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République algérienne démocratique et populaire

Université Djillali Liabes


Faculté de Médecine
Département de Pharmacie

TP N°04
Détermination des
phénotypes sanguins

Réalisée par:
• GHERMI Mohamed.
• CHAREF KHODJA Meriem.
• TAHRI Mahmoud.
• BETTAYEB Mohamed Amine.
• ZIDOUR Mehdi Nabil

4 ème année pharmacie G05.


Année universitaire : 2008 / 2009
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des allèles 34 (Ce) à 38 (cE) aa peuvent différer entre les protéines RhD et RhCE. Seul un nombre limité de
ces différences est en position extracellulaire. En cas d’allèle C ces différences sont limitées aux boucles 3,
4 et 6 qui portent l’antigénicité D (dont certains sont représentés sous forme de cercles noirs). En cas
d’allèle c la boucle 2 est aussi concernée. Les acides aminés considérés comme critiques pour les
spécificités C/c et E/e sont respectivement en position 103 et 226. Les 10 segments identifiés par un trait
gris correspondent aux différents exons. Le résidu Cys16 est habituellement, mais pas exclusivement
associé à l’antigène C et le résidu Trp16 est habituellement, mais pas exclusivement associé à l’antigène c
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