Ak 47

mqx#$ mqx#$ IIMT COLLEGE OF MEDICAL
mqx#$ mqx#$ mqx#$
mqx#$ SCIENCES mqx#$
DEPARTMENT OF PHARMACY mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ (SESSION
mqx#$2020-2021)
Formulation and evaluation of cold creammqx#$ mqx#$ mqx#$ mqx#$ mqx#$
DATE OF SUBMISSION :
mqx#$ mqx#$ mqx#$ mqx#$
CLASS : B.PHARMA 4 YEAR

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
SEC : A mqx#$ mqx#$ mqx#$
SUBMITTED TO mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ SUBMITTED BY mqx#$ mqx#$

Miss. Lovely chaurasia
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ Aakash Kumar mqx#$
Assistant Professor mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ 2117650060006 Department of Pharmacy mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ B.Pharma 4thyear mqx#$
CERTIFICATE FOR DEAN mqx#$ mqx#$
mqx#$ are deeply indebted to the Dean Dr. Anuj Mittal

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ without his guidance and cooperation practice school

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ report project would not be possible. He has taken a

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ lot of efforts for getting success at each and every step
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ and coming along with us.

Signature of DEAN mqx#$ mqx#$ mqx#$
DATE: mqx#$
PLACE: mqx#$
CERTIFICATE FOR HOD mqx#$ mqx#$ mqx#$
This is to certify that our practice school project report

has been successfully completed and we are paying our

mqx#$ sincere mqx#$ gratitude mqx#$ to mqx#$

the head of department DR.
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ SACHIN
mqx#$ SINGHAL mqx#$
Signature of HOD mqx#$ mqx#$ mqx#$

CERTIFICATE FOR TEACHER mqx#$ mqx#$ mqx#$
This is to certify that our practice school project report

has been success fully completed under the guidance of

Miss. Lovely chaurasia during the session (2020-2021).

Signature of TEACHER mqx#$ mqx#$ mqx#$
DATE: mqx#$
PLACE: mqx#$
CERTIFICATE FOR STUDENT mqx#$ mqx#$ mqx#$
This mqx#$ is mqx#$ Aakash Kumar of B.PHARMA 4Th year

to mqx#$ certify mqx#$ that mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
mqx#$ from IIMT university Meerut has completed his practice school
mqx#$ project report under the guidance of

mqx#$ Miss. Lovely
mqx#$ chaurasia. She has taken proper report care and show most
mqx#$ sincerity mqx#$ during mqx#$ project mqx#$ report. mqx#$
Signature of STUDENT mqx#$ mqx#$ mqx#$

CONTENT
 Introduction mqx#$
 mqx#$Historical View mqx#$
 Formulation
 Cold Cream Formula

mqx#$ mqx#$
 Soft Cold Cream Formula

mqx#$ mqx#$ mqx#$
 Winter Protective Cream Formula

mqx#$ mqx#$ mqx#$
 Cosmetic Technology mqx#$
 Evaluation of Cream mqx#$ mqx#$
 Result and Conclusion

mqx#$ mqx#$
 Reference
Cold Cream mqx#$
Introduction mqx#$
.Bombax ceiba is important medicinal plant of tropical and subtropical

India. It is commonly known as silk cotton tree and semal which

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
belongs to family Bombacaceae.

Traditional medicicinal uses of this plant are reported in Ayurveda Sidhha

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
& Unani. It is a lofty, deciduous tree upto 45 m tall and 6 m or

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
more in girth with horizontally spreading branches and young stems

covered with stout, hard prickles1 .

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
The bark is pale ash to silver grey in color. Flowers are

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ large mqx#$in
diameter, red in color and numerous with copious nectar.
The fruits are brown capsule-like upto 15 mm long, filled with

numerous black seeds which are irregular obovoid in shape, smooth and
oily with dense silky hair2 . The fruit pulp is sweet and edible.
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
According to ayurveda, it has stimulant, aphrodiasic, diuretic, cardiotonic,

antidiarrheal, haemostatic, antidysentric3-4etc. Young fruits are useful in

calculus affections, chronic inflammations,anti microbial, and ulceration of

the bladder and kidney5 . Flowers of B. ceiba (25–50 g as feedstuff)

were fed to the animal as anthelmintics6 .
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ Ethnomedicinal mqx#$ uses of
mqx#$ mqx#$ B.
ceiba bark externally for cattle wounds7 .
Cream consist of medicament dissolved or suspended in water removable

or emollient bases, classified as water-inoil or oil-in-water and intended

for application on the skin or accesible mucous membrane to provide

localized and sometimes systemic effects at the site of application. The

function of a skin cream is to protect the skin against harshness from

the environment and any dry conditions of the skin.

A skin cream should aid the skin in carrying out its normal functions
that is, restoring moisture to dry skin, allowing the elimination of waste
matter through the pores, and the cooling of the body by evaporation
of water (perspiration) and radiation, thus aiding in the maintenance of

the normal body temperature8 .

Topical skin infections commonly occur and often present therapeutic

challenges to practitioners, despite the numerous existing antimicrobial

agents available today.

The necessity for developing new antimicrobial means has increased

significantly due to growing concerns regarding multi drug resistant

bacterial, viral, and fungal strains8 .

Consequently, attention has been devoted to safe, new, and/or alternative

antimicrobial materials in the field of antimicrobial chemotherapy.

Common examples for topical skin infections include

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ diaper mqx#$rash, mqx#$ cold
sores, and tinea (also called pityriasis) versicolor
mqx#$ Historical View mqx#$
The term ‘cold’ is possibly due to the cooling sensation caused by

evaporation of the water in the cream after it is applied to the skin.

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$
In the cosmetic industry, cold creams consists water-in-oil emulsions that

are made by using beeswax and alkali, usually borax, as the emulsifying
mqx#$ agent} Many mqx#$ mqx#$ variations mqx#$ and mqx#$ modifications mqx#$ of mqx#$ cold mqx#$ cream mqx#$ formulas mqx#$are
mqx#$ possible.
mqx#$ Cold cream is one of the oldest of cosmetics/ It’s discovery
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ is
mqx#$ attributed to Galen, a physician of the second century AD.
mqx#$ During mqx#$ the mqx#$ course mqx#$ of mqx#$ years mqx#$ many mqx#$ modifications mqx#$ have mqx#$ been mqx#$ made.
The emulsifying agent used in the cold cream type is really a soap
formed in situ by the interaction of borax with the free acid of the
beeswax.
mqx#$
mqx#$ Borax or sodium mqx#$ mqx#$ mqx#$ tetra mqx#$ borate mqx#$ is mqx#$ usually mqx#$ marketed mqx#$ as mqx#$ a mqx#$ decahydrate,
mqx#$ Na2B407 10H20. mqx#$
mqx#$ Borax is mqx#$ mqx#$ hydrolyzrd mqx#$ by mqx#$ water mqx#$ and mqx#$ the mqx#$ solution mqx#$ has mqx#$a mqx#$ marked mqx#$ alkaline
mqx#$ reaction.
mqx#$ Some of the newer type of cold creams, developed to compete with
mqx#$ the old-types are made in combination with absorption bases, emulsifying
mqx#$ waxes and triethanolamine or other additives.

The mqx#$manufacturing mqx#$ procedure mqx#$ for mqx#$ making mqx#$ cold mqx#$ creams mqx#$ is mqx#$ as mqx#$ follows mqx#$ .
Dissolve mqx#$ the mqx#$borax mqx#$ in mqx#$ hot mqx#$ water. mqx#$
Melt the various waxes together and add any fatty substances like lanolin,
lard, petroleum, if desired and run into the oils, keeping the temperature
at about 700C.
mqx#$ mqx#$ mqx#$
mqx#$ Pour in mqx#$ mqx#$the mqx#$ borax mqx#$ solution mqx#$ at mqx#$ the mqx#$ same temperature
mqx#$ mqx#$ with mqx#$ constant
mqx#$ stirring. mqx#$
Mix without heat till it cools to 400C, add the perfume. Pour in the
borax solution at the same temperature with constant stirring. Mix without
heat till it cools to 400C, add the perfume.

It is a necessary precaution in making cold creams to have the molten

mqx#$ fats and water solution at the same temperature before mixing them,
mqx#$ because the addition of cold water to hot waxes is likely to result in
mqx#$ partial solidification of some of the wax in the form of minute

mqx#$ particles that will impart grittiness, an unpleasant defect, when applied to
mqx#$ the skin. mqx#$
mqx#$ In making variations of the usual cold cream with triethanolamine, melt
mqx#$ the waxes, fats and oils to ether, bringing the temperature to about SO
mqx#$ C.
mqx#$ Then, into a separate kettle, put the water, glycerin and triethanolamine
mqx#$ and bring the solution almost to the boiling point. Add the melted fats
mqx#$ to the triethanolamine solution.

mqx#$ mqx#$ mqx#$
mqx#$Stir rapidly until an emulsion forms
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ and mqx#$when mqx#$ the mqx#$ temperature mqx#$ drops mqx#$ to
mqx#$about 450C, add the perfume.
S mqx#$ containing
When making cold creams containing lanolin absorption base, melt the
waxes, add
mqx#$ absorption base to the mineral oil and bring the
temperature of the mixture to about

800C. Then slowly add water heated to the same temperature

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ stirring mqx#$ until
thoroughly emulsified. When cool add the perfume.
The manufacture
mqx#$ mqx#$ of mqx#$ cold mqx#$ cream, mqx#$ containing mqx#$ glyceryl mqx#$ monostearate mqx#$ is mqx#$ very
simple.
mqx#$ mqx#$
All the ingredients in the formula are put into a kettle and heated
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ to
the boiling point with constant stirring until all of the glyceryl
monostearate has melted.

Stirring mqx#$ is mqx#$ continued mqx#$ until mqx#$ cool mqx#$ enough mqx#$ to mqx#$ perfume.
The consistency of any of the following formulas
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ can mqx#$ be mqx#$ adjusted mqx#$ by
increasing or decreasing the wax content.
mqx#$Creams can be better preserved by the addition of 0.15% of

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ a mqx#$ good
mqx#$preservative such as methyl or propyl para hydroxybenzoate.
mqx#$ Borax mqx#$ also mqx#$ exerts mqx#$ a mqx#$mild mqx#$ preservative mqx#$ action.
IV mqx#$ from mqx#$ beeswax mqx#$ The mqx#$ tnanufacture mqx#$ of perfume.
Cold centaining glyceryl tnonostedrdtp is very ,le. All the ingredients
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ in
the formula it into a kettle and heated to the boiling nint with
constant stirring until all of the’l monostearate has melted.

Stirtiney mqx#$ glycery mqx#$ is mqx#$ continued mqx#$ until mqx#$ cool mqx#$ enough mqx#$ to mqx#$ perfume.
Ille consistency of any of the following formulas can be adjusted by
increasing or deaeasing the wax content. Creams can preserved by the

addition of 0.1506 of good preservative such as methyl or propyl para

hydroxybenzoate. Borax also exerts a mild preservative action.

In making a cream, solely from beeswax, mineral

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ oil, mqx#$ water mqx#$ and mqx#$ borax,
mqx#$the following Feral factors should be considered.
--Borax should not be less than 5% of the beeswax used and

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ not mqx#$ more
than depending upon the acid number of the beeswax. 261
As mqx#$ the mqx#$ proportion mqx#$ of mqx#$ beeswax mqx#$ increases, mqx#$ the mqx#$ cream mqx#$ becomes mqx#$ harder.
— Mineral oil in relationship to water, has a stiffening rather than a
softening effect upon the cream, as the proportion is increased.

Above 60% of mineral oil, the cream shows signs of instability.

— Increase of water softens the cream until the product becomes
definitely liquid. When water is too low, the cream may be of

the water in oil type. Increasing amounts of water seem to lead

to finer grained and more lustrous creams.

A good balance seems to be reached when water and oil are present
in approximately equal amounts but good products result when the water-
oil ratio varies from 1 : 2 to 2 : 1.

FORMULATIONS
Cold Cream Formula

mqx#$ mqx#$
White mqx#$ Beeswax 20.0
Light Mineral
mqx#$ mqx#$ Oil 50.0
Distilled mqx#$water 28.8
Borax 0.7
Perfume 0.5
Method : Melt Beeswax in a water bath (to about 700C). Add light
Mineral Oil to it. In another beaker heat water to about 700C and
dissolve borax in it. Mix the aqueous phase to the oily phase with
stirring till a creamy emulsion is prepared. Add perfume at about 400C.

Soft Cold Cream Formula
mqx#$ mqx#$ mqx#$
Beeswax 6.0
Paraffin 12.5
White mqx#$ Petrolatum 8.0
Mineral mqx#$Oil 58.
Water 15.0
Potassium mqx#$carbonate 0.3
Borax 0.2
mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ Method : The waxes, petrolatum and mineral oil are
melted together and brought to 650— 70 0C. The water containing the
potassium carbonate and borax in solution is run in at the same

temperature. Stirring is continued until cool. After adding perfume, the

cream is allowed to stand overnight and filled by warming slightly until

just liquid.
mqx#$ mqx#$
Winter Protective Cream Formula

mqx#$ mqx#$ mqx#$
Part A mqx#$
Polysorbate 80
Sorbitan mqx#$ oleate mqx#$ magnesium mqx#$ stearate mqx#$ and
Aluminium mqx#$ steatrate mqx#$mixture 9.00
Mineral mqx#$Oil 9.00
Squalene 5.00
2-Hexanol mqx#$ ethyl mqx#$salicylate 4.00
Magnesium mqx#$ stearate 3.00
Perfume 0.50
Preservative 0.30
Glycerin 5.00
Distilled mqx#$water 64.20
Part mqx#$ B
Pigment mqx#$ Phase
Cream mqx#$ Base 93.00

Talc 3.00
Titanium mqx#$ Dioxide 3.00
Red mqx#$ Iron mqx#$ Oxide 0.30
Yellow mqx#$ Iron mqx#$ Oxide 0.60
Black Iron
mqx#$ mqx#$ oxide 0.10
Method : Mix well separately part (A) and part (B). Add (B) to (A),
under moderate
mqx#$ mqx#$ mqx#$stirring. mqx#$After mqx#$emulsification, introduce
mqx#$ mqx#$the mqx#$remainder mqx#$of mqx#$
(B) slowly.
mqx#$ mqx#$
Maintain a moderate-to-vigorous
mqx#$ mqx#$ mqx#$ agitation mqx#$ until mqx#$ the mqx#$ cream mqx#$becomes
homogeneous.
mqx#$ mqx#$
Mix all
mqx#$ mqx#$ pigments mqx#$ in mqx#$a mqx#$ suitable mqx#$mixer to
mqx#$ mqx#$ develop a
mqx#$ mqx#$ proper mqx#$ shade. mqx#$
COSMETIC TECHNOLOGY mqx#$
A part of the cream base. Add dispersed pigments to rest of base under
moderate stirring. It may be necessary to pass through a homogeniser to

ensure a better stability.

This cream with its content of 2-hexanol ethyl salicylate (UVB absorber)
and mineral pigments (physical barrier to UV radiation) can be used as

protective make up.

mqx#$ mqx#$ mqx#$
It gives a natural tone on the skin with a non-greasy water

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ resistant
film. This cream does not need any heat to.be manufacture.
Evaluation of Cream: mqx#$ mqx#$
Physical properties: The cream was observed for the color, odor and
mqx#$appearance. mqx#$
Washability: The cream was applied on the hand and observed under
mqx#$the mqx#$ running mqx#$
pH: The pH meter was calibrated with the help of standard buffer
mqx#$solution. Weigh 0.5 gm of cream dissolved it in 50.0ml of distilled

mqx#$water and its p H was measured with the help of digital pH meter.
Viscosity: Viscosity of the cream was determined with the help of

mqx#$Brookfield mqx#$ viscometer mqx#$ at mqx#$ 100 mqx#$ rpm mqx#$ with mqx#$ the mqx#$ spindle mqx#$ no. mqx#$ 7.
Spread ability test [8]: The cream sample was applied between the
mqx#$two glass slides and was compressed between the two-glass slide to
mqx#$uniform thickness by placing 100 gm of weight for 5 minutes then

mqx#$weight was added to the weighing pan. The time in which the upper
mqx#$glass slide moved over the lower slide was taken as a measure of
mqx#$spread ability. [8][9] mqx#$ mqx#$
Spread ability=m
mqx#$ mqx#$ *l/t
M mqx#$=weight mqx#$ tight mqx#$ to mqx#$ upper mqx#$ slide
L mqx#$ =length mqx#$moved mqx#$ on mqx#$ the mqx#$ glass mqx#$ slide
T mqx#$ =time mqx#$ take
Irritancy test: Mark an area (1sq.cm) on the left-hand dorsal surface.

mqx#$The cream was applied to the specified area and time was noted.
mqx#$Irritancy, erythema, edema, was checked if any for regular intervals up

mqx#$to 24 hrs. and reported. [9][10]

Test for microbial growth: Agar media was prepared then the
mqx#$formulated cream was inoculated on the plate’s agar media by steak

mqx#$plate method and a controlled is prepared by omitting the cream. The

mqx#$plates were placed in the incubator and are incubated in 37 C for 24

mqx#$hours. After the incubation period, the plates were taken out and the
mqx#$microbial growth were checked and compared with the control. [9][10][12]
Saponification value: Take 2 gm of the substance and reflux it with
mqx#$ the 25 ml of 0.5 N alcoholic KOH for 30 minutes. Then add 0.1
mqx#$ ml of phenolphthalein as a indicator and titrate it with the 0.5 N

mqx#$ HCL. [9][10][12] mqx#$
Saponification mqx#$ value=(b-a) mqx#$ *28.05/W
A =volume of titrate
mqx# mqx# mqx#
B =volume of titrate
mqx# mqx# mqx#
W =weight of substances in gram

mqx# mqx# mqx# mqx# mqx#
Acid value: Take 10 gm of the cream dissolved in accurately weighed in

mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
mqx#50 ml mixture of the equal volume of alcohol and solvent ether.

Then attached the flask with the condenser and reflux it with the slow
heating until the sample gets completely dissolve then add 1 ml of

phenolphthalein and titrate it with 0.1 N NaOH until it gets faint pink
mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
color appears after shaking in 20 seconds. [9][10][11]

mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
Acid value=n*5.61/w
mqx#
W =weight of the substances

mqx# mqx# mqx# mqx#
N =the number of ml in NaOH required.

mqx# mqx# mqx# mqx# mqx# mqx# mqx#
Dye test: The scarlet red dye is mixed with the cream.
mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
mqx#Place a drop of the cream on a microscopic slide then covers it with a

mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
mqx#cover slip, and examines it under a microscope. If the disperse globules

mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
mqx#appear red the ground colorless.

mqx# mqx# mqx# mqx#
mqx#The cream is o/w type. The reverse condition occurs in w/o type cream
mqx#i.e. the disperse globules appear colorless. [9][10][12]

mqx# mqx# mqx# mqx# mqx# mqx#
Homogeneity: Homogeneity was tested via the visual appearance and test.
mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
[9][10]
mqx#
Result and Conclusion mqx# mqx#
The results of evaluation are shown in table no. 2. Prepared formulation was
pale green in color. It has pleasant odor and smooth texture.

Physical properties: The physical properties of formulated cream were

judged by color, odor and texture.

Washability: The cream applied on skin was easily removed by washing

with tap water.

mqx# mqx# mqx#
Table no. 2: Physical properties

mqx# mqx# mqx# mqx#
Table no. 2: Physical properties

mqx# mqx# mqx# mqx#
pH of the cream: The pH of the cream was found to be in

mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
range of 5.6 to 6.8 which is good for skin pH. The herbal formulation
was shown pH nearer to skin required i.e pH 6.8.

mqx# mqx# mqx# mqx# mqx# Viscosity: Viscosity of formulated cream was determined by brook
field viscometer at 20 rpm using spindle no. LV-4(64). The viscosity of

cream was in the range of 499990 to 30000cp which indicates that the
mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx# mqx#
cream is easily spreadable by small amount of shear. The formulated cream

shows the viscosity within range i.e. 48890cp.

mqx# mqx# mqx# mqx# mqx# Spread ability test: The spread ability test showed that the
formulated cream has good spreadable property.

mqx# mqx# mqx# mqx# mqx# Irritancy test: The formulated cream shows no redness, edema,
irritation and inflammation during studies. The formulated cream is safe to

use.
mqx#
mqx# mqx# mqx# mqx# mqx# Test for microbial growth: There was no signs of microbial
growth after 24 hrs. of incubation at 37ºC and it was comparable with the
control.
mqx#
mqx# mqx# mqx# mqx# mqx# Saponification value: The saponification value results of formulated
cream was shown in table no. 3 and showed satisfactory values.

Table No.3: Saponification value and Acid value

Table No.3: Saponification value and Acid value

mqx mqx mqx mqx mqx Acid value: The acid value results of formulated cream was shown in
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
table no. 3 and showed satisfactory values.

mqx mqx mqx mqx mqx mqx mqx
Dye test: The scarlet red dye is mixed with the cream. Place a drop of
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
the cream on a microscopic slide covers it with a cover slip, and examines it
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
under a microscope. The disperse globules appears colorless in the red ground
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
i.e. w/o type cream.

mqx mqx mqx mqx
mqx mqx mqx mqx mqx mqx Homogeneity: The homogeneity of the formulated cream was judged by
mqx mqx mqx mqx mqx mqx mqx mqx mqx
the visual appearance and touch. The appearance and touch of the cream were
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
good.
mqx
Conclusion
From the above results it is concluded that the formulated cream showed good
consistency and spread ability, homogeneity, pH, non-greasy and there is no

phase separation during study period of research.

mqx mqx mqx mqx mqx mqx mqx mqx
From the above study it can be concluded that the polyherbal cold cream is safe
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
to use as it is developed from herbal extract. Natural remedies are more

acceptable in the belief that they are safer with fewer side effects than the
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
synthetic ones.
mqx mqx
So, the values of herbs in the cosmeceutical has been extensively improved in
personal care system and there is a great demand for the herbal cosmetics
nowadays.
mqx
An herbal cream which is non-toxic, safe, effective and improves patient

compliance by the utilization of herbal extracts would be highly acceptable than

synthetic ones.
mqx mqx
REFERENCES
[1] mqxGovernment mqxof mqxthe mqxHealth mqxand mqxFamily mqxWelfare. mqxThe mqxAyurvedic
Pharmacopoeia of India. Part I. Vol. 3. New Delhi: Government of
mqx mqx mqx mqx mqx mqx mqx mqx mqx mqx
the Health and Family Welfare; 2007. p. 183-4.

[2] Central Drug Research Institute and Publications and Information

Directorate. Compendium of Indian Medicinal Plants. Vol. I. New

Delhi, India: Central Drug Research Institute and Publications and

Information Directorate; 1990. p. 61

mqx mqx mqx mqx
[3] Williamson EM. Major Herbs of Ayurveda. Edinburgh: Churchill

Livingstone Publisher; 2002. p. 261.

mqx mqx mqx mqx
[4] Singh MP, Panda H. Medicinal Herbs and their Formulations. Vol.
1. New Delhi: Daya Publishing House; 2005. p. 176-8.

[5] Kirtikar K, Basu B. Indian Medicinal Plants. 2nd ed., Vol. 1. New
Delhi: BH Publishing Co.; 1994. P. 1401.

mqx mqx mqx mqx mqx mqx
[6] Abdul Jabbar, Muhammad Asif Raza, Z

afar Iqbal and Muhammad

mqx mqx mqx
Nisar Khan. An inventory of the ethnobotanicals used as

anthelmintics in the southern Punjab (Pak) Journal of

Ethnopharmacology 2006; 108:152–54. mqx mqx
[7] Kshirsagar RD, Singh NP. Some less known ethnomedicinal uses
from Mysore & Coorg districts, Karnataka state, India. Journal of

Ethnopharmacology 2001; 75:231–238 mqx mqx
[8] https://www.slideshare.net/AnupriyaSinghRajpoot/Pharmaceutical
mqx
-creams
[9] Akash S. Mali, Karekar P, Dr. Yadav A. V, Formulation and

Evaluation of Multipurpose Herbal Cream, International Journal

of Science and Research (IJSR), 02 May 2017.

[10] Anuradha Keshwar, Unmesh Keshwar, Ashwini Deogirkar, S. S.

Dhurde, Veena Deo and B. K. Shrikhande, Formulation

Development and Evaluation of Cream Containing Natural

Essential Oils having Mosquito Repellent Property, World Journal

of Pharmacy And Pharmaceutical Sciences, Volume 5, Issue 8,

1586-1593.
[11] N. R. Patel, H U Momin, R. L. Dhumal, K. L. Mohite, Prepartion
and evaluation of multipurpose herbal cream, Adv J Pharm Life

sci Res, 2017; 5(1): 27-32.

mqx mqx mqx mqx
[12] Ashwini, S. D., Somishwar, S. K. and Shweta, S. S. Formulation

and evaluation of vanishing herbal cream of crude drugs.

American J. Ethnomedicine., 2014; 1(5): 313-318.

mqx mqx mqx mqx mqx
[13] Malarkodi Velraj, Dhulipalla Sowmya, Sindhukavi. D.

Antibacterial and Antifungal activity of herbal gel from the

ethanolic extract of the stem bark of Bauhinia variegata Linn.

[14] Kamla Pathak, Ankur Vaidya Cosmetics Science Concept and Principles Nirali
Prakashan, second edition 2012; p.g. 63-67


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mqx#$ mqx#$ IIMT COLLEGE OF MEDICAL

mqx#$ mqx#$ mqx#$

mqx#$ SCIENCES mqx#$

DEPARTMENT OF PHARMACY mqx#$ mqx#$ mqx#$

CLASS : B.PHARMA 4 YEAR

SEC : A mqx#$ mqx#$ mqx#$

mqx#$ SUBMITTED BY mqx#$ mqx#$

mqx#$ Aakash Kumar mqx#$

CERTIFICATE FOR DEAN mqx#$ mqx#$

mqx#$ are deeply indebted to the Dean Dr. Anuj Mittal

mqx#$ without his guidance and cooperation practice school

mqx#$ report project would not be possible. He has taken a

mqx#$ and coming along with us.

Signature of DEAN mqx#$ mqx#$ mqx#$

This is to certify that our practice school project report

has been successfully completed and we are paying our

mqx#$ sincere mqx#$ gratitude mqx#$ to mqx#$

Signature of HOD mqx#$ mqx#$ mqx#$

This is to certify that our practice school project report

has been success fully completed under the guidance of

Miss. Lovely chaurasia during the session (2020-2021).

Signature of TEACHER mqx#$ mqx#$ mqx#$

This mqx#$ is mqx#$ Aakash Kumar of B.PHARMA 4Th year

mqx#$ project report under the guidance of

mqx#$ sincerity mqx#$ during mqx#$ project mqx#$ report. mqx#$

Signature of STUDENT mqx#$ mqx#$ mqx#$

 mqx#$Historical View mqx#$

 Cold Cream Formula

 Soft Cold Cream Formula

 Winter Protective Cream Formula

 Cosmetic Technology mqx#$

 Evaluation of Cream mqx#$ mqx#$

 Result and Conclusion

.Bombax ceiba is important medicinal plant of tropical and subtropical

India. It is commonly known as silk cotton tree and semal which

belongs to family Bombacaceae.

Traditional medicicinal uses of this plant are reported in Ayurveda Sidhha

& Unani. It is a lofty, deciduous tree upto 45 m tall and 6 m or

more in girth with horizontally spreading branches and young stems

covered with stout, hard prickles1 .

The bark is pale ash to silver grey in color. Flowers are

The fruits are brown capsule-like upto 15 mm long, filled with

According to ayurveda, it has stimulant, aphrodiasic, diuretic, cardiotonic,

antidiarrheal, haemostatic, antidysentric3-4etc. Young fruits are useful in

calculus affections, chronic inflammations,anti microbial, and ulceration of

the bladder and kidney5 . Flowers of B. ceiba (25–50 g as feedstuff)

Cream consist of medicament dissolved or suspended in water removable

or emollient bases, classified as water-inoil or oil-in-water and intended

for application on the skin or accesible mucous membrane to provide

localized and sometimes systemic effects at the site of application. The

function of a skin cream is to protect the skin against harshness from

the environment and any dry conditions of the skin.

of water (perspiration) and radiation, thus aiding in the maintenance of

the normal body temperature8 .

Topical skin infections commonly occur and often present therapeutic

challenges to practitioners, despite the numerous existing antimicrobial

agents available today.

mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$ mqx#$

The necessity for developing new antimicrobial means has increased

significantly due to growing concerns regarding multi drug resistant

bacterial, viral, and fungal strains8 .

Consequently, attention has been devoted to safe, new, and/or alternative

antimicrobial materials in the field of antimicrobial chemotherapy.