 1.61 10 131.05 132.76

20 29.13 0.30 1.04 20 274.97 279.27
30 33.01 0.25 0.76 30 310.30 310.42
40 34.73 0.98 2.82 40 338.54 333.54
50 41.02 0.33 0.82 50 376.62 376.63
60 47.26 0.22 0.47 60 440.09 442.66
80 53.55 0.09 0.17 80 1005.95 1007.79
100 61.25 0.19 0.31 100 1145.86 1151.15
120 70.51 0.37 0.52 120 1317.22 1315.79
140 87.40 0.27 0.31 140 3153.94 3154.42
160 90.99 0.22 0.24 160 1778.25 1787.03
240 94.11 0.32 0.34 240 7392.36 7421.32
300 99.13 0.07 0.07 300 5797.01 5808.90
Total AUC 23462.16 23521.68
Luas Total 30000.00 30000.00
DE 300 (%) 78.21 78.41

Formula 8 Formula 8

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 25.35 0.36 1.40 10 128.75 126.18

20 27.45 0.29 1.05 20 264.35 264.30
30 31.53 0.26 0.82 30 293.54 294.34
40 33.22 0.29 0.89 40 322.35 323.17
50 39.33 0.17 0.44 50 360.18 364.44
60 45.09 0.35 0.78 60 422.60 420.95
80 51.29 0.36 0.69 80 970.53 956.91
100 60.68 0.29 0.47 100 1122.02 1120.10
120 70.47 0.60 0.85 120 1303.55 1320.42
140 87.16 0.36 0.42 140 3134.01 3171.85
160 90.52 0.31 0.34 160 1771.94 1784.40
240 93.70 0.19 0.20 240 7353.58 7390.67
300 99.12 0.02 0.02 300 5778.19 5791.12
Total AUC 23225.59 23328.88
Luas Total 30000.00 30000.00
DE 300 (%) 77.42 77.76
C (mg/detik) %DE 300 Total

Rep 3 Replikasi F1 F2 F3 F4 F5
106.08 I 74.80 74.53 75.70 75.59 76.94
296.08 II 74.82 74.39 75.63 75.20 76.92
405.91 III 74.81 74.33 75.62 75.40 76.84
432.61 Rata-rata 74.81 74.42 75.65 75.40 76.90
457.98 SD 0.01 0.10 0.04 0.20 0.05
491.37 RSD 0.01 0.14 0.06 0.26 0.07
1048.78
1165.20
1322.76 AUC Total
2904.76 Replikasi F1 F2 F3 F4 F5
1567.06 I 22438.80 22358.93 22710.57 22677.44 23083.32
6761.35 II 22445.38 22289.27 22689.70 22560.35 23076.31
5482.34 III 22442.27 22299.36 22687.17 22619.43 23051.78
22442.27 Rata-rata 22442.15 22315.85 22695.81 22619.07 23070.47
30000 SD 3.29 37.65 12.84 58.54 16.56
74.81 RSD 0.01 0.17 0.06 0.26 0.07

C (mg/detik) Rata - Rata terdisolusi (%)

Waktu (detik)
Rep 3 F2 F1 F4 F3 F6

0 0.00 0.00 0.00 0.00 0.00

110.56 10 21.67 21.20 23.70 23.60 25.08
295.90 20 37.44 36.77 23.89 32.42 27.74
396.54 30 43.12 42.44 26.81 34.54 31.52
439.32 40 43.85 45.38 33.20 41.00 35.25
464.01 50 48.15 48.35 43.98 44.23 39.62
489.02 60 50.48 50.91 46.19 49.27 42.86
1066.29 80 55.05 55.89 52.82 58.19 47.24
1183.25 100 61.45 62.10 58.02 61.37 61.62
1326.07 120 70.69 70.17 70.43 70.78 71.17
2891.40 140 74.29 74.11 74.46 76.10 84.57
1543.33 160 82.04 81.63 89.27 86.50 89.98
6678.89 240 87.35 86.10 93.85 87.71 93.77
5414.77 300 94.90 93.80 96.38 95.32 97.43
22299.36
30000.00
 74.33

C (mg/detik) Profil Pelepasan Obat

120.00
Rep 3
100.00 F1
117.63 F2
% Terdisolusi
80.00 F3
236.75
F4
253.42 60.00
F5
295.13 40.00 F6
385.48 F7
454.44 20.00 F8
989.35 0.00
0 10 20 30 40 50 60 80 100 120 140 160 240 300
1107.03
1291.71 Waktu (detik)
2918.29
1634.59
7306.77
5696.58
22687.17
30000.00
75.62

C (mg/detik)

Rep 3

118.01
282.68
338.56
372.44
417.08
457.37
1063.06
1200.38
1326.41
2905.64
1639.21
7056.22
5442.36
22619.43
30000.00
75.40
C (mg/detik)

Rep 3

125.68
261.53
294.83
334.66
375.16
413.80
901.00
1086.34
1327.88
3123.83
1745.62
7334.33
5727.12
23051.78
30000.00
76.84

C (mg/detik)

Rep 3

123.62
258.26
291.61
332.36
359.27
396.86
883.82
1066.11
1308.17
3085.42
1738.68
7327.71
5727.89
22899.77
30000.00
76.33
C (mg/detik)

Rep 3

135.32
281.88
311.37
343.90
382.93
441.40
1010.32
1146.88
1319.96
3166.30
1786.24
7397.55
5785.54
23509.61
30000.00
78.37

C (mg/detik)

Rep 3

125.33
263.43
296.87
325.76
363.65
422.71
963.93
1116.99
1310.40
3151.39
1773.96
7361.79
5784.45
23260.66
30000.00
77.54
 F6 F7 F8
76.27 78.21 77.42
76.2 78.41 77.76
76.33 78.37 77.54
76.27 78.33 77.57
0.07 0.11 0.17
0.09 0.14 0.22

F6 F7 F8
22879.99 23462.16 23225.59
22859.08 23521.68 23536.27
22899.77 23509.61 23260.66
22879.62 23497.81 23340.84
20.35 31.47 170.16
0.09 0.13 0.73

disolusi (%)

F5 F8 F7

0.00 0.00 0.00

24.50 26.61 25.35
26.81 29.13 27.45
31.10 33.01 31.53
34.84 34.73 33.22
37.27 41.02 39.33
42.59 47.26 45.09
45.78 53.55 51.29
60.82 61.25 60.68
69.76 70.51 70.47
84.27 87.40 87.16
89.58 90.99 90.52
93.59 94.11 93.70
97.09 99.13 99.12
Y = 0,0588x + 0,0985

Formula 1
Replikasi 1
Jumlah Obat
Waktu Kadar Bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.221 1 2.08 1.04 0.000 0.000
20 0.308 1 3.56 1.78 0.021 0.021
30 0.345 1 4.19 2.10 0.036 0.056
40 0.350 1 4.28 2.14 0.042 0.098
50 0.369 1 4.60 2.30 0.043 0.141
60 0.379 1 4.77 2.39 0.046 0.187
80 0.397 1 5.08 2.54 0.048 0.235
100 0.427 1 5.59 2.79 0.051 0.286
120 0.468 1 6.28 3.14 0.056 0.341
140 0.482 1 6.52 3.26 0.063 0.404
160 0.529 1 7.32 3.66 0.065 0.470
240 0.540 1 7.51 3.75 0.073 0.543
300 0.572 1 8.05 4.03 0.075 0.618

Formula 2
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)

10 0.229 1 2.22 1.11 0.000 0.000

20 0.316 1 3.70 1.85 0.022 0.022
30 0.344 1 4.18 2.09 0.037 0.059
40 0.344 1 4.18 2.09 0.042 0.101
50 0.366 1 4.55 2.27 0.042 0.143
60 0.372 1 4.65 2.33 0.045 0.188
80 0.392 1 4.99 2.50 0.047 0.235
100 0.425 1 5.55 2.78 0.050 0.285
120 0.475 1 6.40 3.20 0.056 0.340
140 0.487 1 6.61 3.30 0.064 0.404
160 0.522 1 7.20 3.60 0.066 0.470
240 0.549 1 7.66 3.83 0.072 0.542
300 0.581 1 8.21 4.10 0.077 0.619
Formula 3
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.238 1 2.37 1.19 0.000 0.000
20 0.287 1 3.21 1.60 0.024 0.024
30 0.295 1 3.34 1.67 0.032 0.056
40 0.336 1 4.04 2.02 0.033 0.089
50 0.343 1 4.16 2.08 0.040 0.130
60 0.378 1 4.75 2.38 0.042 0.171
80 0.408 1 5.26 2.63 0.048 0.219
100 0.433 1 5.69 2.84 0.053 0.271
120 0.467 1 6.27 3.13 0.057 0.328
140 0.505 1 6.91 3.46 0.063 0.391
160 0.557 1 7.80 3.90 0.069 0.460
240 0.548 1 7.64 3.82 0.078 0.538
300 0.587 1 8.31 4.15 0.076 0.614

Formula 4
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.238 1 2.37 1.19 0.000 0.000
20 0.235 1 2.32 1.16 0.024 0.024
30 0.249 1 2.56 1.28 0.023 0.047
40 0.296 1 3.36 1.68 0.026 0.073
50 0.334 1 4.01 2.00 0.034 0.106
60 0.354 1 4.35 2.17 0.040 0.146
80 0.383 1 4.84 2.42 0.043 0.190
100 0.412 1 5.33 2.67 0.048 0.238
120 0.469 1 6.30 3.15 0.053 0.291
140 0.494 1 6.73 3.36 0.063 0.354
160 0.573 1 8.07 4.03 0.067 0.422
240 0.588 1 8.32 4.16 0.081 0.502
300 0.594 1 8.43 4.21 0.083 0.586
Formula 5
Replikasi 1

Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.242 1 2.44 1.22 0.000 0.000
20 0.251 1 2.59 1.30 0.024 0.024
30 0.273 1 2.97 1.48 0.026 0.050
40 0.290 1 3.26 1.63 0.030 0.080
50 0.310 1 3.60 1.80 0.033 0.113
60 0.330 1 3.94 1.97 0.036 0.149
80 0.346 1 4.21 2.10 0.039 0.188
100 0.427 1 5.59 2.79 0.042 0.230
120 0.471 1 6.34 3.17 0.056 0.286
140 0.550 1 7.68 3.84 0.063 0.349
160 0.572 1 8.05 4.03 0.077 0.426
240 0.586 1 8.29 4.15 0.081 0.507
300 0.596 1 8.46 4.23 0.083 0.589

Formula 6
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.248 1 2.54 1.27 0.000 0.000
20 0.255 1 2.66 1.33 0.025 0.025
30 0.279 1 3.07 1.53 0.027 0.052
40 0.296 1 3.36 1.68 0.031 0.083
50 0.319 1 3.75 1.88 0.034 0.116
60 0.332 1 3.97 1.99 0.038 0.154
80 0.353 1 4.33 2.16 0.040 0.194
100 0.431 1 5.65 2.83 0.043 0.237
120 0.481 1 6.51 3.25 0.057 0.293
140 0.554 1 7.75 3.87 0.065 0.358
160 0.576 1 8.12 4.06 0.077 0.436
240 0.588 1 8.32 4.16 0.081 0.517
300 0.600 1 8.53 4.26 0.083 0.600
Formula 7
Replikasi 1
Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.249 1 2.56 1.28 0.000 0.000
20 0.254 1 2.64 1.32 0.026 0.026
30 0.277 1 3.04 1.52 0.026 0.052
40 0.281 1 3.10 1.55 0.030 0.082
50 0.314 1 3.66 1.83 0.031 0.113
60 0.346 1 4.21 2.10 0.037 0.150
80 0.378 1 4.75 2.38 0.042 0.192
100 0.424 1 5.54 2.77 0.048 0.240
120 0.472 1 6.35 3.18 0.055 0.295
140 0.564 1 7.92 3.96 0.064 0.359
160 0.575 1 8.10 4.05 0.079 0.438
240 0.584 1 8.26 4.13 0.081 0.519
300 0.607 1 8.65 4.32 0.083 0.601

Formula 8
Replikasi 1

Jumlah Obat
Waktu Kadar bisoprolol yang Koreksi Total Koreksi
Serapan FP
(detik) (ppm) terdisolusi (mg) (mg)
(mg)
10 0.252 1 2.61 1.31 0.000 0.000
20 0.264 1 2.81 1.41 0.026 0.026
30 0.287 1 3.21 1.60 0.028 0.054
40 0.290 1 3.26 1.63 0.032 0.086
50 0.324 1 3.84 1.92 0.033 0.119
60 0.356 1 4.38 2.19 0.038 0.157
80 0.388 1 4.92 2.46 0.044 0.201
100 0.427 1 5.59 2.79 0.049 0.250
120 0.476 1 6.42 3.21 0.056 0.306
140 0.565 1 7.93 3.97 0.064 0.370
160 0.577 1 8.14 4.07 0.079 0.450
240 0.587 1 8.31 4.15 0.081 0.531
300 0.607 1 8.65 4.32 0.083 0.614
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.04 20.88 10 0.219 1 2.05 1.02
1.80 36.12 20 0.313 1 3.65 1.82
2.15 43.14 30 0.337 1 4.06 2.03
2.24 44.83 40 0.354 1 4.35 2.17
2.44 48.92 50 0.368 1 4.58 2.29
2.57 51.55 60 0.372 1 4.65 2.33
2.77 55.57 80 0.399 1 5.11 2.56
3.08 61.70 100 0.429 1 5.62 2.81
3.48 69.81 120 0.470 1 6.32 3.16
3.67 73.45 140 0.487 1 6.61 3.30
4.13 82.77 160 0.523 1 7.22 3.61
4.30 86.11 240 0.533 1 7.39 3.69
4.64 93.07 300 0.580 1 8.19 4.09

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)

1.11 22.28 10 0.225 1 2.15 1.08

1.87 37.58 20 0.312 1 3.63 1.82
2.15 43.11 30 0.345 1 4.19 2.10
2.19 43.95 40 0.347 1 4.23 2.11
2.42 48.54 50 0.362 1 4.48 2.24
2.51 50.48 60 0.376 1 4.72 2.36
2.73 54.83 80 0.397 1 5.08 2.54
3.06 61.47 100 0.425 1 5.55 2.78
3.54 71.12 120 0.472 1 6.35 3.18
3.71 74.45 140 0.485 1 6.57 3.29
4.07 81.76 160 0.527 1 7.29 3.64
4.37 87.81 240 0.548 1 7.64 3.82
4.72 94.81 300 0.579 1 8.17 4.09
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.19 23.87 10 0.236 1 2.34 1.17
1.63 32.73 20 0.282 1 3.12 1.56
1.73 34.74 30 0.293 1 3.31 1.65
2.11 42.43 40 0.329 1 3.92 1.96
2.21 44.44 50 0.346 1 4.21 2.10
2.55 51.27 60 0.366 1 4.55 2.27
2.85 57.35 80 0.419 1 5.45 2.73
3.12 62.69 100 0.420 1 5.47 2.73
3.46 69.65 120 0.482 1 6.52 3.26
3.85 77.42 140 0.505 1 6.91 3.46
4.36 87.70 160 0.528 1 7.30 3.65
4.36 87.73 240 0.559 1 7.83 3.92
4.77 95.94 300 0.588 1 8.32 4.16

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.19 23.77 10 0.237 1 2.36 1.18
1.18 23.74 20 0.236 1 2.34 1.17
1.33 26.59 30 0.250 1 2.58 1.29
1.75 35.11 40 0.278 1 3.05 1.53
2.11 42.26 50 0.347 1 4.23 2.11
2.32 46.47 60 0.350 1 4.28 2.14
2.61 52.28 80 0.386 1 4.89 2.44
2.90 58.19 100 0.409 1 5.28 2.64
3.44 68.97 120 0.477 1 6.44 3.22
3.72 74.50 140 0.490 1 6.66 3.33
4.46 89.31 160 0.570 1 8.02 4.01
4.66 93.48 240 0.589 1 8.34 4.17
4.80 96.17 300 0.593 1 8.41 4.20
 Replikasi 2

Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.22 24.45 10 0.240 1 2.41 1.20
1.32 26.48 20 0.253 1 2.63 1.31
1.53 30.75 30 0.274 1 2.98 1.49
1.71 34.24 40 0.294 1 3.32 1.66
1.91 38.30 50 0.299 1 3.41 1.70
2.12 42.43 60 0.330 1 3.94 1.97
2.29 45.94 80 0.342 1 4.14 2.07
3.02 60.59 100 0.427 1 5.59 2.79
3.45 69.21 120 0.473 1 6.37 3.18
4.19 83.94 140 0.550 1 7.68 3.84
4.45 89.23 160 0.572 1 8.05 4.03
4.65 93.23 240 0.586 1 8.29 4.15
4.82 96.59 300 0.596 1 8.46 4.23

Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.27 25.58 10 0.243 1 2.46 1.23
1.36 27.29 20 0.265 1 2.83 1.42
1.59 31.93 30 0.274 1 2.98 1.49
1.76 35.46 40 0.296 1 3.36 1.68
1.99 40.07 50 0.314 1 3.66 1.83
2.14 43.05 60 0.332 1 3.97 1.99
2.36 47.44 80 0.353 1 4.33 2.16
3.06 61.65 100 0.435 1 5.72 2.86
3.55 71.35 120 0.481 1 6.51 3.25
4.23 85.15 140 0.550 1 7.68 3.84
4.50 90.47 160 0.576 1 8.12 4.06
4.68 94.16 240 0.589 1 8.34 4.17
4.86 97.88 300 0.600 1 8.53 4.26
 Replikasi 2
Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.28 25.70 10 0.246 1 2.51 1.25
1.35 27.07 20 0.257 1 2.70 1.35
1.57 31.52 30 0.275 1 3.00 1.50
1.63 32.82 40 0.284 1 3.15 1.58
1.95 39.07 50 0.316 1 3.70 1.85
2.25 45.27 60 0.342 1 4.14 2.07
2.57 51.58 80 0.374 1 4.69 2.34
3.01 60.39 100 0.427 1 5.59 2.79
3.47 69.70 120 0.479 1 6.47 3.24
4.32 86.69 140 0.568 1 7.98 3.99
4.49 90.15 160 0.578 1 8.15 4.08
4.65 93.32 240 0.586 1 8.29 4.15
4.93 98.90 300 0.607 1 8.65 4.32

Replikasi 2

Jumlah Obat
Jumlah Obat Persen Kadar
Waktu yang
yg terdisolusi Disolusi Serapan FP bisoprolol
(detik) terdisolusi
Total (mg) (%) (ppm)
(mg)
1.31 26.26 10 0.254 1 2.64 1.32
1.43 28.84 20 0.267 1 2.87 1.43
1.66 33.34 30 0.284 1 3.15 1.58
1.71 34.50 40 0.287 1 3.21 1.60
2.04 40.97 50 0.327 1 3.89 1.94
2.35 47.22 60 0.356 1 4.38 2.19
2.66 53.58 80 0.389 1 4.94 2.47
3.04 61.24 100 0.429 1 5.62 2.81
3.52 70.75 120 0.473 1 6.37 3.18
4.34 87.27 140 0.568 1 7.98 3.99
4.52 90.92 160 0.579 1 8.17 4.09
4.68 94.26 240 0.589 1 8.34 4.17
4.94 99.36 300 0.607 1 8.65 4.32
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)
0.00 0.00 1.02 20.53 10 0.228 1
0.02 0.02 1.84 36.96 20 0.313 1
0.04 0.06 2.09 41.78 30 0.339 1
0.04 0.10 2.27 45.49 40 0.354 1
0.04 0.14 2.43 48.75 50 0.358 1
0.05 0.19 2.51 50.35 60 0.373 1
0.05 0.23 2.79 55.88 80 0.399 1
0.05 0.28 3.09 62.02 100 0.430 1
0.06 0.34 3.50 70.13 120 0.470 1
0.06 0.40 3.71 74.30 140 0.486 1
0.07 0.47 4.08 81.76 160 0.512 1
0.07 0.54 4.24 84.91 240 0.544 1
0.07 0.62 4.71 94.40 300 0.574 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.08 21.60 10 0.223 1

0.02 0.02 1.84 36.89 20 0.319 1
0.04 0.06 2.15 43.25 30 0.345 1
0.04 0.10 2.21 44.43 40 0.341 1
0.04 0.14 2.38 47.84 50 0.365 1
0.04 0.19 2.55 51.13 60 0.370 1
0.05 0.23 2.77 55.67 80 0.393 1
0.05 0.28 3.06 61.47 100 0.427 1
0.06 0.34 3.52 70.61 120 0.473 1
0.06 0.40 3.69 74.10 140 0.489 1
0.07 0.47 4.11 82.60 160 0.525 1
0.07 0.54 4.36 87.64 240 0.545 1
0.08 0.62 4.70 94.47 300 0.588 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.17 23.53 10 0.237 1

0.02 0.02 1.58 31.87 20 0.289 1
0.03 0.05 1.71 34.38 30 0.296 1
0.03 0.09 2.05 41.20 40 0.321 1
0.04 0.13 2.23 44.90 50 0.340 1
0.04 0.17 2.44 49.17 60 0.359 1
0.05 0.21 2.94 59.15 80 0.417 1
0.05 0.27 3.00 60.42 100 0.428 1
0.05 0.32 3.58 72.13 120 0.478 1
0.07 0.39 3.85 77.37 140 0.488 1
0.07 0.46 4.11 82.70 160 0.572 1
0.07 0.53 4.45 89.47 240 0.544 1
0.08 0.61 4.77 96.01 300 0.583 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.18 23.60 10 0.236 1

0.02 0.02 1.19 23.90 20 0.235 1
0.02 0.05 1.34 26.76 30 0.250 1
0.03 0.07 1.60 32.05 40 0.278 1
0.03 0.10 2.22 44.42 50 0.349 1
0.04 0.15 2.28 45.77 60 0.350 1
0.04 0.19 2.63 52.77 80 0.386 1
0.05 0.24 2.88 57.66 100 0.408 1
0.05 0.29 3.51 70.31 120 0.482 1
0.06 0.35 3.68 73.82 140 0.492 1
0.07 0.42 4.43 88.78 160 0.569 1
0.08 0.50 4.67 93.63 240 0.587 1
0.08 0.58 4.79 95.98 300 0.592 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.20 24.11 10 0.243 1

0.02 0.02 1.34 26.81 20 0.253 1
0.03 0.05 1.54 30.92 30 0.276 1
0.03 0.08 1.74 34.92 40 0.294 1
0.03 0.11 1.82 36.44 50 0.300 1
0.03 0.15 2.12 42.41 60 0.330 1
0.04 0.19 2.26 45.24 80 0.344 1
0.04 0.23 3.02 60.55 100 0.427 1
0.06 0.28 3.47 69.51 120 0.474 1
0.06 0.35 4.19 83.91 140 0.550 1
0.08 0.42 4.45 89.20 160 0.572 1
0.08 0.51 4.65 93.20 240 0.586 1
0.08 0.59 4.82 96.56 300 0.598 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.23 24.72 10 0.246 1

0.02 0.02 1.44 28.98 20 0.255 1
0.03 0.05 1.55 31.09 30 0.279 1
0.03 0.08 1.76 35.46 40 0.295 1
0.03 0.12 1.95 39.21 50 0.319 1
0.04 0.15 2.14 43.03 60 0.332 1
0.04 0.19 2.36 47.42 80 0.353 1
0.04 0.24 3.10 62.32 100 0.431 1
0.06 0.29 3.55 71.34 120 0.483 1
0.07 0.36 4.20 84.46 140 0.554 1
0.08 0.44 4.50 90.45 160 0.574 1
0.08 0.52 4.69 94.31 240 0.587 1
0.08 0.60 4.86 97.87 300 0.599 1
 Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.25 25.19 10 0.245 1

0.03 0.03 1.37 27.57 20 0.257 1
0.03 0.05 1.55 31.18 30 0.278 1
0.03 0.08 1.66 33.32 40 0.284 1
0.03 0.11 1.96 39.42 50 0.315 1
0.04 0.15 2.22 44.60 60 0.345 1
0.04 0.19 2.53 50.90 80 0.375 1
0.05 0.24 3.03 60.89 100 0.424 1
0.06 0.29 3.53 70.89 120 0.476 1
0.06 0.36 4.35 87.39 140 0.565 1
0.08 0.44 4.52 90.70 160 0.575 1
0.08 0.52 4.67 93.70 240 0.585 1
0.08 0.60 4.93 98.95 300 0.607 1

Replikasi 3

Jumlah Obat Persen

Koreksi Total Koreksi Waktu
yg terdisolusi Disolusi Serapan FP
(mg) (mg) (detik)
Total (mg) (%)

0.00 0.00 1.32 26.61 10 0.257 1

0.03 0.03 1.46 29.36 20 0.267 1
0.03 0.06 1.63 32.85 30 0.285 1
0.03 0.09 1.69 33.99 40 0.298 1
0.03 0.12 2.06 41.48 50 0.323 1
0.04 0.16 2.35 47.23 60 0.358 1
0.04 0.20 2.67 53.75 80 0.388 1
0.05 0.25 3.06 61.59 100 0.427 1
0.06 0.31 3.49 70.25 120 0.477 1
0.06 0.37 4.36 87.79 140 0.567 1
0.08 0.45 4.54 91.28 160 0.579 1
0.08 0.53 4.70 94.63 240 0.585 1
0.08 0.62 4.94 99.39 300 0.606 1
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.20 1.10 0.00 0.00 1.10 22.07
3.65 1.82 0.02 0.02 1.85 36.99
4.09 2.05 0.04 0.06 2.10 42.16
4.35 2.17 0.04 0.10 2.27 45.53
4.41 2.21 0.04 0.14 2.35 47.08
4.67 2.33 0.04 0.19 2.52 50.52
5.11 2.56 0.05 0.23 2.79 55.89
5.64 2.82 0.05 0.28 3.10 62.20
6.32 3.16 0.06 0.34 3.50 70.14
6.59 3.30 0.06 0.40 3.70 74.14
7.03 3.52 0.07 0.47 3.99 79.89
7.58 3.79 0.07 0.54 4.33 86.75
8.09 4.04 0.08 0.62 4.66 93.38

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)

2.12 1.06 0.00 0.00 1.06 21.26

3.75 1.88 0.02 0.02 1.90 38.08
4.19 2.10 0.04 0.06 2.15 43.27
4.12 2.06 0.04 0.10 2.16 43.43
4.53 2.27 0.04 0.14 2.41 48.35
4.62 2.31 0.05 0.19 2.50 50.12
5.01 2.50 0.05 0.23 2.74 54.97
5.59 2.79 0.05 0.28 3.08 61.78
6.37 3.18 0.06 0.34 3.52 70.76
6.64 3.32 0.06 0.40 3.72 74.77
7.25 3.63 0.07 0.47 4.10 82.25
7.59 3.80 0.07 0.54 4.34 87.12
8.32 4.16 0.08 0.62 4.78 95.99
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.36 1.18 0.00 0.00 1.18 23.70
3.24 1.62 0.02 0.02 1.64 33.07
3.36 1.68 0.03 0.06 1.74 34.92
3.78 1.89 0.03 0.09 1.98 39.87
4.11 2.05 0.04 0.13 2.18 43.88
4.43 2.22 0.04 0.17 2.38 47.96
5.42 2.71 0.04 0.21 2.92 58.77
5.60 2.80 0.05 0.27 3.07 61.75
6.45 3.23 0.06 0.32 3.55 71.43
6.62 3.31 0.06 0.39 3.70 74.44
8.05 4.03 0.07 0.45 4.48 90.14
7.58 3.79 0.08 0.53 4.32 86.97
8.24 4.12 0.08 0.61 4.73 95.17

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.34 1.17 0.00 0.00 1.17 23.43
2.32 1.16 0.02 0.02 1.18 23.73
2.58 1.29 0.02 0.05 1.33 26.75
3.05 1.53 0.03 0.07 1.60 32.04
4.26 2.13 0.03 0.10 2.23 44.75
4.28 2.14 0.04 0.15 2.28 45.77
4.89 2.44 0.04 0.19 2.63 52.77
5.26 2.63 0.05 0.24 2.87 57.49
6.52 3.26 0.05 0.29 3.55 71.16
6.69 3.35 0.07 0.36 3.70 74.17
8.00 4.00 0.07 0.42 4.42 88.63
8.31 4.15 0.08 0.50 4.66 93.30
8.39 4.20 0.08 0.59 4.78 95.82
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.46 1.23 0.00 0.00 1.23 24.62
2.63 1.31 0.02 0.02 1.34 26.82
3.02 1.51 0.03 0.05 1.56 31.27
3.32 1.66 0.03 0.08 1.74 34.94
3.43 1.71 0.03 0.11 1.83 36.63
3.94 1.97 0.03 0.15 2.12 42.43
4.18 2.09 0.04 0.19 2.28 45.60
5.59 2.79 0.04 0.23 3.02 60.58
6.39 3.19 0.06 0.29 3.48 69.71
7.68 3.84 0.06 0.35 4.19 83.94
8.05 4.03 0.08 0.43 4.45 89.23
8.29 4.15 0.08 0.51 4.65 93.23
8.49 4.25 0.08 0.59 4.84 96.94

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.51 1.25 0.00 0.00 1.25 25.24
2.66 1.33 0.03 0.03 1.36 27.28
3.07 1.53 0.03 0.05 1.59 31.92
3.34 1.67 0.03 0.08 1.75 35.28
3.75 1.88 0.03 0.12 1.99 40.06
3.97 1.99 0.04 0.15 2.14 43.04
4.33 2.16 0.04 0.19 2.36 47.43
5.65 2.83 0.04 0.24 3.06 61.64
6.54 3.27 0.06 0.29 3.56 71.68
7.75 3.87 0.07 0.36 4.23 85.14
8.09 4.04 0.08 0.44 4.48 90.12
8.31 4.15 0.08 0.52 4.67 93.97
8.51 4.26 0.08 0.60 4.86 97.70
 Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.49 1.25 0.00 0.00 1.25 25.02
2.70 1.35 0.02 0.02 1.37 27.56
3.05 1.53 0.03 0.05 1.58 31.69
3.15 1.58 0.03 0.08 1.66 33.33
3.68 1.84 0.03 0.11 1.95 39.26
4.19 2.10 0.04 0.15 2.25 45.12
4.70 2.35 0.04 0.19 2.54 51.08
5.54 2.77 0.05 0.24 3.01 60.39
6.42 3.21 0.06 0.30 3.51 70.38
7.93 3.97 0.06 0.36 4.33 86.87
8.10 4.05 0.08 0.44 4.49 90.17
8.27 4.14 0.08 0.52 4.66 93.50
8.65 4.32 0.08 0.60 4.93 98.92

Jumlah Obat
Jumlah Obat Persen
Kadar bisoprolol yang Koreksi Total Koreksi
yg terdisolusi Disolusi
(ppm) terdisolusi (mg) (mg)
Total (mg) (%)
(mg)
2.70 1.35 0.00 0.00 1.35 27.12
2.87 1.43 0.03 0.03 1.46 29.37
3.17 1.59 0.03 0.06 1.64 33.03
3.39 1.70 0.03 0.09 1.78 35.89
3.82 1.91 0.03 0.12 2.03 40.85
4.41 2.21 0.04 0.16 2.37 47.61
4.92 2.46 0.04 0.20 2.67 53.63
5.59 2.79 0.05 0.25 3.05 61.29
6.44 3.22 0.06 0.31 3.53 70.97
7.97 3.98 0.06 0.37 4.36 87.66
8.17 4.09 0.08 0.45 4.54 91.32
8.27 4.14 0.08 0.53 4.67 93.99
8.63 4.32 0.08 0.62 4.93 99.25
Formula 1 Formula 1

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 21.16 0.81 3.81 10 104.38 102.67

20 36.69 0.50 1.35 20 284.97 287.49
30 42.36 0.70 1.65 30 396.28 393.74
40 45.29 0.39 0.87 40 439.83 436.39
50 48.25 1.02 2.11 50 468.77 471.22
60 50.81 0.65 1.28 60 502.37 495.51
80 55.78 0.18 0.32 80 1071.24 1062.35
100 61.97 0.25 0.40 100 1172.77 1179.04
120 70.03 0.19 0.27 120 1315.13 1321.54
140 73.96 0.45 0.60 140 2865.29 2888.60
160 81.47 1.46 1.80 160 1562.26 1560.52
240 85.92 0.94 1.09 240 6755.35 6666.46
300 93.62 0.69 0.74 300 5375.50 5379.07
Total AUC 22314.13 22244.60
Luas Total 30000 30000
DE 300 (%) 74.38 74.15

Formula 2 Formula 2

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 21.71 0.52 2.40 10 111.42 108.00

20 37.52 0.60 1.59 20 299.34 292.44
30 43.21 0.09 0.20 30 403.46 400.69
40 43.94 0.50 1.15 40 435.27 438.43
50 48.25 0.36 0.75 50 462.44 461.39
60 50.58 0.52 1.02 60 495.10 494.90
80 55.16 0.45 0.81 80 1053.07 1068.03
100 61.57 0.18 0.30 100 1162.93 1171.37
120 70.83 0.26 0.37 120 1325.83 1320.78
140 74.44 0.33 0.45 140 2911.41 2894.26
160 82.20 0.42 0.51 160 1562.08 1567.00
240 87.53 0.36 0.41 240 6782.71 6809.62
300 95.09 0.80 0.84 300 5478.80 5463.54
Total AUC 22483.86 22490.45
Luas Total 30000.00 30000.00
 DE 300 (%) 74.95 74.97

Formula 3 Formula 3

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 23.70 0.17 0.72 10 119.34 117.63

20 32.55 0.62 1.90 20 282.98 276.96
30 34.68 0.28 0.80 30 337.36 331.21
40 41.17 1.28 3.11 40 385.86 377.89
50 44.41 0.51 1.15 50 434.35 430.50
60 49.46 1.67 3.38 60 478.53 470.33
80 58.43 0.95 1.62 80 1086.19 1083.18
100 61.62 1.14 1.85 100 1200.45 1195.69
120 71.07 1.28 1.79 120 1323.43 1325.45
140 76.41 1.71 2.23 140 2941.36 2990.01
160 86.85 3.79 4.37 160 1651.18 1600.74
240 88.06 1.28 1.46 240 7017.41 6886.97
300 95.71 0.47 0.49 300 5510.26 5564.56
Total AUC 22768.70 22651.14
Luas Total 30000.00 30000.00
DE 300 (%) 75.90 75.50

Formula 4 Formula 4

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 23.60 0.17 0.72 10 118.86 118.01

20 23.79 0.10 0.41 20 237.54 237.52
30 26.70 0.10 0.36 30 251.62 253.30
40 33.06 1.77 5.36 40 308.48 294.01
50 43.81 1.35 3.09 50 386.84 382.30
60 46.01 0.40 0.87 60 443.63 450.94
80 52.60 0.28 0.53 80 987.50 985.39
100 57.78 0.36 0.63 100 1104.74 1104.30
120 70.15 1.10 1.57 120 1271.68 1279.75
140 74.16 0.34 0.46 140 2869.45 2882.53
160 88.91 0.35 0.40 160 1638.06 1625.99
240 93.47 0.16 0.17 240 7311.56 7296.43
300 95.99 0.18 0.18 300 5689.59 5688.26
Total AUC 22619.55 22598.76
Luas Total 30000.00 30000.00
DE 300 (%) 75.40 75.33
Formula 5 Formula 5

AUC (mg/detik)
Rata-rata
Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 24.40 0.26 1.07 10 122.27 120.56

20 26.70 0.20 0.73 20 254.65 254.62
30 30.98 0.27 0.86 30 286.11 288.63
40 34.70 0.40 1.15 40 324.91 329.19
50 37.12 1.02 2.75 50 362.67 356.81
60 42.42 0.01 0.03 60 403.62 394.23
80 45.59 0.35 0.77 80 883.69 876.46
100 60.58 0.02 0.03 100 1065.31 1057.95
120 69.48 0.25 0.37 120 1297.95 1300.68
140 83.93 0.02 0.02 140 3062.89 3068.48
160 89.22 0.02 0.02 160 1731.64 1731.10
240 93.22 0.02 0.02 240 7298.07 7295.88
300 96.70 0.21 0.21 300 5694.50 5692.87
Total AUC 22788.29 22767.47
Luas Total 30000.00 30000.00
DE 300 (%) 75.96 75.89

Formula 6 Formula 6

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 25.18 0.43 1.71 10 127.89 123.62

20 27.85 0.98 3.52 20 264.33 268.52
30 31.65 0.48 1.52 30 296.09 300.37
40 35.40 0.10 0.29 40 336.93 332.74
50 39.78 0.49 1.23 50 377.61 373.34
60 43.04 0.01 0.02 60 415.56 411.20
80 47.43 0.01 0.02 80 904.83 904.49
100 61.87 0.39 0.63 100 1090.92 1097.42
120 71.46 0.19 0.27 120 1330.00 1336.64
140 84.91 0.40 0.47 140 3129.83 3116.01
160 90.35 0.19 0.22 160 1756.13 1749.08
240 94.15 0.17 0.18 240 7384.92 7390.40
300 97.82 0.10 0.11 300 5761.15 5765.36
Total AUC 23176.21 23169.18
Luas Total 30000.00 30000.00
DE 300 (%) 77.25 77.23
Formula 7 Formula 7

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 25.30 0.36 1.40 10 128.49 125.93

20 27.40 0.29 1.05 20 263.82 263.77
30 31.47 0.26 0.82 30 292.95 293.75
40 33.16 0.29 0.89 40 321.70 322.52
50 39.25 0.17 0.44 50 359.46 363.71
60 45.00 0.35 0.78 60 421.75 420.11
80 51.19 0.36 0.69 80 968.59 954.99
100 60.56 0.29 0.47 100 1119.77 1117.86
120 70.32 0.60 0.85 120 1300.94 1317.77
140 86.98 0.36 0.42 140 3127.71 3165.49
160 90.34 0.31 0.34 160 1768.38 1780.81
240 93.51 0.19 0.20 240 7338.81 7375.83
300 98.93 0.02 0.02 300 5766.59 5779.50
Total AUC 23178.95 23282.03
Luas Total 30000.00 30000.00
DE 300 (%) 77.26 77.61

Formula 8 Formula 8

Rata-rata AUC (mg/detik)

Waktu Waktu
terdisolusi SD RSD
(detik) (detik)
(%) Rep 1 Rep 2

10 26.66 0.43 1.61 10 131.32 133.03

20 29.19 0.30 1.04 20 275.52 279.83
30 33.07 0.25 0.76 30 310.92 311.04
40 34.80 0.98 2.82 40 339.22 334.21
50 41.10 0.34 0.82 50 377.37 377.39
60 47.35 0.22 0.47 60 440.97 443.55
80 53.65 0.09 0.17 80 1007.97 1009.82
100 61.37 0.19 0.31 100 1148.16 1153.47
120 70.66 0.37 0.52 120 1319.88 1318.44
140 87.57 0.27 0.31 140 3160.29 3160.77
160 91.17 0.22 0.24 160 1781.83 1790.62
240 94.30 0.32 0.34 240 7407.23 7436.25
300 99.33 0.07 0.07 300 5808.68 5820.59
Total AUC 23509.36 23569.01
Luas Total 30000.00 30000.00
DE 300 (%) 78.36 78.56
C (mg/detik) %DE 300 Total

Rep 3 Replikasi F2 F1 F4 F3 F6
110.34 I 74.80 74.53 75.70 75.59 76.94
295.31 II 74.82 74.39 75.63 75.20 76.92
395.75 III 74.81 74.33 75.62 75.40 76.84
438.44 Rata-rata 74.81 74.42 75.65 75.40 76.90
463.08 SD 0.01 0.10 0.04 0.20 0.05
488.04 RSD 0.01 0.14 0.06 0.26 0.07
1064.15
1180.88
1323.41 AUC Total
2885.60 Replikasi F2 F1 F4 F3 F6
1540.24 I 22438.80 22358.93 22710.57 22677.44 23083.32
6665.51 II 22445.38 22289.27 22689.70 22560.35 23076.31
5403.92 III 22442.27 22299.36 22687.17 22619.43 23051.78
22254.67 Rata-rata 22442.15 22315.85 22695.81 22619.07 23070.47
30000 SD 3.29 37.65 12.84 58.54 16.56
74.18 RSD 0.01 0.17 0.06 0.26 0.07

C (mg/detik) Rata - Rata terdisolusi (%)

Waktu (detik)
Rep 3 F1 F2 F3 F4 F5

0 0.00 0.00 0.00 0.00 0.00

106.29 10 21.67 21.20 23.70 23.60 25.08
296.67 20 37.44 36.77 23.89 32.42 27.74
406.72 30 43.12 42.44 26.81 34.54 31.52
433.48 40 43.85 45.38 33.20 41.00 35.25
458.90 50 48.15 48.35 43.98 44.23 39.62
492.35 60 50.48 50.91 46.19 49.27 42.86
1050.89 80 55.05 55.89 52.82 58.19 47.24
1167.54 100 61.45 62.10 58.02 61.37 61.62
1325.42 120 70.69 70.17 70.43 70.78 71.17
2910.59 140 74.29 74.11 74.46 76.10 84.57
1570.21 160 82.04 81.63 89.27 86.50 89.98
6774.92 240 87.35 86.10 93.85 87.71 93.77
5493.35 300 94.90 93.80 96.38 95.32 97.43
22487.34
30000.00
 74.96

Profil Pelepasan Obat

120.00
C (mg/detik)
100.00
Rep 3
% Terdisolusi 80.00
118.48
283.82 60.00
339.92
373.94 40.00
418.76
459.21 20.00
1067.34
1205.21 0.00
10 20 30 40 50 60 80 100 120 140 160 2
1331.75
2917.33 Waktu (detik)
1645.81
7084.62
5464.27
22710.45
30000.00
75.70

C (mg/detik)

Rep 3

117.16
235.80
252.40
293.95
383.94
452.61
985.39
1102.60
1286.54
2906.60
1628.03
7277.48
5673.75
22596.24
30000.00
75.32
C (mg/detik)

Rep 3

123.12
257.22
290.44
331.03
357.83
395.27
880.28
1061.83
1302.93
3073.05
1731.71
7298.34
5704.93
22807.99
30000.00
76.03

C (mg/detik)

Rep 3

126.18
262.59
296.02
336.00
376.67
415.46
904.63
1090.71
1333.22
3136.40
1752.64
7363.84
5750.16
23144.54
30000.00
77.15
C (mg/detik)

Rep 3

125.08
262.90
296.28
325.10
362.92
421.87
961.99
1114.75
1307.77
3145.06
1770.40
7347.01
5772.84
23213.95
30000.00
77.38

C (mg/detik)

Rep 3

135.59
282.45
312.00
344.59
383.71
442.29
1012.35
1149.19
1322.61
3172.68
1789.84
7412.43
5797.18
23556.91
30000.00
78.52
 F5 F8 F7
76.27 78.21 77.42
76.2 78.41 77.76
76.33 78.37 77.54
76.27 78.33 77.57
0.07 0.11 0.17
0.09 0.14 0.22

F5 F8 F7
22879.99 23462.16 23225.59
22859.08 23521.68 23536.27
22899.77 23509.61 23260.66
22879.62 23497.81 23340.84
20.35 31.47 170.16
0.09 0.13 0.73

rdisolusi (%)

F6 F7 F8

0.00 0.00 0.00

24.50 26.61 25.35
26.81 29.13 27.45
31.10 33.01 31.53
34.84 34.73 33.22
37.27 41.02 39.33
42.59 47.26 45.09
45.78 53.55 51.29
60.82 61.25 60.68
69.76 70.51 70.47
84.27 87.40 87.16
89.58 90.99 90.52
93.59 94.11 93.70
97.09 99.13 99.12
Obat

F1
F2
F3
F4
F5
F6
F7
F8

120 140 160 240 300

 Waktu (detik) % Swelling Index
Formula Replikasi Bobot awal
10 20 30 10 20 30
I 50.30 76.67 102.20 125.67 52.43 103.18 149.84
1 II 49.91 74.56 98.78 120.65 49.39 97.92 141.74
III 50.20 76.65 101.10 124.65 52.69 101.39 148.31
I 50.78 76.57 103.20 126.60 50.79 103.23 149.31
2 II 51.99 78.56 102.78 128.40 51.11 97.69 146.97
III 50.77 77.65 102.10 125.80 52.94 101.10 147.78
I 54.55 90.78 123.54 145.76 66.42 126.47 167.20
3 II 53.67 89.99 120.66 143.98 67.67 124.82 168.27
III 54.08 90.23 122.76 143.45 66.85 127.00 165.26
I 58.87 98.78 123.54 159.76 67.79 109.85 171.38
4 II 58.78 97.99 120.66 159.98 66.71 105.27 172.17
III 57.67 98.23 122.76 159.45 70.33 112.87 176.49
I 64.90 118.78 162.54 - 83.02 150.45 -
5 II 65.80 118.99 161.66 - 80.84 145.68 -
III 65.90 119.23 162.76 - 80.93 146.98 -
I 70.34 130.78 182.54 - 85.93 159.51 -
6 II 70.44 130.99 181.66 - 85.96 157.89 -
III 70.52 130.23 182.76 - 84.67 159.16 -
I 70.52 131.78 184.54 - 86.87 161.68 -
7 II 70.76 131.99 184.66 - 86.53 160.97 -
III 70.76 131.23 184.76 - 85.46 161.11 -
I 71.20 132.78 194.54 - 86.49 173.23 -
8 II 71.44 132.99 194.66 - 86.16 172.48 -
III 71.12 133.23 194.76 - 87.33 173.85 -
 Rata - Rata SD %CV
10 20 30 10 20 30 10 20 30

51.50 100.83 146.63 1.83 2.68 4.31 3.56 2.66 2.94

51.61 100.67 148.02 1.16 2.79 1.19 2.26 2.77 0.80

66.98 126.10 166.91 0.64 1.14 1.53 0.95 0.90 0.92

68.28 109.33 173.34 1.86 3.82 2.75 2.72 3.50 1.59

-
81.59 147.70 - 1.24 2.46 - 1.51 1.67 -
-
-
85.52 158.85 - 0.73 0.85 - 0.86 0.54 -
-
-
86.29 161.25 - 0.74 0.38 - 0.85 0.24 -
-
-
86.66 173.19 - 0.61 0.68 - 0.70 0.40 -
-