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1 -gera:6785/di/ra
ACUPUNCTURE ANAESTHESIA: A REVIEW.
SMALL TJ. american journal of acupuncture.1974,2(3), 147-3.
(eng). réf:33
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3 and 10 mg. kg-1 i. v. was found to reduce the MDA journal of tcm. 1995;16(12):43 (chi).
contents in the cortex, hippocampus and striatum of
cerebral ischemia- reperfused rats in vivo. Sal A 10-100 71- gera: 55075/nd/re
nmol. L-1 was shown to inhibit the brain lipid- EFFECT OF HACHIMI-JIO-GAN ON SCOPOLAMINE-
peroxidation and scavenge the free hydroxyl radical in INDUCED MEMORY IMPAIRMENT AND ON
vitro. These results indicate that the antagonistic effects ACETYLCHOLINE CONTENT IN RAT BRAIN. .
of Sal A on impairment of learning and memory caused HIROKAWA S ET AL. j ethnopharmacol.
by cerebral ischemia-reperefusion may be related with 1996;50(2):77-84 (eng).
its anti-oxidant activity. The effect of Hachimi-jio-gan (HJ) on scopolamine
induced memory impairment was studied using a radial
65- gera: 54495/di/ra maze performance, the effect of HJ on the central
[EFFECTS OF ZHENGDA ZHENHUA 851 ON cholinergic system as measured by acetylcholine (ACh)
IMPROVEMENT OF MEMORY AND FLUENCY OF content, choline acetyltransferase (CAT) and
LANGUAGE OF KIDNEY DEFICIENCY PATIENTS]. acetylcholinesterase (AChE) activities was also
CHEN WEI-ZE ET AL. chinese journal of integrated examined. HJ (0. 01-1. 0 g/kg, p. o. ) showed no
traditional and western medicine. 1995;15(6):343-6 influence on the radial maze performance. However,
(chi*). with the administration of scopolamine (0. 5 mg/kg, i. p.
A study was conducted on the effects of Zhengda ), the number of the correct choices decreased and the
Zhenhua 851-R oral liquor on the improvement of number of the error choices increased. HJ (0. 1 and 0. 5
memory and fluency of language of patients suffering g/kg, p. o. ) reduced this scopolamine-induced cognitive
from Kidney Deficiency and control group. It was found disturbance. The effect of HJ on ACh content and
that the treated group did better in memory tests and enzyme activities in the brain, frontal cortex,
the index of mental quotient (MQ) was higher than that hippocampus and striatum was also investigated. In
of control group. They had markedly higher scores in normal rats, HJ (0. 1 and 0. 5 g/kg, p. o. x 7 days)
the tests of directional memory which requires one's significantly increased ACh content in the frontal cortex,
initiative and the free recollection of pictures. The although it did not increased ACh content in the
scores achieved by the treated group were significantly hippocampus. In scopolamine-treated rats, ACh content
higher than that of control on the tests of the fluency of decreased in the brain regions examined. HJ (0. 5 g/kg,
language and expressions, particularly with words of p. o. ) inhibited a decrease in ACh content in the frontal
different categories. The results showed that Zhengda cortex, and with the same dosage of HJ increased CAT
Zhenhua 851-R oral liquor obviously had the function of activity in the frontal cortex and AChE activity in the
improving the memory and fluency hippocampus. These results suggest that the behavioral
effects of HJ may be related to its effect on the central
66- gera: 54751/di/ra cholinergic system.
[IMPROVING EFFECT OF RHIZOMA GASTRODIAE
ON LEARNING AND MEMORY OF SENILE RATS]. 72- gera: 55672/di/ra
GAO NANNAN ET AL. china journal of chinese [IN MEMORY OF DR. LIEN-TEH WU]. ZHAO
materia medica. 1995;20(9):562-3, 5 (chi*). PUSHAN. chinese journal of medical history.
After giving Rhizoma Gastrodiae to aging rats 1996;26(2):90 (chi*).
continuously for 3 months, the process of their learning Based on materials dealing with early medical activities
and memory was observed through step-down test and of Mr. Lien-teh Wu, this paper gives a description to his
the content of lipid peroxides (LPO) was determined. It contribution to modern medical course in China. For
has been found out that Rhizoma Gastrodiae can examples, he inaugurated the Chinese Medical Journal
effectively improve the ability of learning and memmory both in Chinese and English within the same issue,
of these rats and reduce the content of LPO. The result which is the first of its kind in the history of Chinese
may indicate that it is by clearing away the free-radicals journals. Moreover, Mr. Wu was also the first to
that Rhizoma Gastrodiae improves the brain function. establish modern hospital, port quarantine, banning
drug abuse, and many others. He also advocated
67- gera: 57127/di/ra medical education, gave special attention to traditional
[PROMOTING ACTION OF YIZHILING ORAL LIQUID medical morality and mottoes. He made substantial
(RADIX POLYGALAE, RADIX ASTRAGALI SEU medical writing as well. He was a great contributor to
HEDYSARI, ETC.) ON LEARNING MEMORY OF the development of China's medicine.
MICE]. GU CHANGHONG ET AL. chinese traditional
patent medicine. 1995;17(11):27 (chi*). 73- gera: 57105/di/ra
[ESTABLISHING OF MOUSE LEARNING AND
68- gera: 70198/di/ra MEMORY DYSFUNCTION MODEL BY CEREBRAL
[CHERISH THE MEMORY OF DR. JOSEPH ISCHEMIC REPERFUSION AND THE RELEVANT
NEEDHAM]. ZHIFAN C. chinese journal of medical PROTECTING EFFECT OF YINAO GRANULES]. XU
history. 1995;25(3):163 (chi). QIUPING ET AL. journal of beijing university of tcm.
1996;19(6):65 (chi*).
69- gera: 85020/di/ra
[EFFECTS OF CHINESE GINSENG ROOT AND 74- gera: 67620/di/ra
STEM-LEAF SAPONINS ON LEARNING MEMORY [PROGRESS ON PATHOGENETIC STUDIES OF
AND BIOGENIC MONOAMINES OF BRAIN IN RATS]. ALZHEIMER'S DISEASE AND ITS THERAPEUTIC
AIMIN W ET AL. china journal of chinese materia APPROACH]. SHEN ZI-YIN ET AL. chinese journal of
medica. 1995;20(8):496 (chi*). integrated traditional and western medicine.
1996;16(11):698 (chi).
70- gera: 88762/di/ra
[ON TCM DIAGNOSIS AND TREATMENT OF 75- gera: 84491/di/ra
ALZHEIMER'S DISEASE]. ZHU ZHIBO. jiangsu [CLINICAL OBSERVATION OF IMPROVING
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closely related with improving the cerebral circulation, word journal of acupuncture-moxibustion.
enhancing the ability of 2000;10(2):37 (eng).
Long-term potentiation ( LTP ) is usually induced by
101- gera: 77064/di/ra direct brain stimulation. An at tempt has been made to
[EFFECTS OF ACUPUNCTURE ON THE BEHAVIOR evoke LTP in dentate granule cells of hippocampus by
OF MULTI-INFARCT DEMENTIA MODEL RATS]. LAI acupoint stimulation in anesthetized rats. Assuming a
LIPING ET AL. acupuncture research. 1999;24(3):198 gradual increasing course, LTP rose to 146% at the end
(chi*). of one hour. After applying such stimulation to the
In this research, we observed the effects of the "Tiao awake rats for six days (once everyday), their
Shen Yi Zhi" acupuncture method on the behavior discriminative learning capacity in Y maze test markedly
changes of multi-infarct dementia (MID) model rats. The improved as compared
results show that MID rats manifest the disorder in
learning and memory. The "Tiao Shen Yi Zhi" 107- gera: 72849/di/ra
acupuncture method could obviously improve the ability EFFECT OF BATROXOBIN ON EXPRESSION OF C-
of learning and memory of MID rats which was in JUN IN LEFT TEMPORAL ISCHEMIC RATS WITH
prevention group. The effects of the acupuncture has SPATIAL LEARNING AND MEMORY DISORDER. WU
point specificity. WEIPING ET AL. journal of traditional chinese
medicine. 2000;20(2):147 (eng).
102- gera: 71073/di/ra The effect of Batroxobin on expression of c-dun in left
[EFFECT OF NAOKANGTAI CAPSULE ON ABILITY temporal ischemic rats with spatial memory disorder
OF LEARNING AND MEMORY IN MICE]. YANG JUN was investigated by means of Morri's water maze and
ET AL. traditional chinese drug research and immunohistochemistry methods. The results showed
clinical pharmacology. 2000;11(1):29 (chi*). that the mean reaction time and distance of temporal
ischemic rats for searching a goal were significantly
103- gera: 71085/di/ra longer than those of sham-operated rats, and at the
[THE PROBABLE AFFECTING LINK OF same time c-dun expression of left temporal ischemic
TRADITIONAL CHINESE MEDICINE TREATING region was significantly increased. However, the mean
ALZHEIMER'S DISEASE]. GAO JIE. chinese journal reaction time and distance of Batroxobin-treated rats
of information on tcm. 2000;7(2):5 (chi). were shorter and they used normal strategies more
often and earlier than those of ischemic rats. The
104- gera: 71599/di/ra number of c-dun immune reactive cells of Batroxobin-
[EXPERIMENTAL STUDY ON INFLUENCE OF treated rats was also less than that of ischemic group.
FUSHENG POWDER ON THE MEMORY OF In conclusion, Batroxobin can improve spatial memory
LEARNING DEMENTIAMIMETIC RATS]. LEI YAN ET disorder in temporal ischemic rats, and the down-
AL. journal of tcm. 2000;41(2):108 (chi). regulation of the expression of c-dun is
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model group, acupuncture group. and moxibustion EXPRESSED POSITIVE NEURONS I ALZHEIMER' S
group respectively. Results : There was very significant DISEASE MODEL RATS]. HU JINGQING ET AL.
difference in rat's swimming time between normal group chinese journal of integrated traditional and
and model group, suggesting that rat's swimming time western medicine. 2000;20(7):533 (chi*).
was directly related to memory. when acupuncture
group and moxibustion group were compared with 116- gera: 77823/di/ra
model group respectively. the significant difference in [EFFECTS OF NIUHUANG SHANGQING SOFT
swimming time also appeared. Conclusion The above CAPSULE ON MEMORY OF MICE OF CEREBRAL
results demonstrated that acupuncture and moxibustion ISCHEMIA AND DEMENTIA]. YANG JUN ET AL.
could improve the chinese journal of information on tcm. 2000;7(4):33
(chi).
111- gera: 75090/di/ra
[APPLICATION OF SIX MEMORY METHODS IN 117- gera: 77899/di/ra
TEACHING AND STUDYING]. YAO YUFANG. [CLINICAL STUDY ON HEART AND BRAIN
chinese acupuncture and moxibustion. BENEFITING FORMULA IN TREATING ALZHEIMER'
2000;20(10):631 (chi). S DEMENTIA]. GU YUN ET AL. journal of shandong
university of tcm. 2000;24(4):271 (chi*).
112- gera: 76234/di/ra
[EFFECT OF ACUPUNCTURE ON CHOLINERGIC 118- gera: 77901/di/ra
CENTRAL NERVOUS SYSTEM IN RAT OF [CLINICAL STUDY ON TREATMENT OF
ALZHEIMER DISEASE]. WANG SHAOJIN ET AL. ALZHEIMER' S DEMENTIA WITH YIZHI FANGDAI
acupuncture research. 2000;25(3):175 (chi*). MIXTURE TO IMPROVE THE FACULTY OF
Objective: To explore the effect of acupuncture on MEMORY]. ZHANG QIN YUAN ET AL. journal of
cholinergic central nervous system in rat of Alzheimer shandong university of tcm. 2000;24(4):260 (chi).
disease as well as the way how to create the effect.
Methods: Divided rats into three groups of the normal 119- gera: 78073/di/ra
group, AD group and the acupuncture group. Observed [EFFECT OF ACUPUNCTURE ON LEARNING AND
respectively the behaviour alteration of rats before and MEMORY ABILITIES OF SCOPOLAMINE RATS].
after acupuncture, and observed the change of senile OUYANG QI ET AL. journal of nanjing university
plaques (SPs) and neurofibrillary tangles (NFT) in tcm. 2000;16(5):302 (chi*).
cerebral cortex and hippocampus by special staining for OBJECTIVE To observe the effect of acupuncture on
SPs. Results: The rats of acupuncture group were the reaming and acquisition disturbance of rats caused
found the behaviour had better improvement and the by scopolamine. METHODS Diving platform experiment
SPs number was decreased, but NFT hadn't evidently and water labyrinth experiment were conducted to test
changed. Conclusion: Acupuncture can improve rat's the learning ability of scopolamine rats. RESULTS
function of cholinergic central nervous system. Acupuncture has marked effect of protecting and
improving the reaming and memory abilities. In the
113- gera: 76292/di/ra diving platform experiment, the number of mistakes in
[EFFECT OF POINT INJECTION OF BRAIN learning in the acupuncture group was far less than in
HORMONE ON SPATIAL DISTINCTION LEARNING the model group (P < 0.01) and the incubation period
ABILITY OF MICE AGING MODEL]. WANG ZHONG- WAS prolonged, with marked significance (P < 0.05 or
LIN ET AL. journal of nanjing university tcm. 0.01). In the water labyrinth experiment, the number of
2000;16(6):358 (chi*). mistakes decreased greatly from the second day on,
OBJECTIVE To observe the effect of injection of the with significant statistical significance (P < 0. 05).
same dosage of brain hormone into the acupuncture CONCLUSION Acupuncture is an effective method to
points "Baihui' and "Dazhui" with different amount improve reaming and memory abilities, the mechanism
stimulation on the learning ability of mice aging mode] of which may be related to the fact
made by using D-galactose. METHOD The three-factor
three-level orthogonal design was employed with the Y- 120- gera: 78471/di/ra
labyrinth spatial distinction learning ability as the index. [EFFECTS OF TIAOXIN RECIPE ON THE ABILITIES
RESULT Among the three factors of medicine OF LEARNING AND MEMORY AND CHOLINERGIC
concentration, internal of treatment and time phase of SYSTEM IN ALZHEIMER' S RAT MODEL INDIUED
treatment, the internal of treatment is the main factor, BY INJECTING D GALACTOSE AND IBOTENIC
and the other two factors have little to do with the effect ACID]. LI YA MING ET AL. chinese journal of
of treatment. The optimal method for point injection of traditional medical science and technology.
brain hormone in promoting the learning ability of mice 2000;7(4):237 (chi).
aging model is to use 30-time Fluent of the original
medicine for point 121- gera: 78494/di/ra
[EFFECT OF ZHINAO CAPSULE ON BEHAVIOR OF
114- gera: 77689/di/ra LEARMING AND MEMORY AND METABOLISM OF
[ETHOLOGICAL EXAMINATION OF ALZHEIMER' S PROTEIN AND NUCLEIC ACID IN BRAIN TISSUE OF
DISEASE MODEL RATS TREATED WITH BUSHEN MICE]. YANG WEN MING ET AL. chinese journal of
YIZHI DECOCTION]. WANG HUAIXING ET AL. traditional medical science and technology.
chinese journal of integrated traditional and 2000;7(5):315 (chi*).
western medicine. 2000;20(10):771 (chi*).
122- gera: 79260/di/ra
115- gera: 77733/di/ra [EFFECT OF NAOLIKANG ON THE LEARNING AND
[EFFECT OF BUSHEN YIZHI RECIPE ON MEMORY IN THE RAT WITH SENILE MID]. CHENG
SOMATOSTATIN LIKE IMMUNOPOSITIVE AND JIANZONG ET AL. journal of anhui traditional
SOMATOSTATIN MESSENGER RIBONUCLEIC ACID chinese medical college. 2000;19(2):50 (chi*).
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powerful inhibitors of GSK-3beta. To which extent these acupuncture research. 2001;26(2):106 (chi*).
GSK-3beta effects of CDK inhibitors actually contribute
to their antimitotic and antitumoral properties remains to 147- gera: 95672/di/ra
be determined. Indirubins constitute the first family of THE FUNCTION OF POINT INJECTION IN
low nanomolar inhibitors of GSK-3beta to be described. IMPROVING LEARNING AND MEMORY
DYSFUNCTION CAUSED BY CEREBRAL ISCHEMIA.
140- gera: 89609/di/ra CHEN HUADE. international journal of clinical
[EFFECTS OF CONGSHENG CAPSULES ON THE acupuncture. 2001;12(1):33 (eng).
DISTURBANCE IN LEARNING AND MEMORIZING In this experiment, the author investigated the influence
CAUSED BY CEREBRAL ISCHEMIA REPERFUSION of Yamen (Dul5) point injection on learning and memory
IN PRESENILE MICE]. ZHAO LING ET AL. journal of dysfunction caused by cerebral ischemia and
beijing university of tcm. 2001;24(1):36 (chi*). reprofusion in the bilateral cervical general artery
combined with bleeding on the tail of a mouse to mimic
141- gera: 91563/di/ra vascular dementia in human beings. 40 mice were
[THE IMPROVEMENT OF MEMORY OF VASCULAR divided into 4 groups: group 1-false operation group,
DEMENTIA RATS BY EAR-ACUPUNCTURE AND ITS group 2-model group, and group 3-point injection with
RELATIONSHIP WITH THE EXPRESSION OF NNOS]. Cerebrolysin, group 4-point injection with saline.
ZHANG XUE-CHAO ET AL. shanghai journal of According to random division principles, the author
acupuncture and moxibustion. 2001;20(1):39 (chi*). observed the influence of Yamen (Dul5" point injection
Objective: To probe into the improvement of learning on the time the mice, which had received treatment on
and memory of vascular dementia rats by car different days in different groups, took to swim the
acupuncture and its relationship with expression of entire course, and the number of times they entered a
nNOS. Methods: Vascular dementia rat model was dead end. The results showed that point injection with
established by blocking 4- vessel, then the rats were Cerebrolysin and saline improved learning and memory
treated by acupuncture at car points kidney and Nao, dysfunction caused by cerebral ischemia in mice.
the immunohistochemistry method was used to detect
the nNOS protein, and the lest rate of hippocampus 148- gera: 95724/di/ra
neurons was calculated by NissI staining method [THE TREATMENT OF ALZHEIMER'S DISEASE BY
combined with image analysis. In the meantime, Y-type THE COMBINATION OF ACUPUNCTURE AND
maze was also used to measure the behaviour of the MEDICINE]. MU YANYUN ET AL. shanghai journal of
rats. Results: After acupuncture the expression of acupuncture and moxibustion. 2001;20(3):3 (chi*).
nNOS in CA1, area of rat's hippocampus was reduced Purpose To compare the effects of acupuncture plus
and the lost rate of neurone in CA1, area of rat's medicine and simple acupuncture on intelligence,
hippocampus is less than that in VD model group, gnosis and life self-care ability in AD patients. Methods
which is negatively corrective with learning and Each of the two groups had 21 cases. A score was
memory. Conclusions Ear acupuncture could improve counted according to various neuropsychology scales
the learning and memory of Vdrat and its mechanism before and after treatment. A comparison was made
may be that acupuncture could inhibit the over- between pre-treatment and post-treatment in the same
increased nNOS after cerebral ischemia patient and between the two groups. Results
Intelligence and gnosis was ameliorated in both groups.
142- gera: 92166/di/ra The improving effects on recent and remote memory,
[EFFECT OF FUYUANBUNAO GRANULES ON spatiotemporal orientation, calculation ability and life
MEMORY OF EXPERIMENTAL MICE]. LIU YONG-QI self-care ability were better in acupuncture plus
ET AL. chinese traditional patent medicine. medicine group than in simple acupuncture group
2001;23(2):115 (chi*). (P<O. 05). Conclusion the curative effect of
acupuncture plus medicine is better than that of simple
143- gera: 92512/di/ra acupuncture.
[HISTORICAL MEMORY,THOUGHT RESOURCES
AND REINTERPRETATION IN THE WRITING OF 149- gera: 95873/di/ra
THOUGHT HISTORY]. GE ZHAOGUANG. history of [STUDY ON EFFECTS OF QISHENG PILLS
chinese philosophy. 2001;1:45 (chi). DECOCTION ON MEMORY DISTURBANCE
BEHAVIOR OF RAT]. FUNG YUZHEN ET AL. yunnan
144- gera: 92710/di/ra journal of tcm and materia medica. 2001;22(3):26
[EXPERIMENTAL STUDY ON TREATING (chi*).
ALZHEIMER'S DEMENTIA IN RATS WITH TONGYU
DECOCTION]. FANG HONG ET AL. journal of 150- gera: 96330/di/ra
shandong university of tcm. 2001;25(2):148 (chi). [CLINICAL OBSERVATION OF "CLIMACTERIUM
CAPSULE" IN IMPROVING THE MEMORY OF
145- gera: 94084/di/ra CLIMACTERIC WOMEN]. WEI MEI-JUAN. shanghai
[EFFECT OF DU CHANNEL JING POINTS IN journal of traditional chinese medicine.
ACUPUNCTURE ON MOUSE ABOUT LEARNING 2001;35(8):32 (chi*).
MEMORY AND CEREBRAL CHOLINESTERASE
ACTIVITY]. GAO XIYAN ET AL. forum on tcm. 151- gera: 96582/di/ra
2001;16(2):55 (chi). [EFFECTS OF YIZHILING CAPSULE ON LEARNING
AND MEMORY ABILITY AND CHOLINESTERASE
146- gera: 95635/di/ra ACTIVITIES IN MICE MODEL]. YU JIAN-PING,
[CORRELATION BETWEEN AURICULAR ZHANG CHENG-WEI. journal of anhui traditional
ACUPUNCTURE-INDUCED IMPROVEMENT OF chinese medical colllege. 2001;20(5):47 (chi*).
MEMORY AND BEL-2 EX- PRESSION IN VASCULAR
DEMENTIA RATS]. ZHANG XUEZHAO ET AL. 152- gera: 96746/di/ra
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[EFFECTS OF XUEMAI TONG ON LEARNING AND searching a goal were significantly longer than those of
MEMORY OF MEE]. CHEN JIANPING, CHEN DONG, sham-operated rats and at the same time NCAM
CHEN HAOYU, ET AL. traditional chinese medicinal expression of left temporal ischemic region was
research. 2001;12(4):272 (chi). significantly increased. However, the mean reaction
time and distance of Batroxobin-treated rats were
153- gera: 96747/di/ra shorter and they used normal strategies more often and
[EFFECTS OF LIUWEI DIHUANG TANG ON THE earlier than those of ischemic rats. The number of
LEARNING AND MEMORY OF AGING YIN - NCAM immune reactive cells of Batroxobin-treated rats
DEFICIENCY RATS]. CHEN JINGPING, ZHOU was more than that of ischemic group. In conclusion,
IEQUAN, DING SHENGYUAN ET AL. traditional Batroxobin can improve spatial memory disorder of
chinese medicinal research. 2001;12(4):282 (chi). temporal ischemic rats and the regulation of the
expression of
154- gera: 96937/di/ra
[EFFECTS OF EEL OIL CAPSULE ON BRAIN 161- gera: 98744/di/ra
MEMORY OBSTRUCTION MODEL OF MICE [EFFECT OF NAOYIQING CAPSULE ON LEARNING
INDUCED BY AIC13]. GAO MEI-MEI MEI XUE-TING AND MEMORY ABILITY IN DECLINED MEMORY
ET AL. chinese traditional patent medicine. MICE]. CHEN QIN ET AL. journal of anhui traditional
2001;23(10):737 (chi). chinese medical college. 2001;20(6):30 (chi*).
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198- gera: 106305/di/ra memory abilities of VID rats, which may be realized by
[EFFECT OF ACUPUNCTURE TREATMENT its inhibitory effect on apoptosis and the protection
COMBINED WITH PHARMACOTHERAPY ON action on ischemic hippocampal neurons.
ACETYLCHOLINE AND ACETYLEHOLINESTERASE
IN BRAIN OF RATS WITH MEMORY 200- gera: 106357/di/ra
DISTURBANCE]. SHEN MEI-HONG, LI ZHONG-REN, [MUTUALLY APPROPRIATE FOR BOTH SPRING
MU YAN-YUN, ET AL. journal of nanjing university SILKWORM AND RED CANDLE-IN MEMORY OF
of traditional chinese medicine. 2002;18(4):236 PROF. HUANG WEN-DONG, FAMOUS EDUCATOR
(chi*). OF CHINESE MEDICINE IN SHANGHAI]. LOU SHAO-
OBJECTIVE: To explore into the mechanism of the LAI. knowledge of ancient medical literature.
effect of acupuncture treatment combined with 2002;19(3):21 (chi).
pharmacotherapy in improving neurotransmitter of rat
models. METHOD: Memory disturbance models were 201- gera: 106494/di/ra
made by injecting scopolamine into the rats' abdominal [AN EXPERIMENTAL STUDY ON THE EFFECTS OF
cavity, so as to observe the effect of acupuncture DLXNP ON LEARNING AND MEMORY ABILITY AND
treatment combined with pharmacotherapy on the CEREBRAL EAAS IN RAT MODELS OF VASCULAR
activity of acetylcholine and acetyleholinesterase in the DEMENTIA]. ZHOU XIAOQING, LU WANGHUA LI
cerebral cortex of rats with memory disturbance. HUA ET AL. journal of hunan college of traditional
RESULT Acupuncture treatment combined with chinese medicine. 2002;22(2):4 (chi*).
pharmacotherapy could greatly antagonize
hypofunction of the cholinergic system induced by 202- gera: 106629/di/ra
scopolamine. CONCLUSION Acupuncture treatment [EXPLORE AND CARRY FORWARD A VETERAN
combined with pharmacotherapy has better therapeutic THOROUGHBRED ' S SPINT-IN MEMORY OF PROF.
effect than simple acupuncture treatment or treatment WANG YU- RUN]. XU LIE-MING. knowledge of
with Danggui Shaoyao Powder in treating Alzheimer's ancient medical literature. 2002;2:15 (chi).
disease. Ms study provides scientific basis for the
clinical 203- gera: 106691/di/ra
[THE IMPROVEMENT OF MEMORY IN VASCULAR
199- gera: 106312/di/ra DEMENTIA MODEL OF RATS BY ELECTRO -
EFFECT OF AURICULAR ACUPUNCTURE ON THE ACUPUNCTURE]. WANG LI. new journal of
LEARNING AND MEMORY AND BCL-2 traditional chinese medicine. 2002;34(9):70 (chi).
EXPRESSION IN VASCULAR DEMENTIA RATS.
ZHANG XUEZHAO, ET AL. world journal of 204- gera: 106716/di/ra
acupuncture-moxibustion. 2002;12(2):30 (eng*). [INFLUENCE OF JIAN - NAO - NING ON MEMORY
Objective:: To study the effect of auricular acupuncture BEHAVIOR OF RAT WITH MIDDLE CEREBRAL
on dysmnesia and the relationship between the memory ARTERY OBSTRUCTION.]. SHI JING ET AL .
improvement and bcI-2 protein expression in vascular information on traditional chinese medicine.
dementia (VD) rats. Methods: Forty Wistar rats were 2002;19(3):74 (chi).
randomized into control group, VID group,
acupuncture+ VD group and pseudo-operation group, 205- gera: 106841/di/ra
with 10 cases in each group. Rat VD model was [CLINICAL STUDY ON RELATIONSHIP BETWEEN
established by using 4-vessel occlusion method. MEMORY QUOTIENT , ESTROGEN AND CHINESE
Otopoint " Nao "-point and " Shen " (MA-SC) were NOURISHING KIDNEY HERBS IN
punctured, once daily continuously for 15 days. The PERIMENOPAUSAL WOMEN*]. JING SU-YU, WEI
rats' memory capability was tested with Y- maze MEI-JUAN. chinese journal of integrated traditional
method and bcI-2 expression of the brain tissues and western medicine. 2002;22(7):494 (chi*).
displayed by immunohistochemical method and
measured using MIAS-2000 Image Analyzer. Results: 206- gera: 106984/di/ra
Results showed that the scores of control group, VD [EFFECT AND MECHANISM OF COMPOUND RADIX
group and acupuncture+ VD group before operation ASTRAGELI LIQUID ON LEARNING AND MEMORY
were 5.68 ± 1. 29, 6. 07 ± 1. 67 and 5. 86 ± 1. 74 FUNCTIONS OF SENILE MICE]. HUANG FEIHUA,
respectively, while following auricular acupuncture CHEN YONGCAN, ZHU WANPING, ET AL. journal of
treatment, the scores of the 3 groups were 5. 81 ± 1. zhejiang college traditional chinese medicine.
51, 18. 06 ± 2. 68 and 8. 31 ± 1. 85 separately, 2002;26(4):57 (chi*).
suggesting that the VD rat's learning and memory
abilities in acupuncture+ VD group were raised 207- gera: 107373/di/ra
apparently in comparison with those of VD group (P < 0 ENHANCED EXPRESSION OF PHOSPHO-AKT BY
- 0 1 ). In control, VID and acupuncture + VD group, ELECTRO-ACUPUNCTURE IN NORMAL RAT
bcI-2 immuno-reaction positive neurons in CAI area of BRAIN. WANG SJ ET AL. neurol res. 2002;24(7):719-
the hippocampus were 14.31 ± 4. 87, 28. 67 ± 5. 63 and 24 (eng).
65. 74 ± 8. 19 respectively, displaying that the Electro-acupuncture (EA) is an effective curative
improvement of learning and memory abilities caused method for various diseases in oriental medicine. To
by auricular acupuncture treatment may be related to investigate a detailed molecular mechanism of EA
the up-regulation of bcI-2 expression (an inhibitory gene stimulation, an induction of phospho-Akt (p-Akt) was
of apoptosis). In comparison with control group, the loss examined in normal adult rat brain after 60 min of EA
of neurons in the pyramidal cell layer of the with acupoints of Baihui (D20) and Renzhong (D26). In
hippocampal CA, area of VD group was more severe, the sham control brain, strong neuronal p-Akt
while that of acupuncture group was markedly lighter. expression was found in ventral posterolateral thalamic
Conclusion: Auricular acupuncture of otopoint " Nao "- nucleus (VPL) and medial habenular nuclei (MHb), but
point and "Shen" (MA-SC) can raise the learning and moderate to weak in cortex, caudate, CA1 sector and
gera 2011
19
dentate gyrus of hippocampus, and ventral GENG. journal of anhui traditional chinese medical
posteromedial thalamic nucleus. EA stimulation college. 2002;21(5):45 (chi*).
generally enhanced and sustained p-Akt expression for
at least 24 h especially in the regions listed above, 213- gera: 108011/di/ra
except VPL and MHb where no apparent change was [11 CASES OF ALZHEIMER ' S DISEASE TREATED
found. Western blot analysis of p-Akt confirmed the BY ACUPUNCTURE]. DONG HONG-TAO, JIN YUAN-
enhanced signal intensity after EA at 8 and 24 h. These GUANG, AU YING. acta universitatis traditionis
results suggest that the EA on D20 and D26 acupoints medicalis sinensis pharmacologiaeque shanghai.
activates the survival Akt signal pathway, which may be 2002;16(3):26 (chi*).
maintaining the neural functions such as cell survival In order to observe the therapeutic effect in the
and memory formation in normal brain. acupuncture treatment of Alzheimer's disease , 32
cases of AD patients were divided into the three groups
208- gera: 107432/di/ra of the acupuncture group (acupuncture treatment) ,
[EFFECTS OF ELECTROACUPUNCTURE ON medication group (Hupperzine) and control group (
LEARNING AND MEMORY ABILITY AND psychological consultation) and were treated for three
ULTRASTRUCTURES OF HIPPOCAMPUS months, to observe memory, intelligent status, daily life
NEURONS IN RATS OF WHOLE CEREBRAL ability and improvement of the symptoms in the various
ISCHEMIA]. WANG LI, LAI XINSHENG, LEI WEIWEI. groups by MMSE , ADL scale and integral of clinical
chinese acupuncture and moxibustion. symptoms. The results showed that MMSE integral was
2002;22(1):47 (chi*). enhanced obviously and ADL and symptom integral
Purpose : To observe effects of electroacupuncture ( were obviously decreased in the acupuncture group
EA) on learning and memory ability and neurons of and medication group, but without any obvious change
hippocampus in the rat of vascular dementia ( VD). in the control group. The findings indicate that
Methods : In four vessels occlusion ( 4-vo) model rats, acupuncture and Harboin are somewhat effective for
Morris water maze tests were used for behavioural AD, but the former is better in the improvement of some
study. Ultrastructural changes of neurons in symptoms than the latter.
hippocampus were observed with transmission electron
microscope. Results : The model animals needed more 214- gera: 109116/di/ra
escape time ( latency) than the control animals in place JIAN NAO NING FOR TREATMENT OF MEMORY
navigation test, and they did not swim more times in IMPAIRMENT IN PATIENTS WITH MILD OR
platform quadrant than in the others in spatial probe MODERATE MULTI- INFARCT DEMENTIA. TIAN
test. The ultrastructure of neurons in hippocampus were JINZHOU, YIN JUNXIANG, LIU HUAN, ET AL. journal
altered obviously and damaged severely. In the EA of tcm. 2002;22(4):247 (eng*).
group and Nimoton group, the latencies were not In order to inquire into the therapeutic effects of Xiao
different from control group rats in place navigation test Shi Xiong Huang San qiA--6*jtfA the Nitrum and
and in the spatial probe test, the two groups rats swam Realgar Powder), one of the Dunhuang Prescription, on
more times in platform quadrant than in other three angina pectoris due to coronary heart disease
quadrants. Compared with the model group, the (APCHD), the authors have treated 61 cases of APCHD
damage of the neurons of hippocampus, in the EA and by externally applying paste of the powder on Zhiyang
Nimoton groups was obviously slight. Conclusion : EA (GV 9), with another 30 cases of APCHD treated with
can improve learning and memory ability in VD model the nitroglycerin paste on Zhiyang as the controls. The
rats, and it can also improve markedly ultrastructural results showed that the total effective rate was 82% and
alteration of neurons in brain, inhibiting the demage of markedly effective rate 31.2% in the treatment group
(the Paste of Nitrum and Realgar Powder), and the total
209- gera: 107543/di/ra effective rate was 46.6% and markedly effective rate
[EFFECT OF BUSHEN YIZHI RECIPE ON BRAIN B- 23.2% in the control group (the nitroglycerin paste). The
AMYLOID PRECURSOR PROTEIN IN RAT MODEL difference in therapeutic effects between the two groups
OF ALZHEIMER DISEASE*]. GAO JIE, LAI SHI- was very significant (P<0.01) , indicating that the
LONG, RAO YAN. chinese journal of integrated therapeutic effect of the former was significantly
traditional and western medicine. 2002;22(9):677 superior to that of the latter.
(chi*).
215- gera: 111261/di/ra
210- gera: 107687/di/ra [EFFECTS OF ELECTROACUPUNCTURE ON
[COMPARATIVE RESEARCH OF EFFECT OF LEARNING AND MEMORY ABILITY AND
ZIPIYIZHI DECOCTION ON THREE KINDS OF ULTRASTRUCTURES OF HIPPOCAMPUS
ALZHEIMER ' S DISEASE MOUSE MODELS]. X. NEURONS IN RATS OF WHOLE CEREBRAL
chineses archives of tcm. 2002;20(4):439 (chi*). ISCHEMIA]. WANG LI, LAI XINSHENG, LEI WEIWEI.
chinese acupuncture and moxibustion.
211- gera: 107704/di/ra 2002;22(1):47 (chi*).
[AN EXPERIMENTAL STUDY ON THE EFFECTS OF Purpose : To observe effects of electroacupuncture
DLXNP ON LEARNING AND MEMORY ABILITY, (EA) on learning and memory ability and neurons of
CEREBRAL SOD, MDA AND CA 2+ IN RATS WITH hippocampus in the rat of vascular dementia (VD).
VASCULAR DEMENTIA]. ZHOU XIAOQING, LU Methods : In four vessels occlusion (4-vo) model rats,
WANGHUA, LI HUA, ET AL. journal of hunan college Morris -ater maze tests were used for behavioural
of tcm. 2002;22(3):1 (chi*). study. Ultrastructural changes of neurons in
hippocampus were observed with transmission electron
212- gera: 107748/di/ra microscope. Results : The model animals needed more
[EFFECT OF HUOLIJING GRANULES ON ABILITIES escape time (latency) than the control animals in place
OF LEARNING AND MEMORY IN NORMAL ADULT navigation test, and they did not swim more times in
RATS]. YANG YU-FU, LU XIONG-WEN, MA CHUAN- platform quadrant than in the others in spatial probe
gera 2011
20
test. The ultrastructure of neurons in hippocampus were as a tool in status competitions between regions and
altered obviously and damaged severely. In the EA localities; and others related to the above through
group and Nimoton group, the latencies were not reciprocal social obligations of various kinds. Drawing
different from control group rats in place navigation test inspiration from an interdisciplinary range of sources
and in the spatial probe test, the two groups rats swam that include genealogical approaches in Western
more times in platform quadrant than in other three philosophy, actor-network theory in the cultural studies
quadrants. Compared with the model group, the of science, and work on social memory in anthropology
damage of the neurons of hippocampus in the EA and and area studies, the interaction between these various
Nimoton groups was obviously slight. Conclusion : EA agents is described as an ongoing labour that conjoins
can improve learning and memory ability in VD model the formation of social identities to the shaping of the
rats, and it can also improve markedly ultrastructural clinical practice, doctrinal content and institutional
alteration of neurons in brain, inhibiting the damage of organization of medicine in such a manner that they
neurons. mutually determine each other. As a result of this labour
diverse memories of Chinese medicine circulate in
216- gera: 113320/di/ra networks of different shapes and sizes that are more or
[MEMORY METHODS OF LOCATIONS AND less enduring. Elements of one network can be
INDICATIONS OF SCALP ACUPUNCTURE]. TIAN assimilated into another and thereby brought into its
KAIYU. chinese acupuncture and moxibustion. memory of itself, but also dis-assimilated and thereby
2002;22(2):113 (chi*). forgotten. The value of this approach is, first and
foremost, that it allows for a mode of analysis that
217- gera: 116311/di/ra grasps medicine as intrinsically plural and unstable.
[MEMORY METHODS OF LOCATIONS AND Furthermore, it links work in the social history of
INDICATIONS OF SCALP ACUPUNCTURE ]. TIAN Chinese medicine to that in a variety of other fields and
KAIYU. chinese acupuncture and moxibustion. thereby hopes to benefit all through increased cross-
2002;22(2):113 (chi*). fertilization.
In the 6th edition of TCM higher education textbook,
Acupuncture anti moxibustion, the locations and 220- gera: 111385/di/ra
indications of scalp-acupuncture are introduced in order [MUE NEC OF CORIDUS VERSICOLAR
of the four regions, forehead, vertex, temporal and POLYSACCHARIDE ON THE RAT'S LEARNING AND
occiput, respectively. In order to make the memory MEMORY DISTURBANCE CAUSED BY STRESS].
easier, the author classifies the 14 standard scalp HU WANG-PING, ET AL. journal of traditional
acupuncture lines into two ordinates (IO lines) and medical science and technology. 2003;10(1):32
diagonals (4 lines) I and sub-classifies them according (chi*).
to their anatomic regions and involved acupoints, By
comparing and analyzing their locations and indications, 221- gera: 111391/di/ra
some simple and easy - memory features have been [COMPARATIVE STUDY ON THE EFFECTS OF
summed up. This article win benefit to quickly learn and TONIFYING KIDNEY NOURISHING LIVER AND
practice scalp acupuncture for TCM college students STRENGTHENING SPLEEN ON MOUSE'S MEMORY
and medical workers who have not studied acupuncture DISTURBANCE]. WU ZHENG-ZHI, ET AL. journal of
systematically. traditional medical science and technology.
2003;10(1):41 (chi*).
218- gera: 117352/di/tt
LOS OLVIDOS DE LA MEMORIA - A PROPOSITO 222- gera: 111392/di/ra
DE LA ACUPUNTURA COMO TRATAMIENTO DE LA [EFFECT OF INVIGORATING LIVER AND
ENFERMEDAD DE ALZHEIMER BASADO EN EL NOURISHING MARROW METHOD ON THE
CODIGO GENETICO DESCRITO EN EL I-CHING. DE DISTURBANCE OF MOUSE'S MEMORY
NAVERAN T. miraguano s a ediciones, madrid. ACQUIRENENT, CONSOLIDATION AND
2002;:185P (esp). REPETITION.]. WU ZHENG-ZHI, ET AL. journal of
traditional medical science and technology.
219- gera: 144640/0/tp 2003;10(1):42 (chi).
WUJIN MEDICINE REMEMBERED: MEMORY,
IDENTITY AND SOCIAL NETWORKS IN CHINESE 223- gera: 112058/di/ra
MEDICINE 1800- 2000, SCHEID V. taiwanese journal [EFFECTS OF ELECTROACUPUNCTURE ON
for studies of science, technology, and medicine. LEARNING AND MEMORY AND THE PRODUCING
2002;2:121-84 (eng). SYSTEM OF FREE RADICALS IN BRAIN TISSUE IN
The present article examines by means of a case study THE RAT OF VASCULAR DEMENTIA]. WANG LI,
approach how four different medical traditions that TANG CHUNZHI. journal of tcm. 2003;44(1):25 (chi*).
originated in Wujin County, Jiangsu Province, in late
imperial China have been remembered since. The 224- gera: 112964/di/ra
study shows that representations of Wujin medicine and [EFFECT OF BUSHEN HUOXUE RECIPE ON
the social networks in which these representations LEARNING AND MEMORY DYSFUNCTION AND
circulate change over time as a variety of social agents HIPPOCAMPAL NERVE CELL APOPTOSIS IN MICE
participate in the shaping of social memory. These WITH CEREBRAL ISCHEMIA/REPERFUSION
agents include physicians competing for patients, fame INJURY*]. TIAN GUO-QING, GUO SAI-SHAN, LU HE-
and status, who exploit their relation to medical QI. chinese journal of integrated traditional and
resources for both clinical and non-clinical ends; western medicine. 2003;23(2):123 (chi*).
patients, who seek physicians in order to cure their
afflictions but also to engage with them in a social 225- gera: 112990/di/ra
dialogue; politicians, who import ideological struggles [TANGERINE GREEN IN SOUTHERN YANGTSZ
into the field of medicine; scholars, who use medicine RIVER, FRAGRANCE SPREADING IN NORTHERN
gera 2011
21
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22
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23
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24
operation group (P >0. 05) . It showed that MEMORY AND NOS OF SPONTANEOUS AGED
administration of EA and Nimodipine could improve the DEMENTIA MICE]. WU ZHENGZHI, YOU LONGWU,
learning and memory of VD rats. The apoptotic neurons LI MING, ET AL. chinese journal of integrative
of EA and medication groups were significantly fewer medicine on cardio-/cerebrovascular disease.
than those of model group in both the cerebral cortex 2004;2(3):155 (chi*).
and CAI area of hippocampus, and no significant
difference was found between EA and medication 275- gera: 128423/di/ra
groups, suggesting that both EA and medication could [STUDY ON PHARMACODYNAMICS EFFECT OF
suppress ischemia-reperfusion induced apoptosis. FUYUANBUNAO GRANULES ON ATPASE
Conclusion: Electroacupuncture can improve the ACTIVITIES AND LIPID PEROXIDATION IN
learning and memory of VD rats and inhibit cerebral ALZHEIMER' DISEASE MOUSE]. LIU YONG-GI HE
apoptosis after cerebral ischemia-reperfusion. JIAN-CHENG ET AL. chinese traditional patent
medicine. 2004;26(2):130 (chi*).
270- gera: 142586/di/ra
[INFLUENCE OF COMBINING ACUPUNCTURE AND 276- gera: 128434/di/ra
MEDICINE ON NO AND NOS IN RATS' HIPPOCAMPI [EFFECT OF DIHUANGYINZI ON NO AND NOS
WITH ACQUIRED LEARNING-MEMORY CONTENTS IN BRAIN TISSUE AND BEHAVIOR OF
DISTURBANCE AND THEIR CORRELATION]. MU SENILE RATS WITH ALZHEIMER DISEASE]. ME
YY, LI ZR, SHENG MH,AL. shanghai journal of NING, LIU LIN, ZHOU YAN-YAN, ET AL. chinese
acupuncture and moxibustion. 2003;22(3):3 (chi*). journal of traditional medical science and
Objective To study the correlation between NO and technology. 2004;11(2):84 (chi).
NOS and learning-memory disturbance in rats, and
further to explore the possible mechanism of combining 277- gera: 129172/di/ra
acupuncture and medicine in the treatment of it. [EFFECTS OF MODIFIED DANGGUI SHAOYAO
Methods 10 rats in every group were modeled to be POWDER ON MEMORY AND CONTENTS OF TAU
with learning-memory clisturbance by scopolamine, and PROTEIN AND FAS ANTIGEN IN BRAIN TISSUES
then treated with nimodipine, single acupuncture, and OF ALZHEIMER'S DISEASE MODEL RAT]. LIU
combining acupuncture and medicine respectively. MENGYUAN, XIAO LIUYING, PAN JINGQIANG, ET
Jumping-platform and labyrinth tests were conducted. AL. journal of tcm. 2004;45(5):378 (chi).
The landing period and the contents of NO and NOS in
the rats' hippocampi were compared correlatively. The 278- gera: 129541/di/ra
improvements of learning-memory capacity in every [SUPERFICIAL TALK BOUT THE FACTS OF
group were compared. Results The content of NO(1. TREATING ALZHEIMER'S DISEASE ACCORDING
300-1-0. 14 iimol/g) and activity of NOS (0. 064 ± 0. 007 TO THE CONDITION OF KIDNEY ]. YUAN QUAN ET
u/mg) were significantly lower in single acupuncture AL . academic periodical of changchun college of
group than in nimodipine group (0. 808 ± 0. 23 tnnol/g , tcm. 2004;20(2):3 (chi).
O. 056±0. 012 u/mg) and combining acupuncture and
medicine group(0. 705±0. 52 bnol/g , O. 047±0. 005 279- gera: 129999/di/ra
u/mg) (P <0. 05). The learning-memory disturbance [EFFECTS OF BU SHEN XING NAO (BSXN)
was improved obviously less in single acupuncture PRESCRIPTION ON BEHAVIORS OF LEARNING
group than in nimodipine group and combining AND MEMORY IN VASCULAR DEMENTIA RATS].
acupuncture and medicine group. Conclusion Combing FENG YIN-MAN ZHENG PANG,REN XIAO-QIAO .
acupuncture and medicine has better effects than chinese journal of basic medicine in tcm.
sin-gle 2004;10(5):55 (chi).
gera 2011
25
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26
Inventory (NPI), both validated questionnaires correct rates of EA-multi-session group on the 1st , 2nd,
assessing cognitive impairment and be havioral 3rd days were significantly higher than those of model
disposition. Results Of the 10 pairs enrolled, 9 pairs group , showing an improvement of learning-memory
completed the study: 4 were randomized to the after acupuncture. In model group, the amplitude of
acupuncture group, 2 to the placebo acupuncture group tetanic stimulation induced PS potential was attenuated
and 3 to control treatment. The median total baseline significantly in comparison with that of control group,
score on the MMSE was 10 (range, 0-24); the possible and those of EA-one-session and EA-multi-session
range (from low to high cognitive( ability) was from 0- groups were higher than that of model group,
30. The median severity score on the NPI at baseline suggesting that EA could reverse morphine induced
was 41 (range, 24-71); the possible range (from lowest harmful influence on LTP and better synaptic
to highest fre quency x severity of symptoms) was from transmission of hippocampal neurons. Local application
0-144. Among the 9 pairs, differences between placebo of naloxone to CA3 area, the effect of EA on LTP was
and control observations were all modest, rang ing from inhibit significantly, suggesting an involvement of opium
6 to -5 (median, 0: no change in symptoms). Score system in the therapeutic effect of EA. Conclusion: EA
differences for acupuncture recipients were much can improve morphine-induced lesion of learning-
larger, ranging from -6 to -31 (median between -18 and memory and modulate the synaptic plasticity of neurons
-273). An exact x2 test was made on a 2-x-2 table of in perforant path-CA3 in morphine-dependent rats, and
acupuncture vs other treatments by score differences the effect of EA may be mediated by
greater than vs less than or equal to the median of all 9
score differences. This yielded a 2-sided 296- gera: 140049/di/ra
P=.047.Conclusions The improvement in agitation in [SELECTION OF GENE EXPRESSION PROFILE OF
the acupuncture group was consistent with the known ALZHEIMER'S DISEASE BY CDNA MICROARRAY].
effects of acupuncture on the central nervous system. A FAN XIAO-NONG WEN TING-YI, DU YUAN-HAO, ET
larger randomized trial is needed to generalize any of AL. tianjin journal of tcm. 2004;21(6):450 (chi*).
these findings to the clinical arena. [Objective] To select the abnormal expression genes of
Alzheimer's Disease( AD) in Senescence Accelerated
294- gera: 135129/di/ra Mouse( SAM) and discuss their role in the pathogenesis
INVESTIGACIONES DE LA ESCUELA: of AD. [Methods] Using 15 400 mouse cDNA microarray
ENFERMEDAD DE ALZHEIMER. HERMENEJILDA, the abnormal expression genes in AD were screened.
URSULA, JUAN, CLAUDIA, RAFAEL, MARTA [Results] Two hundred and forty two genes related to
ARAGÓN. medicina tradicional. 2004;193:5 (esp). dementia were selected, 234 genes related to senile
were selected. One hundred and ten genes were
295- gera: 136711/di/ra selected in both groups considered to be related to both
[EFFECT OF ELECTROACUPUNCTURE ON senile and dementia. Most the selected genes were
IMPAIRMENT OF LEARNING-MEMORY AND LONG- down-regulated, the number of them were almost two-
TERM POTENTIATION IN THE RAT HIPPOCAMPAL fold than that of up-regulated. The gene function of 22
CM REGION]. ZENG YAN, LIANG XUN-CHANG, LI in 110 were known. The down-regulated genes were
MAN, ET AL. acupuncture research. 2004;29(4):245 mostly related to the pathological functions in releasing
(chi*). of synaptic vesicle, signal trans-duction, cell skeleton,
Objective: To determine if chronic morphine treatment energy metabolism, etc. On the other hand, the up-
affects the rat's learning-memory ability and the regulated genes were mainly involved in the pathologic
induction of long-term potentiation (LTP) of functions of cell cycle, ion channel, protein synthesis,
hippocampal CA3 region, and to examine if inflammatory reaction, and so on. [Conclusion] "Gene
electroacupuncture (EA) can improve learning-memory expression profile of AD" may find some rules in many
and LTP in morphine-dependent rats. Methods: 64 SD clues in researches of AD and provide
rats were randomized into control, morphine-abstinence
model, EA-one-session and EA-multi-session groups. 297- gera: 119258/di/ra
Morphine-abstinence model was established by i. p. of [CLINICAL OBSERVATION ON ACUPUNCTURE
hydrochloride morphine. EA (2 Hz, 1—3 mA, 30 min) COMBINED WITH MUSIC FOR TREATMENT OF
was applied to bilateral "Zusanli" (ST 36) and ALZHEIMER DISEASE]. LIU G, YUAN LX. chinese
"Sanyinjiao" (SP 6), once and multiple times. The rats' acupuncture and moxibustion. 2005;25(6):390-2.
passive and active avoidance reactions in a (chi).
compartment equipped with a grid floor through which OBJECTIVE: To find the method for increasing clinical
an electric shock (40 V) was delivered were used as the therapeutic effect on Alzheimer disease (AD).
indexes of learning-memory. The population spike (PS) METHODS: The patients of AD meeting American
was recorded from pyramidal cells of CM in vivo, NINCDS-ADRDA Criteria were randomly divided into
following stimulation of lateral perforant path in control group A and group B. The group A (n = 21) were
and morphine-abstinence rats. For the induction of LTP, treated with acupuncture for 10 courses, 10 sessions
4 trains (50 shocks/train, 500 Hz) high-frequency tetanic constituting one course; and the group B (n = 20) were
stimulations were applied to lateral perforant path. treated with combination of acupuncture and music
Results: Results indicated that the attack times of therapy. The acupuncture method was the same as the
morphine withdrawal syndrome of EA-one-session group A and the music therapy was given for 20
group at 24 h and EA-multi- session group at 24 h, 48 h sessions, once every 5 days. After treatment, their
and 72 h times were significantly fewer than those of effectiveness were evaluated with the Mini-Mental State
morphine-abstinence model group (P < 0.05) . Passive Examination (MMSE) and Activities of Daily Living
experiments displayed that the latency values of (ADL). RESULTS: After treatment, the scores for
platform leaving of EA-one-session and EA-multi- MMSE increased significantly (P < 0.05) and the scores
session groups were significantly shorter than that of for ADL decreased significantly (P < 0.05) in the both
model group (P<0.05). Results of active avoidance groups, and the therapeutic effect in the group A was
experiments indicated that the avoidaance-reaction better than the group B (P < 0.05). CONCLUSION:
gera 2011
27
Acupuncture combined with music therapy can increase Objective:Compare the curative effects and features
the therapeutic effect between treating clavicular fracture with re-setting steel
plate and shape-memory alloy. Methods: Treat 25
298- gera: 126012/di/ra cases of mid-clavicular fracture with shape-memory
TRADITIONAL CHINESE HERBS AGAINST alloy,32 with re- setting steel plate. Result:Loose and
HYPERTENSION ENHANCE MEMORY falling happened in 2 cases treated with memory alloy,
ACQUISITION. HO SC, HO YF, LAI TH, LIU TH, WU partly protruding in 1 case with steel plate,they were all
RY. american journal of chinese medicine. clinically cured after timely treatment,the good effective
2005;33(5):787-95. (eng). rates of both groups were above 90%. Conclusion: Two
Recent findings of a link between high blood pressure methods have good curative effect; the shape-memory
(BP) and dementia have given new prospects. The aim alloy is simple and easy for Operation,which should be
of this study is to analyze a mixture of Chinese herbs, carefully applied for the fracture on lateral 1/ 3 point,and
Tianma Gouteng Decoction (TGD), which was the re-setting steel plate is more popular and reliable
traditionally used to treat hypertension, and investigate compared with re-setting steel plate shape-memory
its relation to ameliorating cognitive impairment. We alloy.
discovered that TGD also had properties involving
enhancement of memory acquisition (learning) skills in 304- gera: 140520/di/ra
mice, but not memory consolidation. It was observed POST-ISCHEMIC TREATMENT WITH TOKI-
that TGD could prolong the step-through latency at SHAKUYAKU-SAN (TANG-GUI-SHAO-YAO-SAN)
doses of 1.0 and 2.5 g/kg on passive avoidance task in PREVENTS THE IMPAIRMENT OF SPATIAL
mice. TGD could be developed further to treat mice with MEMORY INDUCED BY REPEATED CEREBRAL
amnesia, which was induced by scopolamine at the ISCHEMIA IN RATS. FENGLING PU, KENICHI
same dose under long-term (8 days) administration. MISHIMA, NOBUAKI EGASHIRA, YUKI AKIYOSHI,
AN-XIN LIU, KAZUNORI SANO, KEIICHI IRIE,
299- gera: 136973/di/ra DAISUKE ET AL. american journal of chinese
[EFFECT OF JIANJIAN DIHUANG YINZI ON medicine. 2005;33(3):475 (eng*).
LEARNING MEMORY AND ANTIOXIDANT ON THE Previously we have reported that Toki-shakuyaku-san
MODEL RATS OF ALZHEIMER'S DISEASE INDUCED (TSS) ameliorated the impairment of spatial memory
BY B-AMYLOID1-4O]. XIE NING, ET AL. chinese induced by single cerebral ischemia (1 × 10 minutes)
archives of tcm. 2005;23(2):212 (chi*). and scopolamine, a muscarinic receptor antagonist. In
this experiment, we studied the effect of TSS on
300- gera: 137482/di/ra repeated cerebral ischemia (2 × 10 minutes, 1-hour
[EFFECT OF SHOU' ERZHI CAPSULE ON interval) induced impairment of spatial memory and
APOPTOSIS OF CULTURED HIPPPOCAMPUS neuronal injury in rats. The 8-day post-ischemic
NEURON CELL IN FENG FANG-JUN, TU JIN-WEN , treatment with TSS (30–300 mg/kg) was administered
DONG MENG-JIU , ET AL. chinese journal of p.o. once per day. TSS dose-dependently prevented
traditional medical science and technology. the impairment of spatial memory, neuronal death and
2005;12(1):40 (chi). TUNEL positive cells induced by repeated cerebral
Objective: The preventive and therapeutic mechanism ischemia. In order to determine the mechanism of TSS,
of Alzheimer' s dementia with traditional Chinese herbs we also studied the effect of TSS on GluR2 mRNA, one
has been studied by observing the effects of Shou' of the glutamate α-amino-3-hydroxy-5- methyl-4-
erzhi capsule upon the apoptosis of hippocampus isoxazole (AMPA) receptor subunits. Repeated cerebral
neurons. Methods: Observing the influence of the ischemia significantly decreased GluR2 flop mRNA at 1
serum with Shou' erzhi capsule upon the apoptosis of and 3 days after the occlusion. TSS (300 mg/kg)
hippocampus neuron cultured in vitro of new — horn significantly suppressed the decrease in GluR2 flop at 3
Wistar rats by seropharmacology and cell — flow days after repeated cerebral ischemia. These results
device. Results: Shou' erzhi capsule could protect suggested that the TSS has neuroprotective action
cultured hippocampus neuron cell from apoptosis, there which may be indirectly mediated by the AMPA
was obvious difference between Shou' erzhi group and receptor, and TSS may be beneficial for the treatment
other groups. Conclusion: Shou' erzhi capsule is helpful of
for the prevention of
305- gera: 141667/di/ra
301- gera: 137937/di/ra [EFFECT OF ACUPUNCTURE OF "BAIHUI -(GV 20)
[INFLUENCE OF GUBEN HUATAN JIANNAO AND "SISHENCONG" (EX-FIN 1) ON MEMORY AND
RECIPE ON THE BEHAVIOR OF RATS WITH CEREBRAL SOD ACTIVITY IN ALZHEIMER' S
ALZHEIMER'S DISEASE]. YOU QIOUYUN, ET AL. DISEASE RATS]. ZHAO LI-GANG, MA LI, ZHENG ZU-
hubei journal of tcm. 2005;27(3):9 (chi). YAN, ET AL. acupuncture research. 2005;30(1):26
(chi*).
302- gera: 138002/di/ra Objective: To investigate the effect of acupuncture on
[THE INFLUENCE OF GMODERMA HUCIDUM SEU the memory and SOD activity in the cerebral issues in
JAPONICUM ON LEARNING AND MEMORY OF Alzheimer' s disease (AD) rats. Methods: 48 healthy
MICE LI YAPING BAI SHUFANG JING XIURONG . Wister rats were randomly divided in-to control group (n
inner mongol journal of tcm. 2005;24(1):33 (chi). =11) , model group ( n = 10) , medication group ( n 10)
and acupuncture group ( n = 11). AD model was
303- gera: 139183/di/ra established by microinjection of 13-amyloid protein ((3-
[CLAVICULAR FRACTURE TREATED BY RE- AP)1-40 (1 uL) into the hippocam-pal CA1 region (AP:
SETTING STEELPLATE INTERNAL FIXATION WITH 2.22 mm; ML: 3.0 mm, DV: 2.8 mm). In acupuncture
TINI SHAPEMEMORY ALLOY AND TITANIUM group, "Baihui"(GV 20) and "Sishencong"(EX-HN 1)
ALLOY]. JIANG TAO. journal of zhejiang college of were punctured with filiform needles which were lifted,
tcm. 2005;29(2):22 (chi*). thrust and twirled continuous-ly for 5 min, and then
gera 2011
28
gera 2011
29
effect on Abeta(25 - 35) induced neurotoxicity in SD platform quadrant than in the others in the Morris water
rats. maze tests. The content of CO in the plasma was
higher than the others. In the EA group, for the most
309- gera: 135877/di/ra part, the animais cut down the escape time and swam
[INFLUENCE OF ELECTROACUPUNCTURE ON longer in the platform quadrant than in the others. The
LEARNING AND MEMORY ABILITY IN DIABETIC content of CO in the plasma was obviously decreased.
COGNITIVE DYSFUNCTION PATIENTS]. XU YUN- Conclusion: EA can improve learning and memory and
XIANG, ZHANG JIA-WEI. acupuncture research. it can also inhibit the increase of CO content in the
2006;31(4):232 (chi*). plasma of VD model rats.
Objective: To observe the effect of electroacupuncture
(EA) on the learning and memory ability in diabetic 311- gera: 141979/nd/re
cognitive dysfunction patients. Methods: Forty-f ive GOMISIN A IMPROVES SCOPOLAMINE-INDUCED
cases of diabetic mellitus (DM) patients with cognitive MEMORY IMPAIRMENT IN MICE. KIM DH, HUNG TM,
dysfunction were ran-domly divided into EA group BAE KH, JUNG JW, LEE S, YOON BH, CHEONG JH,
(n=25) and medication group (n=20). For patients of EA KO KH, RYU JH. eur j pharmacol. 2006;542(1-3):
group, main acupoints as Sishenchong (EX-HN 1), (eng).
Baihui (GV 20) , bilateral Fengchi (GB 20) , Benshen Gomisin A is a component of the fruits of Schizandra
(GB 13) and Neiguan (PC 6) were punctured with chinesis which are widely used as a tonic in traditional
filiform nee-dies and stimulated electrically by setting Chinese medicine. In the present study, we assessed
the stimulating parameters being dense-sparse waves, the effect of gomisin A on the learning and memory
frequency of 14 -26 pulses/min, strength of 3 - 5 mA impairments induced by scopolamine. The cognition-
and duration of 30 min. The treatment was conducted enhancing effect of gomisin A was investigated using a
once daily, 5 times a week and continuously for 6 passive avoidance test, the Y-maze test, and the Morris
weeks. Patients of medication group were ordered to water maze test in mice. Drug-induced amnesia was
take Nimotop (30 mg/time) , 3 times everyday and induced by treating animals with scopolamine (1 mg/kg,
continuously for 6 weeks. Modified Hastgawa Dementia i.p.). Gomisin A (5 mg/kg, p.o.) administration
Scale (HDS) and Wilson's Memory Scale (WMS) were significantly reversed scopolamine-induced cognitive
used to evaluate the patients' cogni-tive function, impairments in mice by the passive avoidance test and
memory ability and general conditions before and after the Y-maze test (P<0.05), and also improved escape
the treatment. Results: After the treatment, according to latency in the Morris water maze test at 5 mg/kg
HDS, of the 20 and 25 cases in medication and EA (P<0.05). Moreover, in an in vitro study, gomisin A was
groups, 1 (5%) and 4 (16%) experienced marked found to inhibit acetylcholinesterase activity in a dose-
improvement, 5 (25%) and 15 (60%) had moderate dependent manner (IC50 value; 15.5 microM). These
improvement, 10 (50% ) and 5 (20%) had mild results suggest that gomisin A may be a useful
improvement, and 4 (20%) and 1 (4%) had no cognitive impairment treatment, and its
im-provement, with the total effective rates being 80%
and 96% respectively. Rank test showed that the 312- gera: 142028/nd/re
therapeutic effect of EA group was significantly superior SPATIAL MEMORY PERFORMANCE AND
to that of medication group (P< O. 05) in improving HIPPOCAMPAL NEURON NUMBER IN
patients' cognitive function. Self-comparison indicated OSTEOPOROTIC SAMP6 MICE. LIU CZ, YU JC,
that WMS of both groups increased significantly after CHENG HY, JIANG ZG, LI T, ZHANG XZ, ZHANG LL,
the treatment ( P< 0.001, 0.05) , including adding test of HAN JX. experimental neurology. 2006;201(2): (eng).
long-term memory and touching test of short-term The senescence-accelerated mouse strain P6
memory in medication group, counting-down test of (SAMP6) is an inbred mouse that represents a clinically
long-term memory, association test and touching test of relevant model of senile osteoporosis. However,
short-term memory in EA group; and the effects of EA whether osteoporotic SAMP6 mice have cognitive
were apparently superior to those of medication in deficits remains largely unexplored. Here, we used
raising WMS (MQ) , counting-down test and association Morris water maze to assess reference memory and
test ( P< 0 . 05 , 0.01). Conclusion: The therapeutic working memory performance in SAMP6 mice and
effect of EA is sig-nificantly superior to that of Nimotop SAMR1 controls, at 4 and 8 months of age. In addition,
in improving DM patients' cognitive function, learning unbiased stereological techniques were used to
and estimate total neuron number in hippocampal CA1
subfield of the mice used in the behavioral study. Morris
310- gera: 141610/di/ra water maze test revealed impairments in working
THE INFLUENCES OF ELECTROACUPUNCTURE memory but not in reference memory of the 4- and 8-
ON LEARNING AND MEMORY AND CARBON month-old SAMP6 mice compared with the SAMR1
MONOXIDE IN THE PLASMA OF VD RATS. BING mice at the same age. However, there were no
YAN, NENGGUI XU AND HUAFENG PAN. significant differences in the total numbers of neurons in
international journal of clinical acupuncture. hippocampal CA1 subfield when comparing 4-month-
2006;14(3):173 (eng). old SAMR1 and 4-month-old SAMP6 and 8-month-old
Objective: To observe the effect of electroacupuncture SAMR1 and 8-month-old SAMP6, which indicate that, in
(EA) on learning and memory and carbon monoxide SAMP6 mice, the structural correlates of working
(CO) in the plasma of vascular dementia (VD) rats. memory deficits are to be found in parameters other
Method: The VD rats were modeled with the method of than the number of neurons in hippocampal CA1
global ischemia reperfusion by 4 vascular occlusions (4- subfield. These findings suggest that SAMP6 mice
vo). Morris water maze tests were used for a behavioral exhibit selective cognitive deficits and highlight the
study. The content of CO in the plasma was measured importance of this mouse model for studying the brain
by a two-wavelength spectrophotometer. Results: The alterations associated with osteoporosis.
model group animais required more escape time than
the control group and they did not swim longer in the 313- gera: 142095/di/ra
gera 2011
30
THE INFLUENCES OF ELECTROACUPUNCTURE AND MEMORY IN MID RATS]. WANG T, YU JC, LIU
ON LEARNING AND MEMORY AND CARBON CZ, ET AL. shanghai journal of acupuncture and
MONOXIDE IN THE PLASMA OF VD RATS. BING moxibustion. 2006;25(10):44 (chi).
YAN, NENGGUI XU,HUAFENG PAN. international Objective To investigate the improving effect of
journal of clinical acupuncture. 2006;14(3):173 (eng). acupuncture on spatial learning and memory in rats with
Objective: To observe the effect of electroacupuncture multiple in farcted dementia( MID). Methods A model of
(EA) on learning and memory and carbon monoxide MID was made by an injection of thrombus through
(CO) in the plasma of vascular dementia (VD) rats. external carotid retrocatheterism. Changes in spatial
Method: The VD rats were modeled with the method of learning and memory were determined by Morris water
global ischemia reperfusion by 4 vascular occlusions (4- maze. Morphological changes in the cortex and
vo). Morris water maze tests were used for a behavioral hippocampus were observed by HE staining. Results In
study. The content of CO in the plasma was measured MID rats, the cortical and hippocampal structures were
by a two-wavelength spectrophotometer. Results: The destroyed, which was more marked in hippocampal
model group animais required more escape time than areas CAI and CA3 ; disorders of spatial learning and
the control group and they did not swim longer in the memory occurred and they were manifested in poor
platform quadrant than in the others in the Morris water abilities in spatial learning, memory maintenance and
maze tests. The content of CO in the plasma was relearning, and prolongation of the learning course.
higher than the others. In the EA group, for the most Acupuncture could ameliorate the above conditions and
part, the animais cut down the escape time and swam improve MID rat' s abilities in, spatial learning and
longer in the platform quadrant than in the others. The memory. Conclusion Acupuncture improves MID rat' -s
content of CO in the plasma was obviously decreased. abilities in spatial learning and memory by reducing
Conclusion: EA can improve learning and memory and cortical and hippocampal injury to protect
it can also inhibit the increase of CO content in the
plasma of VD model rats. 316- gera: 143587/di/ra
USING REIKI TO DECREASE MEMORY AND
314- gera: 142112/nd/re BEHAVIOR PROBLEMS IN MILD COGNITIVE
RELEVANT ACTIVITIES OF EXTRACTS AND IMPAIRMENT AND MILD ALZHEIMER'S DISEASE.
CONSTITUENTS OF ANIMALS USED IN CRAWFORD SE, LEAVER VW, MAHONEY SD.
TRADITIONAL CHINESE MEDICINE FOR CENTRAL journal of alternative and complementary medicine.
NERVOUS SYSTEM EFFECTS ASSOCIATED WITH 2006;12(9):911-3 (eng).
ALZHEIMER'S DISEASE. REN Y, HOUGHTON P, OBJECTIVES: This empirical study explored the
HIDER RC. j pharm pharmacol. 2006;58(7): (eng). efficacy of using Reiki treatment to improve memory
The centipede Scolopendra subspinipes mutilans L. and behavior deficiencies in patients with mild cognitive
Koch ('Wugong'), the beetle Mylabris phalerata Pallas impairment or mild Alzheimer's disease. Reiki is an
('Ban mao') and the earthworm Pheretima aspergillum ancient hands-on healing technique reputedly
Chen ('DiLong') have a reputation in traditional Chinese developed in Tibet 2500 years ago. DESIGN: This
medicine for reducing symptoms of central nervous study was a quasi- experimental study comparing pre-
system decline, including memory loss. A series of and post-test scores of the Annotated Mini-Mental State
extracts of all three organisms was tested for Examination (AMMSE) and Revised Memory and
acetylcholinesterase (AChE) inhibition and copper ion Behavior Problems Checklist (RMBPC) after four
binding effects, the latter likely to reduce oxidative weekly treatments of Reiki to a control group.
damage caused by excess copper. The beetle and SETTINGS/LOCATION: The participants were treated
centipede chloroform extracts showed the strongest at a facility provided by the Pleasant Point Health
AChE inhibitory effects (30.6% inhibition at 105 microg Center on the Passamaquoddy Indian Reservation.
mL(-1) and 32.3% inhibition at 167 microg mL(-1), SUBJECTS: The sample included 24 participants
respectively) and, in the case of the centipede, this was scoring between 20 and 24 on the AMMSE.
traced to the unsaturated fatty acids present using Demographic characteristics of the sample included an
bioassay-guided fractionation. Cantharidin from the age range from 60 to 80, with 67% female, 46%
beetle was shown to have AChE activity (31% inhibition American Indian, and the remainder white.
at 1 muM, 0.196 microg mL(-1)), making it a major INTERVENTIONS: Twelve participants were exposed
contributor to the activity of the beetle extract. The to 4 weeks of weekly treatments of Reiki from two Reiki
earthworm showed no AChE inhibitory activity. Since Master-level practitioners; 12 participants served as
unsaturated fatty acids have not been previously controls and received no treatment. OUTCOME
reported to have AChE inhibitory activity, a series of MEASURES: The two groups were compared on pre-
related compounds was tested to determine structure- and post- treatment scores on the AMMSE and the
activity relationships. It was found that activity existed Revised Memory and Behavior Problems Checklist
where there was a chain length of more than 16 C (RMBPC). RESULTS: Results indicated statistically
atoms with at least one unsaturated bond in the chain. significant increases in mental functioning (as
The carboxylic acid group was also necessary for demonstrated by improved scores of the AMMSE) and
activity. The fatty acids present in the centipede also memory and behavior problems (as measured by the
showed the ability to bind copper ions when tested RMBPC) after Reiki treatment. This research adds to a
using a novel thin layer chromatography method very sparse database from empirical studies on Reiki
designed to detect copper-binding compounds. The results. CONCLUSION: The results indicate that Reiki
activities reported give some support to the use of the treatments show promise for improving certain behavior
beetle and centipede in traditional Chinese medicine for and memory problems in patients with mild cognitive
improving cognitive function. impairment or mild Alzheimer's disease. Caregivers can
administer Reiki at little or no cost, resulting in
315- gera: 143283/di/ra significant societal value by potentially reducing the
[THE INFLUENCE OF ACUPUNCTURE ON needs for medication and hospitalization.
PATHOMORPHOLOGY AND SPATIAL LEARNING
gera 2011
31
317- gera: 143611/di/ra galactose and bilater-al Meynert basal nuclei injections
[EFFECTS OF EAR POINT NEEDLE EMBEDDING of ibotenic acid (IBO) for destruction. Meanwhile,
THERAPY ON MEMORY DISORDER AND Baihui, Dazhui and Fengchi were acupunctured in the
EXPRESSION OF BETA-AMYLOID PROTEIN IN THE acupuncture group. A behavioral examination was
RAT OF VASCULAR DEMENTIA]]. LU YW, LU MZ. made by a Y-shaped electricity maze. Cellular
chinese acupuncture and moxibustion. apoptosis was determined by TUNEL. Results (1) Rat'
2006;26(11):804-8. (chi). learning and memory abilities were significantly lower in
OBJECTIVE: To study the mechanism of auricular the model group than in the blank control group (both P
acupuncture for improvement of learning and memory < 0.01) and significantly higher in the acupuncture
disorders in the rat of vascular dementia (VD). group than in the model group ( both P < 0. 01) . (2)
METHODS: The vascular dementia rat model was Large numbers of apoptosis cells were distributed in the
made by 4-vessel occlusion method. Four groups, a cerebral cortex and hippocampus in the model group of
sham operation group, a normal control group, a model rats, while few were in the acupuncture group. The
group and an auricular acupuncture group were set up. number of apoptosis cells in the cortex were
After acupuncture was given at auricular points, Brain significantly more in the model group (45.34 ± 6. 28)
and Kidney. Immunohistochemical analysis, than in the acupuncture group (20.39 ±5. 48) and in the
behavioural observation and computer image analysis blank control group (9.46 ±1. 86) ( both P < 0. 01) . The
were made. RESULTS: Auricular acupuncture could number of apoptosis cells in the hippo-campus were
decrease significantly the beta-amyloid protein (A beta) also significantly more in the model group (53.64 ± 8.
immunoreactivive neurons and increase its average 20) than in the acupuncture group (11. 38 ± 6. 36) and
optical density in the parietal cortex of the VD rats (P < in the blank control group (3.62 ±0. 89) ( both P < 0.01)
0.05). CONCLUSION: Auricular acupuncture can . The number of apoptosis cells in the cortex were also
reduce or inhibit the over-production of Abeta in the significantly more in the acupuncture group than in the
brain, so as to improve the learning and blank control group (P < 0. 01) . Conclusion
Acupuncture can reduced corticocerebral and
318- gera: 144836/ra/di hipp-ocampine neuron apoptosis to a certain extent and
[EFFECTS OF MODIFIED WUZI YANZONG thereby prevent a decline in learning and memory
GRANULE ON MEMORY ABILITY AND VOLUME OF abilities in a rat model of AD.
HIPPOCAMPUS MEASURED BY MRI IN PATIENTS
WITH MILD COGNITIVE IMPAIRMENT]. FU H, WANG 320- gera: 145743/di/ra
XM, LIU GX. chinese journal of integrated traditional MECHANISM OF ELECTROACUPUNCTURE ON
and western medicine. 2006;26(12):1066 (eng). SYNAPTIC PLASTICITY OF HIPPOCAMPAL
OBJECTIVE: To observe the effect of modified Wuzi NEURONS IN ALZHEIMER DISEASED RATS. SONG
Yanzong Granule (WYG) on memory ability and volume LUO, SHU-GUANG YU, FANGZHENG LIAO, AND
of hippocampus measured by magnetic resonance TING international journal of clinical acupuncture.
imaging (MRI) in patients with mild cognitive impairment 2006;15(4):241 (eng).
(MCI). METHODS: According to the international Background: Electroacupuncture (EA) has a good
accepted diagnostic criteria, 36 MCI patients were clinical effect on Alzheimer's disease, but its
selected and randomly assigned to two groups equally, mechanism remains unclear.Objective: To observe the
the treated group treated with WYG and the control effect of EA on the number of synaptic numeric density
group with placebo, with a course of 3 months for both (Nv), surface density (Sv) and average size of the
groups. Besides, 20 healthy subjects were selected as synaptic junction and ultrastructure in the hippocampal
the normal group. The changes of memory ability were CA3 area of neurons of model rats with Alzheimer's
observed and the volume of hippocampus was detected disease (AD).Design: Completely randomized grouping
by MRI before and after treatment. RESULTS: Memory and controlled study.Setting: Department of Traditional
quotient (MQ) was significantly lower in MCI patients Chinese Medicine of Sichuan Provincial People's
than in healthy subjects (P < 0.01), after treatment it Hospital; College of Acupuncture & Moxibustion and
increased in the treated group as compared with that Massage of Chengdu University of Traditional Chinese
before treatment (P < 0.01), and the increment was Medicine.Materials: A total of 50 male SD rats (24-
higher than that in the control group (P < 0.05); the months old, weighing 480±20 g) and 6 male rats (3-
volume of hippocampus, total or that of either side, as months old, weighing 250±15 g) were selected in this
well as the increment of the total volume of study. A passage water maze (2.1 x 1.7 X 0.6) m3 was
hippocampus in the treated group were all higher than constructed of black glass with 4 inlets and filled to a 40
those in the control group (P < 0.05). CONCLUSION: cm depth with water. A Brain Tridimensional Localizer
WYG could improve memory ability in MCI patients and and WQ1002F Hans electrically heated distilling
could apparatus were used.Methods: The experiment was
carried out at the Grade III Animal Experimental Center
319- gera: 145256/di/ra of Chengdu University of Traditional Chinese Medicine
[THE INFLUENCE OF ACUPUNCTURE ON NEURON between September 2002 and June 2003.The older SD
APOPTOSIS IN A RAT MODEL OF ALZHEIMER rats were grouped on the basis of water-maze test
DISEASE]. JIANG GUI-MEI , JIA CHAO LAIAIN- results. First, 6 young rats were subjected to the water-
SHENG. shanghai journal of acupuncture and maze test 8 days before modeling for 4 consecutive
moxibustion. 2006;25(12):33 (chi). days to obtain an average escape latency. Second, 50
[ Abstract] Objective To observe corticocerebral and older rats were subjected to the water-maze test for 4
hippocampine neuron apoptosis in a rat model of consecutive days before modeling to obtain an average
Alzheimer disease (AD ) and investigate the influence escape latency. A total of 36 rats whose latencies were
of acupuncture on the neuron apoptosis. Methods SD less than the average values plus one standard
rats were randomly allocated to blank control, model deviation of young rats were regarded as normal old
and acupuncture groups. A model of AD was made by a rats. Among them, 12 rats were randomly divided into a
combination of an peritoneal injection of 0.96% D- control group and a sham operation group with 6 in
gera 2011
32
each group. Another 24 rats were transected at the TCM's value in treating VD. Method: The VD model rats
fornix-fimbria for AD modeling. Third, 24 modeled rats were made following the method of global ischemia
were subjected to the water-maze test 2 days after reperfusion by 4 vascular occlusion (4-vo). Morris water
modeling. .i%aw whose latencies flTVl more luau Luc tests were used for a behavioral study. The TXB2 and
average value plus two standard deviations of young 6-keto-PGF1a in plasma was estimated by
rats were chosen as the AD model. Twelve AD models radioimmunoassay. Results: The rats in the model
were randomly divided into the model group and the EA group had lesser learning and memory capability
group with 6 in each group.On the 6th day after compared with those in the control group. They needed
modeling, the rats in the EA group were needled at more time to escape, and they did not swim as long in
Baihui (DU 20) to a 0.5 inch depth and at Yongquan (KI the platform quadrant as the other quadrants in the
1), Taixi (KI 3) and Xuehai (SP 10) to a 0.3 inch in Morris water maze tests. The plasma content of TXB2
depth with No. 30 milli-needles (3.33 cm). The increased and the plasma content of 6-keto-PGFIa,
electrically heated distilling apparatus was used with decreased. The rats in the EA group only required less
successive waves (20 Hz in frequency and 2-4 V in time to escape than those in the model group and they
voltage). The level of stress tolerated by the rats in a swam longer in the platform quadrant than in other
quiet state was regarded as the standard value (2 mA). quadrants. Compared with the model group, the plasma
The needle was retained for 30 minutes and the content of TXB2 decreased and the plasma content of
acupuncture was done once a day for a total of 20 6-keto- PGF1at, increased. Conclusion: EA can
successive days. For the rats in the control group and improve the learning and memory capability of VD rats
sham operation group, the cerebral cortex was exposed and it can also inhibit the increase in the plasma
at the same site as in the model rats and the fornix- content of TXB2 and promote the increase in plasma
fimbria was not removed and the rats in the model content of 6-keto-PGFIa.
group were only fixed and not treated.After treatment,
the ultrastructure in the hippocampal CA3 area of the 322- gera: 145891/di/ra
rats was observed with a transmission electron EFFECTS OF SHENLONG DECOCTION ON
microscope. The synapse numbers and cross-point LEARNING AND MEMORY ABILITIES AS WELL AS
numbers between synaptic junction and test lines were SOD AND MDA IN BRAIN-AGING MODEL MICE
counted with the stereological technique. The INDUCED BY D-GALACTOSE. LIU YI, WANG FAWEI,
stereological parameters, such as numeric density (Nv), YANG MINGHUI, ET AL. journal of traditional
surface are (Sv) and average size of synaptic junction, chinese medicine. 2006;26(4):294 (eng).
which could reflect plastic changes of synaptic form, Brain aging (dementia) model mice were made by
were calculated at the same time.Differences between cervical subcutaneous injection of D-galactose solution.
the two groups were compared with a t test at regular Learning and memory abilities were detected with water
variance and a t test at irregular variance.Main maze test and superoxide dismulase(SOD) activities
Outcome Measures: Comparisons of numeric density and malondiadehyde (MDA) contents in the liver and
(Nv), surface density (Sv) and average size of synaptic brain were determined after intragastrical administration
junction.Results: A total of 24 older rats were involved of Shenlong Decoction (Ji) for 6 weeks. The results
in the final analysis with 6 in each group.Ultrastructure: indicated that the swimming time was shortened and
The synaptic density of the control and sham operation the correct swimming times increased, SOD activity
groups was higher than that of the model group and the raised and MDA content decreased in the three
average area of the synapse was smaller. The synaptic Shenlong Decoction groups with different doses as
density of the EA group increased compared with that compared with the model group. It is concluded that
of the model group and the average area of the Shenlong Decoction has the effects of anti-free radical
synapse was smaller.The numeric density and surface injuries and improving the learning and memory abilities
density in the hippocampal CA3 area in the model and of the brain-aging mice
EA groups were lower than those of the control group
and sham operation group (P < 0.05). There was no 323- gera: 144594/di/ra
significant difference between the sham operation [CLINICAL STUDY OF REINHARTDT AND SEA
group and the control group (P> 0.05) and those of the CUCUMBER CAPSULE COMBINED WITH
EA group were higher than those of the model group DONEPEZIL IN TREATING ALZHEIMER'S DISEASE].
(P<0.01).The average size of the synaptic junction in ZHOU ZL, LIANG LZ, YAN YX. chinese journal of
the hippocampal CA3 of the model and EA groups was integrated traditional and western medicine.
higher than that of the control group and the sham 2007;27(2):110 (eng).
operation group (P <0.05). There was no significant OBJECTIVE: To study the efficacy and safety of
difference between the sham operation group and the Reinhartdt and sea cucumber capsule (RSC) combined
control group (P> with donepezil in treating Alzheimer's disease (AD), and
its effect on thyroid function axis. METHODS: Sixty-
321- gera: 145744/di/ra eight patients were randomly assigned to the RSC
THE INFLUENCE OF ELECTROACUPUNCTURE ON group, the Donepezil group and the combined treatment
LEARNING AND MEMORY AND THE PLASMA group, who were treated for 3 and 6 months with RSC,
CONTENT OF TXB2 AND 6-KETO-PGF,A OF RATS Donepezil and RSC combined with Donepezil,
WITH VASCULAR DEMENTIA. LILEI HE, BING YAN, respectively. The curative effect was evaluated by
CHUNZHI TANG, AND YING SHAO. international scoring according to Mini-Mental State Examination
journal of clinical acupuncture. 2006;15(4):249 (eng). (MMSE), ADAS-Cog and ADL chart, and the level of
Objective: To observe the influence of thyroid hormones, including TSH, FT3, FT4, TT3 and
electroacupuncture (EA) on learning and memory as TT4, were measured with radioimmunoassay before
well as the plasma content of TXB2 and 6-keto-PGF1a treatment, 3 and 6 months after treatment respectively.
of rats with vascular dementia (VD). Also, to discuss the RESULTS: As compared with the baseline, MMSE
mechanism of EA treatment on VI) and offer favorable score increased, ADAS-Cog score and ADL score
conditions to use this method clinically and to illustrate decreased significantly in all the three groups after 3
gera 2011
33
months and 6 months of treatment (P < 0.05 and P < memory in rats using an eight-arm radial maze task.
0.01), but the improvement in the combined treatment Scopolamine (0.5 mg/kg, i.p.), a non-selective
group was more significant than that in the other two muscarinic receptor antagonist, and Delta(9)-
groups (P < 0.01). After 6 months of treatment, the tetrahydrocannabinol (THC; 6 mg/kg, i.p.), a principal
levels of FT3 and FT4 in the combined treatment group psychoactive component of marihuana, each markedly
were significantly changed (P < 0.01), but no significant impaired the spatial memory. KKT (1 and 3 mg/kg, p.o.)
change in all the thyroid hormones was found in the significantly improved the scopolamine-induced
other two groups. No obvious adverse reaction impairment of spatial memory. KKT (30 mg/kg, p.o.)
occurred in all the three groups. CONCLUSION: RSC also improved significantly the THC- induced
combined with Donepezil in treating AD is effective and impairment of spatial memory. Moreover, KKT (3 and
safe with no evident adverse reaction, better than single 30 mg/kg, p.o.) enhanced tremors induced by
drug treatment, which may be through influencing the oxotremorine, a muscarinic M(1) receptor agonist.
metabolism of thyroid hormones to improve the Taken together these findings suggest that KKT is a
cognition function of AD patients. useful drug for treating memory deficits. Copyright (c)
2006 John Wiley & Sons, Ltd.
324- gera: 145413/di/ra
ENHANCEMENT OF LEARNING AND MEMORY BY 326- gera: 145843/di/ra
A MEDICINAL FORMULATION, SAENHYETANG, IN [[EFFECTS OF "WARMTH-PRODUCING NEEDLING
MICE. JIN UH, KIM JH, CHANG GT, KIM JK, CHUNG FOR REMOVING OBSTRUCTION" ON
KH, KIM CH. j ethnopharmacol. 2007;109(2):271-80 HIPP-OCAMPAL MORPHOLOGICAL CHANGES AND
(eng). LEARNING-MEMORY ABILITIES IN VASCULAR
The effects on memory and learning ability of the DEMENTIA RATS]]. YANG XIAO-BO, KOU SUO-
Korean herbal medicine, Saenhyetang (SHT), which is TANG, YANG XIAO-BIN , ET AL. acupuncture
consisted of nine herbs, were investigated. Hot water research. 2007;32(1):29 (chi).
extracts (HWE-SHT) and ethanol extracts (EE-SHT) To observe the effects of "Warmth-producing Needling
were used for the studies. It was shown that N-methyl- for Removing Obstruction" (WPNRO) on the
d-aspartate (NMDA) receptor 2B (NR2B) was increased pathomorphological changes of brain and learning-
in the forebrains of SHT- administrated mice (HWE- memory abilities in vascular dementia (VD) rats.
SHT), leading to enhanced activation of NMDA Methods: A total of 50 Wistar rats were randomly
receptors, facilitating synaptic potentiation in response divided into normal control, model, medication, needle-
to stimulation at 10-100Hz. These HWE-SHT-treated twirling, and WPNRO groups, with 10 cases in each
mice exhibit superior ability in learning and memory in group. VD model was established by repeated cerebral
various behavioral tasks, showing that NR2B is ischemia-reperfusion via repeated occlusion of the
enhanced by HWE-SHT treatment and also is critical in bilateral common carotid arteries under anesthesia (3%
gating the age-dependent threshold for plasticity and embutal 40 mg/kg, i. p.) . "Dazhui" (GV 14) ,
memory formation. NMDA receptor-dependent "Baihui"(GV 20) and "Shuigou"(GV 26) were punctured
modifications, which were mediated in part by HWE- with filiform needles and stimulated with twirling
SHT administration, of synaptic efficacy, therefore, technique and WPNRO technique respectively and
represent a mechanism for associative learning and continuously for 1 min. Animals of medication group
memory. Results suggest that oriental medical were fed with Nimodipine (0. 0108 g/kg). The treatment
enhancement of NR2B attributes such as intelligence was conducted once daily continu-ously for 15 days.
and memory in mammals is feasible. On the other The rats' learning and memory results were detected
hand, to examine the effects of EE-SHT on the learning respectively with step-down avoidance test in the first 6
and memory in experimental mice, the passive and days' training and 24 h later. At the end of experiments
active avoidance responses were studied. The EE-SHT and after decapitation, the right brain was taken, cut
ameliorated the memory retrieval deficit induced by into sections (5 pm) and stained with H & E method for
ethanol, but not other memory impairment in mice. EE- observing structural changes of hippocampus. Results:
SHT (10, 20mg/100g, p.o.) did not affect the passive 1) Behavior reactions: compared withcontrol group, the
avoidance responses of normal mice in the step latency for finding the safe platform and the times of
through and step down tests, the conditioned and error in model group increased significantly. and
unconditioned avoidance responses of normal mice in compared with model group. both latencies and times of
the shuttle box and lever press performance tests, and error in WPNRO, needle-twirling and medication groups
the ambulatory activity of normal mice in normal decreased considerably (P<0. 05, 0. 01) . In
condition. However, EE-SHT was shown to significantly comparison with needle-twirling group, both latencies
decrease the spontaneous motor activity during the and times of error in WPNRO group were significantly
shuttle box test, and also to prolong the sleeping time fewer (P<0. 05, 0. 01) , and no significant differences
induced by pentobarbital in mice at 20mg/kg. These were found between WPNRO and medication groups in
results suggest that EE-SHT has an ameliorating effect these two indexes (P>0.05). It indicated that
on memory retrieval impairment and a weak acupuncture particularly WPNRO could improve both
tranquilizing action. learning and memory abilities in VD rats. 2) Structural
changes of neurons in CA1 region of hippocampus: in
325- gera: 145555/nd/ra normal group, the neurons arranged in order and
KAMIKIHI-TO, A KAMPO MEDICINE, closely, and were normal in the structure; in model
AMELIORATES IMPAIRMENT OF SPATIAL group. the neurons arranged obviously in disorder, had
MEMORY IN RATS. EGASHIRA N, MANOME N, karyopyknosis and hyperplasia in glial cells and
KURAUCHI K, MATSUMOTO Y, IWASAKI K, MISHIMA decreased in the number. In WPNRO group, no evident
K, SHOYAMA Y, FUJIWARA M. phytother res. cellular karyopyknosis or hyperplasia of glial cells was
2007;21(2):126-9 (eng). found, and the structure and number of cells were close
The present study investigated the effects of Kamikihi- to those of normal group. In acupuncture and
to (KKT), a Kampo medicine, on impairment of spatial medication groups, fewer neurons, cellular
gera 2011
34
karyopyknosis and hyperplasia of more glial cells were high dose TCA (P<0.05); during the spatial probe trial
found. Conclusion: "Warming-producing Needling for on the fifth day, the rats in the model group took shorter
Removing Obstruction" can significantly relieve cerebral searching time and distance on the previous flat area
ischemia induced disturbance of learning and memory than those in the control group (P<0.01), which could
and lessen structural injury of be prolonged after TCA treatment (for low dose group,
P<0.05; for high dose group, P<0.01). (2) Analysis of
327- gera: 145861/di/ra cerebral cortical tissues showed that, compared with
[EFFECT OF ELECTROACUPUNCTURE ON the control group, MDA level got significantly increased
CHANGES OF AMINO ACID NEUROTRANSMITTERS and Mn-SOD activity decreased in the model group
IN THE HIPPOCAMPUS OF RATS WITH SPATIAL (both P<0.01). After having been treated with TCA, the
LEARNING AND MEMORY IMPAIRMENT INDUCED MDA level got significantly decreased (P<0.05 and
BY D-GALACTOSE ]. XU YING' , ZHANG ZHI-XIONG' P<0.01 respectively for low and high dose group), while
, SHEN RONG2 , YUAN SHU- JUAN2. shanghai relative increase of Mn-SOD activity only appeared in
journal of acupuncture and moxibustion. high dose group (P<0.05). (3) Immunohistochemistry
2007;26(3):38 (chi). analysis showed the protein expression of NF- kappa B
Objective To investigate the effect of got significantly increased after modeling, while high
electroacupuncture on D-galactose induced spatial dose TCA can significantly inhibit it. CONCLUSION:
learning and memory impair-ment in rats, and to study TCA could improve A beta 25-35 induced dysfunction of
the mechanism of electroacupuncture on amino acid learning and memory in rats, and its protective
neurotransmitters in the hippocampus tissue of rats with mechanism is associated with its actions in decreasing
spatial learning and memory impairment. Methods 24 MDA level, increasing Mn-SOD activity
rats were randomly divided into control group ( n = 8) ,
model group ( n = 8) and electroacupuncture group( n 329- gera: 146565/di/ra
=8). HPLC was used to measure the contents of amino [EFFECT OF ACUPUNCTURE ON LEARNING-
acid neurotransmitters in the hippocampus tis-sue. MEMORY ABILITY IN DIABETIC RATS WITH
Results Contents of Asp , Tau and GABA in the model CONCOMITANT CEREBRAL ISCHEMIA-
group were significantly decreased as compared with REPERFUSION INJURY]. JING XH, CAI H, SHI H,
the control group( P < 0.05) , content of Gly decreased CHEN SL, LU B, JIN ZG. acupuncture research.
too, but showed no significant difference. After applying 2007;32(2):105-10 (chi).
electroacupuncture, contents of Asp, Gly , and Tau OBJECTIVE: To observe the effect of acupuncture on
increased significantly(P <0. 05). Content of Glu learning and memory ability in rats with cognition
increased in the model group and was more higher in impairment due to diabetes mellitus (DM) and cerebral
the electroacupuncture group (P <0.05). Conclusion ischemia (CI)/reperfusion injury (CI/RI). METHODS: A
Electroacupuncture could regulate effectively the total of 87 female Wistar rats were randomly divided
contents of amino acid neurotransmitters in rat' s into 5 groups: normal control, CI, DM+ sham-CI, DM+CI
hippocampus with spatial learning and memory and DM+ CI+ acupuncture (Acup). DM model was
impairment induced by D- induced by intraperitoneal injection of streptozotocin (60
mg/kg), and 3 days later CL/RI was duplicated by
328- gera: 146505/nd/ra occlusion of the bilateral carotid arteries and
PROTECTIVE EFFECTS AND MECHANISM OF reperfusion in the same rats. "Baihui" (GV 20), bilateral
TOTAL COPTIS ALKALOIDS ON A BETA 25-35 "Sanyinjiao" (SP 6), "Pishu" (BL 20), or GV20, bilateral
INDUCED LEARNING AND MEMORY DYSFUNCTION "Shenshu" (BL 23) and "Zusanli" (ST 36) were
IN RATS. YANG ZQ, YANG SF, YANG JQ, ZHOU QX, punctured alternatively with filiform needles and
LI SL. chin j integr med. 2007;13(1):50-54 (eng). stimulated manually. On day 10 and 30 after CI, the
OBJECTIVE: To observe the effect of total coptis rats' learning-memory ability was detected by using
alkaloids (TCA) on beta -amyloid peptide (A beta 25-35) step-down passive and active avoidance tests or Morris
induced learning and memory dysfunction in rats, and water maze test. At the end of the experiments, the
to explore its mechanism. METHODS: Forty male animals anesthetized under 12% urethane (1 g/kg)
Wistar rats were randomly divided into four groups: the were transcardially perfused with PBS fluid containing
control group, the model group, the TCA low dose (60 4% paraform for sampling the brain tissue containing
mg/kg) group and the TCA high dose (120 mg/kg) hippocampus region which was cut into sections (40
group, 10 in each. A beta 25-35 (5microl, 2 microm) and stained with hematoxylin and eosin (H& E)
microg/microl) was injected into bilateral hippocampi of method for observing morphological changes of the
each rat to induce learning and memory dysfunction. hippocampus under light microscope. RESULTS: After
TCA were administered through intragavage for electrical shock stimulation, the latencies of step-down
consecutive 15 days. Morris Water Maze test was used passive avoidance in DM + CI group at 15 min and 24 h
to assess the impairment of learning and memory; shortened significantly in comparison with control, CI,
concentration of malondialdehyde (MDA) in cerebral DM + sham-CI and DM+ CI+ Acup groups (P < 0.05,
cortex was determined by thiobarbituric acid reactive 0.01). Compared with DM + CI group, the avoidance
substance to indicate the level of lipid peroxidation in latency of DM + CI + Acup increased significantly (P <
brain tissues; activity of manganese-superoxide 0.05). In active avoidance test, the training times for
dismutase (Mn-SOD) in cerebral cortex was determined rats to learn making active avoidance reaction in DM +
by xanthine-oxidase to indicate the activity of the CI group were significantly more than those in DM +
enzyme; and NF- kappa B protein expression in sham-CI, CL and DM + CI + Acup groups (P < 0.001),
cerebral cortex was measured by SP the active avoidance correction rate of DM + CI group
immunohistochemistry. RESULTS: (1) Morris Water decreased significantly in comparison with the other 4
Maze test showed that, during the 4 consecutive days groups (P < 0.01), while these two indexes of DM+ CI+
of acquisition trials, the rats in the model group took Acup group were markedly superior to those of DM + CI
longer latency and searching distance than those in the group (P < 0.05). In comparison with DM + CI group,
control group (P<0.01), which could be shortened by the percentages of swimming time and swimming
gera 2011
35
gera 2011
36
gera 2011
37
340- gera: 149715/di/ra on passive avoidance tasks in mice. This result was the
EFFECTS OF ELECTROACUPUNCTURE ON same as the previous study. The active constituents
PLASMA AND CEREBRAL SOMATOSTATIN AND which enhanced the memory acquisition were
13-EP CONTENTS AND LEARNING-MEMORY discovered in the butanol layer and ethyl acetate layer
ABILITY IN VASCULAR DEMENTIA RATS. SHAO after the extraction.
YING, LAI XIN-SHENG , GONG YU-ZHAO,ET EL.
acupuncture research. 2008;33(2):98 (chi). 342- gera: 149927/di/ra
Objective To observe the effect of electroacupuncture [EFFECT AND MECHANISM OF JIANNAO YIZHI
(EA) on learning-memory ability of vascular dementia DECOCTION ON LEARNING AND MEMORY IN RATS
(VD) rats, and the simultaneous changes of plasma and WITH SIMILAR ALZHEIMER'S DISEASE]. ZHANG SL,
cerebral somatostatin (SS) and (3-endorphin (EP) YANG XJ, LIU TF, ET AL. chinese journal of
contents. Methods Forty-one SD rats were randomly integrated traditional and western medicine.
divided into control (n = 8) , model A (n = 8, no 2008;28(6):529 (chi).
treatment) and B •(n =8, intragastric perfusion of 15% OBJECTIVE: To observe the effect of Jiannao Yizhi
saline) , EA (n=9) and medication (n=8, intragastric Decoction (JNYZD) on learning and memory in rats with
perfusion of Nimoldipine, 12 mg/kg) groups. VD model similar Alzheimer's disease (AD), and to investigate its
was established by using modified 4-vessels occlusion possible mechanism. METHODS: The composite AD
method. EA (150 Hz, 1— 2 mA) was applied to "Baihui" rat model was established by injecting aggregated
( GV 20), "Dazhui" (DU 14) , "Pishu" (BL 20) and Abeta25-35 into the lateral cerebral ventricle of senile
"Shenshu" (BL 23) for 20 min, once daily for 15 days. rats, and all the modeled rats were divided into 5
Morris water maze tests were conducted for evaluating groups, the model group, the Donepezil group, the high-
the rats' learning-memory ability. The contents of SS , middle-, and low- dose JNYZD group. All rats, except
and 13-EP in plasma and brain tissue were measured those in the model group, were treated respectively with
by radioimmunoassay (RIA). Results In comparison Donepezil and JNYZD at the daily dose of 0.525 mg/kg,
with sham-operation group, the escape latency (EL) 42.4 g/kg, 21.2 g/kg, 10.6 g/kg for 21 days. The ability
prolonged significantly and the target-platform crossing of learning and memory of rats in different groups was
times decreased remarkably ( P<O. 01) in model group tested using Morris water maze, and the activity of
B. In comparison with model group B, EL shortened and acetylcholine esterase (AchE) and butyrocholin
target- platform crossing times increased both esterase (BehE) in serum were determined, too.
significantly in EA and medication groups ( P<0. 01). RESULTS: The escape latent period was shorter in all
Plasma and cerebral SS, and cerebral 13-EP contents medicated group than in the model group (P<0.01 or
of model groups A and B were significantly lower than P<0.05), and it was insignificantly different among all
those of sham-operation group( P<O. 01)9 while medicated groups (P>0.05). A decreasing trend of
plasma 13-EP level had no obvious change ( P>0. 05). AchE and BchE activity presented in the high- and
Plasma and cerebral SS, and cerebral p-EP contents in middle-dose JNYZD groups, but insignificant difference
both EA and medication groups were considerably was shown as compared these indexes respectively
higher than those in model groups A and B ( P<0. 01). with those in the Donepezil group. Furthermore, the
No significant differences were found between EA and improvement of learning and memory in similar AD rats
medication groups in EL, target-platform crossing times, was insignificantly different between the Donepezil
plasma and cerebral SS and 13-EP levels, and group and the JNYZD groups (P>0.05). CONCLUSION:
betweenW*IBIA5T, 2008 4 A M33t sR2nj • 99 • model JNYZD can improve the learning and memory ability of
group A and model group B in plasma and cerebral SS similar AD rats by influencing the activity of
and (3-EP levels ( P>0. 05). Conclusion EA can raise cholinesterase.
plasma and cerebral SS and cerebral (3-EP levels, and
improve the learning-memory ability in VD rats. 343- gera: 149964/di/ra
PANAX NOTOGINSENG BURK ATTENUATES
341- gera: 149799/di/ra IMPAIRMENT OF LEARNING AND MEMORY
EFFECT OF TIANMA GOUTENG DECOCTION WITH FUNCTIONS AND INCREASES ED1, BDNF AND
SUBTRACTIVE INGREDIENTS AND ITS ACTIVE BETA-SECRETASE IMMUNOREACTIVE CELLS IN
CONSTITUENTS ON MEMORY ACQUISITION. HO CHRONIC STAGE ISCHEMIA- REPERFUSION
SC, HO YF, LAI TH, LIU TH, SU SY, WU RY. the INJURED RATS. CHUANG CM, HSIEH CL, LIN HY,
american journal of chinese medicine. LIN JG. the american journal of chinese medicine.
2008;36(3):593 (eng). 2008;36(4):685 (eng).
Accumulating evidence indicates that the high blood Panax Notoginseng Burk (PN) has been reported to
pressure (BP) is a potent risk factor for dementia in the improve blood circulation, as well as learning and
elderly. In line with this theory, we had found the memory functions. The purpose of the present study
mixture of Chinese herbs (TGD) which were traditionally was to investigate the effect of PN on learning and
used to treat hypertension, could enhance the cognitive memory functions in chronic cerebral infarct rats. A
function. The aim of this study was to decrease the cerebral infarct animal model was established by
number of herbs used from 11 (TGD) to 4 herbs blocking the blood flow of both common carotid arteries
(TGDS) and further to search the active constituents. and right middle cerebral artery for 90 min followed by
After administering a dose of 10 g/kg of TGDS0 to ICR reperfusion for 4 weeks. PN (0.5 g/kg) was
mice, no cholinergic symptoms of lacrimation, administered orally 3 days per week for 4 weeks,
salivation, emesis, eyeclosure, increased respiration whereas the control group provided bait and water only.
and fibrillation were observed. All the mice survived The learning and memory functions were estimated by
without any deaths after 24 hours and 7 days. No measuring how successful rats were able to negotiate
changes were observed in control and experimental an 8- arm radial maze test; the test was performed after
groups on locomotor activity (no stimulant or sedative operation once a week for 4 weeks. Finally, the rats
effects). It was also revealed that TGDS could prolong were sacrificed and their brains were removed. The
the step-through latency at the dose of 1.0 and 2.5 g/kg brains were sectioned and analyzed for ED1, glial
gera 2011
38
fibrillary acid protein (GFAP), nuclear factor-kappaB, increased the step-down latency in passive avoidance
and brain derivative neurotrophin factor (BDNF) and test and accurate rate in active avoidance test,
beta-secretase by immunostaining. Cerebral infarct rats decreased the escape latency in Morris water maze.
given PN were able to successfully navigate the 8-arm After electroacupuncture treatment, the long-term
radial maze test four weeks after cerebral infarction. PN potentiation (LTP) impaired by both diabetes and
also increased ED1, BDNF and beta-secretase cerebral ischemia was restored significantly. These
immunoreactive cells, but did not increase GFAP and results suggest that electroacupuncture can ameliorate
NF-kappaB immunoreactive cells. PN attenuated the learning and memory capacity impaired by
reduction in learning and memory functions induced by hyperglycemia and ischemia. LTP
cerebral infarction in cerebral ischemia-reperfusion
injured rats; it also increased the amount of activated 347- gera: 150241/di/re
microglia and BDNF. These data suggest that the effect ELECTROACUPUNCTURE RESTORES LEARNING
of PN, at least in part, is closely related to the increase AND MEMORY IMPAIRMENT INDUCED BY BOTH
in BDNF that was generated by activated microglia. The DIABETES MELLITUS AND CEREBRAL ISCHEMIA
effect that PN has on astrocytes, NF-kappaB and beta- IN RATS. JING XH, CHEN SL, SHI H, CAI H, JIN ZG.
secreatase immunoreactive cells requires further study. neurosci lett. 2008;aug 3:x (eng).
Previous investigations have demonstrated that
344- gera: 150062/nd/ra electroacupunctural stimulation can ameliorate primary
CHINESE HERBAL MEDICINE FOR MILD and secondary symptoms such as peripheral
COGNITIVE IMPAIRMENT AND AGE ASSOCIATED neuropathy and diabetic encephalopathy in diabetic
MEMORY IMPAIRMENT: A REVIEW OF rats. In this study, we investigated whether
RANDOMISED CONTROLLED TRIALS. MAY BH, electroacupuncture could improve learning and memory
YANG AW, ZHANG AL, OWENS MD, BENNETT L, which was typically impaired in diabetic rats with
HEAD R, COBIAC L, LI CG, HUGEL H, STORY DF, cerebral ischemia. Furthermore, we investigated the
XUE CC. biogerontology. 2008;aug 21:x (eng). mechanisms underlying its effects using passive
This review assesses the effectiveness and safety of avoidance test, active avoidance test, Morris water
Chinese herbal medicines (CHM) for Mild Cognitive maze and electrophysiology. Electroacupuncture
Impairment (MCI) and Age Associated Memory increased the step-down latency in passive avoidance
Impairment (AAMI). Electronic searches of English and test and accurate rate in active avoidance test,
Chinese databases and hand searches of Chinese decreased the escape latency in Morris water maze.
journal holdings were conducted. Randomised After electroacupuncture treatment, the long-term
controlled trials comparing orally administered CHM potentiation (LTP) impaired by both diabetes and
with placebo, no intervention or other therapy were cerebral ischemia was restored significantly. These
considered. Ginkgo biloba was excluded. Ten trials met results suggest that electroacupuncture can ameliorate
inclusion criteria. Eight different CHM were investigated. learning and memory capacity impaired by
Methodological quality was assessed using the Jadad hyperglycemia and ischemia. LTP
scale and five studies scored three or above. Two
studies compared CHM with placebo and eight with 348- gera: 150278/di/ra
another intervention. This review found an overall TAI CHI CHUAN IN THE MANAGEMENT OF
benefit on some outcome measures for the eight CHMs PARKINSON'S DISEASE AND ALZHEIMER'S
involved in the 10 RCTs but methodological and data DISEASE. KLEIN PJ. med sport sci. 2008;52:173-81
reporting issues were evident. Meta-analysis of three (eng).
studies found the effects of the CHMs were at least BACKGROUND: Parkinson's disease (PD) and
equivalent to piracetam on Mini-Mental State Alzheimer's disease (ALZ) represent later-life onset
Examination neurodegenerative disorders that gradually rob those
afflicted of their quality of life. PURPOSE: This chapter
345- gera: 150071/nd/ra offers practice-based recommendations on how
KIHI-TO, A HERBAL TRADITIONAL MEDICINE, instruction and practice of Tai Chi Chuan (TCC) can be
IMPROVES ABETA(25-35)-INDUCED MEMORY adapted for individuals with PD and those with ALZ.
IMPAIRMENT AND LOSSES OF NEURITES AND RESEARCH EVIDENCE: Practice of TCC is widely
SYNAPSES. TOHDA C, NAITO R, JOYASHIKI E. bmc advocated as an exercise option in PD; however, little
complement altern med. 2008;8(1):49 (eng). validating research exists. Even less is known about
feasibility of applications of TCC for individuals with
346- gera: 150236/co/ra ALZ. CLINICAL IMPRESSIONS: The slow, rhythmic
ELECTROACUPUNCTURE RESTORES LEARNING pace of functionally based exercises, internal organ
AND MEMORY IMPAIRMENT INDUCED BY BOTH stimulation, flexibility maintenance, balance-training
DIABETES MELLITUS AND CEREBRAL ISCHEMIA effects, and general health benefits of TCC and Tai Chi-
IN RATS. JING XH, CHEN SL, SHI H, CAI H, JIN ZG. like exercise practice have clinical relevance for both
neurosci lett. 2008;aug 3:x (eng). conditions. Falls prevention, tremor reduction and motor
Previous investigations have demonstrated that control may be of most importance in management of
electroacupunctural stimulation can ameliorate primary PD. Behavioral and general health benefits as well as
and secondary symptoms such as peripheral slowing of functional and cognitive decline are
neuropathy and diabetic encephalopathy in diabetic considerations with ALZ. RECOMMENDATIONS:
rats. In this study, we investigated whether Strategies of exercise adaptation include use of Tai Chi-
electroacupuncture could improve learning and memory like exercise for individuals with ALZ and those in
which was typically impaired in diabetic rats with middle or late stages of PD as well as providing
cerebral ischemia. Furthermore, we investigated the instructional resources and training for caregivers and
mechanisms underlying its effects using passive exercise aides to facilitate practice as a part of daily life.
avoidance test, active avoidance test, Morris water
maze and electrophysiology. Electroacupuncture 349- gera: 150353/nd/ra
gera 2011
39
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40
addition, BWS significantly increased spine synapse Cog decreased in the test group (P < 0.01) and
density. CONCLUSIONS: These results suggested that increased in the control group (P < 0.05), showing
BWS could improve cognitive ability of menopause- statistical significance between the two groups (P <
induced learning and memory impairment. The positive 0.01, P < 0.05). The activated regions related with the
effect of BWS on rat learning and memory was change of MMSE were mainly inferior frontal gyrus,
associated with increase of spinal synapse density and middle frontal gyrus, superior frontal gyrus, transverse
protection of mitochondrial function of the pyramidal cell temporal gyrus, on the left cerebrum and superior
in hippocampal CA1 region from menopause-induced frontal gyrus, middle frontal gyrus, precentral gyrus,
injury. hippocampal gyrus, cingulate gyrus, postcentral gyrus,
paracentral lobule on the right cerebrum; those related
354- gera: 150998/co/ra with change of ADAS-Cog were superior frontal gyrus,
ACUPUNCTURE PROTECTED CEREBRAL MULTI- middle frontal gyrus, fusiform gyrus, inferior temporal
INFARCTION RATS FROM MEMORY IMPAIRMENT gyrus, hippocampal gyrus on the left cerebrum, and
BY REGULATING THE EXPRESSION OF superior frontal gyrus, middle frontal gyrus, precentral
APOPTOSIS RELATED GENES BCL-2 AND BAX IN gyrus, fusiform gyrus, transverse temporal gyrus,
HIPPOCAMPUS. WANG T, LIU CZ, YU JC, JIANG W, postcentral gyrus, middle occipital gyrus on the right
HAN JX. physiol behav. 2008;oct 9:x (eng). cerebrum. CONCLUSION: ATE could improve the
Vascular dementia (VaD) is the second most common cognitive ability of AD patients, its possible mechanism
cause of dementia in the world today. In this paper, we may be through the activation on the cognition related
observed the effect of acupuncture on memory regions of frontal,
impairment, apoptosis and expression of Bcl-2 and Bax
in hippocampus of cerebral multi-infarction rats. The 356- gera: 151105/di/ra
results indicated that acupuncture significantly improved FIGHTING WITH ALZHEIMER'S DISEASE AND
memory impairment induced by cerebral multi- KAMPO MEDICINE. ARAI H. kampo medicine.
infarction, as evaluated by shortened escape latency 2008;59(5):683 (jap).
and increased swimming time in the target quadrant. Alzheimer's disease (AD) research from 1984
Meanwhile, based on the observation in hippocampal disclosed that there is 10-20 years of time for transition
CA1 region through methods of the terminal from normal brain to Alzheimer's disease brain.
deoxynucleotidyl transferase nick end labeling Therefore, AD is a disease with long "Mibyo" phase.
(TUNEL), immunohistochemistry and in situ Since treat' men t effect in AD could be partial and
hybridization, acupuncture decreased the number of limited, we need to consider prevention or "Youjou" not
apoptotic cells and expression of the proapoptotic Bax to develop AD more seriously. Amyloid imaging with
gene, on the contrary, it increased expression of the PET can be promising in the visualization of amyloid
antiapoptotic gene Bcl-2. The result of the research burden or Mibyo state. Several medicinal herbs have a
suggested that acupuncture can exert antiapoptotic potent anti-amyloid aggregation effect as a new class of
effect through counter-regulating Bcl-2 and Bax gene disease.modifying drug. Yi-Gan-San which has been
expression. originally described in Ming dynasty in China is
efficacious in improving behavioral and psychological
355- gera: 151097/di/ra symptoms of dementia without developing falls or extra-
[CORRELATION ANALYSIS ON CHANGES pyramidal adverse effects. Multi-potent traditional
BETWEEN COGNITIVE ABILITY AND BRAIN FMRI medicine doctor with not only practicing traditional
AFTER ACUPOINT THREAD EMBEDDING IN medicine alone, but they can also get insights on
ALZHEIMER'S DISEASE PATIENTS]. ZHOU YL, HAN Western-medicine and collecting information from
HY, JIA JP. chinese journal of integrated traditional abroad is warranted.
and western medicine. 2008;28(8):689 (chi).
OBJECTIVE: To explore the mechanism of acupoint 357- gera: 152430/di/ra
thread embedding (ATE) in treating Alzheimer's disease PROTECTIVE EFFECTS AND MECHANISM OF
(AD) by means of brain functional magnetic resonance PUERARIN ON LEARNING-MEMORY DISORDER
imaging (fMRI). METHODS: Twenty-six patients with AFTER GLOBAL CEREBRAL ISCHEMIA-
mild to moderate AD were assigned to the tested group REPERFUSION INJURY IN RATS. WU HQ, GUO HN,
and the control group in pairing, 13 in each group. ATE WANG HQ, CHANG MZ, ZHANG GL, ZHAO YX.
was performed in patients of the tested group at chinese journal of integrative medicine.
Shenmen (HT7), Fenglong (ST40), Taixi (KI3) and 2009;15(1):54-9 (eng).
Zusanli (ST36) acupoints, once every month for 6 times OBJECTIVE: To observe the effect of puerarin on the
in total; but for patients of the control group only sham learning-memory disorder after global cerebral
operation was done at the same acupoints. The ischemia- reperfusion injury in rats, and to explore its
correlation between cognitive ability and fMRI were mechanism of action. METHODS: The global cerebral
assessed by comparing the scores of Mini-Mental State ischemia- reperfusion injury model was established
Examination (MMSE) and Alzhemer's Disease using the modifified Pulsinelli four-vessel occlusion in
Assessment Scale-Cognitive section (ADAS-Cog), Sprague-Dawley rats. Rats were intraperitoneally
monitored at two time points, namely, in one week injected with puerarin (100 mg/kg) 1 h before ischemia
before starting treatment and 1 week after terminating and once every 6 h afterwards. The learning-memory
6-month treatment. Furthermore, fMRI was detected to ability was evaluated by the passive avoidance test.
obtain the data of the cerebral blood oxygen content The dynamic changes of the cell counts of apoptosis
before treatment and 6 months after completing the 6- and positive expression of Bcl-2 in the hippocampus
month therapeutic course. Correlation analysis was CA1 region were determined by the TUNEL and
conducted on the obtained data using software SPM. immunohistochemical methods, respectively.
RESULTS: After treatment, changes of MMSE score RESULTS: (1) Compared with the reperfusion group,
significently increased in the test group (P < 0.01) and the step through latency (STL) in the passive avoidance
decreased in the control group (P < 0.01), and ADAS- test in the puerarin group was prolonged signifificantly
gera 2011
41
(P<0.01). (2) The apoptotic neurons were injured most with acupuncture for ADL, while the other failed to so.
severely on the 3rd day in the hippocampal CA1 region The meta-analysis of these data showed significant
after global ischemia and reperfusion. In the puerarin effects of drug therapy compared with acupuncture (n =
group, the number of apoptotic cells decreased at 72, WMD, - 1.29; 95% CIs: -1.77 to -0.80, p < 0.001,
respective time points after ischemia-reperfusion heterogeneity: tau(2) = 0, chi(2) = 0.17, p = 0.68, I(2) =
(P<0.01). (3) The level of positive expression of Bcl-2 0%). CONCLUSION: Even though the number of
varied according to the duration of reperfusion and the studies is small, the existing evidence does not
peak level occurred on day 1 in the hippocampal CA1 demonstrate the effectiveness of acupuncture for AD.
region after global cerebral ischemia. Compared with
the reperfusion group, the expression of Bcl-2 in the 361- gera: 153468/di/ra
puerarin group was up- regulated at the respective time [A STUDY OF THE EFFECT OF ACUPUNCTURE
points after ischemia reperfusion (P<0.01), reaching the PRETREATMENT ON LEARNING AND MEMORY
peak on day 1. CONCLUSIONS: Puerarin could ABILITIES IN VASCULAR DEMENTIA RATS]. MENG
improve the learning-memory ability after global PEI-YAN, SUN GUO-JIE,MAO JUAN-JUAN,. shanghai
cerebral ischemia and reperfusion in rats. The journal of acupuncture and moxibustion.
protective mechanism might be related to the effect of 2009;28(5):293 (chi).
inhibiting or delaying the cell apoptosis through up- To investigate the effects of electroacupuncture at
regulating the expression of Bcl-2 after ischemia and Baihui(GV20), Shenshu(BL23) and Housanli(ST36) on
reperfusion. learning and memory abilities in vascular dementia (VD)
rats. Methods SD rats were randomly allocated to
358- gera: 152685/di/ra normal, sham operation, model and electroacupuncture
EFFECTS OF ELECTROACUPUNCTURE ON THE pretreatment groups. A rat model of VD was made by a
ABILITY OF LEARNING AND MEMORY IN RATS modified thread- occlusion method. The effects of
WITH ISCHEMIA-REPERFUSION INJURY. GE LIN- electroacupuncture at Baihui(GVZO), Shenshu(BL23)
BAO. journal of acupuncture and tuina science. and Housanli(ST36) on Monis water maze learning and
2009;7(1):3-7 (eng). memorizing abilities were investigated in the VD rats.
Results The average escape latent period in a water
359- gera: 153071/di/ra maze test lengthened in the model group of rats and
[PROGRESS IN THE RESEARCH ON MULTI- had a statistically significant difference compared with
TARGET-DIRECTED DRUGS AGAINST the sham operation group (P< 0.01). The average
ALZHEIMER'S DISEASE]. LIU RT, LÜ QJ. yao xue escape latent period shortened in the
xue bao. 2009;44(3):258-63 (chi). electroacupuncture pretreatment group of rats and had
Alzheimer's disease (AD) is a chronic a statistically significant difference compared with the
neurodegenerative disorder and one of the earliest model group (P<0.01). There was a statistically
sings of AD is deficit in short term memory. Till now, the significant difference in the orientation navigation test
pathogenesis of AD has not been elucidated and the achievement between the electroacupuncture
present one-drug-one-target paradigm of anti-AD-drug pretreatment group and the model group (P<0.01).
treatment seems not to be effective in clinic. Multi-
target-directed anti-AD-drugs are those agents that may
act on two or more targets implicated in AD. Based on
the brief introduction of progress in the development of
present anti-AD-drugs, the paper mainly focused on the
advances in the field of multi-target- directed drug
development both home and abroad, especially those
studies on selective estrogen receptor
gera 2011
42
gera 2011
43
MING,ET AL¤ 244 , PETKOV VD¤ 8 ,
LI DONG-TENG YE MING-YUAN ¤ 174 , PETKOV VD ET AL¤ 42 ,
LI H, LI SL, GONG L, WANG JL, LI YZ, WU ZH¤ 353 , QIU HONG, JIN GUO-QIN, ZHAO WEI-KANG, ET AL¤
LI HAO, ET AL¤ 181 , 194 , 248 , 257 ,
LI JING-WEI ET AL¤ 44 , QUYANG QI ET AL¤ 88 ,
LI PING ET AL¤ 75 , REN Y, HOUGHTON P, HIDER RC¤ 314 ,
LI XI ET AL¤ 134 , 165 , 170 , REN YING, SONG CHONGSHUN, GUO JING, ET AL¤
LI YA MING ET AL¤ 120 , 265 ,
LI YAMING ET AL¤ 124 , RUCCI FS ET AL¤ 6 ,
LI YAPING BAI SHUFANG JING XIURONG ¤ 302 , SCHEID V¤ 219 ,
LI YONGJIAN¤ 34 , SEKI H¤ 4 ,
LIANG ZONGHAN¤ 49 , SHAO HONGQI ET AL¤ 17 ,
LILEI HE, BING YAN, CHUNZHI TANG, AND YING SHAO YING, LAI XIN-SHENG , GONG YU-ZHAO,ET
SHAO¤ 321 , EL¤ 340 ,
LIN CHEN¤ 23 , SHE JING¤ 32 ,
LIN HQ, HO MT, LAU LS, WONG KK, SHAW PC, SHEN MEI-HONG, LI ZHONG-REN, MU YAN-YUN,
WAN DC¤ 339 , ET AL¤ 198 ,
LIN SHUIMIAO ET AL¤ 52 , SHEN WEI-DONG ET AL¤ 110 ,
LIN SHUI-MIAO, WANG JIAN, ZHOU RU-QIAN, ET SHEN XIAOMING¤ 85 ,
AL¤ 247 , SHEN XIAOMING ET AL¤ 109 ,
LIU CZ, YU JC, CHENG HY, JIANG ZG, LI T, ZHANG SHEN ZI-YIN¤ 47 ,
XZ, ZHANG LL, HAN JX¤ 312 , SHEN ZI-YIN ET AL¤ 74 ,
LIU DE-HUAN, ET AL¤ 186 , SHER L¤ 81 ,
LIU G, YUAN LX¤ 297 , SHI JING ET AL ¤ 204 ,
LIU MENGYUAN, XIAO LIUYING, PAN JINGQIANG, SHI WEI-QING¤ 19 ,
ET AL¤ 251 , 277 , SHI ZHENGGANG¤ 230 , 242 ,
LIU MINGPING,HUANG ZHAOSHENG¤ 262 , SKOLNICK AA ¤ 76 ,
LIU RT, LÜ QJ¤ 359 , SONG LUO, SHU-GUANG YU, FANGZHENG LIAO,
LIU XUE-YUAN, ZHAO WEI-KANG, XU PIN-CHU, ET AND TING HAN¤ 320 ,
AL¤ 252 , SONG QIANLIU ET AL¤ 60 ,
LIU YI, WANG FAWEI, YANG MINGHUI, ET AL¤ 322 , SU ZHAOTIAN ET AL¤ 36 ,
LIU YI-FAN ¤ 173 , SUN QUAN, ET AL¤ 254 ,
LIU YONG-GI HE JIAN-CHENG ET AL¤ 275 , SUN YUN, DENG YANG-MEI, WANG DEJUN, ET AL¤
LIU YONGQI ET AL¤ 125 , 175 ,
LIU YONG-QI ET AL¤ 142 , TADANO TAKESHI ET AL¤ 79 ,
LIU ZHI-CHENG , WU ZHENG-ZHI, LI MING, ET AL¤ TAN BAOXUAN ET AL¤ 136 ,
281 , TIAN GUO-QING, GUO SAI-SHAN, LU HE-QI¤ 224 ,
LIU ZU-YI ET AL¤ 48 , 236 ,
LIU ZY ET AL¤ 46 , TIAN JINZHOU ET AL¤ 97 ,
LOU SHAO-LAI¤ 200 , TIAN JINZHOU, YIN JUNXIANG, LIU HUAN, ET AL¤
LU MING-CHIN¤ 78 , 214 ,
LU YW, LU MZ¤ 317 , TIAN KAIYU¤ 216 , 217 ,
MA BING-QUAN , TANG RONG-HUA¤ 332 , TOHDA C, NAITO R, JOYASHIKI E¤ 345 , 352 ,
MA KAN-WEN¤ 27 , TORIIZUKA K ET AL¤ 90 ,
MA TIAN CAI ET AL¤ 21 , TUSDA T ET AL¤ 55 ,
MA X, GANG DR¤ 337 , 349 , WANG CAIXIA ET AL¤ 86 ,
MANUCHARIAN GG ET AL¤ 31 , WANG HUAIXING ET AL¤ 114 ,
MAY BH, YANG AW, ZHANG AL, OWENS MD, WANG JIAN, LIN SHIMIAO, ZHOU RUQING, ET AL¤
BENNETT L, HEAD R, COBIAC 344 , 185 ,
ME NING, LIU LIN, ZHOU YAN-YAN, ET AL¤ 276 , WANG JIAN, LIN SHUI-MIAO, ZHOU RU-QIAN, ET
MENG PEI-YAN, SUN GUO-JIE,MAO JUAN-JUAN,¤ AL¤ 187 ,
361 , WANG LI¤ 203 ,
MILLEA PJ, REED BR¤ 293 , WANG LI, LAI XINSHENG, LEI WEIWEI¤ 208 , 215 ,
MO FEIZHI¤ 105 , WANG LI, TANG CHUNZHI¤ 223 , 235 , 282 ,
MO FEIZHI, LI JIANQIANG, LEI LIPING, ET AL¤ 159 , WANG LINJIANG ET AL¤ 87 ,
MORANDOTTI R¤ 89 , WANG PING, MA ZUO-FENG, LIU PING¤ 260 ,
MOSCA U ET AL¤ 84 , WANG RUI ET AL¤ 16 ,
MU JINGWEN ET AL¤ 189 , WANG SHAO JING , LI AI-YING, ZHANG XUE JING ¤
MU YANYUN ET AL¤ 148 , 286 ,
MU YY LI ZR SHENG MH ET AL¤ 228 , 240 , WANG SHAOJIN ET AL¤ 112 ,
MU YY, LI ZR, SHENG MH,AL¤ 270 , WANG SHAO-JIN, KANG SUO-BIN, LI AI-YING¤ 290 ,
NAGURA SHIGERU¤ 176 , WANG SJ ET AL¤ 207 ,
NGUYEN TRONG KHANH¤ 93 , WANG T, LIU CZ, YU JC, JIANG W, HAN JX¤ 351 ,
NIE CHUN¤ 138 , 354 ,
NISHIYAMA N ET AL¤ 57 , 58 , WANG T, YU JC, LIU CZ, ET AL¤ 315 ,
NOGIER¤ 1 , WANG YUAN-CHAO, ZHU LI-XIA, LIU ZHONG-WU,
OMURA Y¤ 2 , ET AL¤ 259 ,
OU YANG-QI ET AL¤ 126 , WANG ZHONG-LIN ET AL¤ 113 ,
OUYANG QI ET AL¤ 119 , 178 , WANGYAN WU, CUEN-HUA- DE¤ 350 ,
PENG KANG ET AL¤ 95 , WEI HUILI¤ 246 ,
gera 2010
44
WEI MEI-JUAN¤ 150 , ZHANG SL, YANG XJ, LIU TF, ET AL¤ 342 ,
WI ZM ET AL¤ 41 , ZHANG WEI, LIU LAI-HU, WEI PEI-FENG, ET AL¤
WU DINGZONG ET AL¤ 106 , 158 ,
WU DONG¤ 33 , ZHANG WEI-JUAN , AN YU-HUI, FANG NA¤ 289 ,
WU HQ, GUO HN, WANG HQ, CHANG MZ, ZHANG ZHANG XUE-CHAO ET AL¤ 141 ,
GL, ZHAO YX¤ 357 , ZHANG XUE-LING, DING XIN-SHENG, CHENG
WU HY, XU JP, LI L, ZHU BH¤ 308 , HONG, ET AL¤ 255 ,
WU WEIPING ET AL¤ 107 , 123 , 160 , ZHANG XUESHAO, LU MINGZHUANG, JIANG
WU YING-HONG, ET AL ¤ 292 , NAICHANG, E¤ 171 ,
WU ZHENGZHI ET AL¤ 96 , ZHANG XUEZHAO ET AL¤ 146 ,
WU ZHENG-ZHI, ET AL¤ 221 , 222 , 233 , 234 , ZHANG XUEZHAO, ET AL¤ 199 ,
WU ZHENGZHI, YOU LONGWU, LI MING, ET AL¤ ZHANG Y ET AL¤ 53 ,
274 , ZHANG YI, ZHANG SHENGLIN ¤ 271 ,
WU ZI-MING ET AL¤ 39 , ZHANG ZHIXIONG, YUAN SHUJUAN, WU
X¤ 99 , 210 , 288 , DINGZONG¤ 182 ,
XIE NING, ET AL¤ 299 , ZHAO CHANG-AN, LI EN ZHAO JING-SHAN¤ 195 ,
XING BIN, YAN QIANLIN¤ 226 , 238 , ZHAO FAN-GUI, WANG WEN-JUN, ZHOU WEN-
XU J ET AL¤ 127 , JIANG, ET AL¤ 335 ,
XU LIE-MING¤ 202 , ZHAO Jing-kun and WANG De-shen¤ 334 ,
XU QIUPING ET AL¤ 73 , ZHAO LI-GANG, MA LI, ZHENG ZU-YAN, ET AL¤ 305
XU SHIKAI ET AL¤ 22 , ,
XU YING' , ZHANG ZHI-XIONG' , SHEN RONG2 , ZHAO LING ET AL¤ 140 ,
YUAN SHU-JUAN2¤ 327 , ZHAO PUSHAN¤ 72 ,
XU YUN-XIANG, ZHANG JIA-WEI¤ 309 , ZHAO SHUMIN ET AL¤ 83 ,
YAN QIANLIN, XING BIN ¤ 266 , 268 , ZHIFAN C¤ 68 ,
YAN SHUXUN , ET AL¤ 250 , ZHOU DAN ET AL¤ 61 ,
YANG BAI-CHAN ET AL¤ 132 , ZHOU DA-XING ET AL¤ 38 ,
YANG JUN ET AL¤ 102 , 116 , ZHOU JIANYING, JIANG CHUNHUA, WANG
YANG WEN MING ET AL¤ 121 , MINGYAN¤ 253 ,
YANG XIAO-BO, KOU SUO-TANG, YANG XIAO-BIN , ZHOU JIEMING, LAI SHILONG, HU JINGQING, ET
ET AL¤ 326 , AL¤ 231 , 243 ,
YANG YU-FU, LU XIONG-WEN, MA CHUAN-GENG¤ ZHOU WEN-XIA, ZHANG YONG-XIANG¤ 190 ,
212 , ZHOU XIAOQING, LU WANGHUA LI HUA ET AL¤ 201
YANG ZQ, YANG SF, YANG JQ, ZHOU QX, LI SL¤ ,
328 , ZHOU XIAOQING, LU WANGHUA, LI HUA, ET AL¤
YAO FENGLI, ET AL¤ 273 , 211 ,
YAO SHAO-WU¤ 225 , 237 , ZHOU YL, HAN HY, JIA JP¤ 355 ,
YAO YUFANG¤ 111 , ZHOU YL, JIA JP¤ 333 ,
YIFANG TIAN¤ 331 , ZHOU ZHONGGUANG¤ 131 ,
YING SHAO, YANQIAN FU, LIHUA QIU, AND ZHOU ZL, LIANG LZ, YAN YX¤ 323 ,
CHUNZHI TANG¤ 338 , ZHU CHENG-QUAN, LI RUI, ZHOU LI-LIN, ET AL¤
YING-LIN C ET AL¤ 18 , 267 ,
YONG TANG ET AL¤ 330 , ZHU CUI-QING ET AL¤ 164 , 169 ,
YOU QIOUYUN, ET AL¤ 301 , ZHU KANG-MEI¤ 192 ,
YOU YANWEN, TIAN XINHONG¤ 264 , ZHU PEI-LI ET AL¤ 12 ,
YU JIAN-PING, ZHANG CHENG-WEI¤ 151 , ZHU XIAO DONG ET AL¤ 15 ,
YU SHU REN ET AL¤ 14 , ZHU ZHAO-GANG¤ 191 ,
YU XUE-RU¤ 261 , ZHU ZHIBO¤ 70 ,
YUAN CHEN¤ 35 ,
YUAN HONG WANG QING CUI XU, ET AL¤ 196 ,
YUAN LIREN¤ 43 ,
YUAN QUAN ET AL ¤ 278 ,
YUAN SHUJUAN, ZHANG ZHIXIONG, QIU HONG, ET
AL¤ 157 ,
YUE REN-SONG , CHEN ZHONG-YI¤ 285 ,
YUNG-HSIEN CHANG ET AL¤ 94 ,
ZENG YAN, LIANG XUN-CHANG, LI MAN, ET AL¤
295 ,
ZHANG JUEREN¤ 28 ,
ZHANG LEI ET AL¤ 9 , 13 ,
ZHANG MENG-REN, GUO SAI-SHAN, XU HUI-YUAN,
ET AL¤ 272 ,
ZHANG MING ET AL¤ 29 ,
ZHANG MING, ZHOU MIN,DING XIANG-DONG¤ 283 ,
ZHANG PING ¤ 172 ,
ZHANG QIGUI¤ 40 ,
ZHANG QIN YUAN ET AL¤ 118 ,
ZHANG SHAOYAN ET AL¤ 50 ,
ZHANG SHENGLIN XIN HUICHUEN GAO
BINGBING¤ 256 ,
gera 2010
45
5,10 -¤ ear acupuncture. auricular medicine/ 22,07 -¤ urologic and male genital diseases/
auriculopuncture. auriculomédecine appareil génital masculin
*¤ 141 , testostérone¤ 5 ,
gera 2010
46
26,03 -¤ plants/ plantes 301 , 304 ,
*¤ 5 , 8 , 9 , 18 , 20 , 21 , expérimentation animale (phytothérapie) / rat¤ 55 ,
acorus gramineus soland.¤ 38 , expérimentation animale (phytothérapie) / souris¤ 26 ,
coix¤ 26 , 38 , 56 , 57 , 58 , 64 ,
ginkgo biloba l.¤ 79 , revue générale¤ 82 , 87 , 125 , 133 ,
rheum¤ 80 ,
27,02 -¤ / techniques d'exploration
26,04 -¤ animal products/ produits animaux EEG¤ 31 ,
*¤ 107 , rhéoencéphalogramme¤ 31 ,
gera 2010
47
276 , 281 , 300 ,
Index des sources chinese journal of traditional medical science and
technology (¤ 155 , 156 ,
1 - divers à vérifier
chinese traditional and herbal drugs¤ 21 , 38 , 60 , 61 ,
chinese journal of integrated traditional and western
chinese traditional patent medicine¤ 59 , 67 , 142 , 154
medicine¤ 318 ,
, 174 , 180 , 275 ,
chineses archives of tcm¤ 210 ,
2 - extraits de traités
chinesetraditional and herbal drugs¤ 138 ,
in chinese acupuncture and moxibustion, foreign
eastwest integration medicine¤ 331 ,
languages press, *¤ 10 ,
forum on tcm¤ 145 ,
fujian journal of tcm¤ 227 , 239 ,
3 - revues d'acupuncture et MTC
guang ming journal of tcm¤ 283 ,
academic periodical of changchun college of tcm¤ 278
henan journal of traditional chinese medicine and
,
pharmacy¤ 172 ,
acta chinese medicine and pharmacology¤ 131 ,
history of chinese philosophy¤ 143 ,
acta medica sinica¤ 22 ,
hubei journal of tcm¤ 250 , 301 ,
acta pharmaceutica sinica¤ 64 ,
hunan journal of tcm¤ 179 ,
acta universitatis traditionis medicalis sinensis information on traditional chinese medicine¤ 189 , 204 ,
pharmacologiaeque shanghai¤ 213 ,
inner mongol journal of tcm¤ 302 ,
acupuncture and electrotherapeutics research¤ 2 , 4 ,
international journal of clinical acupuncture¤ 30 , 147 ,
acupuncture research¤ 25 , 85 , 99 , 100 , 101 , 112 ,
310 , 313 , 320 , 321 , 338 ,
130 , 146 , 182 , 259 , 269 , 290 , 291 , 295 , 305 , 309 ,
j ethnopharmacol¤ 324 , 353 ,
326 , 329 , 340 ,
jiangsu journal of tcm¤ 70 , 226 , 238 ,
agopunctura e tecniche di terapia antalgica¤ 6 ,
jiangsu journal of traditional chinese medicine¤ 34 ,
american journal of chinese medicine¤ 8 , 63 , 78 , 79 ,
157 ,
92 , 94 , 298 , 304 ,
journal journal of anhui traditional chinese medical
auriculomedecine¤ 1 ,
college¤ 184 ,
beijing journal of traditional chinese medicine¤ 32 , 33 ,
journal of acupuncture and tuina science¤ 358 ,
35 , 36 , 40 , 43 , 49 , 50 ,
journal of alternative and complementary medicine¤
biogerontology¤ 344 ,
316 , 330 ,
bmc complement altern med¤ 345 , 352 ,
journal of anhui traditional chinese medical college¤
breath exercise (an exercise for health and longevity)¤
122 , 161 , 166 , 212 , 267 ,
11 , 12 ,
journal of anhui traditional chinese medical colllege¤
chem biol interact¤ 339 ,
151 ,
chin j integr med¤ 328 ,
journal of beijing college of traditional chinese
china journal of chinese materia medica¤ 26 , 56 , 66 ,
medicine¤ 23 ,
69 ,
journal of beijing university of tcm¤ 73 , 75 , 97 , 140 ,
china journal of traditional chinese medicine and
265 ,
pharmacy¤ 96 , 165 , 170 ,
journal of beijing university of traditional chinese
chinese acupuncture and moxibustion¤ 37 , 88 , 108 ,
medicine¤ 83 , 185 ,
109 , 111 , 171 , 208 , 215 , 216 , 217 , 297 , 317 , 333 ,
journal of cervicodynia and lumbodynia¤ 244 ,
chinese archives of tcm¤ 299 ,
journal of chengdu university of tcm¤ 284 , 285 ,
chinese journal of basic medicine in tcm¤ 260 , 263 ,
journal of chengdu university of traditional chinese
279 ,
medicine¤ 158 ,
chinese journal of basic medicine in traditional chinese
journal of chinese medicine¤ 45 ,
medicine¤ 177 , 194 , 195 , 196 , 197 ,
journal of clinical acupuncture and moxibustion¤ 350 ,
chinese journal of information on tcm¤ 103 , chinese
journal of emergency in tcm¤ 273 ,
journal of information on tcm¤ 116 , 128 , 292 ,
journal of external therapy of traditional chinese
chinese journal of information on traditional chinese
medicine¤ 164 , 169 , 193 ,
medicine¤ 181 ,
journal of fujian college of tcm¤ 245 ,
chinese journal of integrated traditional and western
journal of gansu college of tcm¤ 124 , 125 , 230 , 242 ,
medicine¤ 334 ,
journal of henan university of chinese medicine¤ 264 ,
chinese journal of integrated traditional and western
journal of hunan college of tcm¤ 211 ,
medicine¤ 272 ,
journal of hunan college of traditional chinese
chinese journal of integrated traditional and western
medicine¤ 201 ,
medecine¤ 9 ,
journal of nanjing university of tcm¤ 286 , 287 ,
chinese journal of integrated traditional and western
journal of nanjing university of traditional chinese
medicine¤ 5 , 13 , 39 , 41 , 46 , 47 , 48 , 51 , 65 , 74 ,
medicine¤ 198 ,
82 , 114 , 115 , 190 , 205 , 209 , 224 , 236 , 247 , 248 ,
journal of nanjing university of traditional chinese
249 , 323 , 335 , 342 , 355 ,
medicine (natural science)¤ 178 ,
chinese journal of integrated traditional and western
journal of nanjing university tcm¤ 113 , 119 ,
medicine (english edition)¤ 175 ,
journal of shandong university of tcm¤ 117 , 118 , 144 ,
chinese journal of integrative medicine¤ 257 , 307 , 308
journal of tcm¤ 24 , 62 , 95 , 104 , 123 , 214 , 223 , 235
, 357 ,
, 251 , 266 , 268 , 277 , 282 ,
chinese journal of integrative medicine on cardio-
journal of tcm (english edition)¤ 160 ,
/cerebrovascular disease¤ 256 , 271 , 274 ,
journal of traditional chinese medicine¤ 107 , 159 , 322
chinese journal of medical history¤ 27 , 44 , 68 , 72 ,
,
chinese journal of traditional medical science and
journal of traditional medical science and technology¤
technology¤ 120 , 121 , 134 , 186 , chinese journal of
220 , 221 , 222 , 232 , 233 , 234 ,
traditional medical science and technology¤ 254 , 258 ,
journal of zhejiang college of tcm¤ 129 , 303 ,
gera 2010
48
journal of zhejiang college traditional chinese tianjin journal of tcm¤ 296 ,
medicine¤ 206 , traditional chinese drug research and clinical
kampo medicine¤ 356 , pharmacology¤ 102 , 136 , 137 , 162 , 163 , 167 , 168 ,
khoe newsletter¤ 3 , 231 , 243 , 253 , 280 ,
knowledge ancient medical literature¤ 225 , 237 , traditional chinese medicinal research¤ 152 , 153 , 262
knowledge of ancient medical literature¤ 191 , 192 , ,
200 , 202 , 261 , word journal of acupuncture-moxibustion¤ 105 , 106 ,
liaoning journal of tcm¤ 87 , 135 , 229 , 241 , world journal of acupuncture moxibustion¤ 332 ,
liaoning journal of traditional chinese medicine¤ 28 , 86 world journal of acupuncture-moxibustion¤ 176 , 199 ,
, 188 , yao xue xue bao¤ 359 ,
med sport sci¤ 348 , yunnan journal of tcm and materia medica¤ 149 ,
medical acupuncture¤ 91 , 293 ,
medicina tradicional¤ 288 , 294 , 4 - revues extérieures
modern journal of integrated traditional chinese and acta pharmacologica sinica¤ 14 , 15 ,
western medicine ¤ 252 , 255 , acupuncture electrotherapeutic research¤ 90 ,
mtc et acupuncture¤ 7 , biol pharm bull¤ 53 , 54 , 57 , 58 ,
neurol res¤ 207 , chinese pharmaceutical bulletin¤ 16 ,
neurosci lett¤ 346 , chinese traditional and herbal drugs¤ 18 , 20 ,
new journal of traditional chinese medicine¤ 203 , eur j pharmacol¤ 311 ,
physiol behav¤ 354 , experimental neurology¤ 312 ,
phytochemistry¤ 337 , 349 , int j clin pract¤ 360 ,
phytother res¤ 325 , j biol chem¤ 139 ,
qi-gong (an exercice for health and longevity)¤ 19 , j ethnopharmacol¤ 55 , 71 , 77 , 127 ,
qigong journal¤ 98 , j pharm pharmacol¤ 314 ,
revue francaise medecine traditionnelle chinoise¤ 93 , jama¤ 76 ,
rivista italiana di agopuntura¤ 84 , 89 , med hypotheses¤ 81 ,
rivista italiana di medicina tradizionale cinese¤ 80 , neurosci lett¤ 347 ,
shaanxi journal of tcm¤ 246 , physiol behav¤ 351 ,
shandong journal of tcm¤ 289 , planta med¤ 42 ,
shandong journal of traditional chinese medicine¤ 17 , zh nevropatol psikhiatr¤ 31 ,
173 ,
shanghai journal of acupuncture and moxibustion¤ 110 5 - tirés- à- part ou manscrits non publiés
, 126 , 141 , 148 , 228 , 240 , 270 , 306 , 315 , 319 , 327 taiwanese journal for studies of science, technology,
, 361 , and medicine¤ 219 ,
shanghai journal of tcm¤ 132 , 133 , 183 ,
shanghai journal of traditional chinese medicine¤ 29 , 6 - traités
52 , 150 , 187 , miraguano s a ediciones, madrid¤ 218 ,
the american journal of chinese medicine¤ 336 , 341 ,
343 ,
gera 2010