7.8.

Nghin cu hot tnh khng khun v c tnh

89

7.9. Nghin cu v dc l v iu tr ca khng sinh 90

7.10. Tiu chun i vi mt khng sinh 90
7.11. Phng php nh lng khng sinh

91

7.12. ng dng khng sinh ngoi lnh vc y hc 94

Chng 8. Sn xut khng sinh nhm -lactam
8.1. i cng v cc -lactam

100

8.2. Sinh tng hp cc khng sinh Penicillin

100

8.3. Sn xut 6-APA v cc Penicillin bn tng hp

8.4. Sn xut cc Cephalosporin

110

116

8.5. Sn xut 7ACA; 7ADCA v cc khng sinh bn tng hp

nhm cephalosporin 120
8.6. Sinh tng hp acid clavulanic 122
Chng 9. sn xut khng sinh nhm Tetracyclin
9.1. i cng

128

9.2. Cng thc cu to v tnh cht

128

9.3. Sinh tng hp cc Tetracyclin t nhin

130

9.4. Sinh tng hp Clotetracyclin 134

9.5. Sinh tng hp Tetracyclin

136

9.6. Sinh tng hp Oxytetracyclin 139

9.7. Cc Tetracyclin bn tng hp 142
Chng 10. sn xut khng sinh nhm aminoglycosid
10.1. i cng chung v cc aminoglycosid

146

10.2. Sinh tng hp Streptomycin 150

10.3. Sinh tng hp Gentamicin

157

Chng 11. sn xut khng sinh nhm macrolid

11.1. Tng quan v cc Macrolid
11..2. Sinh tng hp Erythromycin

162
165

chng 12. sn xut khng sinh chng ung th

12.1. i cng

168

12.2. Cc phng hng iu tr bnh ung th 168

9