&%

%" #$ !
' ( )*+,
)* - ./ 01$ 2 3 4 *5
6 78 1
..

"# $%
& !
#= :*;< -. &/ " 0 1 23 4 5 &6 789
" )*+,! '(
27" C" A 12 " .= # > 9
5. %?7%
5 @A ' B A
LM JK =? " 0 G
*;< ( H7I= 9
D7 E 9 ' 6" F,
D %
"& Q OP
5 7>% 7A 5 % 5' .NKKK 7
'C5 . 5R
S2 $ %G + &6 = >A = O> 7 . >
3 :7%
I
F( RV% W X 7"&'" I 9 "U '+ G
*; ?S 7T
Z 5TT 5 52 Y*;

%
" [\# H 9
A9>
] .^7U7" \# H7I ! %
94 9 "#
< " 0 ` \ W2 ' EX5" Y #< _ %
Z - % C

)* ;<= :!9 :

9H 0 X5 . 96 7A c"> "a C9
& I bA &
E U e /5 d RV% W X "A F,1 5 RV% "' (
h0 *; ' 0 &
7 g*aF, 9
T5'C"& .? T f T $ &7 X "
@(% $D" 0 7A 7/5 j I .? " k7 F( 0 *; i
ZZ # l e m 7% ln A H &&% / o p7 E *

B*; 0 7A 69
5j I .f 3 k7 F( 0 *; i>a
ZZ # l 0 C "" &
\ ( 6" lb 9
" $T 5 -79 H*mA

' 5- + 7> 17A . F( '& 7 [X50 *; iPa

eT9 / H" A 4/6 7 " 165 0 7A W 5j I .'&
79
ZZ # l RV% & 3 0 U V " H I

+ E 2 e /5.[*( , 6" g*P 5&

7 " 0 *; 27 ,
"2 %& - q ' < r0 & H E W7 % /A d& ' Y D '
. 2 ; 0&
7 " b"2 F( 789
" >
` R 23 Y #< '
h &" #S27>

F, 79
t"/& 2 0 As F( '& 7 k X&
,E7+ ;
O />. # l 'U %" ' .'9
D7" l + ;. '
0 1V # s .0 As" [\#'( "5G A /">E7+ >#-
$ E X&" f79" f " o 8 A " WS * '
u F(d&
S95 d%%5dv='D7" ; G1V%= 6 X '(
ZZbG7
. RV% W X F( '& 7 %
" & 3 RV% 0 E72 ' b
h'9
a'& " WX \ ' b"2' e /&\#

'C"& .'U %" 0 Db $ xL’Efficacitéw 7 7 "#

[ &" 1 0 1 23 4 5 . U %" d /&" X ) 6 H*;' #W ,
Z U %" T %&f\ % 7>%
#\ & 0 1 23 0 % 7C5 f >?@# 7 >P "
F( 8 " 7# .?( $C6 & 3 ' F;7" Y A9 op7"
Z$" 89
" 7>% #7X B " . T" & T" ' W7

V5 96" 0 T 0 7 _ H A' 9" X /5

E+ " X&
3 % 6> q ' -,. RV% W X E7T
G T" E (,$ %
" .E-6 5 7A a
q5' X EA +9
Z T" T +9 (
9 72 ; H*; ' A "" ? " e $" 1e( o 5
5
7 172 '( . RV % W X ' ' A ("2
$+ 7 = 6 = 9
"# D " D G '( X59 %I
ZZZ=$ 5 = =$ = B A F( "R% % = &7"(= ;
0 0& >>
< 0 (S9 ' T 6 0( T ' $%
.$" 4 '&;` ^%
&3 l e%
"
?7%
5 G
*;< (7% C . (7% $&
S9 E( "
ZZ I %/5 6>F( ( 5 >
7>% E(% $"C"

)* ;<= B 2@C D!?A

F( E G IT R 2,0 zbU e /&.[*( E/ " Y #< y7 ,

op7& 'T " #- & I X @ G $2
' '(7>' D3 \# S " 'C"& ZZ 769
" )*+3 789 j a
q5 {* A*
h0 `

5 F G$ DE :

*X eI+ 9( RV% " $ 6 )*+3 789 D >

789 )*+, AA T9
( O 2 .JMMK O6l JM n /;
 +] 5 OP
"5 " E7/ H ^/G ( 0 "X O G.1V%
9
A EV% 9 & 7 0 + \C# r{7 (7G 9" % + ; 0 >
h9 &7 @R " 12 " . 9
"U .= RV% % > |
= JMMK
b"X" 9>
q"D ? 5 U % {7A C 5 Y (< % % ' (7"X =
} RV% % > " .d#S> d5
1 d>TI d*%A ( 5# ( .d I d ,
&S" 0 T F( *; ' b"X" U%Y & D,} 0 %/9
" [\# '
.=EV% Y D' e27

{7A G: P = JMNM 9
AH p7 & 0 + 2'
. 9" 5I 4V n & "G$ G
*; b2 P
" 7C .=4V
F( '& 7 b \ / "' b 5G
*( 4U #( &
ZZ

?S = q 4V n ' >"&
,.: P" 2 & " . -12 G
' ( T RV% " ' Y D' FV 0 A "" G
*;< %
1A , % & U D $C6&. + ; T 4V DY D
&T G ("2 "9 B A # D %
"& O P
5 7>%
Z= %
P

• D, ' 7 ' %a
7 '5# E 1V% " ~ G
_ \ .4V n ' RV% '% " TT " " " AA< '&
7C
ZH ' RV% 'U7" RV% 9" 0 t

# H7 DE ,

. RV% " ' 9" {7 % 0> +, X ,

\ 9 0 z' 7 T 'C& k7 F(E72 " [ "a 5
s& 'C"&
 ) %
>: \# . 5A9 X 7&|
"# $X C "
h&

x4V {7A G: P RV% % > w 9" {7 0> "5

.1 ; H ( . 7 .4U n .EVG
w RV% W X ' F(
xZZ "2 5.'%
a7
.E7 " 9
D7 ?7 w " + 9
D7 ?&
< 1 I,
ZZZ # l 0 %
T b&
W75 A 0 > (xZZE7X A 9
D7 ?7
&T( H %A e5Cw " & 3 RV% 7 " ~77 $ 5
xZZZ0 7 € R 2,0 &
7/ € 1 7p7 hES X
b &
72 &
S {7 % E" + 9
&7C 0 % ' o P
C
.1V% f ( EV% ' p7" F( ""5E U
. " F('& 7 b $+ 7 0 9
% + 9
&7C 0 ' oP
C
RV% W X ' ( b"2 { , " I7 " n 7< A A $ 5
. Dq (3
e5 UG 17A " $ P
" T9 &&%
5 "A g I,
?A .OG
7 ? I ?A .c V> ?A . #S9 ?A w ZZZ ; 7( 4U
.xZZZ 9" 0 27 ?S
. " HX" C " ^ " op7" X650 g I,
.=? " ; %
a•A 5
= H7I A ?& 0 > %
(
79 7T # Ds&. 7 0 *; A " & 50 G
,
. 277C 277A7
$P 96" 0 7 E2S >
7>% ‚ 7T9 H*; ' A " ?8>$ 5
241 H7T w H7 < B*; . x~ . : ' 249 248 $T w 165 ƒ
243 H7T w m .x ~ . : ' 250 $T w -79 H*mA .x ~ . : ' 242
7 " .xJ„… 245 H7T w >
7>G lb 9 $T 5.x~ . : ' 244
†„‡' T w > < >; / H" A 4/6 .x~.: ' 254 $T w
.ˆx~ Z: ' L…‡ 334' T w &S .x~Z: ' †††
P
C < - r&7"( % " HX" 9 E % T9
( F( q
a7 F, $" ~ 5 . 9" 7 (7% G
*;< % '
%
& 9 E % &D '( 'C"& % .0 7A 0 >
469 op7" .F>< op7" F(< op7" B ‰" @ R
P F,~ 5 E#6 7& G A " "(*&
S95# ( ZZ@(%"
Z) 6 '

% .E P e>72 f 3 $" 9 E % [\# 85 'C"&

.Y T> 7V $" 0 Gq?S .$" "8> '>7%
4 " b $+ 7 ' I .'%5" %
" E72 $" 89
5
e>7X ' # l ZZZ 2 8" ? 9 . 2 ;
ZH7G
< ' P H"(< F,~ 5

WX %
R* l 7 #8" _ ‚ 7T 2750 \ +,
. RV%
G
*; 0 *; 72 9
( #S9 6 $C &q 1" $ 5
. 9
7 ( " C RV% W X ' &q 0 7% ,
H p7 & H E W7 &6 7" &&" > C3
t n m" ' " "2 EV% f > EV% 9 &7
+ 9 ŠV & - q ' < .' RV% 'U7" t# H 9
D7
ZZ #8" ER bA75' & RV% W X EA

1V% %
P & q$ )X> ,H7%
>. ;
Zd# 4/ ' R; d9>7GH (' @R& ld ( &' $ $ X& . m"