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f3\fs18\cf0\b0\i0\ul0\strike0 Pharmacia\f3\fs18\cf0\b0\i0\ul0\strike0 and\f3\f


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ST\par\pard\plain\intbl\li122\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 9/10\f3\fs16\
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tbl\li263\sl-72\f3\fs16\cf0\b0\i0\ul0\strike0 3\f3\fs16\cf0\b0\i0\ul0\strike0 I
ST\par\pard\plain\intbl\li288\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 MUD\par\pard\
plain\intbl\li150\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 HALPLO\par\pard\plain\int
bl\li253\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 CORD\cell
\cell
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strike0 HSCT\cell
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intbl\li348\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 BST\cell
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x2016
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x3024
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
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\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
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rdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cellx10080
\pard\plain\intbl\li765\sl-544\f3\fs16\cf0\b\i0\ul0\strike0 HSCT\cell
\pard\plain\intbl\li323\sl-182\f3\fs8\cf0\b0\i0\ul0\strike0 RD\par\pard\plain\in
tbl\li243\sl-72\f3\fs16\cf0\b0\i0\ul0\strike0 3\f3\fs16\cf0\b0\i0\ul0\strike0 I
ST\par\pard\plain\intbl\li122\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 9/10\f3\fs16\

cf0\b0\i0\ul0\strike0 MUD\par\pard\plain\intbl\li199\sl-192\f3\fs16\cf0\b0\i0\u
l0\strike0 HAPLO\par\pard\plain\intbl\li253\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0
CORD\cell
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\pard\plain\intbl\li261\sl-544\f3\fs16\cf0\b\i0\ul0\strike0 HSCT\cell
\pard\plain\intbl\li343\sl-182\f3\fs8\cf0\b0\i0\ul0\strike0 rd\par\pard\plain\in
tbl\li263\sl-72\f3\fs16\cf0\b0\i0\ul0\strike0 3\f3\fs16\cf0\b0\i0\ul0\strike0 I
ST\par\pard\plain\intbl\li288\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 MUD\par\pard\
plain\intbl\li150\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 HALPLO\par\pard\plain\int
bl\li253\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 CORD\cell
\pard\plain\intbl\li234\sl-323\f3\fs16\cf0\b0\i0\ul0\strike0 relapse\cell
\pard\plain\intbl\li6\sl-447\f3\fs16\cf0\b0\i0\ul0\strike0 Sibling\f3\fs16\cf0\b
0\i0\ul0\strike0 donor\par\pard\plain\intbl\li274\sl-191\f3\fs16\cf0\b0\i0\ul0\
strike0 HSCT\cell
\pard\plain\intbl\li337\sl-447\f3\fs16\cf0\b0\i0\ul0\strike0 EXP\par\pard\plain\
intbl\li348\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 BST\cell
\pard\plain\intbl\li212\sl-206\f3\fs16\cf0\b0\i0\ul0\strike0 Relapse\cell
\row
\trowd\irow10\trgaph0\trrh-232\trql\trleft0
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x2016
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x3024
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x4032
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x5040
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x6048
\clvmrg\clvertalt\clbrdrt\brdrs\brdrw12\brdrcf0\clbrdrl\brdrs\brdrw12\brdrcf0\cl
brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x7056
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brdrr\brdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cell
x8064
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x9072
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rdrs\brdrw12\brdrcf0\clbrdrb\brdrs\brdrw12\brdrcf0\clcbpat1\cltxlrtb\cellx10080
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\pard\plain\intbl\li323\sl-182\f3\fs8\cf0\b0\i0\ul0\strike0 RD\par\pard\plain\in
tbl\li243\sl-72\f3\fs16\cf0\b0\i0\ul0\strike0 3\f3\fs16\cf0\b0\i0\ul0\strike0 I
ST\par\pard\plain\intbl\li122\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 9/10\f3\fs16\
cf0\b0\i0\ul0\strike0 MUD\par\pard\plain\intbl\li199\sl-192\f3\fs16\cf0\b0\i0\u
l0\strike0 HAPLO\par\pard\plain\intbl\li253\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0
CORD\cell
\pard\plain\intbl\li234\sl-323\f3\fs16\cf0\b0\i0\ul0\strike0 relapse\cell
\pard\plain\intbl\li261\sl-544\f3\fs16\cf0\b\i0\ul0\strike0 HSCT\cell
\pard\plain\intbl\li343\sl-182\f3\fs8\cf0\b0\i0\ul0\strike0 rd\par\pard\plain\in
tbl\li263\sl-72\f3\fs16\cf0\b0\i0\ul0\strike0 3\f3\fs16\cf0\b0\i0\ul0\strike0 I
ST\par\pard\plain\intbl\li288\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 MUD\par\pard\
plain\intbl\li150\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 HALPLO\par\pard\plain\int
bl\li253\sl-192\f3\fs16\cf0\b0\i0\ul0\strike0 CORD\cell
\pard\plain\intbl\li234\sl-323\f3\fs16\cf0\b0\i0\ul0\strike0 relapse\cell

\pard\plain\intbl\li6\sl-447\f3\fs16\cf0\b0\i0\ul0\strike0 Sibling\f3\fs16\cf0\b
0\i0\ul0\strike0 donor\par\pard\plain\intbl\li274\sl-191\f3\fs16\cf0\b0\i0\ul0\
strike0 HSCT\cell
\pard\plain\intbl\li337\sl-447\f3\fs16\cf0\b0\i0\ul0\strike0 EXP\par\pard\plain\
intbl\li348\sl-191\f3\fs16\cf0\b0\i0\ul0\strike0 BST\cell
\pard\plain\intbl\li348\sl-221\f3\fs16\cf0\b0\i0\ul0\strike0 BST\cell
\row
}{\par}
}}\sect\sectd\sbkpage\pgwsxn12132\pghsxn15987\sected\cols2\colno1\colw3390\colsr
10\colno2\colw8720\pard\plain\sl-200\par\pard\plain\sl-200\par\pard\plain\sl-200
\par\pard\plain\sl-207\par\pard\plain\li1021\sl-228\f0\fs18\cf0\b0\i0\ul0\strike
0 18\f0\fs12\cf0\b0\i0\ul0\strike0 \par\pard\column\plain\sl-200\par\pard\plain
\sl-200\par\pard\plain\sl-200\par\pard\plain\sl-262\par\pard\plain\li0\sl-152\f0
\fs12\cf0\b0\i0\ul0\strike0 supplement to Journal of the association of physicia
ns of india \u183? published on 1st of every month 1st march, 2015\par\sect\sect
ed\sbknone\cols2\colno1\colw6290\colsr10\colno2\colw5820\pard\plain\sl-396\par\p
ard\plain\li1021\sl-254\f3\fs18\cf0\b0\i0\ul0\strike0 starting\f3\fs18\cf0\b0\i0
\ul0\strike0 ATG.\f3\fs10\cf0\b0\i0\ul0\strike0 11\f3\fs18\cf0\b0\i0\ul0\strik
e0 However,\f3\fs18\cf0\b0\i0\ul0\strike0 it\f3\fs18\cf0\b0\i0\ul0\strike0 is
\f3\fs18\cf0\b0\i0\ul0\strike0 important\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\f
s18\cf0\b0\i0\ul0\strike0 note\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\u
l0\strike0 that\f3\fs18\cf0\b0\i0\ul0\strike0 prolonged\f3\fs18\cf0\b0\i0\ul0\s
trike0 attempts\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0
clear\f3\fs18\cf0\b0\i0\ul0\strike0 fungal\f3\fs18\cf0\b0\i0\ul0\strike0 inf
ections\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 or\f3\fs18\cf
0\b0\i0\ul0\strike0 extensive\f3\fs18\cf0\b0\i0\ul0\strike0 bacterial\f3\fs18\
cf0\b0\i0\ul0\strike0 infections\f3\fs18\cf0\b0\i0\ul0\strike0 can\f3\fs18\cf0
\b0\i0\ul0\strike0 defer\f3\fs18\cf0\b0\i0\ul0\strike0 definitive\par\pard\pla
in\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 IST\f3\fs18\cf0\b0\i0\ul0\strike0
or\f3\fs18\cf0\b0\i0\ul0\strike0 HSCT\f3\fs18\cf0\b0\i0\ul0\strike0 therapie
s.\f3\fs18\cf0\b0\i0\ul0\strike0 b-blockers\f3\fs18\cf0\b0\i0\ul0\strike0 may\
f3\fs18\cf0\b0\i0\ul0\strike0 be\f3\fs18\cf0\b0\i0\ul0\strike0 withheld\par\pa
rd\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 before\f3\fs18\cf0\b0\i0\ul
0\strike0 ATG\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0
evade\f3\fs18\cf0\b0\i0\ul0\strike0 suppression\f3\fs18\cf0\b0\i0\ul0\strike0
of\f3\fs18\cf0\b0\i0\ul0\strike0 physiologic\par\pard\plain\li1021\sl-230\f3\fs
18\cf0\b0\i0\ul0\strike0 compensatory\f3\fs18\cf0\b0\i0\ul0\strike0 responses\f
3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 anaphylaxis.\f3\
fs18\cf0\b0\i0\ul0\strike0 It\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b0\
i0\ul0\strike0 also\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0
advisable\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 not\f
3\fs18\cf0\b0\i0\ul0\strike0 initiate\f3\fs18\cf0\b0\i0\ul0\strike0 ATG\f3\fs1
8\cf0\b0\i0\ul0\strike0 late\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i
0\ul0\strike0 the\f3\fs18\cf0\b0\i0\ul0\strike0 day\f3\fs18\cf0\b0\i0\ul0\stri
ke0 or\f3\fs18\cf0\b0\i0\ul0\strike0 on\par\pard\plain\li1021\sl-230\f3\fs18\c
f0\b0\i0\ul0\strike0 weekends\f3\fs18\cf0\b0\i0\ul0\strike0 when\f3\fs18\cf0\b0
\i0\ul0\strike0 hospitals\f3\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\
ul0\strike0 be\f3\fs18\cf0\b0\i0\ul0\strike0 understaffed.\f3\fs10\cf0\b0\i0\u
l0\strike0 11\par\pard\plain\li1261\sl-282\f3\fs18\cf0\b0\i0\ul0\strike0 The\f3
\fs18\cf0\b0\i0\ul0\strike0 normal\f3\fs18\cf0\b0\i0\ul0\strike0 daily\f3\fs18
\cf0\b0\i0\ul0\strike0 dose\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0
\ul0\strike0 ATG\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b0\i0\ul0\strike
0 40mg/kg\f3\fs18\cf0\b0\i0\ul0\strike0 over\par\pard\plain\li1021\sl-230\f3\f
s18\cf0\b0\i0\ul0\strike0 4\f3\fs18\cf0\b0\i0\ul0\strike0 hours,\f3\fs18\cf0\b0
\i0\ul0\strike0 for\f3\fs18\cf0\b0\i0\ul0\strike0 4\f3\fs18\cf0\b0\i0\ul0\stri
ke0 days.\f3\fs18\cf0\b0\i0\ul0\strike0 Prophylactic\f3\fs18\cf0\b0\i0\ul0\str
ike0 treatment\f3\fs18\cf0\b0\i0\ul0\strike0 for\par\pard\plain\li1021\sl-230\
f3\fs18\cf0\b0\i0\ul0\strike0 serum\f3\fs18\cf0\b0\i0\ul0\strike0 sickness\f3\f
s18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\strike0 be\f3\fs18\cf0\b0\

i0\ul0\strike0 initiated\f3\fs18\cf0\b0\i0\ul0\strike0 on\f3\fs18\cf0\b0\i0\ul


0\strike0 day\f3\fs18\cf0\b0\i0\ul0\strike0 1\f3\fs18\cf0\b0\i0\ul0\strike0 w
ith\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 Prednisone\f3\fs1
8\cf0\b0\i0\ul0\strike0 1\f3\fs18\cf0\b0\i0\ul0\strike0 mg/kg,\f3\fs18\cf0\b0\
i0\ul0\strike0 which\f3\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\s
trike0 be\f3\fs18\cf0\b0\i0\ul0\strike0 continued\par\pard\plain\li1021\sl-230
\f3\fs18\cf0\b0\i0\ul0\strike0 for\f3\fs18\cf0\b0\i0\ul0\strike0 2\f3\fs18\cf0\
b0\i0\ul0\strike0 weeks.\f3\fs18\cf0\b0\i0\ul0\strike0 Conventional\f3\fs18\cf
0\b0\i0\ul0\strike0 premedication\f3\fs18\cf0\b0\i0\ul0\strike0 prior\par\pard
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ke0 every\f3\fs18\cf0\b0\i0\ul0\strike0 ATG\f3\fs18\cf0\b0\i0\ul0\strike0 dos
e\f3\fs18\cf0\b0\i0\ul0\strike0 involves\f3\fs18\cf0\b0\i0\ul0\strike0 acetami
nophen\f3\fs18\cf0\b0\i0\ul0\strike0 and\par\pard\plain\li1021\sl-230\f3\fs18\c
f0\b0\i0\ul0\strike0 diphenhydramine.\f3\fs18\cf0\b0\i0\ul0\strike0 Furthermore
,\f3\fs18\cf0\b0\i0\ul0\strike0 symptomatic\par\pard\plain\li1021\sl-230\f3\fs1
8\cf0\b0\i0\ul0\strike0 management\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0
\b0\i0\ul0\strike0 common\f3\fs18\cf0\b0\i0\ul0\strike0 infusion\f3\fs18\cf0\b
0\i0\ul0\strike0 reactions\f3\fs18\cf0\b0\i0\ul0\strike0 may\par\pard\plain\li
1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 comprise\f3\fs18\cf0\b0\i0\ul0\strike0
of\f3\fs18\cf0\b0\i0\ul0\strike0 meperidine\f3\fs18\cf0\b0\i0\ul0\strike0 (r
igors),\f3\fs18\cf0\b0\i0\ul0\strike0 acetaminophen\par\pard\plain\li1021\sl-23
0\f3\fs18\cf0\b0\i0\ul0\strike0 (\f3\fs18\cf0\b0\i0\ul0\strike0 f\f3\fs18\cf0\b
0\i0\ul0\strike0 e\f3\fs18\cf0\b0\i0\ul0\strike0 ve\f3\fs18\cf0\b0\i0\ul0\stri
ke0 r\f3\fs18\cf0\b0\i0\ul0\strike0 s\f3\fs18\cf0\b0\i0\ul0\strike0 )\f3\fs18
\cf0\b0\i0\ul0\strike0 ,\f3\fs18\cf0\b0\i0\ul0\strike0 d\f3\fs18\cf0\b0\i0\ul0
\strike0 i\f3\fs18\cf0\b0\i0\ul0\strike0 p\f3\fs18\cf0\b0\i0\ul0\strike0 h\f3
\fs18\cf0\b0\i0\ul0\strike0 e\f3\fs18\cf0\b0\i0\ul0\strike0 n\f3\fs18\cf0\b0\i
0\ul0\strike0 h\f3\fs18\cf0\b0\i0\ul0\strike0 y\f3\fs18\cf0\b0\i0\ul0\strike0
d\f3\fs18\cf0\b0\i0\ul0\strike0 r\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0
\b0\i0\ul0\strike0 m\f3\fs18\cf0\b0\i0\ul0\strike0 i\f3\fs18\cf0\b0\i0\ul0\str
ike0 n\f3\fs18\cf0\b0\i0\ul0\strike0 e\f3\fs18\cf0\b0\i0\ul0\strike0 (\f3\fs1
8\cf0\b0\i0\ul0\strike0 r\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul
0\strike0 s\f3\fs18\cf0\b0\i0\ul0\strike0 h\f3\fs18\cf0\b0\i0\ul0\strike0 )\f
3\fs18\cf0\b0\i0\ul0\strike0 ,\f3\fs18\cf0\b0\i0\ul0\strike0 i\f3\fs18\cf0\b0\
i0\ul0\strike0 n\f3\fs18\cf0\b0\i0\ul0\strike0 t\f3\fs18\cf0\b0\i0\ul0\strike0
r\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul0\strike0 ve\f3\fs18\c
f0\b0\i0\ul0\strike0 n\f3\fs18\cf0\b0\i0\ul0\strike0 o\f3\fs18\cf0\b0\i0\ul0\s
trike0 u\f3\fs18\cf0\b0\i0\ul0\strike0 s\par\pard\plain\li1021\sl-230\f3\fs18\
cf0\b0\i0\ul0\strike0 hydration\f3\fs18\cf0\b0\i0\ul0\strike0 (hypotension),\f3
\fs18\cf0\b0\i0\ul0\strike0 and\f3\fs18\cf0\b0\i0\ul0\strike0 supplemental\f3\
fs18\cf0\b0\i0\ul0\strike0 oxygen\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i
0\ul0\strike0 (hypoxaemia).\f3\fs10\cf0\b0\i0\ul0\strike0 11\f3\fs18\cf0\b0\i0\
ul0\strike0 Haemodynamic\f3\fs18\cf0\b0\i0\ul0\strike0 and/or\f3\fs18\cf0\b0\i
0\ul0\strike0 respiratory\par\pard\plain\li1021\sl-229\f3\fs18\cf0\b0\i0\ul0\st
rike0 compromise\f3\fs18\cf0\b0\i0\ul0\strike0 can\f3\fs18\cf0\b0\i0\ul0\strike
0 result\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 admit
tances\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 the\f3\f
s18\cf0\b0\i0\ul0\strike0 intensive\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0
\i0\ul0\strike0 care\f3\fs18\cf0\b0\i0\ul0\strike0 unit,\f3\fs18\cf0\b0\i0\ul0\
strike0 vasopressor\f3\fs18\cf0\b0\i0\ul0\strike0 support,\f3\fs18\cf0\b0\i0\u
l0\strike0 and\f3\fs18\cf0\b0\i0\ul0\strike0 even,\f3\fs18\cf0\b0\i0\ul0\strik
e0 although\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 infreque
ntly,\f3\fs18\cf0\b0\i0\ul0\strike0 intubation.\f3\fs18\cf0\b0\i0\ul0\strike0
Under\f3\fs18\cf0\b0\i0\ul0\strike0 life-threatening\par\pard\plain\li1021\sl-2
30\f3\fs18\cf0\b0\i0\ul0\strike0 circumstances,\f3\fs18\cf0\b0\i0\ul0\strike0 i
t\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b0\i0\ul0\strike0 recommended\f
3\fs18\cf0\b0\i0\ul0\strike0 that\f3\fs18\cf0\b0\i0\ul0\strike0 the\f3\fs18\cf
0\b0\i0\ul0\strike0 ATG\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\stri
ke0 infusion\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b0\i0\ul0\strike0 sl
owed\f3\fs18\cf0\b0\i0\ul0\strike0 or\f3\fs18\cf0\b0\i0\ul0\strike0 briefly\f3

\fs18\cf0\b0\i0\ul0\strike0 stopped\f3\fs18\cf0\b0\i0\ul0\strike0 till\f3\fs18


\cf0\b0\i0\ul0\strike0 severe\f3\fs18\cf0\b0\i0\ul0\strike0 signs\par\pard\pla
in\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 and\f3\fs18\cf0\b0\i0\ul0\strike0
symptoms\f3\fs18\cf0\b0\i0\ul0\strike0 recede.\f3\fs18\cf0\b0\i0\ul0\strike0
ATG\f3\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\strike0 be\f3\fs1
8\cf0\b0\i0\ul0\strike0 reinitiated\f3\fs18\cf0\b0\i0\ul0\strike0 at\f3\fs18\c
f0\b0\i0\ul0\strike0 a\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strik
e0 normal\f3\fs18\cf0\b0\i0\ul0\strike0 or\f3\fs18\cf0\b0\i0\ul0\strike0 slowe
r\f3\fs18\cf0\b0\i0\ul0\strike0 infusion\f3\fs18\cf0\b0\i0\ul0\strike0 rate\f3
\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\
i0\ul0\strike0 monitored\f3\fs18\cf0\b0\i0\ul0\strike0 setting,\par\pard\plain
\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 occasionally\f3\fs18\cf0\b0\i0\ul0\
strike0 over\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul0\strike0 24
\f3\fs18\cf0\b0\i0\ul0\strike0 hour\f3\fs18\cf0\b0\i0\ul0\strike0 period,\f3\f
s18\cf0\b0\i0\ul0\strike0 subject\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0
\b0\i0\ul0\strike0 the\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strik
e0 severity\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0 the
\f3\fs18\cf0\b0\i0\ul0\strike0 reactions.\f3\fs18\cf0\b0\i0\ul0\strike0 ATG\f3
\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\strike0 be\f3\fs18\cf0\b
0\i0\ul0\strike0 infused\f3\fs18\cf0\b0\i0\ul0\strike0 even\par\pard\plain\li1
021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 if\f3\fs18\cf0\b0\i0\ul0\strike0 patie
nts\f3\fs18\cf0\b0\i0\ul0\strike0 experience\f3\fs18\cf0\b0\i0\ul0\strike0 mil
d\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 moderate\f3\f
s18\cf0\b0\i0\ul0\strike0 elevation\f3\fs18\cf0\b0\i0\ul0\strike0 in\par\pard\
plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 transaminases,\f3\fs18\cf0\b0\
i0\ul0\strike0 and\f3\fs18\cf0\b0\i0\ul0\strike0 increased\f3\fs18\cf0\b0\i0\u
l0\strike0 liver\f3\fs18\cf0\b0\i0\ul0\strike0 enzymes\f3\fs18\cf0\b0\i0\ul0\s
trike0 tend\f3\fs18\cf0\b0\i0\ul0\strike0 to\par\pard\plain\li1021\sl-230\f3\f
s18\cf0\b0\i0\ul0\strike0 normalise\f3\fs18\cf0\b0\i0\ul0\strike0 over\f3\fs18\
cf0\b0\i0\ul0\strike0 several\f3\fs18\cf0\b0\i0\ul0\strike0 days.\f3\fs18\cf0\
b0\i0\ul0\strike0 Management\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i
0\ul0\strike0 infusion\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strik
e0 related\f3\fs18\cf0\b0\i0\ul0\strike0 toxicities\f3\fs18\cf0\b0\i0\ul0\strik
e0 should\f3\fs18\cf0\b0\i0\ul0\strike0 not\f3\fs18\cf0\b0\i0\ul0\strike0 com
prise\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0 switching
\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 ATG\f3\fs18\cf0\b0\i
0\ul0\strike0 formulations,\f3\fs18\cf0\b0\i0\ul0\strike0 for\f3\fs18\cf0\b0\i
0\ul0\strike0 example,\f3\fs18\cf0\b0\i0\ul0\strike0 from\f3\fs18\cf0\b0\i0\ul
0\strike0 horse\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0
rabbit.\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 Moreover,\f
3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 manage\f3\fs18\c
f0\b0\i0\ul0\strike0 rising\f3\fs18\cf0\b0\i0\ul0\strike0 creatinine,\f3\fs18\
cf0\b0\i0\ul0\strike0 CsA\f3\fs18\cf0\b0\i0\ul0\strike0 can\par\pard\plain\li1
021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 be\f3\fs18\cf0\b0\i0\ul0\strike0 withh
eld\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 the\f3\fs18
\cf0\b0\i0\ul0\strike0 short\f3\fs18\cf0\b0\i0\ul0\strike0 term\f3\fs18\cf0\b0
\i0\ul0\strike0 until\f3\fs18\cf0\b0\i0\ul0\strike0 renal\f3\fs18\cf0\b0\i0\ul
0\strike0 function\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 r
ecovers.\f3\fs10\cf0\b0\i0\ul0\strike0 11\par\pard\plain\li1021\sl-257\f2\fs18\
cf0\b\i0\ul0\strike0 Cyclosporine\par\pard\plain\li1261\sl-300\f3\fs18\cf0\b0\i0
\ul0\strike0 CsA\f3\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\strike
0 be\f3\fs18\cf0\b0\i0\ul0\strike0 initiated\f3\fs18\cf0\b0\i0\ul0\strike0 on
\f3\fs18\cf0\b0\i0\ul0\strike0 day\f3\fs18\cf0\b0\i0\ul0\strike0 1\f3\fs18\cf0
\b0\i0\ul0\strike0 at\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul0\st
rike0 daily\f3\fs18\cf0\b0\i0\ul0\strike0 dose\f3\fs18\cf0\b0\i0\ul0\strike0
of\f3\fs18\cf0\b0\i0\ul0\strike0 10\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0
\i0\ul0\strike0 mg/kg\f3\fs18\cf0\b0\i0\ul0\strike0 (15\f3\fs18\cf0\b0\i0\ul0\s
trike0 mg/kg\f3\fs18\cf0\b0\i0\ul0\strike0 per\f3\fs18\cf0\b0\i0\ul0\strike0
day\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 children)\f
3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0

\i0\ul0\strike0 target\f3\fs18\cf0\b0\i0\ul0\strike0 trough\par\pard\plain\li1


021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 level\f3\fs18\cf0\b0\i0\ul0\strike0 be
tween\f3\fs18\cf0\b0\i0\ul0\strike0 200\f3\fs18\cf0\b0\i0\ul0\strike0 and\f3\f
s18\cf0\b0\i0\ul0\strike0 400\f3\fs18\cf0\b0\i0\ul0\strike0 ng/mL.\f3\fs10\cf0
\b0\i0\ul0\strike0 22\f3\fs18\cf0\b0\i0\ul0\strike0 Patient\f3\fs18\cf0\b0\i0\
ul0\strike0 frequently\par\pard\plain\li1021\sl-229\f3\fs18\cf0\b0\i0\ul0\strik
e0 develop\f3\fs18\cf0\b0\i0\ul0\strike0 hypertension\f3\fs18\cf0\b0\i0\ul0\str
ike0 during\f3\fs18\cf0\b0\i0\ul0\strike0 CsA\f3\fs18\cf0\b0\i0\ul0\strike0 t
reatment,\f3\fs18\cf0\b0\i0\ul0\strike0 and\par\pard\plain\li1021\sl-230\f3\fs1
8\cf0\b0\i0\ul0\strike0 management\f3\fs18\cf0\b0\i0\ul0\strike0 with\f3\fs18\c
f0\b0\i0\ul0\strike0 amlodipine\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b
0\i0\ul0\strike0 recommended\f3\fs18\cf0\b0\i0\ul0\strike0 owing\par\pard\plai
n\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0
minimal\f3\fs18\cf0\b0\i0\ul0\strike0 overlap\f3\fs18\cf0\b0\i0\ul0\strike0 wi
th\f3\fs18\cf0\b0\i0\ul0\strike0 CsA\f3\fs18\cf0\b0\i0\ul0\strike0 related\f3\
fs18\cf0\b0\i0\ul0\strike0 toxicities.\f3\fs18\cf0\b0\i0\ul0\strike0 A\f3\fs18
\cf0\b0\i0\ul0\strike0 short\par\pard\plain\li1021\sl-230\f3\fs18\cf0\b0\i0\ul0
\strike0 course\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0
azithromycin\f3\fs18\cf0\b0\i0\ul0\strike0 is\f3\fs18\cf0\b0\i0\ul0\strike0 r
ecommended\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 impr
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30\f3\fs18\cf0\b0\i0\ul0\strike0 but\f3\fs18\cf0\b0\i0\ul0\strike0 most\f3\fs18
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0\i0\ul0\strike0 sustain\f3\fs18\cf0\b0\i0\ul0\strike0 their\f3\fs18\cf0\b0\i0

\ul0\strike0 response:\f3\fs18\cf0\b0\i0\ul0\strike0 even\f3\fs18\cf0\b0\i0\ul


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f3\fs18\cf0\b0\i0\ul0\strike0 25%\f3\fs18\cf0\b0\i0\ul0\strike0 and\par\pard\p
lain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 50%\f3\fs18\cf0\b0\i0\ul0\strike0
of\f3\fs18\cf0\b0\i0\ul0\strike0 patients.\f3\fs10\cf0\b0\i0\ul0\strike0 38-4
0\f3\fs18\cf0\b0\i0\ul0\strike0 Nevertheless,\f3\fs18\cf0\b0\i0\ul0\strike0 re
lapses\f3\fs18\cf0\b0\i0\ul0\strike0 after\f3\fs18\cf0\b0\i0\ul0\strike0 an\pa
r\pard\plain\li0\sl-229\f3\fs18\cf0\b0\i0\ul0\strike0 initial\f3\fs18\cf0\b0\i0\
ul0\strike0 response\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\st
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quent:\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 about\f3
\fs18\cf0\b0\i0\ul0\strike0 30\f3\fs18\cf0\b0\i0\ul0\strike0 \u8211?50%\par\par
d\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike
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n\f3\fs18\cf0\b0\i0\ul0\strike0 months\f3\fs18\cf0\b0\i0\ul0\strike0 or\par\pa
rd\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 years\f3\fs18\cf0\b0\i0\ul0\st
rike0 from\f3\fs18\cf0\b0\i0\ul0\strike0 IST\f3\fs18\cf0\b0\i0\ul0\strike0 di
scontinuation.\f3\fs10\cf0\b0\i0\ul0\strike0 38-40\f3\fs18\cf0\b0\i0\ul0\strike
0 In\f3\fs18\cf0\b0\i0\ul0\strike0 the\f3\fs18\cf0\b0\i0\ul0\strike0 most\f3\
fs18\cf0\b0\i0\ul0\strike0 recent\par\pard\plain\li0\sl-229\f3\fs18\cf0\b0\i0\u
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ke0 CyA\f3\fs18\cf0\b0\i0\ul0\strike0 therapy\f3\fs18\cf0\b0\i0\ul0\strike0 b
eyond\f3\fs18\cf0\b0\i0\ul0\strike0 6\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\
i0\ul0\strike0 months\f3\fs18\cf0\b0\i0\ul0\strike0 resulted\f3\fs18\cf0\b0\i0\
ul0\strike0 in\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul0\strike0
reduction\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0 the\f
3\fs18\cf0\b0\i0\ul0\strike0 relapse\f3\fs18\cf0\b0\i0\ul0\strike0 rate;\f3\fs
18\cf0\b0\i0\ul0\strike0 the\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\st
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0\strike0 is\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 t
aper\f3\fs18\cf0\b0\i0\ul0\strike0 CyA\f3\fs18\cf0\b0\i0\ul0\strike0 by\f3\fs1
8\cf0\b0\i0\ul0\strike0 10%\f3\fs18\cf0\b0\i0\ul0\strike0 every\par\pard\plain
\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 month,\f3\fs18\cf0\b0\i0\ul0\strike0
starting\f3\fs18\cf0\b0\i0\ul0\strike0 at\f3\fs18\cf0\b0\i0\ul0\strike0 least\
f3\fs18\cf0\b0\i0\ul0\strike0 1\f3\fs18\cf0\b0\i0\ul0\strike0 year\f3\fs18\cf0
\b0\i0\ul0\strike0 from\f3\fs18\cf0\b0\i0\ul0\strike0 IST.\f3\fs10\cf0\b0\i0\u
l0\strike0 41\f3\fs18\cf0\b0\i0\ul0\strike0 Late\f3\fs18\cf0\b0\i0\ul0\strike0
relapses\par\pard\plain\li0\sl-229\f3\fs18\cf0\b0\i0\ul0\strike0 remain\f3\fs1
8\cf0\b0\i0\ul0\strike0 possible,\f3\fs18\cf0\b0\i0\ul0\strike0 maybe\f3\fs18\
cf0\b0\i0\ul0\strike0 also\f3\fs18\cf0\b0\i0\ul0\strike0 due\f3\fs18\cf0\b0\i0
\ul0\strike0 to\f3\fs18\cf0\b0\i0\ul0\strike0 a\f3\fs18\cf0\b0\i0\ul0\strike0
suboptimal\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 therapeutic\
f3\fs18\cf0\b0\i0\ul0\strike0 range\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\c
f0\b0\i0\ul0\strike0 CyA\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\fs18\cf0\b0\i0\ul
0\strike0 long-term\f3\fs18\cf0\b0\i0\ul0\strike0 responders\par\pard\plain\li
0\sl-230\f3\fs18\cf0\b0\i0\ul0\strike0 (due\f3\fs18\cf0\b0\i0\ul0\strike0 to\f3
\fs18\cf0\b0\i0\ul0\strike0 tolerability\f3\fs18\cf0\b0\i0\ul0\strike0 or\f3\f
s18\cf0\b0\i0\ul0\strike0 scarce\f3\fs18\cf0\b0\i0\ul0\strike0 compliance).\f3
\fs18\cf0\b0\i0\ul0\strike0 Treatment\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\
i0\ul0\strike0 failure-free\f3\fs18\cf0\b0\i0\ul0\strike0 survival\f3\fs18\cf0\
b0\i0\ul0\strike0 at\f3\fs18\cf0\b0\i0\ul0\strike0 5\f3\fs18\cf0\b0\i0\ul0\str
ike0 years\f3\fs18\cf0\b0\i0\ul0\strike0 may\f3\fs18\cf0\b0\i0\ul0\strike0 be
\f3\fs18\cf0\b0\i0\ul0\strike0 estimated\f3\fs18\cf0\b0\i0\ul0\strike0 in\f3\f
s18\cf0\b0\i0\ul0\strike0 the\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\s
trike0 range\f3\fs18\cf0\b0\i0\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0 30
\f3\fs18\cf0\b0\i0\ul0\strike0 \u8211?50%,\f3\fs18\cf0\b0\i0\ul0\strike0 althou

gh\f3\fs18\cf0\b0\i0\ul0\strike0 overall\f3\fs18\cf0\b0\i0\ul0\strike0 surviva


l\f3\fs18\cf0\b0\i0\ul0\strike0 remains\par\pard\plain\li0\sl-230\f3\fs18\cf0\b
0\i0\ul0\strike0 significantly\f3\fs18\cf0\b0\i0\ul0\strike0 higher\f3\fs18\cf0
\b0\i0\ul0\strike0 (55\f3\fs18\cf0\b0\i0\ul0\strike0 \u8211?85%),\f3\fs10\cf0\b
0\i0\ul0\strike0 38-40\f3\fs18\cf0\b0\i0\ul0\strike0 because\f3\fs18\cf0\b0\i0
\ul0\strike0 of\f3\fs18\cf0\b0\i0\ul0\strike0 available\par\pard\plain\li0\sl229\f3\fs18\cf0\b0\i0\ul0\strike0 salvage\f3\fs18\cf0\b0\i0\ul0\strike0 treatme
nts\f3\fs18\cf0\b0\i0\ul0\strike0 (either\f3\fs18\cf0\b0\i0\ul0\strike0 furthe
r\f3\fs18\cf0\b0\i0\ul0\strike0 IST\f3\fs18\cf0\b0\i0\ul0\strike0 courses\f3\f
s18\cf0\b0\i0\ul0\strike0 or\par\pard\plain\li0\sl-230\f3\fs18\cf0\b0\i0\ul0\st
rike0 HSCT).\f3\fs18\cf0\b0\i0\ul0\strike0 In\f3\fs18\cf0\b0\i0\ul0\strike0 re
lapsed\f3\fs18\cf0\b0\i0\ul0\strike0 patients,\f3\fs18\cf0\b0\i0\ul0\strike0 t
he\f3\fs18\cf0\b0\i0\ul0\strike0 expected\f3\fs18\cf0\b0\i0\ul0\strike0 respon
se\f3\fs18\cf0\b0\i0\ul0\strike0 rate\sect\sectd\sbkpage\pgwsxn12132\pghsxn1598
7\sected\cols2\colno1\colw10910\colsr10\colno2\colw1200\pard\plain\sl-200\par\pa
rd\plain\sl-200\par\pard\plain\sl-200\par\pard\plain\sl-262\par\pard\plain\li102
2\sl-152\f0\fs12\cf0\b0\i0\ul0\strike0 supplement to Journal of the association
of physicians of india \u183? published on 1st of every month 1st march, 2015\pa
r\pard\column\plain\sl-200\par\pard\plain\sl-200\par\pard\plain\sl-200\par\pard\
plain\sl-207\par\pard\plain\li0\sl-228\f0\fs18\cf0\b0\i0\ul0\strike0 19\par\sect
\sected\sbknone\cols3\colno1\colw6290\colsr10\colno2\colw350\colsr10\colno3\colw
5460\pard\plain\sl-200\par\pard\plain\sl-213\par\pard\plain\li1021\sl-223\f2\fs1
8\cf0\b\i0\ul\strike0 Table 1 : India\f2\fs18\cf0\b\i0\ul0\strike0
n\f2\fs18
\cf0\b\i0\ul0\strike0 data\f2\fs18\cf0\b\i0\ul0\strike0 on\f2\fs18\cf0\b\i0\ul
0\strike0 IST\par\pard\plain\li1352\sl-250\f3\fs16\cf0\b\i0\ul0\strike0 Study\f
3\fs16\cf0\b\i0\ul0\strike0
Patient\f3\fs16\cf0\b\i0\ul0\strike0 no.
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OR\f3\fs16\cf0\b\i0\ul0\strike0
OS\f3\
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f/u\par\pard\plain\li1021\sl-202\f3\fs16\cf0\b0\i0
\ul0\strike0 George\f3\fs16\cf0\b0\i0\ul0\strike0 et\f3\fs16\cf0\b0\i0\ul0\stri
ke0 al\f3\fs8\cf0\b0\i0\ul0\strike0 48\f3\fs16\cf0\b0\i0\ul0\strike0 322\f3\f
s16\cf0\b0\i0\ul0\strike0 (Adults\f3\fs16\cf0\b0\i0\ul0\strike0 and\f3\fs16\cf
0\b0\i0\ul0\strike0 children)\f3\fs16\cf0\b0\i0\ul0\strike0 63%\f3\fs16\cf0\b0
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67%\f3\fs16\cf0\b0\i0\ul0\strike0 32\f3\fs16\cf0\b0\i0\ul0\s
trike0 mths\par\pard\plain\li1021\sl-203\f3\fs16\cf0\b0\i0\ul0\strike0 Nair\f3\
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\b0\i0\ul0\strike0 M, Imashuku\f1\fs16\cf0\b0\i0\ul0\strike0 S, Ohta\f1\fs16\c
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