BAI THUC HANH SO 12

1. MO TA BO SO LIEU

Cau 1.1. Luu ket qua phan tich vao tep Gout.log

C1.2. Mo ta bo so lieu Gout.dta, xd so luong truong, ban ghi

des

Ket qua: So luong truong=46 So luong ban ghi=483

Cau 1.3. Dem, liet ke ho ten, tuoi, gioi cua nhung bn nam tren 45 tuoi

count if a4==1 & a6>45

list a3 a6 a4 if a4==1 & a6>45

Ket qua: 135 doi tuong thoa man dieu kien

C1.4. Dem va liet ke t.tin bn co xh con dau Gout trong 6th gan day

list if b1==1

count if b1==1

Ket qua: 459 doi tuong thoa man dieu kien

C1.5. Dem va liet ke thong tin cua nhung benh nhan tren 45 tuoi xuat hien con dau
Gout trong 6 thang gan day co chi so Uric > 340.

count if a6>45 & b1==1 & c24>340

list if a6>45 & b1==1 & c24>340

KET QUA: So luong = 124

2. TAO BIEN MOI

Cau 2.1. Tao bien NT (nhom tuoi) biet rang neu benh nhan duoi 45 tuoi thi nhom tuoi
=1, nguoc lai nhom tuoi =2.

recode a6 (min/44=1 "Duoi 45") (45/max=2 "Tu 45t tro len"),gen(nt) label(Nhom_tuoi)
tab1 nt

Nhom tuoi So luong Ty le

Duoi 45 tuoi 221 45.76

Tu 45 tuoi tro len 262 54.24

Tong 483 100.00

Cau 2.2. Tao bien BEOPHI (beo phi) theo bang phan loai beo - gay cua to chuc y te the
gioi (WHO), sau do dien thong tin tinh duoc vao bang duoi day:

Phan loai BMI (kg/m2) - WHO Ket qua thong ke

So luong Ty le %

Can nang thap (gay) <18,5 82 17.8

Binh thuong 18,5 - 24,9 164 35.6

Thua can >=25 214=108+67+31+8 46.3

Tien beo phi 25 - 29,9 108 23.4

Beo phi do I 30 - 34,9 67 14.5

Beo phi do II 35 - 39,9 31 6.7

Beo phi do III >=40 8 1.7

recode b63 (40/max=6 "Beo phi do 3") (35/40=5 "Beo phi do 2") (30/35=4 "Beo phi do
1") (25/30=3 "Tien beo phi") (18.5/25=2 "Binh thuong") (min/18.5=1 "Can nang thap
(gay)"), gen(plbmi) label(Phan_loai_BMI)

tab1 plbmi

Cau 2.3. Tao bien TD (nguy co tieu duong) dua tren nghiem phap dung nap glucose
biet rang nguoi binh thuong co chi so glucose duoi 7.8mmol/l; nguoi tien tieu duong co
chi so tu 7.8 den 11.1 mmol/l, nguoi bi tieu duong neu chi so glucose tren 11.1 mmol/l
cho trong bang sau:
Thong ke ty le tieu duong theo gioi tinh benh nhan

Gioi Nam Nu

Tieu duong So luong Ty le So luong Ty le

Bi tieu duong 0 0 0 0

Tien tieu duong 61 23.28 54 24.43

Binh thuong 201 76.72 167 75.57

recode c21 (7.8/11.1=2 "Tien tieu duong") (11.1/max=1 "Bi tieu duong") (min/7.8=3
"Binh thuong"), gen(td) label(Nguy_co_tieu_duong)

tab2 td a4, col

Cau 2.4. Tao bien GOUT biet nguoi bi Gout neu chi so URIC cao hon gioi han binh
thuong sau do dien thong tin vao bang sau:

gen byte gout=0

replace gout=1 if (c24>420 & a4==1) | (c24>360 & a4==2)

label define gout_lbl 1 "Bi gout" 0 "Binh thuong"

label value gout gout_lbl

tab2 gout a4, column

Gioi Nam Nu

GOUT So luong Ty le So luong Ty le

Bi gout 133 50.76 75 33.94

Binh thuong 129 49.24 146 66.06

Cau 2.5. Tao bien NCTB (nguy co tai bien) biet rang nhung nguoi tren 45 tuoi ma bi
beo phi hoac co uong ruou hoac co su dung thuoc la thi co nguy co tai bien, nguoc lai la
khong co nguy co tai bien.

gen byte nctb=0

replace nctb=1 if a6>45 & (plbmi>=4 | b61==1 | b62 ==1)

tab2 nctb a4, column

label variable nctb "nguy co tai bien"

label define nctb_lbl 0 "Khong co nguy co" 1 "co nguy co tai bien"

label value nctb nctb_lbl

Gioi Nam Nu

Nguy co tai bien So luong Ty le So luong Ty le

Co nguy co 102 38.93 95 42.99

Khong co nguy co 160 61.07 126 57.01

3. THONG KE MO TA BO SO LIEU

3.1. Tinh do tuoi trung binh trong nghien cuu va tra loi cau hoi:

sum a6

Ket qua: Do tuoi trung binh = 45.86 Do tuoi lon nhat=64

3.2. Thong ke mo ta ket qua xet nghiem mau cua nhung benh nhan nam tren 45 tuoi

sum c21 c22 c23 c24 c25 if a4==1 & a6>45,d

Chi so xet nghiem Mean SD Min Max Median Variance

Glucose 5.83 1.8 3.2 9 5.5 3.24

SGOT 30.69 13.998 8.1 56 29.8 195.96

SGPT 28.88 15.71 4.1 55.7 28.5 246.95

URIC 402.56 145.09 157 648 403 21050

Ure 5.66 2.53 1 9.9 5.8 6.38

3.3. Thong ke ty le gioi tinh trong nghien cuu

tab1 a4
Ket qua

Gioi tinh N % Cum

Nam 262 54.24 54.24

Nu 221 45.76 100.00

Tong 483 100.00

3.3. Thong ke thoi diem xuat hien con dau Gout cua nhung benh nhan tren 45 tuoi co
xuat hien con dau Gout cap tinh trong 6 thang gan day.

tab1 b2 if a6>45 & b1==1

ket qua:

Thoi diem xuat hien con dau N %

Ban ngay 89 38.36

Ban dem 73 69.3

Khong biet 70 30.17

3.4. Thong ke vi tri xuat hien con dau Gout cua nhung benh nhan tren 45 tuoi co xuat
hien con dau Gout cap tinh trong 6 thang gan day.

mrtab b31 b32 b33 b34 if a6>45 & b1==1,name(b3n)

Ket qua:

Vi tri N % responses %case Cum

Khop ban ngon chan cai 107 23.16 48.64

Khop co chan 110 23.81 50.00

Khop goi 125 27.06 56.82

Khop khuyu 120 25.97 54.55

Tong 462 100.0 210.0

3.5. Thong ke vi tri xuat hien co dau theo nghe nghiep cua benh nhan (ty le % theo
tong)

mrtab b31 b32 b33 b34, by(a11) cell

ket qua

Nghe nghiep Lao dong tay chan L.dong tri oc Tong

Vi tri SL Ty le SL Ty le SL Ty le

Khop ban ngon chan cai 99 22.97 119 27.61 218 50.58

Khop co chan 108 25.06 121 28.07 229 53.13

Khop goi 116 26.91 133 30.86 249 57.77

Khop khuyu 119 27.61 118 27.38 237 54.99

Tong 442 102.55 491 113.92 933 216.47

valid case 431

3.6. Thong ke cac bieu hien o khop khi xuat hien co dau Gout cua nhung benh nhan
xuat hien viem tai khop ban ngon chan cai.

mrtab b41 b42 b43 b44 if b31==1

Bieu hien viem So luong Ty le% responses %cases Ty le cong don

Sung 103 25.69 51.24

Nong 93 23.19 46.27

Do 105 26.18 52.24

Bam tim 100 24.94 49.75

3.7. Danh gia cac yeu to thuan loi xuat hien con dau Gout cua nhung nguoi co chi so
URIC trong gioi han binh thuong va nhung nguoi co chi so URIC tren gioi han binh
thuong.

gen byte pluric=0

replace pluric=1 if (a4==1 & c24<=180 & c24<=420) | (a4==2 & c24<=150 &
c24<=360)

mrtab b51 b52 b53 b54, by(pluric) column

Yeu to thuan loi URIC trong gioi han URIC ngoai gioi han Tong

SL Ty le SL Ty le SL Ty le

Bua an nhieu ruou thit 207 48.94 18 48.65 225 48.91

Stress 227 53.66 16 43.24 243 52.83

Nhiem trung 218 51.54 22 59.46 240 52.17

Khong biet 47 11.11 6 16.22 53 11.52

Tong 699 165.25 62 167.57 761 165.43

cases 460

3.8. Thong ke mo ta (gia tri trung binh, do lech chuan, gia tri trung vi) cac chi so xet
nghiem theo gioi tinh va nghe nghiep cua benh nhan duoc chi dinh xet nghiem mau

Cach 1

tabstat c21 c22 c23 c24 c25,stat(mean median sd) by(a4)

tabstat c21 c22 c23 c24 c25,stat(mean median sd) by(a11)

Cach 2

table a4 a11,content(mean c21 median c21 mean c22 median c22 mean c23)

table a4 a11,content(median c23 mean c24 median c24 mean c25 median c25)
3.9. Thong ke mo ta (gia tri trung binh, do lech chuan, khoang tin cay 95%) cua huyet
ap toi da, huyet ap toi thieu cua benh nhan nam va benh nhan nu trong nghien cuu.

tabstat b641 b642,stat(mean median) by(a4)

Huyet ap Huyet ap toi da Huyet ap toi thieu

Gioi tinh Trung binh Trung vi Trung binh Trung vi

Nam 115.04 116 76.61 74

Nu 114.40 111 74.48 74

Tong 114.75 114 74.01 74

mci= (mean +/- 1.96*sqrt(sd/n) = 95% Confidence Interval)

4. Thong ke suy luan

4.1. Kiem dinh xem co su khac biet ve do tuoi trung binh cua nhung nguoi mac Gout
(chi so URIC cao hon gioi han binh thuong) va nhung nguoi khong mac Gout hay
khong va tra loi cau hoi:

sktest a6

- Kiem dinh phan phoi chuan cua bien tuoi:

p-value (sktest): 0.000 Ket luan: khong phan phoi chuan

ranksum a6, by(gout)

- Kiem dinh su khac biet ve tuoi TB giua nguoi mac va khong mac Gout.

p-value = 0.6949 Ket luan: Khong co y nghia thong ke

4.2. Kiem dinh xem co su khac biet ve chi so URIC cua nam gioi va nu gioi tren 45 tuoi
hay khong va tra loi cau hoi:

sktest c24 if a6>45

- Kiem dinh phan phoi chuan cua bien URIC:

p-value (sktest): 0.000 Ket luan: khong chuan

ranksum c24 if a6>45, by(a4)

- Kiem dinh su khac biet ve chi so URIC cua nam va nu tren 45 tuoi:

p-value = 0.000 Ket luan: Co y nghia thong ke

4.3. Trong mot nghien cuu ve chi so URIC trong nam 2000 cua nhung benh nhan nam
tren 45 tuoi thay chi so URIC trung binh cua ho la 540. Kiem dinh xem co su khac biet
ve chi so URIC trung binh cua nhung benh nhan nam tren 45 tuoi trong nghien cuu nay
voi chi so URIC trong nghien cuu nam 2000 khong. Tra loi cau hoi sau:

signtest c24=540 if a6>45

p-value = 0.000 Ket luan: co y nghia thong ke

4.4. Kiem dinh xem co su khac biet ve nguy co tai bien giua nam va nu hay khong?

tab2 nctb a4,expected

tab2 nctb a4,chi2

p-value = 0.366 Ket luan: Khong co y nghia thong ke

4.6. Kiem dinh xem co su khac biet ve muc do tieu duong cua nhung nguoi co uong
ruou va khong uong ruou hay khong?

tab2 td b61, expected

tab2 td b61 , chi2

p-value = 0.622 Ket luan: Khong co y nghia thong ke

4.7. Kiem dinh xem co su khac biet ve luong ruou uong trung binh giua nhung nguoi co
chi so URIC trong gioi han va nhung nguoi co chi so URIC tren gioi han hay khong?

sktest b611 khong phan phoi chuan

ranksum b611, by(pluric)

p-value = 0.9567 Ket luan: Khong co y nghia thong ke

4.8. Kiem dinh xem co su khac biet ve muc do beo phi cua nhung nguoi mac va khong
mac tieu duong hay khong?

recode td (1/2=1 "Mac Tieu duong") (3=0 "Khong mac tieu duong"),gen(pltd)
label(phan_loai_tieu_duong)

tab2 plbmi pltd if plbmi>2, expected

tab2 plbmi pltd if plbmi>2, chi2

p-value = 0.383 Ket luan: Khong co y nghia thong ke

/* -------------------5. Tinh tuong quan -----------------*/

5.1. Xac dinh moi tuong quan giua huyet ap toi da TB va huyet ap toi thieu TB bang
cach ve bieu do tuong quan va tinh he so tuong quan. Sau do tra loi cau hoi:

corr b641 b642

scatter b641 b642 cach 1

twoway scatter b641 b642 cach 2

He so tuong quan = -0.0839 Ket luan: Khong tuong quan

5.2. Xac dinh moi tuong quan giua ruou va chi so men gan (SGPT) trong nghien cuu
cua nhung benh nhan nam hien tai dang uong ruou va dua ra ket luan:
corr b611 c23 if b61==1

He so tuong quan = -0.0142 Ket luan: Khong tuong quan

5.3. Xac dinh moi tuong quan giua chi so SGOT va SGPT cua nhung benh nhan tren 45
tuoi trong nghien cuu

corr c22 c23 if a6>45

He so tuong quan = 0.1644 Ket luan: Khong tuong quan